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CATH Superfamily 2.120.10.100

Apyrase

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Apyrase
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 1: Soluble calcium-activated nucleotidase 1

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Nucleoside diphosphate phosphatase. [EC: 3.6.1.6]
A nucleoside diphosphate + H(2)O = a nucleoside phosphate + phosphate.
  • The enzyme, which appears to be limited to metazoa, acts on multiple nucleoside diphosphates as well as on D-ribose 5-diphosphate.
  • Specificity depends on species and isoform.
 7 A0A024R8U8 A0A024R8U8 Q19202 Q8K4Y7 Q8VCF1 Q8WVQ1 Q8WVQ1
Apyrase. [EC: 3.6.1.5]
A nucleoside 5'-triphosphate + 2 H(2)O = a nucleoside 5'-phosphate + 2 phosphate.
  • Apyrases are active against both di- and triphosphate nucleotides (NDPs and NTPs) and hydrolyze NTPs to nucleotide monophosphates (NMPs) in two distinct successive phosphate-releasing steps, with NDPs as intermediates.
  • They differ from ATPases, which specifically hydrolyze ATP, by hydrolyzing both ATP and ADP.
  • Most of the ecto-ATPases that occur on the cell surface and hydrolyze extracellular nucleotides belong to this enzyme family.
 1 O96559
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