The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Leucine-rich Repeat Variant
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 13: Importin subunit alpha

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 5 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
21 O15131 (/IPI) O35345 (/IPI) O35345 (/IPI) O60684 (/IPI) O60684 (/IPI) O60684 (/IPI) O60684 (/IPI) O60684 (/IPI) O60684 (/IPI) O60684 (/IPI)
(11 more)
Nuclear import signal receptor activity GO:0061608
Combining with a nuclear import signal (NIS) on a cargo to be transported, to mediate transport of the cargo through the nuclear pore, from the cytoplasm to the nuclear lumen. The cargo can be either a RNA or a protein.
2 O35345 (/IDA) O35345 (/IDA)
Nuclear localization sequence binding GO:0008139
Interacting selectively and non-covalently with a nuclear localization sequence, a specific peptide sequence that acts as a signal to localize the protein within the nucleus.
1 P83953 (/IDA)
Nuclear localization sequence binding GO:0008139
Interacting selectively and non-covalently with a nuclear localization sequence, a specific peptide sequence that acts as a signal to localize the protein within the nucleus.
1 Q60960 (/ISO)
Nuclear localization sequence binding GO:0008139
Interacting selectively and non-covalently with a nuclear localization sequence, a specific peptide sequence that acts as a signal to localize the protein within the nucleus.
1 P52294 (/TAS)

There are 18 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
NLS-bearing protein import into nucleus GO:0006607
The directed movement of a protein bearing a nuclear localization signal (NLS) from the cytoplasm into the nucleus, across the nuclear envelope.
17 O15131 (/TAS) O60684 (/TAS) O60684 (/TAS) O60684 (/TAS) O60684 (/TAS) O60684 (/TAS) O60684 (/TAS) O60684 (/TAS) O60684 (/TAS) O60684 (/TAS)
(7 more)
Entry of viral genome into host nucleus through nuclear pore complex via importin GO:0075506
Viral penetration into the host nucleus where the viral genome passes through the nuclear pore complex (NPC) using the cellular importin transport machinery.
17 O35345 (/IMP) O35345 (/IMP) O60684 (/IMP) O60684 (/IMP) O60684 (/IMP) O60684 (/IMP) O60684 (/IMP) O60684 (/IMP) O60684 (/IMP) O60684 (/IMP)
(7 more)
Positive regulation of viral life cycle GO:1903902
Any process that activates or increases the frequency, rate or extent of viral life cycle.
17 O35345 (/IMP) O35345 (/IMP) O60684 (/IMP) O60684 (/IMP) O60684 (/IMP) O60684 (/IMP) O60684 (/IMP) O60684 (/IMP) O60684 (/IMP) O60684 (/IMP)
(7 more)
Protein import into nucleus GO:0006606
The directed movement of a protein from the cytoplasm to the nucleus.
2 O35345 (/IDA) O35345 (/IDA)
Modulation by virus of host cellular process GO:0019054
The process in which a virus effects a change in the processes and activities of its host organism.
2 O15131 (/TAS) P52294 (/TAS)
Evasion or tolerance by virus of host immune response GO:0030683
Any process, either active or passive, by which a virus avoids the effects of the host organism's immune response. The host is defined as the larger of the organisms involved in a symbiotic interaction.
2 O35345 (/IMP) O35345 (/IMP)
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
2 O35345 (/IMP) O35345 (/IMP)
Maternal process involved in female pregnancy GO:0060135
A reproductive process occurring in the mother that allows an embryo or fetus to develop within it.
2 O35345 (/IMP) O35345 (/IMP)
Entry of viral genome into host nucleus through nuclear pore complex via importin GO:0075506
Viral penetration into the host nucleus where the viral genome passes through the nuclear pore complex (NPC) using the cellular importin transport machinery.
2 O35345 (/ISO) O35345 (/ISO)
Postsynapse to nucleus signaling pathway GO:0099527
A series of molecular signals that conveys information from the postsynapse to the nucleus via cytoskeletal transport of a protein from a postsynapse to the component to the nucleus where it affects biochemical processes that occur in the nucleus (e.g DNA transcription, mRNA splicing, or DNA/histone modifications).
2 P83953 (/IDA) Q60960 (/IDA)
Positive regulation of cytokine production involved in inflammatory response GO:1900017
Any process that activates or increases the frequency, rate or extent of cytokine production involved in inflammatory response.
2 O35345 (/IMP) O35345 (/IMP)
Positive regulation of viral life cycle GO:1903902
Any process that activates or increases the frequency, rate or extent of viral life cycle.
2 O35345 (/ISO) O35345 (/ISO)
Regulation of DNA recombination GO:0000018
Any process that modulates the frequency, rate or extent of DNA recombination, a DNA metabolic process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents.
1 P52294 (/TAS)
Apoptotic DNA fragmentation GO:0006309
The cleavage of DNA during apoptosis, which usually occurs in two stages: cleavage into fragments of about 50 kbp followed by cleavage between nucleosomes to yield 200 bp fragments.
1 P52294 (/TAS)
NLS-bearing protein import into nucleus GO:0006607
The directed movement of a protein bearing a nuclear localization signal (NLS) from the cytoplasm into the nucleus, across the nuclear envelope.
1 P83953 (/IMP)
NLS-bearing protein import into nucleus GO:0006607
The directed movement of a protein bearing a nuclear localization signal (NLS) from the cytoplasm into the nucleus, across the nuclear envelope.
1 Q60960 (/ISO)
Intracellular transport of virus GO:0075733
The directed movement of a virus, or part of a virus, within the host cell.
1 P52294 (/TAS)
Postsynapse to nucleus signaling pathway GO:0099527
A series of molecular signals that conveys information from the postsynapse to the nucleus via cytoskeletal transport of a protein from a postsynapse to the component to the nucleus where it affects biochemical processes that occur in the nucleus (e.g DNA transcription, mRNA splicing, or DNA/histone modifications).
1 Q60960 (/ISO)

There are 17 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
22 A2VE08 (/ISS) P52294 (/ISS) Q5R909 (/ISS) Q5R909 (/ISS) Q5R909 (/ISS) Q5R909 (/ISS) Q5R909 (/ISS) Q5R909 (/ISS) Q5R909 (/ISS) Q5R909 (/ISS)
(12 more)
Dendrite GO:0030425
A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
22 A2VE08 (/ISS) P52294 (/ISS) Q5R909 (/ISS) Q5R909 (/ISS) Q5R909 (/ISS) Q5R909 (/ISS) Q5R909 (/ISS) Q5R909 (/ISS) Q5R909 (/ISS) Q5R909 (/ISS)
(12 more)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
15 O60684 (/HDA) O60684 (/HDA) O60684 (/HDA) O60684 (/HDA) O60684 (/HDA) O60684 (/HDA) O60684 (/HDA) O60684 (/HDA) O60684 (/HDA) O60684 (/HDA)
(5 more)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
2 P52294 (/IDA) P83953 (/IDA)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
2 O15131 (/TAS) P52294 (/TAS)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 O15131 (/IDA) P52294 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 O15131 (/TAS) P52294 (/TAS)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q60960 (/ISO)
Nuclear pore GO:0005643
Any of the numerous similar discrete openings in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined.
1 P52294 (/TAS)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
1 P52294 (/IDA)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
1 Q60960 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 P52294 (/TAS)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q60960 (/ISO)
Postsynaptic density GO:0014069
An electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymmetric, neuron-neuron synapse. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components.
1 Q60960 (/IDA)
Dendrite GO:0030425
A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
1 P83953 (/IDA)
Dendrite GO:0030425
A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
1 Q60960 (/ISO)
Glutamatergic synapse GO:0098978
A synapse that uses glutamate as a neurotransmitter.
1 Q60960 (/IDA)
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