Any process that stops, prevents, or reduces the frequency, rate or extent of the BMP signaling pathway.

Determination of the identity of part of an organism or organ where those parts are of the type that occur in the dorsal region. Identity is considered to be the aggregate of characteristics by which a structure is recognized.

The process in which the anatomical structures of the embryonic soma are generated and organized.

A series of molecular signals initiated by the binding of a cytokine to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.

A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.

Any process that stops, prevents, or reduces the frequency, rate or extent of the BMP signaling pathway.

Any process that stops, prevents, or reduces the frequency, rate or extent of osteoblast differentiation.

Any process that modulates the rate, frequency or extent of the activity of a molecule that controls the survival, growth, differentiation and effector function of tissues and cells.

The developmental process in which the size or shape of a cell is generated and organized.

The orderly movement of endothelial cells into the extracellular matrix in order to form new blood vessels involved in sprouting angiogenesis.

Any process that activates or increases the frequency, rate or extent of receptor internalization.

Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the differentiation of a myocardial precursor cell.

The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.

Any process that activates or increases the rate or extent of cell proliferation.

Any process that modulates the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell.

Any process that determines the size and arrangement of collagen fibrils within an extracellular matrix.

Any process that stops, prevents, or reduces the frequency, rate or extent of bone mineralization.

Any process that stops, prevents, or reduces the frequency, rate or extent of the BMP signaling pathway.

Any process that stops, prevents, or reduces the frequency, rate or extent of chondrocyte differentiation.

Any process that stops, prevents or reduces the rate or extent of osteoblast proliferation.

Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.

Any process that stops, prevents, or reduces the frequency, rate or extent of osteoblast differentiation.

Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.

Any process that stops, prevents, or reduces the frequency, rate or extent of bone remodeling.

Any process that activates or increases the frequency, rate or extent of telomerase activity, the catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).

The process whose specific outcome is the progression of a limb over time, from its formation to the mature structure. A limb is an appendage of an animal used for locomotion or grasping. Examples include legs, arms or some types of fin.

Any process that decreases the rate, frequency or extent of pathway-restricted SMAD protein phosphorylation. Pathway-restricted SMAD proteins and common-partner SMAD proteins are involved in the transforming growth factor beta receptor signaling pathways.

Any process that decreases the frequency, rate, or extent of monocyte chemotaxis.

Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes.

Any process that decreases the rate, frequency, or extent of the multiplication or reproduction of osteoclasts, resulting in the expansion of an osteoclast cell population.

Any process that activates or increases the frequency, rate or extent of peptidyl-tyrosine autophosphorylation.

Any process that stops, prevents or reduces the frequency, rate or extent of bone trabecula formation.

Any process that stops, prevents or reduces the frequency, rate or extent of bone mineralization involved in bone maturation.

Any process that activates or increases the frequency, rate or extent of signaling receptor activity.

Any process that activates or increases the frequency, rate or extent of cardiac muscle cell differentiation.

Any process that activates or increases angiogenesis.

The progression of a cardiac chamber over time, from its formation to the mature structure. A cardiac chamber is an enclosed cavity within the heart.

The process whose specific outcome is the progression of a cardiac atrium over time, from its formation to the mature structure. A cardiac atrium receives blood from a vein and pumps it to a cardiac ventricle.

The process whose specific outcome is the progression of a cardiac atrium over time, from its formation to the mature structure. A cardiac atrium receives blood from a vein and pumps it to a cardiac ventricle.

The process in which the anatomical structures of the embryonic soma are generated and organized.

A series of molecular signals initiated by the binding of a cytokine to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.

Binding to a bone morphogenetic protein (BMP) in the extracellular region, and inhibiting BMP signaling by preventing BMP from binding to its cell surface receptor.

The process whose specific outcome is the progression of a cartilage element over time, from its formation to the mature structure. Cartilage elements are skeletal elements that consist of connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate.

Any process that modulates the rate, frequency or extent of the activity of a molecule that controls the survival, growth, differentiation and effector function of tissues and cells.

The process in which the anatomical structures of cartilage are generated and organized.

A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to the progression of the heart over time.

The developmental process in which the size or shape of a cell is generated and organized.

Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels.

The orderly movement of endothelial cells into the extracellular matrix in order to form new blood vessels involved in sprouting angiogenesis.

Any process that activates or increases the frequency, rate or extent of receptor internalization.

Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte chemotaxis.

Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte chemotaxis.

Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the differentiation of a myocardial precursor cell.

A transition where a mesenchymal cell establishes apical/basolateral polarity,forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell that will contribute to the shaping of the metanephros.

A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.

The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.

Any process that mediates the transfer of information from one cell to another. This process includes signal transduction in the receiving cell and, where applicable, release of a ligand and any processes that actively facilitate its transport and presentation to the receiving cell. Examples include signaling via soluble ligands, via cell adhesion molecules and via gap junctions.

The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state.

Any process that activates or increases the rate or extent of cell proliferation.

Morphogenesis of an animal organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.

The regionalization process in which specific areas of cell differentiation are determined along a proximal/distal axis. The proximal/distal axis is defined by a line that runs from main body (proximal end) of an organism outward (distal end).

Any process that modulates the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell.

The formation of the specialized region of ectoderm between the neural ectoderm (neural plate) and non-neural ectoderm. The neural crest gives rise to the neural crest cells that migrate away from this region as neural tube formation procedes.

The process aimed at the progression of a neural crest cell over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell.

Any process that determines the size and arrangement of collagen fibrils within an extracellular matrix.

Any process that stops, prevents, or reduces the frequency, rate, extent or direction of cell growth.

Any process that stops, prevents, or reduces the frequency, rate, extent or direction of cell growth.

The process, occurring in the embryo, by which the anatomical structures of the limb are generated and organized. A limb is an appendage of an animal used for locomotion or grasping.

Any process that stops, prevents, or reduces the frequency, rate or extent of bone mineralization.

Any process that stops, prevents, or reduces the frequency, rate or extent of the BMP signaling pathway.

Any process that stops, prevents, or reduces the frequency, rate or extent of chondrocyte differentiation.

The establishment, maintenance and elaboration of the rostro-caudal axis of a somite, prior to the morphological formation of a somite boundary.

Any process that stops, prevents or reduces the rate or extent of osteoblast proliferation.

Confining a bone morphogenetic protein (BMP) to the extracellular matrix (ECM), such that it is separated from other components of the signaling pathway, including its cell surface receptor. Bone morphogenetic proteins (BMPs) are secreted as homodimers, non-covalently associated with N-terminal pro-peptides, and are targeted to the extracellular matrix through interaction with matrix proteins.

The process whose specific outcome is the progression of the pronephric duct over time, from its formation to the mature structure. The pronephric duct collects the filtrate from the pronephric tubules and opens to the exterior of the pronephric kidney.

Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.

Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.

The orderly movement of an endothelial cell into the extracellular matrix to form an endothelium.

Any process that stops, prevents, or reduces the frequency, rate or extent of osteoblast differentiation.

Any process that activates or increases angiogenesis.

Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.

Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.

Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.

Any process that stops, prevents, or reduces the frequency, rate or extent of bone remodeling.

Determination of the identity of part of an organism or organ where those parts are of the type that occur in the dorsal region. Identity is considered to be the aggregate of characteristics by which a structure is recognized.

Any process that activates or increases the frequency, rate or extent of activity of the transcription factor NF-kappaB.

Any process that modulates the frequency, rate or extent of focal adhesion formation, the establishment and maturation of focal adhesions.

Any process that activates or increases the frequency, rate or extent of telomerase activity, the catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).

The process whose specific outcome is the progression of a limb over time, from its formation to the mature structure. A limb is an appendage of an animal used for locomotion or grasping. Examples include legs, arms or some types of fin.

Any process that decreases the rate, frequency or extent of pathway-restricted SMAD protein phosphorylation. Pathway-restricted SMAD proteins and common-partner SMAD proteins are involved in the transforming growth factor beta receptor signaling pathways.

The developmental process pertaining to the initial formation of the ureteric bud from the Wolffian duct. This process begins when the bud protrudes from the duct and ends when it is a recognizable bud.

Any process that increases the rate, frequency, or extent of protein tyrosine kinase activity.

Any process that decreases the frequency, rate, or extent of monocyte chemotaxis.

Any process that decreases the frequency, rate, or extent of monocyte chemotaxis.

Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes.

Any process that increases the rate, frequency or extent of branching involved in ureteric bud morphogenesis, the process in which the branching structure of the ureteric bud is generated and organized. The ureteric bud is an epithelial tube that grows out from the metanephric duct. The bud elongates and branches to give rise to the ureter and kidney collecting tubules.

Any process that increases the rate, frequency or extent of branching involved in ureteric bud morphogenesis, the process in which the branching structure of the ureteric bud is generated and organized. The ureteric bud is an epithelial tube that grows out from the metanephric duct. The bud elongates and branches to give rise to the ureter and kidney collecting tubules.

Any process that decreases the rate, frequency, or extent of the multiplication or reproduction of osteoclasts, resulting in the expansion of an osteoclast cell population.

Any process that activates or increases the frequency, rate or extent of peptidyl-tyrosine autophosphorylation.

Any process that stops, prevents or reduces the frequency, rate or extent of bone trabecula formation.

Any process that stops, prevents or reduces the frequency, rate or extent of bone mineralization involved in bone maturation.

Any process that activates or increases the frequency, rate or extent of NIK/NF-kappaB signaling.

Any process that activates or increases the frequency, rate or extent of signaling receptor activity.

Any process that activates or increases the frequency, rate or extent of cardiac muscle cell differentiation.

Any process that stops, prevents, or reduces the frequency, rate or extent of chondrocyte differentiation.

Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.

The process whose specific outcome is the progression of a limb over time, from its formation to the mature structure. A limb is an appendage of an animal used for locomotion or grasping. Examples include legs, arms or some types of fin.

The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.

That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.

An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells.

That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.

That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.

That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.

The external part of the cell wall and/or plasma membrane.

The external part of the cell wall and/or plasma membrane.