The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
CD59
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 25: Receptor protein serine/threonine kinase

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 6 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Transforming growth factor beta receptor activity, type I GO:0005025
Combining with a complex of transforming growth factor beta and a type II TGF-beta receptor to initiate a change in cell activity; upon binding, acts as a downstream transducer of TGF-beta signals.
6 A0A0B4K7J3 (/NAS) Q7JPM7 (/NAS) Q7JPN8 (/NAS) Q7JQ36 (/NAS) Q7JQ39 (/NAS) Q95U21 (/NAS)
Transmembrane receptor protein serine/threonine kinase activity GO:0004675
Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
1 A0A0B4K7J3 (/IDA)
BMP binding GO:0036122
Interacting selectively and non-covalently with a member of the bone morphogenetic protein (BMP) family.
1 A0A0B4K7J3 (/IDA)
I-SMAD binding GO:0070411
Interacting selectively and non-covalently with an inhibitory SMAD signaling protein.
1 A0A0B4K7J3 (/IPI)
BMP receptor activity GO:0098821
Combining with a member of the bone morphogenetic protein (BMP) family, and transmitting a signal across the plasma membrane to initiate a change in cell activity.
1 A0A0B4K7J3 (/IDA)
BMP receptor activity GO:0098821
Combining with a member of the bone morphogenetic protein (BMP) family, and transmitting a signal across the plasma membrane to initiate a change in cell activity.
1 A0A0B4K7J3 (/IMP)

There are 17 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Compound eye morphogenesis GO:0001745
The morphogenetic process in which the anatomical structures of the compound eye are generated and organized. The adult compound eye is a precise assembly of 700-800 ommatidia. Each ommatidium is composed of 20 cells, identified by cell type and position. An example of compound eye morphogenesis is found in Drosophila melanogaster.
6 A0A0B4K7J3 (/NAS) Q7JPM7 (/NAS) Q7JPN8 (/NAS) Q7JQ36 (/NAS) Q7JQ39 (/NAS) Q95U21 (/NAS)
Anterior/posterior pattern specification, imaginal disc GO:0007448
The establishment, maintenance and elaboration of the anterior/posterior axis of the imaginal disc. Imaginal discs are epithelial infoldings in the larvae of holometabolous insects that rapidly develop into adult appendages during metamorphosis from larval to adult form.
6 A0A0B4K7J3 (/IMP) Q7JPM7 (/IMP) Q7JPN8 (/IMP) Q7JQ36 (/IMP) Q7JQ39 (/IMP) Q95U21 (/IMP)
Imaginal disc-derived wing morphogenesis GO:0007476
The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying.
6 A0A0B4K7J3 (/IMP) Q7JPM7 (/IMP) Q7JPN8 (/IMP) Q7JQ36 (/IMP) Q7JQ39 (/IMP) Q95U21 (/IMP)
Maternal determination of anterior/posterior axis, embryo GO:0008358
The specification of the anterior/posterior axis of the embryo by gradients of maternally-transcribed gene products; exemplified in insects by the morphogens, bicoid and nanos.
6 A0A0B4K7J3 (/HMP) Q7JPM7 (/HMP) Q7JPN8 (/HMP) Q7JQ36 (/HMP) Q7JQ39 (/HMP) Q95U21 (/HMP)
Ovarian follicle cell development GO:0030707
The process that occurs during oogenesis involving the ovarian follicle cells, somatic cells which surround the germ cells of an ovary. An example of this is found in Drosophila melanogaster.
6 A0A0B4K7J3 (/TAS) Q7JPM7 (/TAS) Q7JPN8 (/TAS) Q7JQ36 (/TAS) Q7JQ39 (/TAS) Q95U21 (/TAS)
Germ-line stem cell population maintenance GO:0030718
Any process by which an organism or tissue maintains a population of germ-line stem cells.
6 A0A0B4K7J3 (/IMP) Q7JPM7 (/IMP) Q7JPN8 (/IMP) Q7JQ36 (/IMP) Q7JQ39 (/IMP) Q95U21 (/IMP)
Germ-line stem cell division GO:0042078
The self-renewing division of a germline stem cell to produce a daughter stem cell and a daughter germ cell, which will divide to form the gametes.
6 A0A0B4K7J3 (/IMP) Q7JPM7 (/IMP) Q7JPN8 (/IMP) Q7JQ36 (/IMP) Q7JQ39 (/IMP) Q95U21 (/IMP)
Negative regulation of innate immune response GO:0045824
Any process that stops, prevents, or reduces the frequency, rate or extent of the innate immune response.
6 A0A0B4K7J3 (/HMP) Q7JPM7 (/HMP) Q7JPN8 (/HMP) Q7JQ36 (/HMP) Q7JQ39 (/HMP) Q95U21 (/HMP)
Defense response to Gram-negative bacterium GO:0050829
Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism.
6 A0A0B4K7J3 (/HMP) Q7JPM7 (/HMP) Q7JPN8 (/HMP) Q7JQ36 (/HMP) Q7JQ39 (/HMP) Q95U21 (/HMP)
Dorsal/ventral pattern formation GO:0009953
The regionalization process in which the areas along the dorsal/ventral axis are established that will lead to differences in cell differentiation. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism.
1 A0A0B4K7J3 (/IGI)
Dorsal/ventral pattern formation GO:0009953
The regionalization process in which the areas along the dorsal/ventral axis are established that will lead to differences in cell differentiation. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism.
1 A0A0B4K7J3 (/IMP)
BMP signaling pathway GO:0030509
A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
1 A0A0B4K7J3 (/IDA)
BMP signaling pathway GO:0030509
A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
1 A0A0B4K7J3 (/IGI)
BMP signaling pathway GO:0030509
A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
1 A0A0B4K7J3 (/IMP)
Ovarian follicle cell development GO:0030707
The process that occurs during oogenesis involving the ovarian follicle cells, somatic cells which surround the germ cells of an ovary. An example of this is found in Drosophila melanogaster.
1 A0A0B4K7J3 (/IMP)
Wing disc pattern formation GO:0035222
The process giving rise to the pattern of cell differentiation in the wing imaginal disc.
1 A0A0B4K7J3 (/IMP)
Positive regulation of synaptic growth at neuromuscular junction GO:0045887
Any process that activates or increases the frequency, rate or extent of synaptic growth at neuromuscular junction.
1 A0A0B4K7J3 (/IMP)

There are 3 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 A0A0B4K7J3 (/HDA)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 A0A0B4K7J3 (/ISS)
BMP receptor complex GO:0070724
A protein complex that acts as a receptor for bone morphogenetic proteins (BMPs); a homo- or heterodimer of type I and/or type II BMP receptor subunits.
1 A0A0B4K7J3 (/IPI)
CATH-Gene3D is a Global Biodata Core Resource Learn more...