The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Leucine-rich Repeat Variant
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 16: Serine/threonine-protein phosphatase 2A 56 kDa reg...

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 4 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein phosphatase regulator activity GO:0019888
Modulates the activity of a protein phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a protein substrate molecule.
5 P38903 (/IDA) P38903 (/IDA) P38903 (/IDA) P38903 (/IDA) P38903 (/IDA)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
2 A9UJN4 (/IPI) O18178 (/IPI)
Protein kinase binding GO:0019901
Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
1 O18178 (/IPI)
Protein phosphatase activator activity GO:0072542
Increases the activity of a protein phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a protein substrate molecule.
1 O18178 (/IMP)

There are 18 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein dephosphorylation GO:0006470
The process of removing one or more phosphoric residues from a protein.
6 O18178 (/IDA) P38903 (/IDA) P38903 (/IDA) P38903 (/IDA) P38903 (/IDA) P38903 (/IDA)
Protein dephosphorylation GO:0006470
The process of removing one or more phosphoric residues from a protein.
6 O18178 (/IMP) P38903 (/IMP) P38903 (/IMP) P38903 (/IMP) P38903 (/IMP) P38903 (/IMP)
Septin ring disassembly GO:0031107
The controlled breakdown of a septin ring.
5 P38903 (/IMP) P38903 (/IMP) P38903 (/IMP) P38903 (/IMP) P38903 (/IMP)
Sister chromatid biorientation GO:0031134
The cell cycle process in which sister chromatids establish stable attachments to microtubules emanating from opposite spindle poles.
5 P38903 (/IGI) P38903 (/IGI) P38903 (/IGI) P38903 (/IGI) P38903 (/IGI)
Mitotic spindle orientation checkpoint GO:0031578
A cell cycle checkpoint that monitors and signals errors in the placement or orientation of the spindle in the cell. This delays the completion of anaphase until errors are corrected.
5 P38903 (/IGI) P38903 (/IGI) P38903 (/IGI) P38903 (/IGI) P38903 (/IGI)
Cellular bud neck septin ring organization GO:0032186
Control of the formation, spatial distribution, and breakdown of a septin ring located at the bud neck.
5 P38903 (/IGI) P38903 (/IGI) P38903 (/IGI) P38903 (/IGI) P38903 (/IGI)
Cellular bud neck septin ring organization GO:0032186
Control of the formation, spatial distribution, and breakdown of a septin ring located at the bud neck.
5 P38903 (/IMP) P38903 (/IMP) P38903 (/IMP) P38903 (/IMP) P38903 (/IMP)
Cellular protein localization GO:0034613
Any process in which a protein is transported to, and/or maintained in, a specific location at the level of a cell. Localization at the cellular level encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell.
5 P38903 (/IMP) P38903 (/IMP) P38903 (/IMP) P38903 (/IMP) P38903 (/IMP)
Meiotic sister chromatid cohesion, centromeric GO:0051754
The cell cycle process in which centromeres of sister chromatids are joined during meiosis.
5 P38903 (/IMP) P38903 (/IMP) P38903 (/IMP) P38903 (/IMP) P38903 (/IMP)
Establishment of protein localization to chromosome GO:0070199
The directed movement of a protein to a specific location on a chromosome.
5 P38903 (/IMP) P38903 (/IMP) P38903 (/IMP) P38903 (/IMP) P38903 (/IMP)
Positive regulation of autophagosome assembly GO:2000786
Any process that activates or increases the frequency, rate or extent of autophagic vacuole assembly.
5 P38903 (/IGI) P38903 (/IGI) P38903 (/IGI) P38903 (/IGI) P38903 (/IGI)
P granule assembly GO:1903863
The aggregation, arrangement and bonding together of a set of components to form a P granule.
2 A9UJN4 (/IGI) O18178 (/IGI)
Determination of adult lifespan GO:0008340
The control of viability and duration in the adult phase of the life-cycle.
1 O18178 (/IGI)
Response to heat GO:0009408
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.
1 O18178 (/IGI)
Regulation of lipid storage GO:0010883
Any process that modulates the rate, frequency or extent of lipid storage. Lipid storage is the accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development.
1 O18178 (/IGI)
Dauer larval development GO:0040024
The process whose specific outcome is the progression of the dauer larva over time, through the facultative diapause of the dauer (enduring) larval stage, with specialized traits adapted for dispersal and long-term survival, with elevated stress resistance and without feeding.
1 O18178 (/IGI)
Negative regulation of insulin receptor signaling pathway GO:0046627
Any process that stops, prevents, or reduces the frequency, rate or extent of insulin receptor signaling.
1 O18178 (/IGI)
P granule assembly GO:1903863
The aggregation, arrangement and bonding together of a set of components to form a P granule.
1 O18178 (/IMP)

There are 9 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Kinetochore GO:0000776
A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules.
5 P38903 (/IDA) P38903 (/IDA) P38903 (/IDA) P38903 (/IDA) P38903 (/IDA)
Condensed nuclear chromosome, centromeric region GO:0000780
The region of a condensed nuclear chromosome that includes the centromere and associated proteins, including the kinetochore. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome.
5 P38903 (/IDA) P38903 (/IDA) P38903 (/IDA) P38903 (/IDA) P38903 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
5 P38903 (/HDA) P38903 (/HDA) P38903 (/HDA) P38903 (/HDA) P38903 (/HDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
5 P38903 (/IDA) P38903 (/IDA) P38903 (/IDA) P38903 (/IDA) P38903 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
5 P38903 (/HDA) P38903 (/HDA) P38903 (/HDA) P38903 (/HDA) P38903 (/HDA)
Spindle pole body GO:0005816
The microtubule organizing center in fungi; functionally homologous to the animal cell centrosome.
5 P38903 (/IDA) P38903 (/IDA) P38903 (/IDA) P38903 (/IDA) P38903 (/IDA)
Cellular bud neck GO:0005935
The constriction between the mother cell and daughter cell (bud) in an organism that reproduces by budding.
5 P38903 (/IDA) P38903 (/IDA) P38903 (/IDA) P38903 (/IDA) P38903 (/IDA)
Protein phosphatase type 2A complex GO:0000159
A protein complex that has protein serine/threonine phosphatase activity that is polycation-stimulated (PCS), being directly stimulated by protamine, polylysine, or histone H1; it constitutes a subclass of several enzymes activated by different histones and polylysine, and consists of catalytic, scaffolding, and regulatory subunits. The catalytic and scaffolding subunits form the core enzyme, and the holoenzyme also includes the regulatory subunit.
1 O18178 (/IC)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 O18178 (/IDA)
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