The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Leucine-rich Repeat Variant
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 41: Serine/threonine protein phosphatase 2A regulatory...

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 2 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
9 O04375 (/IPI) O04375 (/IPI) O04376 (/IPI) O04376 (/IPI) Q8LF36 (/IPI) Q8RW96 (/IPI) Q8RW96 (/IPI) Q8RW96 (/IPI) Q9LU89 (/IPI)
Poly(U) RNA binding GO:0008266
Interacting selectively and non-covalently with a sequence of uracil residues in an RNA molecule.
3 Q8RW96 (/IDA) Q8RW96 (/IDA) Q8RW96 (/IDA)

There are 15 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Megasporogenesis GO:0009554
The process in which the megasporocyte undergoes meiosis, giving rise to four haploid megaspores in the nucellus.
4 O04375 (/IGI) O04375 (/IGI) O04376 (/IGI) O04376 (/IGI)
Microsporogenesis GO:0009556
The process in which the microsporocyte undergoes meiosis, giving rise to four haploid microspores.
4 O04375 (/IGI) O04375 (/IGI) O04376 (/IGI) O04376 (/IGI)
Meiotic sister chromatid cohesion GO:0051177
The cell cycle process in which sister chromatids of a replicated chromosome are joined along the entire length of the chromosome during meiosis.
4 O04375 (/IGI) O04375 (/IGI) O04376 (/IGI) O04376 (/IGI)
Methionine metabolic process GO:0006555
The chemical reactions and pathways involving methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins.
3 Q8RW96 (/IMP) Q8RW96 (/IMP) Q8RW96 (/IMP)
Indole glucosinolate biosynthetic process GO:0009759
The chemical reactions and pathways resulting in the formation of indole glucosinolates, sulfur-containing compounds that have a common structure linked to an R group derived from tryptophan.
3 Q8RW96 (/IMP) Q8RW96 (/IMP) Q8RW96 (/IMP)
Trichome morphogenesis GO:0010090
The process in which the structures of a hair cell (trichome) cell are generated and organized. This process occurs while the initially relatively unspecialized epidermal cell is acquiring the specialized features of a hair cell. An example of this process is found in Arabidopsis thaliana.
3 Q8RW96 (/IGI) Q8RW96 (/IGI) Q8RW96 (/IGI)
Negative regulation of defense response GO:0031348
Any process that stops, prevents, or reduces the frequency, rate or extent of a defense response.
3 Q8RW96 (/IMP) Q8RW96 (/IMP) Q8RW96 (/IMP)
S-adenosylmethionine cycle GO:0033353
A cyclic series of interconversions involving S-adenosylmethionine, S-adenosyl-L-homocysteine, L-cysteine, and L-methionine. Couples utilization of the methyl group of SAM with recycling of the homocysteinyl group and regeneration of methionine.
3 Q8RW96 (/IMP) Q8RW96 (/IMP) Q8RW96 (/IMP)
Regulation of cell aging GO:0090342
Any process that modulates the rate, frequency, or extent of cell aging. Cell aging is the progression of the cell from its inception to the end of its lifespan.
3 Q8RW96 (/IMP) Q8RW96 (/IMP) Q8RW96 (/IMP)
Negative regulation of brassinosteroid mediated signaling pathway GO:1900458
Any process that stops, prevents or reduces the frequency, rate or extent of brassinosteroid mediated signaling pathway.
3 Q8LF36 (/IDA) Q9LVE2 (/IDA) Q9LVE2 (/IDA)
Regulation of reactive oxygen species metabolic process GO:2000377
Any process that modulates the frequency, rate or extent of reactive oxygen species metabolic process.
3 Q8RW96 (/IMP) Q8RW96 (/IMP) Q8RW96 (/IMP)
Regulation of phosphorylation GO:0042325
Any process that modulates the frequency, rate or extent of addition of phosphate groups into a molecule.
2 O04375 (/ISS) O04375 (/ISS)
Negative regulation of innate immune response GO:0045824
Any process that stops, prevents, or reduces the frequency, rate or extent of the innate immune response.
2 Q9LVE2 (/IDA) Q9LVE2 (/IDA)
Response to photooxidative stress GO:0080183
Any process that results in a change in state or activity of a cell or organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as the result of a photooxidative stress, the light-dependent generation of active oxygen species. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism.
2 Q9LVE2 (/IMP) Q9LVE2 (/IMP)
Positive regulation of fatty acid beta-oxidation GO:0032000
Any process that activates or increases the frequency, rate or extent of fatty acid beta-oxidation.
1 Q8LF36 (/IMP)

There are 7 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
10 O04375 (/IDA) O04375 (/IDA) O04376 (/IDA) O04376 (/IDA) Q8RW96 (/IDA) Q8RW96 (/IDA) Q8RW96 (/IDA) Q93YV6 (/IDA) Q93YV6 (/IDA) Q9LU89 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
7 O04375 (/IDA) O04375 (/IDA) O04376 (/IDA) O04376 (/IDA) Q8RW96 (/IDA) Q8RW96 (/IDA) Q8RW96 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
3 Q8LF36 (/IDA) Q9LVE2 (/IDA) Q9LVE2 (/IDA)
Protein phosphatase type 2A complex GO:0000159
A protein complex that has protein serine/threonine phosphatase activity that is polycation-stimulated (PCS), being directly stimulated by protamine, polylysine, or histone H1; it constitutes a subclass of several enzymes activated by different histones and polylysine, and consists of catalytic, scaffolding, and regulatory subunits. The catalytic and scaffolding subunits form the core enzyme, and the holoenzyme also includes the regulatory subunit.
2 O04375 (/ISS) O04375 (/ISS)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
2 Q9LVE2 (/IDA) Q9LVE2 (/IDA)
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
1 Q9LU89 (/IDA)
Peroxisome GO:0005777
A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism.
1 Q8LF36 (/IDA)
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