CATH Superfamily 1.20.58.480
The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.
FunFam 3: Indoleamine 2,3-dioxygenase 1
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 11 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Indoleamine 2,3-dioxygenase activity GO:0033754
Catalysis of the reaction: tryptophan + O2 = N-formylkynurenine. The product of the reaction depends on the substrate; D-tryptophan produces N-formyl-D-kynurenine, and L-tryptophan produces N-formyl-L-kynurenine.
|
3 | Q6ZQW0 (/IDA) Q8R0V5 (/IDA) Q9ERD9 (/IDA) |
|
Indoleamine 2,3-dioxygenase activity GO:0033754
Catalysis of the reaction: tryptophan + O2 = N-formylkynurenine. The product of the reaction depends on the substrate; D-tryptophan produces N-formyl-D-kynurenine, and L-tryptophan produces N-formyl-L-kynurenine.
|
3 | P14902 (/IMP) P14902 (/IMP) Q8R0V5 (/IMP) |
|
Electron transfer activity GO:0009055
Any molecular entity that serves as an electron acceptor and electron donor in an electron transport chain. An electron transport chain is a process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient.
|
2 | P14902 (/TAS) P14902 (/TAS) |
|
Indoleamine 2,3-dioxygenase activity GO:0033754
Catalysis of the reaction: tryptophan + O2 = N-formylkynurenine. The product of the reaction depends on the substrate; D-tryptophan produces N-formyl-D-kynurenine, and L-tryptophan produces N-formyl-L-kynurenine.
|
2 | P28776 (/ISO) Q8R0V5 (/ISO) |
|
Tryptophan 2,3-dioxygenase activity GO:0004833
Catalysis of the reaction: L-tryptophan + O2 = N-formyl-L-kynurenine.
|
1 | P28776 (/IDA) |
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
1 | P28776 (/IPI) |
|
Amino acid binding GO:0016597
Interacting selectively and non-covalently with an amino acid, organic acids containing one or more amino substituents.
|
1 | Q9ERD9 (/IDA) |
|
Amino acid binding GO:0016597
Interacting selectively and non-covalently with an amino acid, organic acids containing one or more amino substituents.
|
1 | P28776 (/ISO) |
|
Oxygen binding GO:0019825
Interacting selectively and non-covalently with oxygen (O2).
|
1 | Q9ERD9 (/IDA) |
|
Oxygen binding GO:0019825
Interacting selectively and non-covalently with oxygen (O2).
|
1 | P28776 (/ISO) |
|
Indoleamine 2,3-dioxygenase activity GO:0033754
Catalysis of the reaction: tryptophan + O2 = N-formylkynurenine. The product of the reaction depends on the substrate; D-tryptophan produces N-formyl-D-kynurenine, and L-tryptophan produces N-formyl-L-kynurenine.
|
1 | Q6ZQW0 (/ISS) |
There are 24 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Tryptophan catabolic process to kynurenine GO:0019441
The chemical reactions and pathways resulting in the breakdown of tryptophan into other compounds, including kynurenine.
|
4 | P28776 (/IDA) Q6ZQW0 (/IDA) Q8R0V5 (/IDA) Q9ERD9 (/IDA) |
|
Tryptophan catabolic process GO:0006569
The chemical reactions and pathways resulting in the breakdown of tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid.
|
3 | P14902 (/TAS) P14902 (/TAS) Q6ZQW0 (/TAS) |
|
Female pregnancy GO:0007565
The set of physiological processes that allow an embryo or foetus to develop within the body of a female animal. It covers the time from fertilization of a female ovum by a male spermatozoon until birth.
|
2 | P14902 (/TAS) P14902 (/TAS) |
|
Tryptophan catabolic process to kynurenine GO:0019441
The chemical reactions and pathways resulting in the breakdown of tryptophan into other compounds, including kynurenine.
|
2 | P28776 (/ISO) Q8R0V5 (/ISO) |
|
Positive regulation of T cell apoptotic process GO:0070234
Any process that activates or increases the frequency, rate or extent of T cell death by apoptotic process.
|
2 | P14902 (/IMP) P14902 (/IMP) |
|
Cytokine production involved in inflammatory response GO:0002534
The synthesis or release of a cytokine following a inflammatory stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels.
|
1 | P28776 (/IMP) |
|
Positive regulation of T cell tolerance induction GO:0002666
Any process that activates or increases the frequency, rate, or extent of T cell tolerance induction.
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1 | P28776 (/IMP) |
|
Positive regulation of chronic inflammatory response GO:0002678
Any process that activates or increases the frequency, rate, or extent of a chronic inflammatory response.
|
1 | P28776 (/IMP) |
|
Positive regulation of type 2 immune response GO:0002830
Any process that activates or increases the frequency, rate, or extent of a type 2 immune response.
|
1 | P28776 (/IMP) |
|
Defense response GO:0006952
Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack.
|
1 | P28776 (/TAS) |
|
Inflammatory response GO:0006954
The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.
|
1 | P28776 (/IMP) |
|
Tryptophan catabolic process to kynurenine GO:0019441
The chemical reactions and pathways resulting in the breakdown of tryptophan into other compounds, including kynurenine.
|
1 | Q8R0V5 (/IMP) |
|
Tryptophan catabolic process to kynurenine GO:0019441
The chemical reactions and pathways resulting in the breakdown of tryptophan into other compounds, including kynurenine.
|
1 | Q6ZQW0 (/ISS) |
|
Response to lipopolysaccharide GO:0032496
Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.
|
1 | P28776 (/IMP) |
|
Negative regulation of interleukin-10 production GO:0032693
Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-10 production.
|
1 | P28776 (/IMP) |
|
Positive regulation of interleukin-12 production GO:0032735
Any process that activates or increases the frequency, rate, or extent of interleukin-12 production.
|
1 | P28776 (/IMP) |
|
Multicellular organismal response to stress GO:0033555
Any process that results in a change in state or activity of a multicellular organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).
|
1 | P28776 (/IMP) |
|
Kynurenic acid biosynthetic process GO:0034276
The chemical reactions and pathways resulting in the formation of kynurenic acid, 4-hydroxyquinoline-2-carboxylic acid.
|
1 | P28776 (/IMP) |
|
Swimming behavior GO:0036269
The response to external or internal stimuli that results in the locomotory process of swimming. Swimming is the self-propelled movement of an organism through the water.
|
1 | P28776 (/IMP) |
|
Negative regulation of T cell proliferation GO:0042130
Any process that stops, prevents or reduces the rate or extent of T cell proliferation.
|
1 | P28776 (/IMP) |
|
Positive regulation of apoptotic process GO:0043065
Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
|
1 | P28776 (/IMP) |
|
Negative regulation of activated T cell proliferation GO:0046007
Any process that stops, prevents or reduces the rate or extent of activated T cell proliferation.
|
1 | P28776 (/IMP) |
|
Negative regulation of T cell apoptotic process GO:0070233
Any process that stops, prevents, or reduces the frequency, rate or extent of T cell death by apoptotic process.
|
1 | P28776 (/IMP) |
|
Positive regulation of T cell apoptotic process GO:0070234
Any process that activates or increases the frequency, rate or extent of T cell death by apoptotic process.
|
1 | P28776 (/ISO) |
There are 7 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
3 | P14902 (/TAS) P14902 (/TAS) Q6ZQW0 (/TAS) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
2 | P28776 (/IDA) Q8R0V5 (/IDA) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
1 | Q6ZQW0 (/ISS) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
1 | Q9ERD9 (/IDA) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
1 | P28776 (/ISO) |
|
Smooth muscle contractile fiber GO:0030485
The contractile fiber of smooth muscle cells.
|
1 | P28776 (/IDA) |
|
Stereocilium bundle GO:0032421
A bundle of cross-linked stereocilia, arranged around a kinocilium on the apical surface of a sensory hair cell (e.g. a neuromast, auditory or vestibular hair cell). Stereocilium bundles act as mechanosensory organelles by responding to fluid motion or fluid pressure changes.
|
1 | P28776 (/IDA) |