The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Leucine-rich Repeat Variant
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 92: apoptosis inhibitor 5 isoform X2

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 5 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
13 Q9BZZ5 (/HDA) Q9BZZ5 (/HDA) Q9BZZ5 (/HDA) Q9BZZ5 (/HDA) Q9BZZ5 (/HDA) Q9BZZ5 (/HDA) Q9BZZ5 (/HDA) Q9BZZ5 (/HDA) Q9BZZ5 (/HDA) Q9BZZ5 (/HDA)
(3 more)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
13 Q9BZZ5 (/IPI) Q9BZZ5 (/IPI) Q9BZZ5 (/IPI) Q9BZZ5 (/IPI) Q9BZZ5 (/IPI) Q9BZZ5 (/IPI) Q9BZZ5 (/IPI) Q9BZZ5 (/IPI) Q9BZZ5 (/IPI) Q9BZZ5 (/IPI)
(3 more)
Fibroblast growth factor binding GO:0017134
Interacting selectively and non-covalently with a fibroblast growth factor.
13 Q9BZZ5 (/IPI) Q9BZZ5 (/IPI) Q9BZZ5 (/IPI) Q9BZZ5 (/IPI) Q9BZZ5 (/IPI) Q9BZZ5 (/IPI) Q9BZZ5 (/IPI) Q9BZZ5 (/IPI) Q9BZZ5 (/IPI) Q9BZZ5 (/IPI)
(3 more)
Fibroblast growth factor binding GO:0017134
Interacting selectively and non-covalently with a fibroblast growth factor.
7 O35841 (/ISS) Q5R644 (/ISS) Q5R644 (/ISS) Q5R644 (/ISS) Q5R644 (/ISS) Q5R644 (/ISS) Q5ZMW3 (/ISS)
Fibroblast growth factor binding GO:0017134
Interacting selectively and non-covalently with a fibroblast growth factor.
1 O35841 (/ISO)

There are 6 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
19 Q5R644 (/ISS) Q5R644 (/ISS) Q5R644 (/ISS) Q5R644 (/ISS) Q5R644 (/ISS) Q5ZMW3 (/ISS) Q9BZZ5 (/ISS) Q9BZZ5 (/ISS) Q9BZZ5 (/ISS) Q9BZZ5 (/ISS)
(9 more)
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
13 Q9BZZ5 (/IMP) Q9BZZ5 (/IMP) Q9BZZ5 (/IMP) Q9BZZ5 (/IMP) Q9BZZ5 (/IMP) Q9BZZ5 (/IMP) Q9BZZ5 (/IMP) Q9BZZ5 (/IMP) Q9BZZ5 (/IMP) Q9BZZ5 (/IMP)
(3 more)
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
13 Q9BZZ5 (/NAS) Q9BZZ5 (/NAS) Q9BZZ5 (/NAS) Q9BZZ5 (/NAS) Q9BZZ5 (/NAS) Q9BZZ5 (/NAS) Q9BZZ5 (/NAS) Q9BZZ5 (/NAS) Q9BZZ5 (/NAS) Q9BZZ5 (/NAS)
(3 more)
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
13 Q9BZZ5 (/TAS) Q9BZZ5 (/TAS) Q9BZZ5 (/TAS) Q9BZZ5 (/TAS) Q9BZZ5 (/TAS) Q9BZZ5 (/TAS) Q9BZZ5 (/TAS) Q9BZZ5 (/TAS) Q9BZZ5 (/TAS) Q9BZZ5 (/TAS)
(3 more)
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
1 O35841 (/ISO)
Negative regulation of fibroblast apoptotic process GO:2000270
Any process that stops, prevents or reduces the frequency, rate or extent of fibroblast apoptotic process.
1 O35841 (/IDA)

There are 8 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nuclear speck GO:0016607
A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy.
16 G3V1C3 (/IDA) G3V1C3 (/IDA) G3V1C3 (/IDA) Q9BZZ5 (/IDA) Q9BZZ5 (/IDA) Q9BZZ5 (/IDA) Q9BZZ5 (/IDA) Q9BZZ5 (/IDA) Q9BZZ5 (/IDA) Q9BZZ5 (/IDA)
(6 more)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
13 Q9BZZ5 (/IDA) Q9BZZ5 (/IDA) Q9BZZ5 (/IDA) Q9BZZ5 (/IDA) Q9BZZ5 (/IDA) Q9BZZ5 (/IDA) Q9BZZ5 (/IDA) Q9BZZ5 (/IDA) Q9BZZ5 (/IDA) Q9BZZ5 (/IDA)
(3 more)
Spliceosomal complex GO:0005681
Any of a series of ribonucleoprotein complexes that contain snRNA(s) and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the spliceosomal splicing of one or more substrate RNAs, and which also contain the RNA substrate(s) from the initial target RNAs of splicing, the splicing intermediate RNA(s), to the final RNA products. During cis-splicing, the initial target RNA is a single, contiguous RNA transcript, whether mRNA, snoRNA, etc., and the released products are a spliced RNA and an excised intron, generally as a lariat structure. During trans-splicing, there are two initial substrate RNAs, the spliced leader RNA and a pre-mRNA.
13 Q9BZZ5 (/ISS) Q9BZZ5 (/ISS) Q9BZZ5 (/ISS) Q9BZZ5 (/ISS) Q9BZZ5 (/ISS) Q9BZZ5 (/ISS) Q9BZZ5 (/ISS) Q9BZZ5 (/ISS) Q9BZZ5 (/ISS) Q9BZZ5 (/ISS)
(3 more)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
13 Q9BZZ5 (/NAS) Q9BZZ5 (/NAS) Q9BZZ5 (/NAS) Q9BZZ5 (/NAS) Q9BZZ5 (/NAS) Q9BZZ5 (/NAS) Q9BZZ5 (/NAS) Q9BZZ5 (/NAS) Q9BZZ5 (/NAS) Q9BZZ5 (/NAS)
(3 more)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
13 Q9BZZ5 (/HDA) Q9BZZ5 (/HDA) Q9BZZ5 (/HDA) Q9BZZ5 (/HDA) Q9BZZ5 (/HDA) Q9BZZ5 (/HDA) Q9BZZ5 (/HDA) Q9BZZ5 (/HDA) Q9BZZ5 (/HDA) Q9BZZ5 (/HDA)
(3 more)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 O35841 (/ISO)
Spliceosomal complex GO:0005681
Any of a series of ribonucleoprotein complexes that contain snRNA(s) and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the spliceosomal splicing of one or more substrate RNAs, and which also contain the RNA substrate(s) from the initial target RNAs of splicing, the splicing intermediate RNA(s), to the final RNA products. During cis-splicing, the initial target RNA is a single, contiguous RNA transcript, whether mRNA, snoRNA, etc., and the released products are a spliced RNA and an excised intron, generally as a lariat structure. During trans-splicing, there are two initial substrate RNAs, the spliced leader RNA and a pre-mRNA.
1 O35841 (/IDA)
Nuclear speck GO:0016607
A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy.
1 O35841 (/ISO)
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