The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"TolB, C-terminal domain
".
FunFam 8: Low-density lipoprotein receptor-related protein 4
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 32 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
14 |
A2ARV4 (/IPI)
C0HL13 (/IPI)
O75096 (/IPI)
O75096 (/IPI)
O75096 (/IPI)
P98158 (/IPI)
P98164 (/IPI)
Q7Z5C0 (/IPI)
Q8VI56 (/IPI)
Q8VI56 (/IPI)
(4 more) |
Receptor tyrosine kinase binding GO:0030971
Interacting selectively and non-covalently with a receptor that possesses protein tyrosine kinase activity.
|
12 |
H2Q3I3 (/ISS)
H2Q3I3 (/ISS)
H2Q3I3 (/ISS)
H9FUD8 (/ISS)
H9FUD8 (/ISS)
H9FUD8 (/ISS)
O75096 (/ISS)
O75096 (/ISS)
O75096 (/ISS)
Q9QYP1 (/ISS)
(2 more) |
Scaffold protein binding GO:0097110
Interacting selectively and non-covalently with a scaffold protein. Scaffold proteins are crucial regulators of many key signaling pathways. Although not strictly defined in function, they are known to interact and/or bind with multiple members of a signaling pathway, tethering them into complexes.
|
12 |
H2Q3I3 (/ISS)
H2Q3I3 (/ISS)
H2Q3I3 (/ISS)
H9FUD8 (/ISS)
H9FUD8 (/ISS)
H9FUD8 (/ISS)
O75096 (/ISS)
O75096 (/ISS)
O75096 (/ISS)
Q8VI56 (/ISS)
(2 more) |
Receptor tyrosine kinase binding GO:0030971
Interacting selectively and non-covalently with a receptor that possesses protein tyrosine kinase activity.
|
6 | Q8VI56 (/IPI) Q8VI56 (/IPI) Q8VI56 (/IPI) Q9QYP1 (/IPI) Q9QYP1 (/IPI) Q9QYP1 (/IPI) |
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
|
3 | A2ARV4 (/ISS) C0HL13 (/ISS) P98158 (/ISS) |
Drug binding GO:0008144
Interacting selectively and non-covalently with a drug, any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease.
|
3 | A2ARV4 (/ISS) C0HL13 (/ISS) P98164 (/ISS) |
Receptor tyrosine kinase binding GO:0030971
Interacting selectively and non-covalently with a receptor that possesses protein tyrosine kinase activity.
|
3 | Q8VI56 (/ISO) Q8VI56 (/ISO) Q8VI56 (/ISO) |
Apolipoprotein binding GO:0034185
Interacting selectively and non-covalently with an apolipoprotein, the protein component of a lipoprotein complex.
|
3 | Q9QYP1 (/IPI) Q9QYP1 (/IPI) Q9QYP1 (/IPI) |
Apolipoprotein binding GO:0034185
Interacting selectively and non-covalently with an apolipoprotein, the protein component of a lipoprotein complex.
|
3 | Q8VI56 (/ISO) Q8VI56 (/ISO) Q8VI56 (/ISO) |
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
|
3 | Q8VI56 (/IDA) Q8VI56 (/IDA) Q8VI56 (/IDA) |
Showing 1 to 10 of 32 entries
There are 127 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Dendrite morphogenesis GO:0048813
The process in which the anatomical structures of a dendrite are generated and organized.
|
12 |
H2Q3I3 (/ISS)
H2Q3I3 (/ISS)
H2Q3I3 (/ISS)
H9FUD8 (/ISS)
H9FUD8 (/ISS)
H9FUD8 (/ISS)
O75096 (/ISS)
O75096 (/ISS)
O75096 (/ISS)
Q8VI56 (/ISS)
(2 more) |
Negative regulation of axonogenesis GO:0050771
Any process that stops, prevents, or reduces the frequency, rate or extent of axonogenesis.
|
12 |
H2Q3I3 (/ISS)
H2Q3I3 (/ISS)
H2Q3I3 (/ISS)
H9FUD8 (/ISS)
H9FUD8 (/ISS)
H9FUD8 (/ISS)
O75096 (/ISS)
O75096 (/ISS)
O75096 (/ISS)
Q9QYP1 (/ISS)
(2 more) |
Synapse organization GO:0050808
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell).
|
12 |
H2Q3I3 (/ISS)
H2Q3I3 (/ISS)
H2Q3I3 (/ISS)
H9FUD8 (/ISS)
H9FUD8 (/ISS)
H9FUD8 (/ISS)
O75096 (/ISS)
O75096 (/ISS)
O75096 (/ISS)
Q8VI56 (/ISS)
(2 more) |
Synaptic growth at neuromuscular junction GO:0051124
The growth of a synapse at a neuromuscular junction, the site of apposition of a motor end plate and the subneural cleft of the skeletal muscle fiber that it innervates.
|
12 |
H2Q3I3 (/ISS)
H2Q3I3 (/ISS)
H2Q3I3 (/ISS)
H9FUD8 (/ISS)
H9FUD8 (/ISS)
H9FUD8 (/ISS)
O75096 (/ISS)
O75096 (/ISS)
O75096 (/ISS)
Q9QYP1 (/ISS)
(2 more) |
Protein heterotetramerization GO:0051290
The formation of a protein heterotetramer, a macromolecular structure consisting of four noncovalently associated subunits, of which not all are identical.
|
12 |
H2Q3I3 (/ISS)
H2Q3I3 (/ISS)
H2Q3I3 (/ISS)
H9FUD8 (/ISS)
H9FUD8 (/ISS)
H9FUD8 (/ISS)
O75096 (/ISS)
O75096 (/ISS)
O75096 (/ISS)
Q8VI56 (/ISS)
(2 more) |
Skeletal muscle acetylcholine-gated channel clustering GO:0071340
The accumulation of acetylcholine-gated cation channels in a narrow, central region of muscle fibers, in apposition to nerve terminals.
|
12 |
H2Q3I3 (/ISS)
H2Q3I3 (/ISS)
H2Q3I3 (/ISS)
H9FUD8 (/ISS)
H9FUD8 (/ISS)
H9FUD8 (/ISS)
O75096 (/ISS)
O75096 (/ISS)
O75096 (/ISS)
Q9QYP1 (/ISS)
(2 more) |
Postsynaptic membrane assembly GO:0097104
The aggregation, arrangement and bonding together of a set of components to form a postsynaptic membrane, a specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft).
|
12 |
H2Q3I3 (/ISS)
H2Q3I3 (/ISS)
H2Q3I3 (/ISS)
H9FUD8 (/ISS)
H9FUD8 (/ISS)
H9FUD8 (/ISS)
O75096 (/ISS)
O75096 (/ISS)
O75096 (/ISS)
Q9QYP1 (/ISS)
(2 more) |
Presynaptic membrane assembly GO:0097105
The aggregation, arrangement and bonding together of a set of components to form a presynaptic membrane, including any proteins associated with the membrane, but excluding other cellular components. A presynaptic membrane is a specialized area of membrane of the axon terminal that faces the plasma membrane of the neuron or muscle fiber with which the axon terminal establishes a synaptic junction.
|
12 |
H2Q3I3 (/ISS)
H2Q3I3 (/ISS)
H2Q3I3 (/ISS)
H9FUD8 (/ISS)
H9FUD8 (/ISS)
H9FUD8 (/ISS)
O75096 (/ISS)
O75096 (/ISS)
O75096 (/ISS)
Q9QYP1 (/ISS)
(2 more) |
Positive regulation of presynaptic membrane organization GO:1901631
Any process that activates or increases the frequency, rate or extent of presynaptic membrane organization.
|
12 |
H2Q3I3 (/ISS)
H2Q3I3 (/ISS)
H2Q3I3 (/ISS)
H9FUD8 (/ISS)
H9FUD8 (/ISS)
H9FUD8 (/ISS)
O75096 (/ISS)
O75096 (/ISS)
O75096 (/ISS)
Q9QYP1 (/ISS)
(2 more) |
Negative regulation of canonical Wnt signaling pathway GO:0090090
Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes.
|
6 | O75096 (/IDA) O75096 (/IDA) O75096 (/IDA) Q8VI56 (/IDA) Q8VI56 (/IDA) Q8VI56 (/IDA) |
Showing 1 to 10 of 127 entries
There are 64 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Dendrite GO:0030425
A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
|
15 |
C0HL13 (/ISS)
H2Q3I3 (/ISS)
H2Q3I3 (/ISS)
H2Q3I3 (/ISS)
H9FUD8 (/ISS)
H9FUD8 (/ISS)
H9FUD8 (/ISS)
O75096 (/ISS)
O75096 (/ISS)
O75096 (/ISS)
(5 more) |
Synaptic membrane GO:0097060
A specialized area of membrane on either the presynaptic or the postsynaptic side of a synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell.
|
13 |
H2Q3I3 (/ISS)
H2Q3I3 (/ISS)
H2Q3I3 (/ISS)
H9FUD8 (/ISS)
H9FUD8 (/ISS)
H9FUD8 (/ISS)
O75096 (/ISS)
O75096 (/ISS)
O75096 (/ISS)
Q8VI56 (/ISS)
(3 more) |
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
|
12 |
H2Q3I3 (/ISS)
H2Q3I3 (/ISS)
H2Q3I3 (/ISS)
H9FUD8 (/ISS)
H9FUD8 (/ISS)
H9FUD8 (/ISS)
O75096 (/ISS)
O75096 (/ISS)
O75096 (/ISS)
Q8VI56 (/ISS)
(2 more) |
Postsynaptic density GO:0014069
An electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymmetric, neuron-neuron synapse. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components.
|
12 |
H2Q3I3 (/ISS)
H2Q3I3 (/ISS)
H2Q3I3 (/ISS)
H9FUD8 (/ISS)
H9FUD8 (/ISS)
H9FUD8 (/ISS)
O75096 (/ISS)
O75096 (/ISS)
O75096 (/ISS)
Q8VI56 (/ISS)
(2 more) |
Neuromuscular junction GO:0031594
The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential.
|
12 |
H2Q3I3 (/ISS)
H2Q3I3 (/ISS)
H2Q3I3 (/ISS)
H9FUD8 (/ISS)
H9FUD8 (/ISS)
H9FUD8 (/ISS)
O75096 (/ISS)
O75096 (/ISS)
O75096 (/ISS)
Q9QYP1 (/ISS)
(2 more) |
Neuronal cell body GO:0043025
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
|
12 |
H2Q3I3 (/ISS)
H2Q3I3 (/ISS)
H2Q3I3 (/ISS)
H9FUD8 (/ISS)
H9FUD8 (/ISS)
H9FUD8 (/ISS)
O75096 (/ISS)
O75096 (/ISS)
O75096 (/ISS)
Q8VI56 (/ISS)
(2 more) |
Plasma membrane raft GO:0044853
A membrane raft that is part of the plasma membrane.
|
12 |
H2Q3I3 (/ISS)
H2Q3I3 (/ISS)
H2Q3I3 (/ISS)
H9FUD8 (/ISS)
H9FUD8 (/ISS)
H9FUD8 (/ISS)
O75096 (/ISS)
O75096 (/ISS)
O75096 (/ISS)
Q8VI56 (/ISS)
(2 more) |
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
|
7 | O75096 (/IDA) O75096 (/IDA) O75096 (/IDA) P98158 (/IDA) Q9QYP1 (/IDA) Q9QYP1 (/IDA) Q9QYP1 (/IDA) |
Lysosomal membrane GO:0005765
The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm.
|
4 | P98164 (/HDA) Q4ZG84 (/HDA) Q7Z5C0 (/HDA) Q7Z5C1 (/HDA) |
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
4 | P98164 (/TAS) Q9QYP1 (/TAS) Q9QYP1 (/TAS) Q9QYP1 (/TAS) |
Showing 1 to 10 of 64 entries