The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Cystine-knot cytokines
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 11: Glycoprotein hormones alpha chain

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 9 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Follicle-stimulating hormone activity GO:0016913
The action characteristic of follicle-stimulating hormone (FSH), a gonadotrophic glycoprotein hormone secreted, in mammals, by the anterior pituitary gland. Upon receptor binding, FSH stimulates growth of Graafian follicles in the ovaries in females, and stimulates the epithelium of the seminiferous tubules to increase spermatogenesis.
80 O46642 (/ISS) P01216 (/ISS) P01216 (/ISS) P01217 (/ISS) P01217 (/ISS) P01217 (/ISS) P01217 (/ISS) P01217 (/ISS) P01218 (/ISS) P01218 (/ISS)
(70 more)
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
38 B2BEA6 (/ISS) D0ETM2 (/ISS) F1ACG4 (/ISS) F1ACG5 (/ISS) F1ACG5 (/ISS) F1ACG5 (/ISS) F1ACG6 (/ISS) F1ACG7 (/ISS) F1ACG8 (/ISS) F1ACG9 (/ISS)
(28 more)
Follicle-stimulating hormone activity GO:0016913
The action characteristic of follicle-stimulating hormone (FSH), a gonadotrophic glycoprotein hormone secreted, in mammals, by the anterior pituitary gland. Upon receptor binding, FSH stimulates growth of Graafian follicles in the ovaries in females, and stimulates the epithelium of the seminiferous tubules to increase spermatogenesis.
4 P01215 (/IDA) P01215 (/IDA) Q9BEH3 (/IDA) Q9BEH3 (/IDA)
Hormone activity GO:0005179
The action characteristic of a hormone, any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. The term was originally applied to agents with a stimulatory physiological action in vertebrate animals (as opposed to a chalone, which has a depressant action). Usage is now extended to regulatory compounds in lower animals and plants, and to synthetic substances having comparable effects; all bind receptors and trigger some biological process.
2 P01215 (/IMP) P01215 (/IMP)
Hormone activity GO:0005179
The action characteristic of a hormone, any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. The term was originally applied to agents with a stimulatory physiological action in vertebrate animals (as opposed to a chalone, which has a depressant action). Usage is now extended to regulatory compounds in lower animals and plants, and to synthetic substances having comparable effects; all bind receptors and trigger some biological process.
2 P01216 (/ISO) P01216 (/ISO)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
2 P01215 (/IPI) P01215 (/IPI)
Follicle-stimulating hormone activity GO:0016913
The action characteristic of follicle-stimulating hormone (FSH), a gonadotrophic glycoprotein hormone secreted, in mammals, by the anterior pituitary gland. Upon receptor binding, FSH stimulates growth of Graafian follicles in the ovaries in females, and stimulates the epithelium of the seminiferous tubules to increase spermatogenesis.
2 P01216 (/ISO) P01216 (/ISO)
Follicle-stimulating hormone activity GO:0016913
The action characteristic of follicle-stimulating hormone (FSH), a gonadotrophic glycoprotein hormone secreted, in mammals, by the anterior pituitary gland. Upon receptor binding, FSH stimulates growth of Graafian follicles in the ovaries in females, and stimulates the epithelium of the seminiferous tubules to increase spermatogenesis.
1 Q9DG94 (/IMP)
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
1 Q9YGP3 (/IPI)

There are 26 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
G protein-coupled receptor signaling pathway GO:0007186
A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576).
80 O46642 (/ISS) P01216 (/ISS) P01216 (/ISS) P01217 (/ISS) P01217 (/ISS) P01217 (/ISS) P01217 (/ISS) P01217 (/ISS) P01218 (/ISS) P01218 (/ISS)
(70 more)
Regulation of signaling receptor activity GO:0010469
Any process that modulates the frequency, rate or extent of a signaling receptor activity. Receptor activity is when a molecule combines with an extracellular or intracellular messenger to initiate a change in cell activity.
80 O46642 (/ISS) P01216 (/ISS) P01216 (/ISS) P01217 (/ISS) P01217 (/ISS) P01217 (/ISS) P01217 (/ISS) P01217 (/ISS) P01218 (/ISS) P01218 (/ISS)
(70 more)
Positive regulation of steroid biosynthetic process GO:0010893
Any process that increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus.
80 O46642 (/ISS) P01216 (/ISS) P01216 (/ISS) P01217 (/ISS) P01217 (/ISS) P01217 (/ISS) P01217 (/ISS) P01217 (/ISS) P01218 (/ISS) P01218 (/ISS)
(70 more)
G protein-coupled receptor signaling pathway GO:0007186
A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576).
4 P01215 (/IDA) P01215 (/IDA) Q9BEH3 (/IDA) Q9BEH3 (/IDA)
Regulation of signaling receptor activity GO:0010469
Any process that modulates the frequency, rate or extent of a signaling receptor activity. Receptor activity is when a molecule combines with an extracellular or intracellular messenger to initiate a change in cell activity.
4 P01215 (/IDA) P01215 (/IDA) Q9BEH3 (/IDA) Q9BEH3 (/IDA)
Regulation of transcription by RNA polymerase II GO:0006357
Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
2 P01215 (/TAS) P01215 (/TAS)
Thyroid hormone generation GO:0006590
The formation of either of the compounds secreted by the thyroid gland, mainly thyroxine and triiodothyronine. This is achieved by the iodination and joining of tyrosine molecules to form the precursor thyroglobin, proteolysis of this precursor gives rise to the thyroid hormones.
2 P01216 (/IMP) P01216 (/IMP)
G protein-coupled receptor signaling pathway GO:0007186
A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576).
2 P01216 (/ISO) P01216 (/ISO)
G protein-coupled receptor signaling pathway GO:0007186
A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576).
2 P01215 (/TAS) P01215 (/TAS)
Positive regulation of cell population proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
2 P01215 (/NAS) P01215 (/NAS)
Gonad development GO:0008406
The process whose specific outcome is the progression of the gonad over time, from its formation to the mature structure. The gonad is an animal organ that produces gametes; in some species it also produces hormones.
2 P01216 (/IMP) P01216 (/IMP)
Regulation of signaling receptor activity GO:0010469
Any process that modulates the frequency, rate or extent of a signaling receptor activity. Receptor activity is when a molecule combines with an extracellular or intracellular messenger to initiate a change in cell activity.
2 P01216 (/ISO) P01216 (/ISO)
Positive regulation of steroid biosynthetic process GO:0010893
Any process that increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus.
2 P01215 (/IDA) P01215 (/IDA)
Positive regulation of steroid biosynthetic process GO:0010893
Any process that increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus.
2 P01216 (/ISO) P01216 (/ISO)
Peptide hormone processing GO:0016486
The generation of a mature peptide hormone by posttranslational processing of a prohormone.
2 P01215 (/TAS) P01215 (/TAS)
Positive regulation of cell migration GO:0030335
Any process that activates or increases the frequency, rate or extent of cell migration.
2 P01215 (/NAS) P01215 (/NAS)
Thyroid gland development GO:0030878
The process whose specific outcome is the progression of the thyroid gland over time, from its formation to the mature structure. The thyroid gland is an endoderm-derived gland that produces thyroid hormone.
2 P01216 (/IMP) P01216 (/IMP)
Luteinizing hormone secretion GO:0032275
The regulated release of luteinizing hormone, a gonadotropic glycoprotein hormone secreted by the anterior pituitary.
2 P01216 (/IMP) P01216 (/IMP)
Cellular response to hormone stimulus GO:0032870
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus.
2 P01216 (/IMP) P01216 (/IMP)
Follicle-stimulating hormone signaling pathway GO:0042699
The series of molecular signals mediated by follicle-stimulating hormone.
2 Q9BEH3 (/IDA) Q9BEH3 (/IDA)
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
2 P01215 (/NAS) P01215 (/NAS)
Negative regulation of organ growth GO:0046621
Any process that stops, prevents, or reduces the frequency, rate or extent of growth of an organ of an organism.
2 P01216 (/IMP) P01216 (/IMP)
Follicle-stimulating hormone secretion GO:0046884
The regulated release of follicle-stimulating hormone, a gonadotropic glycoprotein hormone secreted by the anterior pituitary.
2 P01216 (/IMP) P01216 (/IMP)
Developmental growth GO:0048589
The increase in size or mass of an entire organism, a part of an organism or a cell, where the increase in size or mass has the specific outcome of the progression of the organism over time from one condition to another.
2 P01216 (/IMP) P01216 (/IMP)
Androgen biosynthetic process GO:0006702
The chemical reactions and pathways resulting in the formation of androgens, C19 steroid hormones that can stimulate the development of male sexual characteristics.
1 Q9DG94 (/IDA)
Gene expression GO:0010467
The process in which a gene's sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
1 Q9DG94 (/IDA)

There are 9 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Follicle-stimulating hormone complex GO:0016914
A gonadotrophic glycoprotein hormone secreted, in mammals, by the anterior pituitary gland; consists of alpha and beta subunits, the latter of which confers hormonal specificity.
80 O46642 (/ISS) P01216 (/ISS) P01216 (/ISS) P01217 (/ISS) P01217 (/ISS) P01217 (/ISS) P01217 (/ISS) P01217 (/ISS) P01218 (/ISS) P01218 (/ISS)
(70 more)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
78 O46642 (/ISS) P01216 (/ISS) P01216 (/ISS) P01217 (/ISS) P01217 (/ISS) P01217 (/ISS) P01217 (/ISS) P01217 (/ISS) P01218 (/ISS) P01218 (/ISS)
(68 more)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
5 P01215 (/IDA) P01215 (/IDA) Q9BEH3 (/IDA) Q9BEH3 (/IDA) Q9DG94 (/IDA)
Follicle-stimulating hormone complex GO:0016914
A gonadotrophic glycoprotein hormone secreted, in mammals, by the anterior pituitary gland; consists of alpha and beta subunits, the latter of which confers hormonal specificity.
4 P01215 (/IDA) P01215 (/IDA) Q9BEH3 (/IDA) Q9BEH3 (/IDA)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
2 P01215 (/TAS) P01215 (/TAS)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
2 P01216 (/ISO) P01216 (/ISO)
Golgi lumen GO:0005796
The volume enclosed by the membranes of any cisterna or subcompartment of the Golgi apparatus, including the cis- and trans-Golgi networks.
2 P01215 (/TAS) P01215 (/TAS)
Follicle-stimulating hormone complex GO:0016914
A gonadotrophic glycoprotein hormone secreted, in mammals, by the anterior pituitary gland; consists of alpha and beta subunits, the latter of which confers hormonal specificity.
2 P01216 (/ISO) P01216 (/ISO)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
1 Q9DG94 (/TAS)
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