The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Peptidase M1, leukotriene A4 hydrolase/aminopeptidase C-terminal domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 2: Leukotriene A(4) hydrolase

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 22 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Aminopeptidase activity GO:0004177
Catalysis of the hydrolysis of N-terminal amino acid residues from in a polypeptide chain.
5 P19602 (/ISS) P24527 (/ISS) P30349 (/ISS) Q3SZH7 (/ISS) Q6S9C8 (/ISS)
Epoxide hydrolase activity GO:0004301
Catalysis of the reaction: an epoxide + H2O = a glycol.
5 P19602 (/ISS) P24527 (/ISS) P30349 (/ISS) Q3SZH7 (/ISS) Q6S9C8 (/ISS)
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
5 P19602 (/ISS) P24527 (/ISS) P30349 (/ISS) Q3SZH7 (/ISS) Q6S9C8 (/ISS)
Leukotriene-A4 hydrolase activity GO:0004463
Catalysis of the reaction: H(2)O + leukotriene A(4) = leukotriene B(4).
4 P09960 (/IDA) P09960 (/IDA) P09960 (/IDA) P30349 (/IDA)
Leukotriene-A4 hydrolase activity GO:0004463
Catalysis of the reaction: H(2)O + leukotriene A(4) = leukotriene B(4).
4 P19602 (/ISS) P24527 (/ISS) Q3SZH7 (/ISS) Q6S9C8 (/ISS)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
4 P09960 (/IPI) P09960 (/IPI) P09960 (/IPI) P24527 (/IPI)
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
3 P09960 (/HDA) P09960 (/HDA) P09960 (/HDA)
Aminopeptidase activity GO:0004177
Catalysis of the hydrolysis of N-terminal amino acid residues from in a polypeptide chain.
3 P09960 (/IDA) P09960 (/IDA) P09960 (/IDA)
Epoxide hydrolase activity GO:0004301
Catalysis of the reaction: an epoxide + H2O = a glycol.
3 P09960 (/IDA) P09960 (/IDA) P09960 (/IDA)
Epoxide hydrolase activity GO:0004301
Catalysis of the reaction: an epoxide + H2O = a glycol.
3 P09960 (/IMP) P09960 (/IMP) P09960 (/IMP)
Epoxide hydrolase activity GO:0004301
Catalysis of the reaction: an epoxide + H2O = a glycol.
3 P09960 (/TAS) P09960 (/TAS) P09960 (/TAS)
Leukotriene-A4 hydrolase activity GO:0004463
Catalysis of the reaction: H(2)O + leukotriene A(4) = leukotriene B(4).
3 P09960 (/TAS) P09960 (/TAS) P09960 (/TAS)
Peptidase activity GO:0008233
Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid.
3 P09960 (/TAS) P09960 (/TAS) P09960 (/TAS)
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
3 P09960 (/IDA) P09960 (/IDA) P09960 (/IDA)
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
3 P09960 (/IMP) P09960 (/IMP) P09960 (/IMP)
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
3 P09960 (/TAS) P09960 (/TAS) P09960 (/TAS)
Metalloaminopeptidase activity GO:0070006
Catalysis of the hydrolysis of N-terminal amino acid residues from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
3 P09960 (/IMP) P09960 (/IMP) P09960 (/IMP)
Aminopeptidase activity GO:0004177
Catalysis of the hydrolysis of N-terminal amino acid residues from in a polypeptide chain.
1 P24527 (/ISO)
Epoxide hydrolase activity GO:0004301
Catalysis of the reaction: an epoxide + H2O = a glycol.
1 P24527 (/ISO)
Leukotriene-A4 hydrolase activity GO:0004463
Catalysis of the reaction: H(2)O + leukotriene A(4) = leukotriene B(4).
1 P24527 (/ISO)
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
1 P24527 (/ISO)
Metalloaminopeptidase activity GO:0070006
Catalysis of the hydrolysis of N-terminal amino acid residues from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
1 P24527 (/ISO)

There are 18 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Leukotriene biosynthetic process GO:0019370
The chemical reactions and pathways resulting in the formation of leukotriene, a pharmacologically active substance derived from a polyunsaturated fatty acid, such as arachidonic acid.
5 P19602 (/ISS) P24527 (/ISS) P30349 (/ISS) Q3SZH7 (/ISS) Q6S9C8 (/ISS)
Peptide catabolic process GO:0043171
The chemical reactions and pathways resulting in the breakdown of peptides, compounds of 2 or more (but usually less than 100) amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another.
5 P19602 (/ISS) P24527 (/ISS) P30349 (/ISS) Q3SZH7 (/ISS) Q6S9C8 (/ISS)
Leukotriene metabolic process GO:0006691
The chemical reactions and pathways involving leukotriene, a pharmacologically active substance derived from a polyunsaturated fatty acid, such as arachidonic acid.
3 P09960 (/TAS) P09960 (/TAS) P09960 (/TAS)
Leukotriene biosynthetic process GO:0019370
The chemical reactions and pathways resulting in the formation of leukotriene, a pharmacologically active substance derived from a polyunsaturated fatty acid, such as arachidonic acid.
3 P09960 (/IDA) P09960 (/IDA) P09960 (/IDA)
Leukotriene biosynthetic process GO:0019370
The chemical reactions and pathways resulting in the formation of leukotriene, a pharmacologically active substance derived from a polyunsaturated fatty acid, such as arachidonic acid.
3 P09960 (/IMP) P09960 (/IMP) P09960 (/IMP)
Leukotriene biosynthetic process GO:0019370
The chemical reactions and pathways resulting in the formation of leukotriene, a pharmacologically active substance derived from a polyunsaturated fatty acid, such as arachidonic acid.
3 P09960 (/TAS) P09960 (/TAS) P09960 (/TAS)
Long-chain fatty acid biosynthetic process GO:0042759
The chemical reactions and pathways resulting in the formation of long-chain fatty acids, any fatty acid with a chain length between C13 and C22.
3 P09960 (/TAS) P09960 (/TAS) P09960 (/TAS)
Peptide catabolic process GO:0043171
The chemical reactions and pathways resulting in the breakdown of peptides, compounds of 2 or more (but usually less than 100) amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another.
3 P09960 (/IDA) P09960 (/IDA) P09960 (/IDA)
Neutrophil degranulation GO:0043312
The regulated exocytosis of secretory granules containing preformed mediators such as proteases, lipases, and inflammatory mediators by a neutrophil.
3 P09960 (/TAS) P09960 (/TAS) P09960 (/TAS)
Cellular protein metabolic process GO:0044267
The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes cellular protein modification.
3 P09960 (/IMP) P09960 (/IMP) P09960 (/IMP)
Leukotriene metabolic process GO:0006691
The chemical reactions and pathways involving leukotriene, a pharmacologically active substance derived from a polyunsaturated fatty acid, such as arachidonic acid.
1 P30349 (/IDA)
Leukotriene metabolic process GO:0006691
The chemical reactions and pathways involving leukotriene, a pharmacologically active substance derived from a polyunsaturated fatty acid, such as arachidonic acid.
1 P24527 (/ISO)
Response to zinc ion GO:0010043
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a zinc ion stimulus.
1 P30349 (/IEP)
Leukotriene biosynthetic process GO:0019370
The chemical reactions and pathways resulting in the formation of leukotriene, a pharmacologically active substance derived from a polyunsaturated fatty acid, such as arachidonic acid.
1 P24527 (/ISO)
Peptide catabolic process GO:0043171
The chemical reactions and pathways resulting in the breakdown of peptides, compounds of 2 or more (but usually less than 100) amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another.
1 P24527 (/ISO)
Response to peptide hormone GO:0043434
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide hormone stimulus. A peptide hormone is any of a class of peptides that are secreted into the blood stream and have endocrine functions in living animals.
1 P30349 (/IEP)
Cellular protein metabolic process GO:0044267
The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes cellular protein modification.
1 P24527 (/ISO)
Type I pneumocyte differentiation GO:0060509
The process in which a relatively unspecialized cell acquires specialized features of a type I pneumocyte. A type I pneumocyte is a flattened cell with greatly attenuated cytoplasm and a paucity of organelles.
1 P30349 (/IEP)

There are 13 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
7 A0A140VK27 (/IDA) A0A140VK27 (/IDA) A0A140VK27 (/IDA) P09960 (/IDA) P09960 (/IDA) P09960 (/IDA) P30349 (/IDA)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
6 A0A140VK27 (/IDA) A0A140VK27 (/IDA) A0A140VK27 (/IDA) P09960 (/IDA) P09960 (/IDA) P09960 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
6 A0A140VK27 (/IDA) A0A140VK27 (/IDA) A0A140VK27 (/IDA) P09960 (/IDA) P09960 (/IDA) P09960 (/IDA)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
3 P09960 (/TAS) P09960 (/TAS) P09960 (/TAS)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
3 P09960 (/TAS) P09960 (/TAS) P09960 (/TAS)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
3 P09960 (/HDA) P09960 (/HDA) P09960 (/HDA)
Tertiary granule lumen GO:1904724
Any membrane-enclosed lumen that is part of a tertiary granule.
3 P09960 (/TAS) P09960 (/TAS) P09960 (/TAS)
Ficolin-1-rich granule lumen GO:1904813
Any membrane-enclosed lumen that is part of a ficolin-1-rich granule.
3 P09960 (/TAS) P09960 (/TAS) P09960 (/TAS)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 P24527 (/ISO)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
1 P24527 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 P30349 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 P24527 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 P24527 (/ISO)
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