The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Cystine-knot cytokines
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 6: growth/differentiation factor 8

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 15 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
114 A1C2U3 (/ISS) A1C2U3 (/ISS) A1C2U3 (/ISS) A1C2U3 (/ISS) A1C2U3 (/ISS) A1C2U3 (/ISS) A1C2U3 (/ISS) A1C2U3 (/ISS) A1C2U3 (/ISS) A1C2U3 (/ISS)
(104 more)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
8 O08689 (/IPI) O08689 (/IPI) O14793 (/IPI) O14793 (/IPI) O95390 (/IPI) O95390 (/IPI) O95390 (/IPI) Q9Z1W4 (/IPI)
Signaling receptor binding GO:0005102
Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
4 O08689 (/IPI) O08689 (/IPI) O14793 (/IPI) O14793 (/IPI)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
4 O08689 (/IDA) O08689 (/IDA) O14793 (/IDA) O14793 (/IDA)
Signaling receptor binding GO:0005102
Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
2 O08689 (/ISO) O08689 (/ISO)
Growth factor activity GO:0008083
The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation.
2 O14793 (/TAS) O14793 (/TAS)
Heparin binding GO:0008201
Interacting selectively and non-covalently with heparin, any member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells and which consist predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues.
2 O08689 (/IDA) O08689 (/IDA)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
2 O14793 (/IPI) O14793 (/IPI)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
2 O08689 (/ISO) O08689 (/ISO)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
2 O08689 (/IDA) O08689 (/IDA)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
2 Q5I3Q2 (/ISS) Q5I3Q2 (/ISS)
Growth factor activity GO:0008083
The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation.
1 O42222 (/IDA)
Growth factor activity GO:0008083
The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation.
1 O42222 (/NAS)
Receptor ligand activity GO:0048018
The activity of a gene product that interacts with a receptor to effect a change in the activity of the receptor. Ligands may be produced by the same, or different, cell that expresses the receptor. Ligands may diffuse extracellularly from their point of origin to the receiving cell, or remain attached to an adjacent cell surface (e.g. Notch ligands).
1 Q9V4F4 (/IDA)
Activin receptor binding GO:0070697
Interacting selectively and non-covalently with an activin receptor.
1 Q9V4F4 (/IPI)

There are 91 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Negative regulation of skeletal muscle satellite cell proliferation GO:1902723
Any process that stops, prevents or reduces the frequency, rate or extent of satellite cell proliferation.
216 A0A087QXT3 (/ISS) A0A087VRB9 (/ISS) A0A091E8A7 (/ISS) A0A091GMQ5 (/ISS) A0A091GVW3 (/ISS) A0A091I502 (/ISS) A0A091JJ06 (/ISS) A0A091K9F0 (/ISS) A0A091KHY6 (/ISS) A0A091N1L5 (/ISS)
(206 more)
Negative regulation of satellite cell differentiation GO:1902725
Any process that stops, prevents or reduces the frequency, rate or extent of satellite cell differentiation.
216 A0A087QXT3 (/ISS) A0A087VRB9 (/ISS) A0A091E8A7 (/ISS) A0A091GMQ5 (/ISS) A0A091GVW3 (/ISS) A0A091I502 (/ISS) A0A091JJ06 (/ISS) A0A091K9F0 (/ISS) A0A091KHY6 (/ISS) A0A091N1L5 (/ISS)
(206 more)
Negative regulation of myoblast proliferation GO:2000818
Any process that stops, prevents or reduces the frequency, rate or extent of myoblast proliferation.
216 A0A087QXT3 (/ISS) A0A087VRB9 (/ISS) A0A091E8A7 (/ISS) A0A091GMQ5 (/ISS) A0A091GVW3 (/ISS) A0A091I502 (/ISS) A0A091JJ06 (/ISS) A0A091K9F0 (/ISS) A0A091KHY6 (/ISS) A0A091N1L5 (/ISS)
(206 more)
Positive regulation of lamellipodium assembly GO:0010592
Any process that increases the rate, frequency or extent of the formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell.
117 A1C2U3 (/ISS) A1C2U3 (/ISS) A1C2U3 (/ISS) A1C2U3 (/ISS) A1C2U3 (/ISS) A1C2U3 (/ISS) A1C2U3 (/ISS) A1C2U3 (/ISS) A1C2U3 (/ISS) A1C2U3 (/ISS)
(107 more)
Positive regulation of macrophage chemotaxis GO:0010759
Any process that increases the rate, frequency or extent of macrophage chemotaxis. Macrophage chemotaxis is the movement of a macrophage in response to an external stimulus.
117 A1C2U3 (/ISS) A1C2U3 (/ISS) A1C2U3 (/ISS) A1C2U3 (/ISS) A1C2U3 (/ISS) A1C2U3 (/ISS) A1C2U3 (/ISS) A1C2U3 (/ISS) A1C2U3 (/ISS) A1C2U3 (/ISS)
(107 more)
Myoblast migration involved in skeletal muscle regeneration GO:0014839
The process in which a myoblast migrates along an entire fiber to the site of injury. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers.
117 A1C2U3 (/ISS) A1C2U3 (/ISS) A1C2U3 (/ISS) A1C2U3 (/ISS) A1C2U3 (/ISS) A1C2U3 (/ISS) A1C2U3 (/ISS) A1C2U3 (/ISS) A1C2U3 (/ISS) A1C2U3 (/ISS)
(107 more)
Muscle cell proliferation GO:0033002
The expansion of a muscle cell population by cell division.
57 A0A087QXT3 (/ISS) A0A087VRB9 (/ISS) A0A091E8A7 (/ISS) A0A091GMQ5 (/ISS) A0A091GVW3 (/ISS) A0A091I502 (/ISS) A0A091JJ06 (/ISS) A0A091K9F0 (/ISS) A0A091KHY6 (/ISS) A0A091N1L5 (/ISS)
(47 more)
Muscle cell proliferation GO:0033002
The expansion of a muscle cell population by cell division.
8 D1LWV1 (/IDA) D1LWV2 (/IDA) O42220 (/IDA) O42220 (/IDA) O42220 (/IDA) Q06BS3 (/IDA) Q06BS3 (/IDA) Q06BS3 (/IDA)
Negative regulation of fibroblast proliferation GO:0048147
Any process that stops, prevents, or reduces the frequency, rate or extent of multiplication or reproduction of fibroblast cells.
6 O18836 (/IDA) O18836 (/IDA) O18836 (/IDA) O18836 (/IDA) O18836 (/IDA) O18836 (/IDA)
Immune response GO:0006955
Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat.
5 B3DIZ5 (/IMP) O42222 (/IMP) Q4VV68 (/IMP) Q5MNY3 (/IMP) Q68IN2 (/IMP)
Negative regulation of skeletal muscle tissue growth GO:0048632
Any process that stops, prevents, or reduces the frequency, rate or extent of skeletal muscle growth.
5 O08689 (/IMP) O08689 (/IMP) O14793 (/IMP) O14793 (/IMP) O35312 (/IMP)
Skeletal system development GO:0001501
The process whose specific outcome is the progression of the skeleton over time, from its formation to the mature structure. The skeleton is the bony framework of the body in vertebrates (endoskeleton) or the hard outer envelope of insects (exoskeleton or dermoskeleton).
3 O95390 (/TAS) O95390 (/TAS) O95390 (/TAS)
Transforming growth factor beta receptor signaling pathway GO:0007179
A series of molecular signals initiated by the binding of an extracellular ligand to a transforming growth factor beta receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
3 O08689 (/IDA) O08689 (/IDA) O42222 (/IDA)
Nervous system development GO:0007399
The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state.
3 O95390 (/TAS) O95390 (/TAS) O95390 (/TAS)
Mesoderm development GO:0007498
The process whose specific outcome is the progression of the mesoderm over time, from its formation to the mature structure. The mesoderm is the middle germ layer that develops into muscle, bone, cartilage, blood and connective tissue.
3 O95390 (/TAS) O95390 (/TAS) O95390 (/TAS)
Skeletal muscle tissue development GO:0007519
The developmental sequence of events leading to the formation of adult skeletal muscle tissue. The main events are: the fusion of myoblasts to form myotubes that increase in size by further fusion to them of myoblasts, the formation of myofibrils within their cytoplasm and the establishment of functional neuromuscular junctions with motor neurons. At this stage they can be regarded as mature muscle fibers.
3 O42220 (/IEP) O42220 (/IEP) O42220 (/IEP)
Embryo development ending in birth or egg hatching GO:0009792
The process whose specific outcome is the progression of an embryo over time, from zygote formation until the end of the embryonic life stage. The end of the embryonic life stage is organism-specific and may be somewhat arbitrary; for mammals it is usually considered to be birth, for insects the hatching of the first instar larva from the eggshell.
3 O42220 (/IEP) O42220 (/IEP) O42220 (/IEP)
Anterior/posterior pattern specification GO:0009952
The regionalization process in which specific areas of cell differentiation are determined along the anterior-posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism.
3 A0A0B5JSE4 (/IMP) Q8JFP9 (/IMP) Q9Z1W4 (/IMP)
Regulation of growth GO:0040008
Any process that modulates the frequency, rate or extent of the growth of all or part of an organism so that it occurs at its proper speed, either globally or in a specific part of the organism's development.
3 O42220 (/NAS) O42220 (/NAS) O42220 (/NAS)
Regulation of cell differentiation GO:0045595
Any process that modulates the frequency, rate or extent of cell differentiation, the process in which relatively unspecialized cells acquire specialized structural and functional features.
3 O42220 (/NAS) O42220 (/NAS) O42220 (/NAS)
SMAD protein signal transduction GO:0060395
The cascade of processes by which a signal interacts with a receptor, causing a change in the activity of a SMAD protein, and ultimately effecting a change in the functioning of the cell.
3 O95390 (/IMP) O95390 (/IMP) O95390 (/IMP)
Transforming growth factor beta receptor signaling pathway GO:0007179
A series of molecular signals initiated by the binding of an extracellular ligand to a transforming growth factor beta receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
2 Q5I3Q2 (/ISS) Q5I3Q2 (/ISS)
Muscle organ development GO:0007517
The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work.
2 O14793 (/TAS) O14793 (/TAS)
Positive regulation of lamellipodium assembly GO:0010592
Any process that increases the rate, frequency or extent of the formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell.
2 O08689 (/IMP) O08689 (/IMP)
Positive regulation of macrophage chemotaxis GO:0010759
Any process that increases the rate, frequency or extent of macrophage chemotaxis. Macrophage chemotaxis is the movement of a macrophage in response to an external stimulus.
2 O08689 (/IMP) O08689 (/IMP)
Negative regulation of muscle hypertrophy GO:0014741
Any process that stops, prevents, or reduces the frequency, rate, or extent of muscle hypertrophy.
2 O08689 (/ISO) O08689 (/ISO)
Myoblast migration involved in skeletal muscle regeneration GO:0014839
The process in which a myoblast migrates along an entire fiber to the site of injury. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers.
2 O08689 (/IMP) O08689 (/IMP)
Mushroom body development GO:0016319
The process whose specific outcome is the progression of the mushroom body over time, from its formation to the mature structure. The mushroom body is composed of the prominent neuropil structures of the insect central brain, thought to be crucial for olfactory associated learning. These consist mainly of a bulbous calyx and tightly packaged arrays of thin parallel fibers of the Kenyon cells.
2 Q9V4F4 (/IMP) Q9XZ62 (/IMP)
Negative regulation of kinase activity GO:0033673
Any process that stops, prevents, or reduces the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
2 O08689 (/IMP) O08689 (/IMP)
Negative regulation of myoblast differentiation GO:0045662
Any process that stops, prevents, or reduces the frequency, rate or extent of myoblast differentiation. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers.
2 O14793 (/IDA) O14793 (/IDA)
Negative regulation of myoblast differentiation GO:0045662
Any process that stops, prevents, or reduces the frequency, rate or extent of myoblast differentiation. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers.
2 O08689 (/ISO) O08689 (/ISO)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
2 O14793 (/IDA) O14793 (/IDA)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
2 O08689 (/ISO) O08689 (/ISO)
Negative regulation of insulin receptor signaling pathway GO:0046627
Any process that stops, prevents, or reduces the frequency, rate or extent of insulin receptor signaling.
2 O08689 (/IMP) O08689 (/IMP)
Muscle cell cellular homeostasis GO:0046716
The cellular homeostatic process that preserves a muscle cell in a stable functional or structural state.
2 O14793 (/IDA) O14793 (/IDA)
Muscle cell cellular homeostasis GO:0046716
The cellular homeostatic process that preserves a muscle cell in a stable functional or structural state.
2 O08689 (/ISO) O08689 (/ISO)
Negative regulation of skeletal muscle tissue growth GO:0048632
Any process that stops, prevents, or reduces the frequency, rate or extent of skeletal muscle growth.
2 O08689 (/ISO) O08689 (/ISO)
Negative regulation of skeletal muscle tissue growth GO:0048632
Any process that stops, prevents, or reduces the frequency, rate or extent of skeletal muscle growth.
2 Q5I3Q2 (/ISS) Q5I3Q2 (/ISS)
Negative regulation of protein kinase B signaling GO:0051898
Any process that stops, prevents, or reduces the frequency, rate or extent of protein kinase B signaling, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B.
2 O14793 (/IDA) O14793 (/IDA)
Negative regulation of protein kinase B signaling GO:0051898
Any process that stops, prevents, or reduces the frequency, rate or extent of protein kinase B signaling, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B.
2 O08689 (/ISO) O08689 (/ISO)
SMAD protein signal transduction GO:0060395
The cascade of processes by which a signal interacts with a receptor, causing a change in the activity of a SMAD protein, and ultimately effecting a change in the functioning of the cell.
2 Q9Z1W4 (/ISS) Q9Z217 (/ISS)
Cellular response to dexamethasone stimulus GO:0071549
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dexamethasone stimulus.
2 O08689 (/IDA) O08689 (/IDA)
Skeletal system development GO:0001501
The process whose specific outcome is the progression of the skeleton over time, from its formation to the mature structure. The skeleton is the bony framework of the body in vertebrates (endoskeleton) or the hard outer envelope of insects (exoskeleton or dermoskeleton).
1 Q9Z1W4 (/IGI)
Metanephros development GO:0001656
The process whose specific outcome is the progression of the metanephros over time, from its formation to the mature structure. In mammals, the metanephros is the excretory organ of the fetus, which develops into the mature kidney and is formed from the rear portion of the nephrogenic cord. The metanephros is an endocrine and metabolic organ that filters the blood and excretes the end products of body metabolism in the form of urine.
1 Q9Z1W4 (/IDA)
Ureteric bud development GO:0001657
The process whose specific outcome is the progression of the ureteric bud over time, from its formation to the mature structure.
1 Q9Z1W4 (/IMP)
Ventricular trabecula myocardium morphogenesis GO:0003222
The process in which the anatomical structures of the trabecular cardiac ventricle muscle are generated and organized.
1 O42222 (/IMP)
Transforming growth factor beta receptor signaling pathway GO:0007179
A series of molecular signals initiated by the binding of an extracellular ligand to a transforming growth factor beta receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
1 O42222 (/NAS)
Muscle organ development GO:0007517
The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work.
1 O42222 (/IDA)
Skeletal muscle tissue development GO:0007519
The developmental sequence of events leading to the formation of adult skeletal muscle tissue. The main events are: the fusion of myoblasts to form myotubes that increase in size by further fusion to them of myoblasts, the formation of myofibrils within their cytoplasm and the establishment of functional neuromuscular junctions with motor neurons. At this stage they can be regarded as mature muscle fibers.
1 O42222 (/IDA)
Negative regulation of cell population proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
1 Q9Z1W4 (/IMP)
Response to heat GO:0009408
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.
1 O35312 (/IEP)
Response to gravity GO:0009629
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gravitational stimulus.
1 O35312 (/IEP)
Animal organ morphogenesis GO:0009887
Morphogenesis of an animal organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.
1 Q9Z1W4 (/IMP)
Skeletal muscle atrophy GO:0014732
A process, occurring in skeletal muscle, that is characterized by a decrease in protein content, fiber diameter, force production and fatigue resistance in response to different conditions such as starvation, aging and disuse.
1 O35312 (/IEP)
Regulation of muscle hyperplasia GO:0014738
Any process that modulates the frequency, rate or extent of muscle hyperplasia.
1 O42222 (/IMP)
Negative regulation of muscle hypertrophy GO:0014741
Any process that stops, prevents, or reduces the frequency, rate, or extent of muscle hypertrophy.
1 O35312 (/IMP)
Response to muscle activity GO:0014850
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a muscle activity stimulus.
1 O35312 (/IEP)
Spinal cord anterior/posterior patterning GO:0021512
The process that regulates the coordinated growth and differentiation that establishes the non-random anterior-posterior spatial arrangement of the spinal cord.
1 Q9Z1W4 (/IMP)
Ovulation cycle process GO:0022602
A process involved in the sexual cycle seen in females, often with physiologic changes in the endometrium that recur at regular intervals during the reproductive years.
1 O35312 (/IEP)
Pancreas development GO:0031016
The process whose specific outcome is the progression of the pancreas over time, from its formation to the mature structure. The pancreas is an endoderm derived structure that produces precursors of digestive enzymes and blood glucose regulating enzymes.
1 Q9Z1W4 (/IMP)
Activin receptor signaling pathway GO:0032924
A series of molecular signals initiated by the binding of an extracellular ligand to an activin receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
1 Q9V4F4 (/IDA)
Activin receptor signaling pathway GO:0032924
A series of molecular signals initiated by the binding of an extracellular ligand to an activin receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
1 Q9V4F4 (/IGI)
Activin receptor signaling pathway GO:0032924
A series of molecular signals initiated by the binding of an extracellular ligand to an activin receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
1 Q9V4F4 (/IMP)
Response to testosterone GO:0033574
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a testosterone stimulus.
1 O35312 (/IEP)
Skeletal muscle tissue regeneration GO:0043403
The regrowth of skeletal muscle tissue to repair injured or damaged muscle fibers in the postnatal stage.
1 O35312 (/IEP)
Response to estrogen GO:0043627
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by an estrogen, C18 steroid hormones that can stimulate the development of female sexual characteristics.
1 O35312 (/IEP)
Regulation of imaginal disc-derived wing size GO:0044719
Any process that modulates the size of an imaginal disc-derived wing.
1 Q9V4F4 (/IMP)
R8 cell fate specification GO:0045464
The process in which a cell becomes capable of differentiating autonomously into an R8 cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed.
1 Q9V4F4 (/IMP)
Response to ethanol GO:0045471
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethanol stimulus.
1 O35312 (/IEP)
Negative regulation of cell differentiation GO:0045596
Any process that stops, prevents, or reduces the frequency, rate or extent of cell differentiation.
1 Q9Z1W4 (/IDA)
Negative regulation of neuron differentiation GO:0045665
Any process that stops, prevents, or reduces the frequency, rate or extent of neuron differentiation.
1 Q9Z217 (/IMP)
Negative regulation of neuron differentiation GO:0045665
Any process that stops, prevents, or reduces the frequency, rate or extent of neuron differentiation.
1 Q9Z1W4 (/ISO)
Negative regulation of striated muscle tissue development GO:0045843
Any process that stops, prevents, or reduces the frequency, rate or extent of striated muscle development.
1 O42222 (/IDA)
Negative regulation of growth GO:0045926
Any process that stops, prevents or reduces the rate or extent of growth, the increase in size or mass of all or part of an organism.
1 O42222 (/IDA)
Negative regulation of growth rate GO:0045967
Any process that reduces the rate of growth of all or part of an organism.
1 O42222 (/IDA)
Cell maturation GO:0048469
A developmental process, independent of morphogenetic (shape) change, that is required for a cell to attain its fully functional state.
1 Q9Z1W4 (/IMP)
Camera-type eye morphogenesis GO:0048593
The process in which the anatomical structures of the eye are generated and organized. The camera-type eye is an organ of sight that receives light through an aperture and focuses it through a lens, projecting it on a photoreceptor field.
1 Q9Z1W4 (/IMP)
Negative regulation of skeletal muscle tissue development GO:0048642
Any process that stops, prevents, or reduces the frequency, rate or extent of skeletal muscle tissue development.
1 O42222 (/IMP)
Skeletal muscle fiber development GO:0048741
The process whose specific outcome is the progression of the skeletal muscle fiber over time, from its formation to the mature structure. Muscle fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast.
1 Q9GM97 (/IMP)
Regulation of synapse structure or activity GO:0050803
Any process that modulates the physical form or the activity of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell).
1 Q9V4F4 (/IMP)
Response to glucocorticoid GO:0051384
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucocorticoid stimulus. Glucocorticoids are hormonal C21 corticosteroids synthesized from cholesterol with the ability to bind with the cortisol receptor and trigger similar effects. Glucocorticoids act primarily on carbohydrate and protein metabolism, and have anti-inflammatory effects.
1 O35312 (/IEP)
Response to electrical stimulus GO:0051602
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electrical stimulus.
1 O35312 (/IEP)
Roof of mouth development GO:0060021
The biological process whose specific outcome is the progression of the roof of the mouth from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure. The roof of the mouth is the partition that separates the nasal and oral cavities.
1 Q9Z1W4 (/IGI)
Positive regulation of SMAD protein signal transduction GO:0060391
Any process that increases the rate, frequency or extent of SMAD protein signal transduction. Pathway-restricted SMAD proteins and common-partner SMAD proteins are involved in the transforming growth factor beta receptor signaling pathways.
1 Q9V4F4 (/IDA)
SMAD protein signal transduction GO:0060395
The cascade of processes by which a signal interacts with a receptor, causing a change in the activity of a SMAD protein, and ultimately effecting a change in the functioning of the cell.
1 Q9Z1W4 (/IDA)
SMAD protein signal transduction GO:0060395
The cascade of processes by which a signal interacts with a receptor, causing a change in the activity of a SMAD protein, and ultimately effecting a change in the functioning of the cell.
1 Q9Z1W4 (/ISO)
Cardiac muscle myoblast proliferation GO:0110021
The multiplication or reproduction of cardiac muscle myoblasts, resulting in the expansion of a cardiac muscle myoblast cell population. A cardiac myoblast is a precursor cell that has been committed to a cardiac muscle cell fate but retains the ability to divide and proliferate throughout life.
1 O42222 (/IMP)
Negative regulation of cardiac muscle myoblast proliferation GO:0110023
Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle myoblast proliferation.
1 O42222 (/IMP)
Negative regulation of skeletal muscle satellite cell proliferation GO:1902723
Any process that stops, prevents or reduces the frequency, rate or extent of satellite cell proliferation.
1 O42221 (/IDA)
Negative regulation of satellite cell differentiation GO:1902725
Any process that stops, prevents or reduces the frequency, rate or extent of satellite cell differentiation.
1 O42221 (/IDA)
Negative regulation of myoblast proliferation GO:2000818
Any process that stops, prevents or reduces the frequency, rate or extent of myoblast proliferation.
1 O42221 (/IDA)

There are 15 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
57 A0A087QXT3 (/ISS) A0A087VRB9 (/ISS) A0A091E8A7 (/ISS) A0A091GMQ5 (/ISS) A0A091GVW3 (/ISS) A0A091I502 (/ISS) A0A091JJ06 (/ISS) A0A091K9F0 (/ISS) A0A091KHY6 (/ISS) A0A091N1L5 (/ISS)
(47 more)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
14 D1LWV1 (/IDA) D1LWV2 (/IDA) O08689 (/IDA) O08689 (/IDA) O14793 (/IDA) O14793 (/IDA) O35312 (/IDA) O42220 (/IDA) O42220 (/IDA) O42220 (/IDA)
(4 more)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
7 A0A024RB20 (/IDA) A0A024RB20 (/IDA) A0A024RB20 (/IDA) H0YI30 (/IDA) O95390 (/IDA) O95390 (/IDA) O95390 (/IDA)
Intracellular membrane-bounded organelle GO:0043231
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
7 A0A024RB20 (/IDA) A0A024RB20 (/IDA) A0A024RB20 (/IDA) H0YI30 (/IDA) O95390 (/IDA) O95390 (/IDA) O95390 (/IDA)
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
3 O95390 (/IDA) O95390 (/IDA) O95390 (/IDA)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
2 Q5I3Q2 (/IDA) Q5I3Q2 (/IDA)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
2 O08689 (/TAS) O08689 (/TAS)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
2 O08689 (/ISO) O08689 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
2 O08689 (/ISO) O08689 (/ISO)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
1 O42222 (/NAS)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q9V4F4 (/HDA)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
1 Q9Z1W4 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 O35312 (/IDA)
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
1 Q9Z1W4 (/ISO)
Intracellular membrane-bounded organelle GO:0043231
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
1 Q9Z1W4 (/ISO)