The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Bromodomain-like
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 46: Histone acetyltransferase GCN5

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 12 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
H3 histone acetyltransferase activity GO:0010484
Catalysis of the reaction: acetyl-CoA + histone H3 = CoA + acetyl-histone H3.
12 Q03330 (/IDA) Q03330 (/IDA) Q03330 (/IDA) Q03330 (/IDA) Q03330 (/IDA) Q03330 (/IDA) Q03330 (/IDA) Q03330 (/IDA) Q03330 (/IDA) Q9AR19 (/IDA)
(2 more)
Histone acetyltransferase activity GO:0004402
Catalysis of the reaction: acetyl-CoA + histone = CoA + acetyl-histone.
11 Q03330 (/IDA) Q03330 (/IDA) Q03330 (/IDA) Q03330 (/IDA) Q03330 (/IDA) Q03330 (/IDA) Q03330 (/IDA) Q03330 (/IDA) Q03330 (/IDA) Q9AR19 (/IDA)
(1 more)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
11 Q03330 (/IPI) Q03330 (/IPI) Q03330 (/IPI) Q03330 (/IPI) Q03330 (/IPI) Q03330 (/IPI) Q03330 (/IPI) Q03330 (/IPI) Q03330 (/IPI) Q9AR19 (/IPI)
(1 more)
H3 histone acetyltransferase activity GO:0010484
Catalysis of the reaction: acetyl-CoA + histone H3 = CoA + acetyl-histone H3.
10 Q03330 (/IMP) Q03330 (/IMP) Q03330 (/IMP) Q03330 (/IMP) Q03330 (/IMP) Q03330 (/IMP) Q03330 (/IMP) Q03330 (/IMP) Q03330 (/IMP) Q59PZ5 (/IMP)
Transcription coactivator activity GO:0003713
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to activate the transcription of specific genes. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. Another type of coregulator activity is the bridging of a DNA-binding transcription factor to the basal transcription machinery. The Mediator complex, which bridges transcription factors and RNA polymerase, is also a transcription coactivator.
9 Q03330 (/TAS) Q03330 (/TAS) Q03330 (/TAS) Q03330 (/TAS) Q03330 (/TAS) Q03330 (/TAS) Q03330 (/TAS) Q03330 (/TAS) Q03330 (/TAS)
H3 histone acetyltransferase activity GO:0010484
Catalysis of the reaction: acetyl-CoA + histone H3 = CoA + acetyl-histone H3.
9 Q03330 (/IGI) Q03330 (/IGI) Q03330 (/IGI) Q03330 (/IGI) Q03330 (/IGI) Q03330 (/IGI) Q03330 (/IGI) Q03330 (/IGI) Q03330 (/IGI)
Lysine-acetylated histone binding GO:0070577
Interacting selectively and non-covalently with a histone in which a lysine residue has been modified by acetylation.
9 Q03330 (/IDA) Q03330 (/IDA) Q03330 (/IDA) Q03330 (/IDA) Q03330 (/IDA) Q03330 (/IDA) Q03330 (/IDA) Q03330 (/IDA) Q03330 (/IDA)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
2 Q9AR19 (/IDA) Q9AR19 (/IDA)
Acetyltransferase activity GO:0016407
Catalysis of the transfer of an acetyl group to an acceptor molecule.
2 Q9AR19 (/IDA) Q9AR19 (/IDA)
Histone acetyltransferase activity GO:0004402
Catalysis of the reaction: acetyl-CoA + histone = CoA + acetyl-histone.
1 Q54R05 (/ISS)
Histone acetyltransferase activity (H3-K14 specific) GO:0036408
Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 14) = CoA + histone H3 N6-acetyl-L-lysine (position 14).
1 Q9UUK2 (/IMP)
Histone acetyltransferase activity (H3-K9 specific) GO:0043992
Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 9) = CoA + histone H3 N6-acetyl-L-lysine (position 9).
1 Q9UUK2 (/IMP)

There are 31 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Histone acetylation GO:0016573
The modification of a histone by the addition of an acetyl group.
11 Q03330 (/IDA) Q03330 (/IDA) Q03330 (/IDA) Q03330 (/IDA) Q03330 (/IDA) Q03330 (/IDA) Q03330 (/IDA) Q03330 (/IDA) Q03330 (/IDA) Q9AR19 (/IDA)
(1 more)
Chromatin remodeling GO:0006338
Dynamic structural changes to eukaryotic chromatin occurring throughout the cell division cycle. These changes range from the local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation.
10 Q03330 (/IMP) Q03330 (/IMP) Q03330 (/IMP) Q03330 (/IMP) Q03330 (/IMP) Q03330 (/IMP) Q03330 (/IMP) Q03330 (/IMP) Q03330 (/IMP) Q9UUK2 (/IMP)
Chromatin organization GO:0006325
Any process that results in the specification, formation or maintenance of the physical structure of eukaryotic chromatin.
9 Q03330 (/IDA) Q03330 (/IDA) Q03330 (/IDA) Q03330 (/IDA) Q03330 (/IDA) Q03330 (/IDA) Q03330 (/IDA) Q03330 (/IDA) Q03330 (/IDA)
Histone acetylation GO:0016573
The modification of a histone by the addition of an acetyl group.
9 Q03330 (/IGI) Q03330 (/IGI) Q03330 (/IGI) Q03330 (/IGI) Q03330 (/IGI) Q03330 (/IGI) Q03330 (/IGI) Q03330 (/IGI) Q03330 (/IGI)
Histone acetylation GO:0016573
The modification of a histone by the addition of an acetyl group.
9 Q03330 (/IMP) Q03330 (/IMP) Q03330 (/IMP) Q03330 (/IMP) Q03330 (/IMP) Q03330 (/IMP) Q03330 (/IMP) Q03330 (/IMP) Q03330 (/IMP)
Positive regulation of transcription elongation from RNA polymerase II promoter GO:0032968
Any process that activates or increases the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides, catalyzed by RNA polymerase II.
9 Q03330 (/IGI) Q03330 (/IGI) Q03330 (/IGI) Q03330 (/IGI) Q03330 (/IGI) Q03330 (/IGI) Q03330 (/IGI) Q03330 (/IGI) Q03330 (/IGI)
Positive regulation of transcription elongation from RNA polymerase II promoter GO:0032968
Any process that activates or increases the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides, catalyzed by RNA polymerase II.
9 Q03330 (/IMP) Q03330 (/IMP) Q03330 (/IMP) Q03330 (/IMP) Q03330 (/IMP) Q03330 (/IMP) Q03330 (/IMP) Q03330 (/IMP) Q03330 (/IMP)
Response to light stimulus GO:0009416
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light.
2 Q9AR19 (/IMP) Q9AR19 (/IMP)
Flower development GO:0009908
The process whose specific outcome is the progression of the flower over time, from its formation to the mature structure. The flower is the reproductive structure in a plant, and its development begins with the transition of the vegetative or inflorescence meristem into a floral meristem.
2 Q9AR19 (/IMP) Q9AR19 (/IMP)
Root morphogenesis GO:0010015
The process in which the anatomical structures of roots are generated and organized. The root is the usually underground part of a seed plant body that originates from the hypocotyl, functions as an organ of absorption, aeration, and food storage or as a means of anchorage and support.
2 Q9AR19 (/IMP) Q9AR19 (/IMP)
Regulation of vegetative phase change GO:0010321
Any process that modulates the frequency, rate or extent of vegetative phase change. Vegetative phase change is the set of post-embryonic processes involved in the transition of a plant from a juvenile phase of vegetative development to an adult phase of vegetative development.
2 Q9AR19 (/IMP) Q9AR19 (/IMP)
Histone H3-K9 acetylation GO:0043970
The modification of histone H3 by the addition of an acetyl group to a lysine residue at position 9 of the histone.
2 Q9AR19 (/IDA) Q9AR19 (/IDA)
Histone H3-K14 acetylation GO:0044154
The modification of histone H3 by the addition of an acetyl group to a lysine residue at position 14 of the histone.
2 Q9AR19 (/IDA) Q9AR19 (/IDA)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
2 Q9AR19 (/TAS) Q9AR19 (/TAS)
Positive regulation of wax biosynthetic process GO:1904278
Any process that activates or increases the frequency, rate or extent of wax biosynthetic process.
2 Q9AR19 (/IDA) Q9AR19 (/IDA)
Positive regulation of wax biosynthetic process GO:1904278
Any process that activates or increases the frequency, rate or extent of wax biosynthetic process.
2 Q9AR19 (/IMP) Q9AR19 (/IMP)
Chromatin organization GO:0006325
Any process that results in the specification, formation or maintenance of the physical structure of eukaryotic chromatin.
1 Q54R05 (/ISS)
Chromatin remodeling GO:0006338
Dynamic structural changes to eukaryotic chromatin occurring throughout the cell division cycle. These changes range from the local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation.
1 Q9UUK2 (/IGI)
Regulation of transcription by RNA polymerase II GO:0006357
Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
1 Q9UUK2 (/EXP)
Regulation of transcription by RNA polymerase II GO:0006357
Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
1 Q9UUK2 (/IMP)
Reciprocal meiotic recombination GO:0007131
The cell cycle process in which double strand breaks are formed and repaired through a double Holliday junction intermediate. This results in the equal exchange of genetic material between non-sister chromatids in a pair of homologous chromosomes. These reciprocal recombinant products ensure the proper segregation of homologous chromosomes during meiosis I and create genetic diversity.
1 Q9UUK2 (/IMP)
Pathogenesis GO:0009405
The set of specific processes that generate the ability of an organism to induce an abnormal, generally detrimental state in another organism.
1 Q59PZ5 (/IMP)
Negative regulation of induction of conjugation with cellular fusion GO:0010515
Any process that stops, prevents, or reduces the frequency or rate of initiation of conjugation with cellular fusion.
1 Q9UUK2 (/IGI)
Histone acetylation GO:0016573
The modification of a histone by the addition of an acetyl group.
1 Q54R05 (/ISS)
Fungal-type cell wall organization GO:0031505
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the fungal-type cell wall.
1 Q59PZ5 (/IMP)
Cellular response to drug GO:0035690
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
1 Q59PZ5 (/IMP)
Histone H3 acetylation GO:0043966
The modification of histone H3 by the addition of an acetyl group.
1 Q9UUK2 (/IDA)
Histone H3 acetylation GO:0043966
The modification of histone H3 by the addition of an acetyl group.
1 Q59PZ5 (/IMP)
Filamentous growth of a population of unicellular organisms GO:0044182
The process in which a group of unicellular organisms grow in a threadlike, filamentous shape.
1 Q59PZ5 (/IMP)
Negative regulation of induction of conjugation with cellular fusion by negative regulation of transcription from RNA polymerase II promoter GO:1902625
A negative regulation of transcription from RNA polymerase II promoter that results in negative regulation of induction of conjugation with cellular fusion.
1 Q9UUK2 (/IMP)
Negative regulation of leucine import across plasma membrane GO:1905533
Any process that stops, prevents or reduces the frequency, rate or extent of leucine import across plasma membrane.
1 Q9UUK2 (/IMP)

There are 13 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
12 Q03330 (/IDA) Q03330 (/IDA) Q03330 (/IDA) Q03330 (/IDA) Q03330 (/IDA) Q03330 (/IDA) Q03330 (/IDA) Q03330 (/IDA) Q03330 (/IDA) Q59PZ5 (/IDA)
(2 more)
SAGA complex GO:0000124
A SAGA-type histone acetyltransferase complex that contains Spt8 (in budding yeast) or a homolog thereof; additional polypeptides include Spt group, consisting of Spt7, Spt3, and Spt20/Ada5, which interact with the TATA-binding protein (TBP); the Ada group, consisting of Ada1, Ada2, Ada3, Ada4/Gcn5, and Ada5/Spt20, which is functionally linked to the nucleosomal HAT activity; Tra1, an ATM/PI-3 kinase-related protein that targets DNA-bound activators for recruitment to promoters; the TBP-associated factor (TAF) proteins, consisting of Taf5, Taf6, Taf9, Taf10, and Taf12, which mediate nucleosomal HAT activity and are thought to help recruit the basal transcription machinery; the ubiquitin specifc protease Ubp-8.
10 Q03330 (/IDA) Q03330 (/IDA) Q03330 (/IDA) Q03330 (/IDA) Q03330 (/IDA) Q03330 (/IDA) Q03330 (/IDA) Q03330 (/IDA) Q03330 (/IDA) Q9UUK2 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
10 Q03330 (/IDA) Q03330 (/IDA) Q03330 (/IDA) Q03330 (/IDA) Q03330 (/IDA) Q03330 (/IDA) Q03330 (/IDA) Q03330 (/IDA) Q03330 (/IDA) Q59PZ5 (/IDA)
Chromosome, centromeric region GO:0000775
The region of a chromosome that includes the centromeric DNA and associated proteins. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome.
9 Q03330 (/IDA) Q03330 (/IDA) Q03330 (/IDA) Q03330 (/IDA) Q03330 (/IDA) Q03330 (/IDA) Q03330 (/IDA) Q03330 (/IDA) Q03330 (/IDA)
Ada2/Gcn5/Ada3 transcription activator complex GO:0005671
A multiprotein complex that possesses histone acetyltransferase and is involved in regulation of transcription. Contains either GCN5 or PCAF in a mutually exclusive manner. The budding yeast complex includes Gcn5p, two proteins of the Ada family, and two TBP-associate proteins (TAFs); analogous complexes in other species have analogous compositions, and usually contain homologs of the yeast proteins. Both ATAC- or SAGA (see GO:0000124, SAGA complex) are involved in the acetylation of histone H3K9 and K14 residues.
9 Q03330 (/IDA) Q03330 (/IDA) Q03330 (/IDA) Q03330 (/IDA) Q03330 (/IDA) Q03330 (/IDA) Q03330 (/IDA) Q03330 (/IDA) Q03330 (/IDA)
SLIK (SAGA-like) complex GO:0046695
A SAGA-type histone acetyltransferase complex that contains Rtg2 and a smaller form of Spt7 than the fungal SAGA complex, and lacks Spt8. The complex is involved in the yeast retrograde response pathway, which is important for gene expression changes during mitochondrial dysfunction.
9 Q03330 (/IDA) Q03330 (/IDA) Q03330 (/IDA) Q03330 (/IDA) Q03330 (/IDA) Q03330 (/IDA) Q03330 (/IDA) Q03330 (/IDA) Q03330 (/IDA)
Histone acetyltransferase complex GO:0000123
A protein complex that possesses histone acetyltransferase activity.
2 Q9AR19 (/IPI) Q9AR19 (/IPI)
Histone acetyltransferase complex GO:0000123
A protein complex that possesses histone acetyltransferase activity.
1 Q54R05 (/ISS)
SAGA complex GO:0000124
A SAGA-type histone acetyltransferase complex that contains Spt8 (in budding yeast) or a homolog thereof; additional polypeptides include Spt group, consisting of Spt7, Spt3, and Spt20/Ada5, which interact with the TATA-binding protein (TBP); the Ada group, consisting of Ada1, Ada2, Ada3, Ada4/Gcn5, and Ada5/Spt20, which is functionally linked to the nucleosomal HAT activity; Tra1, an ATM/PI-3 kinase-related protein that targets DNA-bound activators for recruitment to promoters; the TBP-associated factor (TAF) proteins, consisting of Taf5, Taf6, Taf9, Taf10, and Taf12, which mediate nucleosomal HAT activity and are thought to help recruit the basal transcription machinery; the ubiquitin specifc protease Ubp-8.
1 Q9UUK2 (/IPI)
SAGA complex GO:0000124
A SAGA-type histone acetyltransferase complex that contains Spt8 (in budding yeast) or a homolog thereof; additional polypeptides include Spt group, consisting of Spt7, Spt3, and Spt20/Ada5, which interact with the TATA-binding protein (TBP); the Ada group, consisting of Ada1, Ada2, Ada3, Ada4/Gcn5, and Ada5/Spt20, which is functionally linked to the nucleosomal HAT activity; Tra1, an ATM/PI-3 kinase-related protein that targets DNA-bound activators for recruitment to promoters; the TBP-associated factor (TAF) proteins, consisting of Taf5, Taf6, Taf9, Taf10, and Taf12, which mediate nucleosomal HAT activity and are thought to help recruit the basal transcription machinery; the ubiquitin specifc protease Ubp-8.
1 Q54R05 (/ISS)
Nuclear chromatin GO:0000790
The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome in the nucleus.
1 Q9UUK2 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q9UUK2 (/HDA)
Ada2/Gcn5/Ada3 transcription activator complex GO:0005671
A multiprotein complex that possesses histone acetyltransferase and is involved in regulation of transcription. Contains either GCN5 or PCAF in a mutually exclusive manner. The budding yeast complex includes Gcn5p, two proteins of the Ada family, and two TBP-associate proteins (TAFs); analogous complexes in other species have analogous compositions, and usually contain homologs of the yeast proteins. Both ATAC- or SAGA (see GO:0000124, SAGA complex) are involved in the acetylation of histone H3K9 and K14 residues.
1 Q54R05 (/ISS)