The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Leucine-rich Repeat Variant
".
FunFam 761: Adenomatous polyposis coli protein-related protein...
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 3 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
1 | Q21227 (/IPI) |
Beta-catenin binding GO:0008013
Interacting selectively and non-covalently with the beta subunit of the catenin complex.
|
1 | Q21227 (/IPI) |
Protein N-terminus binding GO:0047485
Interacting selectively and non-covalently with a protein N-terminus, the end of any peptide chain at which the 2-amino (or 2-imino) function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue.
|
1 | Q21227 (/IPI) |
There are 31 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Reproduction GO:0000003
The production of new individuals that contain some portion of genetic material inherited from one or more parent organisms.
|
1 | Q21227 (/IMP) |
Cell fate specification GO:0001708
The process involved in the specification of cell identity. Once specification has taken place, a cell will be committed to differentiate down a specific pathway if left in its normal environment.
|
1 | Q21227 (/IGI) |
Cell fate specification GO:0001708
The process involved in the specification of cell identity. Once specification has taken place, a cell will be committed to differentiate down a specific pathway if left in its normal environment.
|
1 | Q21227 (/IMP) |
Endodermal cell fate specification GO:0001714
The cell fate determination process that results in a cell becoming capable of differentiating autonomously into an endoderm cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed.
|
1 | Q21227 (/IGI) |
Endodermal cell fate specification GO:0001714
The cell fate determination process that results in a cell becoming capable of differentiating autonomously into an endoderm cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed.
|
1 | Q21227 (/IMP) |
Nematode larval development GO:0002119
The process whose specific outcome is the progression of the nematode larva over time, from its formation to the mature structure. Nematode larval development begins with the newly hatched first-stage larva (L1) and ends with the end of the last larval stage (for example the fourth larval stage (L4) in C. elegans). Each stage of nematode larval development is characterized by proliferation of specific cell lineages and an increase in body size without alteration of the basic body plan. Nematode larval stages are separated by molts in which each stage-specific exoskeleton, or cuticle, is shed and replaced anew.
|
1 | Q21227 (/IMP) |
Endoderm development GO:0007492
The process whose specific outcome is the progression of the endoderm over time, from its formation to the mature structure. The endoderm is the innermost germ layer that develops into the gastrointestinal tract, the lungs and associated tissues.
|
1 | Q21227 (/IMP) |
Endoderm development GO:0007492
The process whose specific outcome is the progression of the endoderm over time, from its formation to the mature structure. The endoderm is the innermost germ layer that develops into the gastrointestinal tract, the lungs and associated tissues.
|
1 | A8X633 (/ISS) |
Asymmetric cell division GO:0008356
The asymmetric division of cells to produce two daughter cells with different developmental potentials. It is of fundamental significance for the generation of cell diversity.
|
1 | Q21227 (/IMP) |
Asymmetric cell division GO:0008356
The asymmetric division of cells to produce two daughter cells with different developmental potentials. It is of fundamental significance for the generation of cell diversity.
|
1 | A8X633 (/ISS) |
Embryo development ending in birth or egg hatching GO:0009792
The process whose specific outcome is the progression of an embryo over time, from zygote formation until the end of the embryonic life stage. The end of the embryonic life stage is organism-specific and may be somewhat arbitrary; for mammals it is usually considered to be birth, for insects the hatching of the first instar larva from the eggshell.
|
1 | Q21227 (/IMP) |
Regulation of embryonic cell shape GO:0016476
Any process that modulates the surface configuration of an embryonic cell.
|
1 | Q21227 (/IMP) |
Positive regulation of Wnt signaling pathway GO:0030177
Any process that activates or increases the frequency, rate or extent of Wnt signal transduction.
|
1 | Q21227 (/IGI) |
Negative regulation of Wnt signaling pathway GO:0030178
Any process that stops, prevents, or reduces the frequency, rate or extent of the Wnt signaling pathway.
|
1 | Q21227 (/IGI) |
Negative regulation of Wnt signaling pathway GO:0030178
Any process that stops, prevents, or reduces the frequency, rate or extent of the Wnt signaling pathway.
|
1 | Q21227 (/IMP) |
Negative regulation of Wnt signaling pathway GO:0030178
Any process that stops, prevents, or reduces the frequency, rate or extent of the Wnt signaling pathway.
|
1 | A8X633 (/ISS) |
Regulation of cell migration GO:0030334
Any process that modulates the frequency, rate or extent of cell migration.
|
1 | Q21227 (/IMP) |
Vulval development GO:0040025
The process whose specific outcome is the progression of the egg-laying organ of female and hermaphrodite nematodes over time, from its formation to the mature structure. In nematodes, the vulva is formed from ventral epidermal cells during larval stages to give rise to a fully formed vulva in the adult.
|
1 | Q21227 (/IGI) |
Vulval development GO:0040025
The process whose specific outcome is the progression of the egg-laying organ of female and hermaphrodite nematodes over time, from its formation to the mature structure. In nematodes, the vulva is formed from ventral epidermal cells during larval stages to give rise to a fully formed vulva in the adult.
|
1 | Q21227 (/IMP) |
Negative regulation of vulval development GO:0040027
Any process that stops, prevents, or reduces the frequency, rate or extent of development of the vulva. Vulval development is the process whose specific outcome is the progression of the egg-laying organ of female and hermaphrodite nematodes over time, from its formation to the mature structure. In nematodes, the vulva is formed from ventral epidermal cells during larval stages to give rise to a fully formed vulva in the adult.
|
1 | Q21227 (/IGI) |
Engulfment of apoptotic cell GO:0043652
The removal of the apoptotic cell by phagocytosis, by a neighboring cell or by a phagocyte.
|
1 | Q21227 (/IMP) |
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
1 | Q21227 (/IMP) |
Embryonic digestive tract morphogenesis GO:0048557
The process in which the anatomical structures of the digestive tract are generated and organized during embryonic development. The digestive tract is the anatomical structure through which food passes and is processed.
|
1 | Q21227 (/IGI) |
Embryonic morphogenesis GO:0048598
The process in which anatomical structures are generated and organized during the embryonic phase. The embryonic phase begins with zygote formation. The end of the embryonic phase is organism-specific. For example, it would be at birth for mammals, larval hatching for insects and seed dormancy in plants.
|
1 | Q21227 (/IMP) |
Embryonic morphogenesis GO:0048598
The process in which anatomical structures are generated and organized during the embryonic phase. The embryonic phase begins with zygote formation. The end of the embryonic phase is organism-specific. For example, it would be at birth for mammals, larval hatching for insects and seed dormancy in plants.
|
1 | A8X633 (/ISS) |
Negative regulation of cell division GO:0051782
Any process that stops, prevents, or reduces the frequency, rate or extent of cell division.
|
1 | Q21227 (/IGI) |
Negative regulation of cell division GO:0051782
Any process that stops, prevents, or reduces the frequency, rate or extent of cell division.
|
1 | Q21227 (/IMP) |
Canonical Wnt signaling pathway GO:0060070
The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes.
|
1 | Q21227 (/IGI) |
Canonical Wnt signaling pathway GO:0060070
The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes.
|
1 | Q21227 (/IMP) |
Negative regulation of canonical Wnt signaling pathway GO:0090090
Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes.
|
1 | Q21227 (/IGI) |
Negative regulation of canonical Wnt signaling pathway GO:0090090
Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes.
|
1 | Q21227 (/IMP) |
There are 7 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
1 | Q21227 (/IDA) |
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
1 | Q21227 (/IDA) |
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
1 | A8X633 (/ISS) |
Adherens junction GO:0005912
A cell junction at which anchoring proteins (cadherins or integrins) extend through the plasma membrane and are attached to actin filaments.
|
1 | Q21227 (/IDA) |
Adherens junction GO:0005912
A cell junction at which anchoring proteins (cadherins or integrins) extend through the plasma membrane and are attached to actin filaments.
|
1 | A8X633 (/ISS) |
Cell cortex GO:0005938
The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins.
|
1 | Q21227 (/IDA) |
Cell cortex GO:0005938
The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins.
|
1 | A8X633 (/ISS) |