The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Ankyrin repeat-containing domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 17: KN motif and ankyrin repeat domain-containing prot...

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 3 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Beta-catenin binding GO:0008013
Interacting selectively and non-covalently with the beta subunit of the catenin complex.
5 E9Q238 (/ISO) Q6AXG6 (/ISO) Q6PDJ3 (/ISO) Q810T9 (/ISO) Q8BUK3 (/ISO)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
3 D3ZD05 (/IPI) Q14678 (/IPI) Q63ZY3 (/IPI)
Beta-catenin binding GO:0008013
Interacting selectively and non-covalently with the beta subunit of the catenin complex.
1 Q14678 (/IDA)

There are 58 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Regulation of Rho protein signal transduction GO:0035023
Any process that modulates the frequency, rate or extent of Rho protein signal transduction.
6 E9Q238 (/ISO) Q6AXG6 (/ISO) Q6PDJ3 (/ISO) Q810T9 (/ISO) Q8BUK3 (/ISO) Q8BX02 (/ISO)
Glomerular visceral epithelial cell migration GO:0090521
The orderly movement of a podocyte from one site to another, often during the development of a multicellular organism or multicellular structure. A podocyte is a specialized kidney epithelial cell.
6 E9Q238 (/ISO) Q6AXG6 (/ISO) Q6PDJ3 (/ISO) Q810T9 (/ISO) Q8BUK3 (/ISO) Q8BX02 (/ISO)
Cell population proliferation GO:0008283
The multiplication or reproduction of cells, resulting in the expansion of a cell population.
5 E9Q238 (/ISO) Q6AXG6 (/ISO) Q6PDJ3 (/ISO) Q810T9 (/ISO) Q8BUK3 (/ISO)
Negative regulation of neuron projection development GO:0010977
Any process that decreases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
5 E9Q238 (/ISO) Q6AXG6 (/ISO) Q6PDJ3 (/ISO) Q810T9 (/ISO) Q8BUK3 (/ISO)
Actin cytoskeleton organization GO:0030036
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.
5 E9Q238 (/ISO) Q6AXG6 (/ISO) Q6PDJ3 (/ISO) Q810T9 (/ISO) Q8BUK3 (/ISO)
Positive regulation of Wnt signaling pathway GO:0030177
Any process that activates or increases the frequency, rate or extent of Wnt signal transduction.
5 E9Q238 (/ISO) Q6AXG6 (/ISO) Q6PDJ3 (/ISO) Q810T9 (/ISO) Q8BUK3 (/ISO)
Negative regulation of cell migration GO:0030336
Any process that stops, prevents, or reduces the frequency, rate or extent of cell migration.
5 E9Q238 (/ISO) Q6AXG6 (/ISO) Q6PDJ3 (/ISO) Q810T9 (/ISO) Q8BUK3 (/ISO)
Negative regulation of actin filament polymerization GO:0030837
Any process that stops, prevents, or reduces the frequency, rate or extent of actin polymerization.
5 E9Q238 (/ISO) Q6AXG6 (/ISO) Q6PDJ3 (/ISO) Q810T9 (/ISO) Q8BUK3 (/ISO)
Negative regulation of Rho protein signal transduction GO:0035024
Any process that stops, prevents, or reduces the frequency, rate or extent of Rho protein signal transduction.
5 E9Q238 (/ISO) Q6AXG6 (/ISO) Q6PDJ3 (/ISO) Q810T9 (/ISO) Q8BUK3 (/ISO)
Negative regulation of insulin receptor signaling pathway GO:0046627
Any process that stops, prevents, or reduces the frequency, rate or extent of insulin receptor signaling.
5 E9Q238 (/ISO) Q6AXG6 (/ISO) Q6PDJ3 (/ISO) Q810T9 (/ISO) Q8BUK3 (/ISO)
Positive regulation of canonical Wnt signaling pathway GO:0090263
Any process that increases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes.
5 E9Q238 (/ISO) Q6AXG6 (/ISO) Q6PDJ3 (/ISO) Q810T9 (/ISO) Q8BUK3 (/ISO)
Positive regulation of wound healing GO:0090303
Any process that increases the rate, frequency, or extent of the series of events that restore integrity to a damaged tissue, following an injury.
5 E9Q238 (/ISO) Q6AXG6 (/ISO) Q6PDJ3 (/ISO) Q810T9 (/ISO) Q8BUK3 (/ISO)
Negative regulation of substrate adhesion-dependent cell spreading GO:1900025
Any process that stops, prevents or reduces the frequency, rate or extent of substrate adhesion-dependent cell spreading.
5 E9Q238 (/ISO) Q6AXG6 (/ISO) Q6PDJ3 (/ISO) Q810T9 (/ISO) Q8BUK3 (/ISO)
Negative regulation of ruffle assembly GO:1900028
Any process that stops, prevents or reduces the frequency, rate or extent of ruffle assembly.
5 E9Q238 (/ISO) Q6AXG6 (/ISO) Q6PDJ3 (/ISO) Q810T9 (/ISO) Q8BUK3 (/ISO)
Regulation of establishment of cell polarity GO:2000114
Any process that modulates the frequency, rate or extent of establishment of cell polarity.
5 E9Q238 (/ISO) Q6AXG6 (/ISO) Q6PDJ3 (/ISO) Q810T9 (/ISO) Q8BUK3 (/ISO)
Negative regulation of lamellipodium morphogenesis GO:2000393
Any process that stops, prevents or reduces the frequency, rate or extent of lamellipodium morphogenesis.
5 E9Q238 (/ISO) Q6AXG6 (/ISO) Q6PDJ3 (/ISO) Q810T9 (/ISO) Q8BUK3 (/ISO)
Regulation of Rho protein signal transduction GO:0035023
Any process that modulates the frequency, rate or extent of Rho protein signal transduction.
3 Q14678 (/IMP) Q63ZY3 (/IMP) Q8BX02 (/IMP)
Regulation of Rho protein signal transduction GO:0035023
Any process that modulates the frequency, rate or extent of Rho protein signal transduction.
3 D3ZD05 (/ISS) Q1LZH7 (/ISS) X1WE18 (/ISS)
Kidney epithelium development GO:0072073
The process whose specific outcome is the progression of an epithelium in the kidney over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure.
3 D3ZD05 (/ISS) Q1LZH7 (/ISS) Q8BX02 (/ISS)
Glomerular visceral epithelial cell migration GO:0090521
The orderly movement of a podocyte from one site to another, often during the development of a multicellular organism or multicellular structure. A podocyte is a specialized kidney epithelial cell.
3 Q14678 (/IMP) Q63ZY3 (/IMP) Q8BX02 (/IMP)
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
2 Q1LZH7 (/ISS) Q8BX02 (/ISS)
Negative regulation of cell population proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
2 Q1LZH7 (/ISS) Q8BX02 (/ISS)
Negative regulation of intracellular estrogen receptor signaling pathway GO:0033147
Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of an intracellular estrogen receptor signaling pathway.
2 Q1LZH7 (/ISS) Q8BX02 (/ISS)
Negative regulation of programmed cell death GO:0043069
Any process that stops, prevents, or reduces the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes.
2 Q1LZH7 (/ISS) Q8BX02 (/ISS)
Negative regulation of vitamin D receptor signaling pathway GO:0070563
Any process that stops, prevents, or reduces the frequency, rate or extent of the vitamin D receptor signaling pathway activity.
2 Q1LZH7 (/ISS) Q8BX02 (/ISS)
Glomerular visceral epithelial cell migration GO:0090521
The orderly movement of a podocyte from one site to another, often during the development of a multicellular organism or multicellular structure. A podocyte is a specialized kidney epithelial cell.
2 D3ZD05 (/ISS) Q1LZH7 (/ISS)
Negative regulation of G1/S transition of mitotic cell cycle GO:2000134
Any signalling pathway that decreases or inhibits the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the mitotic cell cycle.
2 Q1LZH7 (/ISS) Q8BX02 (/ISS)
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
1 Q63ZY3 (/IDA)
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
1 Q8BX02 (/ISO)
Cell population proliferation GO:0008283
The multiplication or reproduction of cells, resulting in the expansion of a cell population.
1 Q14678 (/IMP)
Negative regulation of cell population proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
1 Q63ZY3 (/IDA)
Negative regulation of cell population proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
1 Q8BX02 (/ISO)
Negative regulation of neuron projection development GO:0010977
Any process that decreases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
1 Q14678 (/IDA)
Actin cytoskeleton organization GO:0030036
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.
1 Q14678 (/IMP)
Positive regulation of Wnt signaling pathway GO:0030177
Any process that activates or increases the frequency, rate or extent of Wnt signal transduction.
1 Q14678 (/IDA)
Negative regulation of cell migration GO:0030336
Any process that stops, prevents, or reduces the frequency, rate or extent of cell migration.
1 Q14678 (/IMP)
Negative regulation of actin filament polymerization GO:0030837
Any process that stops, prevents, or reduces the frequency, rate or extent of actin polymerization.
1 Q14678 (/IDA)
Glomerular basement membrane development GO:0032836
The process whose specific outcome is the progression of the glomerular basement membrane over time, from its formation to the mature structure. The glomerular basement membrane is the basal laminal portion of the glomerulus which performs the actual filtration.
1 X1WE18 (/IMP)
Negative regulation of intracellular estrogen receptor signaling pathway GO:0033147
Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of an intracellular estrogen receptor signaling pathway.
1 Q63ZY3 (/IDA)
Negative regulation of intracellular estrogen receptor signaling pathway GO:0033147
Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of an intracellular estrogen receptor signaling pathway.
1 Q8BX02 (/ISO)
Negative regulation of Rho protein signal transduction GO:0035024
Any process that stops, prevents, or reduces the frequency, rate or extent of Rho protein signal transduction.
1 Q14678 (/IMP)
Negative regulation of programmed cell death GO:0043069
Any process that stops, prevents, or reduces the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes.
1 Q63ZY3 (/IDA)
Negative regulation of programmed cell death GO:0043069
Any process that stops, prevents, or reduces the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes.
1 Q8BX02 (/ISO)
Negative regulation of insulin receptor signaling pathway GO:0046627
Any process that stops, prevents, or reduces the frequency, rate or extent of insulin receptor signaling.
1 Q14678 (/IMP)
Negative regulation of stress fiber assembly GO:0051497
Any process that stops, prevents, or reduces the frequency, rate or extent of the assembly a stress fiber, a bundle of microfilaments and other proteins found in fibroblasts.
1 Q8BX02 (/ISO)
Negative regulation of vitamin D receptor signaling pathway GO:0070563
Any process that stops, prevents, or reduces the frequency, rate or extent of the vitamin D receptor signaling pathway activity.
1 Q63ZY3 (/IMP)
Negative regulation of vitamin D receptor signaling pathway GO:0070563
Any process that stops, prevents, or reduces the frequency, rate or extent of the vitamin D receptor signaling pathway activity.
1 Q8BX02 (/ISO)
Glomerular visceral epithelial cell development GO:0072015
The process whose specific outcome is the progression of a glomerular visceral epithelial cell over time, from its formation to the mature structure. A glomerular visceral epithelial cell is a specialized epithelial cell that contains \feet\ that interdigitate with the \feet\ of other glomerular epithelial cells.
1 X1WE18 (/IMP)
Kidney epithelium development GO:0072073
The process whose specific outcome is the progression of an epithelium in the kidney over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure.
1 Q63ZY3 (/IMP)
Kidney epithelium development GO:0072073
The process whose specific outcome is the progression of an epithelium in the kidney over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure.
1 Q8BX02 (/ISO)
Positive regulation of canonical Wnt signaling pathway GO:0090263
Any process that increases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes.
1 Q14678 (/IMP)
Positive regulation of wound healing GO:0090303
Any process that increases the rate, frequency, or extent of the series of events that restore integrity to a damaged tissue, following an injury.
1 Q14678 (/IMP)
Negative regulation of substrate adhesion-dependent cell spreading GO:1900025
Any process that stops, prevents or reduces the frequency, rate or extent of substrate adhesion-dependent cell spreading.
1 Q14678 (/IDA)
Negative regulation of ruffle assembly GO:1900028
Any process that stops, prevents or reduces the frequency, rate or extent of ruffle assembly.
1 Q14678 (/IDA)
Regulation of establishment of cell polarity GO:2000114
Any process that modulates the frequency, rate or extent of establishment of cell polarity.
1 Q14678 (/IMP)
Negative regulation of G1/S transition of mitotic cell cycle GO:2000134
Any signalling pathway that decreases or inhibits the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the mitotic cell cycle.
1 Q63ZY3 (/IDA)
Negative regulation of G1/S transition of mitotic cell cycle GO:2000134
Any signalling pathway that decreases or inhibits the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the mitotic cell cycle.
1 Q8BX02 (/ISO)
Negative regulation of lamellipodium morphogenesis GO:2000393
Any process that stops, prevents or reduces the frequency, rate or extent of lamellipodium morphogenesis.
1 Q14678 (/IDA)

There are 11 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
6 E9Q238 (/ISO) Q6AXG6 (/ISO) Q6PDJ3 (/ISO) Q810T9 (/ISO) Q8BUK3 (/ISO) Q8BX02 (/ISO)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
5 E9Q238 (/ISO) Q6AXG6 (/ISO) Q6PDJ3 (/ISO) Q810T9 (/ISO) Q8BUK3 (/ISO)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
5 E9Q238 (/ISO) Q6AXG6 (/ISO) Q6PDJ3 (/ISO) Q810T9 (/ISO) Q8BUK3 (/ISO)
Ruffle membrane GO:0032587
The portion of the plasma membrane surrounding a ruffle.
5 E9Q238 (/ISO) Q6AXG6 (/ISO) Q6PDJ3 (/ISO) Q810T9 (/ISO) Q8BUK3 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
2 Q14678 (/IDA) Q63ZY3 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
2 Q1LZH7 (/ISS) Q8BX02 (/ISS)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
2 Q1LZH7 (/ISS) Q8BX02 (/ISS)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 Q63ZY3 (/IDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 Q8BX02 (/ISO)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 Q14678 (/IDA)
Ruffle membrane GO:0032587
The portion of the plasma membrane surrounding a ruffle.
1 Q14678 (/IDA)