The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"eIF4G, eIF4E-binding domain
".
FunFam 2: Translation initiation factor eIF4G
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 10 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
MRNA binding GO:0003729
Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns.
|
7 | P39935 (/HDA) P39935 (/HDA) P39935 (/HDA) P39935 (/HDA) P39936 (/HDA) P39936 (/HDA) P39936 (/HDA) |
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
7 | P39935 (/IPI) P39935 (/IPI) P39935 (/IPI) P39935 (/IPI) P39936 (/IPI) P39936 (/IPI) P39936 (/IPI) |
|
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
|
4 | P39935 (/IDA) P39935 (/IDA) P39935 (/IDA) P39935 (/IDA) |
|
Translation initiation factor activity GO:0003743
Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide.
|
4 | P39935 (/TAS) P39935 (/TAS) P39935 (/TAS) P39935 (/TAS) |
|
MRNA binding GO:0003729
Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns.
|
3 | P39936 (/IDA) P39936 (/IDA) P39936 (/IDA) |
|
Translation initiation factor activity GO:0003743
Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide.
|
3 | P39936 (/IDA) P39936 (/IDA) P39936 (/IDA) |
|
Translation initiation factor activity GO:0003743
Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide.
|
3 | P39936 (/IMP) P39936 (/IMP) P39936 (/IMP) |
|
Translation initiation factor binding GO:0031369
Interacting selectively and non-covalently with a translation initiation factor, any polypeptide factor involved in the initiation of ribosome-mediated translation.
|
3 | P39936 (/IDA) P39936 (/IDA) P39936 (/IDA) |
|
Translation initiation factor binding GO:0031369
Interacting selectively and non-covalently with a translation initiation factor, any polypeptide factor involved in the initiation of ribosome-mediated translation.
|
3 | P39936 (/IMP) P39936 (/IMP) P39936 (/IMP) |
|
Translation initiation factor binding GO:0031369
Interacting selectively and non-covalently with a translation initiation factor, any polypeptide factor involved in the initiation of ribosome-mediated translation.
|
3 | P39936 (/IPI) P39936 (/IPI) P39936 (/IPI) |
There are 7 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Translational initiation GO:0006413
The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA.
|
7 | P39935 (/IMP) P39935 (/IMP) P39935 (/IMP) P39935 (/IMP) P39936 (/IMP) P39936 (/IMP) P39936 (/IMP) |
|
Stress granule assembly GO:0034063
The aggregation, arrangement and bonding together of proteins and RNA molecules to form a stress granule.
|
7 | P39935 (/IMP) P39935 (/IMP) P39935 (/IMP) P39935 (/IMP) P39936 (/IMP) P39936 (/IMP) P39936 (/IMP) |
|
Positive regulation of cell death GO:0010942
Any process that increases the rate or frequency of cell death. Cell death is the specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death.
|
4 | P39935 (/IGI) P39935 (/IGI) P39935 (/IGI) P39935 (/IGI) |
|
Regulation of cellular protein metabolic process GO:0032268
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein, occurring at the level of an individual cell.
|
4 | P39935 (/IGI) P39935 (/IGI) P39935 (/IGI) P39935 (/IGI) |
|
Ribosomal large subunit biogenesis GO:0042273
A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a large ribosomal subunit; includes transport to the sites of protein synthesis.
|
4 | P39935 (/IMP) P39935 (/IMP) P39935 (/IMP) P39935 (/IMP) |
|
Positive regulation of endoplasmic reticulum unfolded protein response GO:1900103
Any process that activates or increases the frequency, rate or extent of endoplasmic reticulum unfolded protein response.
|
4 | P39935 (/IGI) P39935 (/IGI) P39935 (/IGI) P39935 (/IGI) |
|
Translational initiation GO:0006413
The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA.
|
3 | P39936 (/IDA) P39936 (/IDA) P39936 (/IDA) |
There are 5 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
P-body GO:0000932
A focus in the cytoplasm where mRNAs may become inactivated by decapping or some other mechanism. Protein and RNA localized to these foci are involved in mRNA degradation, nonsense-mediated mRNA decay (NMD), translational repression, and RNA-mediated gene silencing.
|
7 | P39935 (/IDA) P39935 (/IDA) P39935 (/IDA) P39935 (/IDA) P39936 (/IDA) P39936 (/IDA) P39936 (/IDA) |
|
Cytoplasmic stress granule GO:0010494
A dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress.
|
7 | P39935 (/IDA) P39935 (/IDA) P39935 (/IDA) P39935 (/IDA) P39936 (/IDA) P39936 (/IDA) P39936 (/IDA) |
|
Eukaryotic translation initiation factor 4F complex GO:0016281
The eukaryotic translation initiation factor 4F complex is composed of eIF4E, eIF4A and eIF4G; it is involved in the recognition of the mRNA cap, ATP-dependent unwinding of the 5'-terminal secondary structure and recruitment of the mRNA to the ribosome.
|
7 | P39935 (/IMP) P39935 (/IMP) P39935 (/IMP) P39935 (/IMP) P39936 (/IMP) P39936 (/IMP) P39936 (/IMP) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
4 | P39935 (/IDA) P39935 (/IDA) P39935 (/IDA) P39935 (/IDA) |
|
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
|
4 | P39935 (/HDA) P39935 (/HDA) P39935 (/HDA) P39935 (/HDA) |