The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
CD59
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 27: Receptor protein serine/threonine kinase

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 7 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Activin binding GO:0048185
Interacting selectively and non-covalently with activin, a dimer of inhibin-beta subunits.
4 A1Z7L8 (/IDA) A1Z7L9 (/IDA) Q23975 (/IDA) Q7YU60 (/IDA)
Protein serine/threonine kinase activity GO:0004674
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
1 A1Z7L9 (/IDA)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
1 A1Z7L8 (/IPI)
Activin receptor activity, type I GO:0016361
Combining with activin-bound type II activin receptor to initiate a change in cell activity; upon binding, acts as a downstream transducer of activin signals.
1 A1Z7L8 (/IDA)
Activin receptor activity, type I GO:0016361
Combining with activin-bound type II activin receptor to initiate a change in cell activity; upon binding, acts as a downstream transducer of activin signals.
1 Q7YU60 (/IMP)
Activin-activated receptor activity GO:0017002
Combining with activin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. Activin is one of two gonadal glycoproteins related to transforming growth factor beta.
1 A1Z7L8 (/IDA)
Activin binding GO:0048185
Interacting selectively and non-covalently with activin, a dimer of inhibin-beta subunits.
1 A1Z7L8 (/IPI)

There are 21 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Positive regulation of neuroblast proliferation GO:0002052
Any process that activates or increases the rate of neuroblast proliferation.
4 A1Z7L8 (/IMP) A1Z7L9 (/IMP) Q23975 (/IMP) Q7YU60 (/IMP)
Axon guidance GO:0007411
The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues.
4 A1Z7L8 (/IMP) A1Z7L9 (/IMP) Q23975 (/IMP) Q7YU60 (/IMP)
Eye-antennal disc morphogenesis GO:0007455
The process in which the anatomical structures derived from the eye-antennal disc are generated and organized. This includes the transformation of an eye-antennal imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into recognizable adult structures including the eye, antenna, head capsule and maxillary palps.
4 A1Z7L8 (/IGI) A1Z7L9 (/IGI) Q23975 (/IGI) Q7YU60 (/IGI)
Imaginal disc-derived wing morphogenesis GO:0007476
The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying.
4 A1Z7L8 (/IMP) A1Z7L9 (/IMP) Q23975 (/IMP) Q7YU60 (/IMP)
Determination of adult lifespan GO:0008340
The control of viability and duration in the adult phase of the life-cycle.
4 A1Z7L8 (/IMP) A1Z7L9 (/IMP) Q23975 (/IMP) Q7YU60 (/IMP)
Response to UV GO:0009411
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ultraviolet radiation (UV light) stimulus. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers.
4 A1Z7L8 (/IDA) A1Z7L9 (/IDA) Q23975 (/IDA) Q7YU60 (/IDA)
Negative regulation of autophagy GO:0010507
Any process that stops, prevents, or reduces the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm.
4 A1Z7L8 (/IMP) A1Z7L9 (/IMP) Q23975 (/IMP) Q7YU60 (/IMP)
Mushroom body development GO:0016319
The process whose specific outcome is the progression of the mushroom body over time, from its formation to the mature structure. The mushroom body is composed of the prominent neuropil structures of the insect central brain, thought to be crucial for olfactory associated learning. These consist mainly of a bulbous calyx and tightly packaged arrays of thin parallel fibers of the Kenyon cells.
4 A1Z7L8 (/IMP) A1Z7L9 (/IMP) Q23975 (/IMP) Q7YU60 (/IMP)
Neuron development GO:0048666
The process whose specific outcome is the progression of a neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell.
4 A1Z7L8 (/IMP) A1Z7L9 (/IMP) Q23975 (/IMP) Q7YU60 (/IMP)
Dendrite morphogenesis GO:0048813
The process in which the anatomical structures of a dendrite are generated and organized.
4 A1Z7L8 (/NAS) A1Z7L9 (/NAS) Q23975 (/NAS) Q7YU60 (/NAS)
Activin receptor signaling pathway GO:0032924
A series of molecular signals initiated by the binding of an extracellular ligand to an activin receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
3 A1Z7L8 (/IMP) A1Z7L9 (/IMP) Q7YU60 (/IMP)
Pathway-restricted SMAD protein phosphorylation GO:0060389
The process of introducing a phosphate group on to a pathway restricted SMAD protein. A pathway restricted SMAD protein is an effector protein that acts directly downstream of the transforming growth factor family receptor.
3 A1Z7L8 (/IMP) A1Z7L9 (/IMP) Q7YU60 (/IMP)
Activin receptor signaling pathway GO:0032924
A series of molecular signals initiated by the binding of an extracellular ligand to an activin receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
2 A1Z7L8 (/IDA) A1Z7L9 (/IDA)
Activin receptor signaling pathway GO:0032924
A series of molecular signals initiated by the binding of an extracellular ligand to an activin receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
2 A1Z7L8 (/IGI) A1Z7L9 (/IGI)
R8 cell fate specification GO:0045464
The process in which a cell becomes capable of differentiating autonomously into an R8 cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed.
2 A1Z7L8 (/IMP) A1Z7L9 (/IMP)
Positive regulation of imaginal disc growth GO:0045572
Any process that activates or increases the frequency, rate or extent of imaginal disc growth.
2 A1Z7L8 (/IMP) A1Z7L9 (/IMP)
Glucose homeostasis GO:0042593
Any process involved in the maintenance of an internal steady state of glucose within an organism or cell.
1 A1Z7L9 (/IMP)
Regulation of imaginal disc-derived wing size GO:0044719
Any process that modulates the size of an imaginal disc-derived wing.
1 A1Z7L8 (/IMP)
Regulation of synapse structure or activity GO:0050803
Any process that modulates the physical form or the activity of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell).
1 A1Z7L8 (/IMP)
SMAD protein signal transduction GO:0060395
The cascade of processes by which a signal interacts with a receptor, causing a change in the activity of a SMAD protein, and ultimately effecting a change in the functioning of the cell.
1 A1Z7L8 (/IDA)
Cellular response to glucose stimulus GO:0071333
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucose stimulus.
1 Q7YU60 (/IMP)

There are 2 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Activin receptor complex GO:0048179
A protein complex that acts as an activin receptor. Heterodimeric activin receptors, comprising one Type I activin receptor and one Type II receptor polypeptide, and heterotrimeric receptors have been observed.
3 A1Z7L8 (/IPI) A1Z7L9 (/IPI) Q7YU60 (/IPI)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 A1Z7L8 (/HDA)
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