The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Cystine-knot cytokines
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 10: Platelet derived growth factor C

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 6 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Platelet-derived growth factor receptor binding GO:0005161
Interacting selectively and non-covalently with the platelet-derived growth factor receptor.
2 Q9NRA1 (/IPI) Q9NRA1 (/IPI)
Platelet-derived growth factor receptor binding GO:0005161
Interacting selectively and non-covalently with the platelet-derived growth factor receptor.
2 Q8CI19 (/ISO) Q925I7 (/ISO)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
2 Q9NRA1 (/IPI) Q9NRA1 (/IPI)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
2 Q9NRA1 (/IPI) Q9NRA1 (/IPI)
Platelet-derived growth factor receptor binding GO:0005161
Interacting selectively and non-covalently with the platelet-derived growth factor receptor.
1 Q8CI19 (/IDA)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
1 Q8CI19 (/ISO)

There are 29 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Positive regulation of cold-induced thermogenesis GO:0120162
Any process that activates or increases the frequency, rate or extent of cold-induced thermogenesis.
4 A0A0G2JTE4 (/ISS) Q9EQX6 (/ISS) Q9NRA1 (/ISS) Q9NRA1 (/ISS)
Positive regulation of cell population proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
3 Q8CI19 (/IDA) Q9NRA1 (/IDA) Q9NRA1 (/IDA)
Platelet-derived growth factor receptor signaling pathway GO:0048008
The series of molecular signals generated as a consequence of a platelet-derived growth factor receptor binding to one of its physiological ligands.
3 Q8CI19 (/IDA) Q9NRA1 (/IDA) Q9NRA1 (/IDA)
Positive regulation of fibroblast proliferation GO:0048146
Any process that activates or increases the frequency, rate or extent of multiplication or reproduction of fibroblast cells.
3 Q9EQT1 (/IDA) Q9NRA1 (/IDA) Q9NRA1 (/IDA)
Central nervous system development GO:0007417
The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord.
2 Q9NRA1 (/TAS) Q9NRA1 (/TAS)
Positive regulation of fibroblast proliferation GO:0048146
Any process that activates or increases the frequency, rate or extent of multiplication or reproduction of fibroblast cells.
2 Q8CI19 (/ISO) Q925I7 (/ISO)
Regulation of peptidyl-tyrosine phosphorylation GO:0050730
Any process that modulates the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine.
2 Q8CI19 (/IDA) Q925I7 (/IDA)
Cellular response to amino acid stimulus GO:0071230
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amino acid stimulus. An amino acid is a carboxylic acids containing one or more amino groups.
2 Q8CI19 (/IDA) Q925I7 (/IDA)
Activation of transmembrane receptor protein tyrosine kinase activity GO:0007171
Any process that initiates the activity of the inactive transmembrane receptor protein tyrosine kinase activity.
1 Q8CI19 (/IDA)
Positive regulation of cell population proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
1 Q8CI19 (/ISO)
Animal organ morphogenesis GO:0009887
Morphogenesis of an animal organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.
1 Q8CI19 (/IGI)
Animal organ morphogenesis GO:0009887
Morphogenesis of an animal organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.
1 Q8CI19 (/IMP)
Cellular process GO:0009987
Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
1 Q925I7 (/ISO)
Cellular response to platelet-derived growth factor stimulus GO:0036120
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a platelet-derived growth factor stimulus.
1 Q9EQT1 (/IEP)
Platelet-derived growth factor receptor signaling pathway GO:0048008
The series of molecular signals generated as a consequence of a platelet-derived growth factor receptor binding to one of its physiological ligands.
1 Q8CI19 (/ISO)
Digestive tract development GO:0048565
The process whose specific outcome is the progression of the digestive tract over time, from its formation to the mature structure. The digestive tract is the anatomical structure through which food passes and is processed.
1 Q8CI19 (/IGI)
Positive regulation of smooth muscle cell proliferation GO:0048661
Any process that activates or increases the rate or extent of smooth muscle cell proliferation.
1 Q9EQT1 (/IDA)
Positive regulation of smooth muscle cell proliferation GO:0048661
Any process that activates or increases the rate or extent of smooth muscle cell proliferation.
1 Q925I7 (/ISO)
Bone development GO:0060348
The process whose specific outcome is the progression of bone over time, from its formation to the mature structure. Bone is the hard skeletal connective tissue consisting of both mineral and cellular components.
1 Q8CI19 (/IGI)
Cellular response to hydrogen peroxide GO:0070301
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus.
1 Q9EQT1 (/IEP)
Cellular response to transforming growth factor beta stimulus GO:0071560
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a transforming growth factor beta stimulus.
1 Q9EQT1 (/IMP)
Cellular response to transforming growth factor beta stimulus GO:0071560
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a transforming growth factor beta stimulus.
1 Q925I7 (/ISO)
Positive regulation of smooth muscle cell chemotaxis GO:0071673
Any process that activates or increases the frequency, rate, or extent of smooth muscle cell chemotaxis.
1 Q9EQT1 (/IMP)
Positive regulation of smooth muscle cell chemotaxis GO:0071673
Any process that activates or increases the frequency, rate, or extent of smooth muscle cell chemotaxis.
1 Q925I7 (/ISO)
Positive regulation of glomerular mesangial cell proliferation GO:0072126
Any process that increases the frequency, rate or extent of glomerular mesangial cell proliferation.
1 Q9EQT1 (/IMP)
Positive regulation of glomerular mesangial cell proliferation GO:0072126
Any process that increases the frequency, rate or extent of glomerular mesangial cell proliferation.
1 Q925I7 (/ISO)
Positive regulation of cold-induced thermogenesis GO:0120162
Any process that activates or increases the frequency, rate or extent of cold-induced thermogenesis.
1 Q8CI19 (/IMP)
Positive regulation of monocyte extravasation GO:2000439
Any process that activates or increases the frequency, rate or extent of monocyte extravasation.
1 Q9EQT1 (/IMP)
Positive regulation of monocyte extravasation GO:2000439
Any process that activates or increases the frequency, rate or extent of monocyte extravasation.
1 Q925I7 (/ISO)

There are 14 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Golgi membrane GO:0000139
The lipid bilayer surrounding any of the compartments of the Golgi apparatus.
5 Q9GZP0 (/TAS) Q9GZP0 (/TAS) Q9GZP0 (/TAS) Q9NRA1 (/TAS) Q9NRA1 (/TAS)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
5 Q9GZP0 (/TAS) Q9GZP0 (/TAS) Q9GZP0 (/TAS) Q9NRA1 (/TAS) Q9NRA1 (/TAS)
Endoplasmic reticulum lumen GO:0005788
The volume enclosed by the membranes of the endoplasmic reticulum.
5 Q9GZP0 (/TAS) Q9GZP0 (/TAS) Q9GZP0 (/TAS) Q9NRA1 (/TAS) Q9NRA1 (/TAS)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
3 Q9EQT1 (/IDA) Q9NRA1 (/IDA) Q9NRA1 (/IDA)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
2 Q8CI19 (/ISO) Q925I7 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 Q9NRA1 (/IDA) Q9NRA1 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
2 Q9NRA1 (/IDA) Q9NRA1 (/IDA)
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
2 Q9NRA1 (/IDA) Q9NRA1 (/IDA)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
2 Q9NRA1 (/HDA) Q9NRA1 (/HDA)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
1 Q8CI19 (/IDA)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
1 Q925I7 (/HDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q8CI19 (/ISO)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 Q8CI19 (/ISO)
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
1 Q8CI19 (/ISO)
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