The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Geminin coiled-coil domain
".
FunFam 1: Truncated geminin
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 10 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
9 | D6RGH6 (/IPI) O75496 (/IPI) O75496 (/IPI) O88513 (/IPI) O88513 (/IPI) Q08B36 (/IPI) Q1LU98 (/IPI) Q1LWU6 (/IPI) Q7SXL0 (/IPI) |
|
Chromatin binding GO:0003682
Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
|
2 | O75496 (/IDA) O75496 (/IDA) |
|
Transcription corepressor activity GO:0003714
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to repress the transcription of specific genes. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. A third class occludes DNA-binding transcription factor protein-protein interaction domains. A fourth class of corepressors prevents interactions of DNA bound DNA-binding transcription factor with coactivators.
|
2 | O88513 (/IDA) O88513 (/IDA) |
|
Histone deacetylase binding GO:0042826
Interacting selectively and non-covalently with the enzyme histone deacetylase.
|
2 | O75496 (/IPI) O75496 (/IPI) |
|
Histone deacetylase binding GO:0042826
Interacting selectively and non-covalently with the enzyme histone deacetylase.
|
2 | O88513 (/ISS) O88513 (/ISS) |
|
Repressing transcription factor binding GO:0070491
Interacting selectively and non-covalently with a transcription repressor, any protein whose activity is required to prevent or downregulate transcription.
|
2 | O88513 (/IPI) O88513 (/IPI) |
|
Transcription coactivator activity GO:0003713
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to activate the transcription of specific genes. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. Another type of coregulator activity is the bridging of a DNA-binding transcription factor to the basal transcription machinery. The Mediator complex, which bridges transcription factors and RNA polymerase, is also a transcription coactivator.
|
1 | Q08B36 (/IDA) |
|
Transcription coactivator activity GO:0003713
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to activate the transcription of specific genes. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. Another type of coregulator activity is the bridging of a DNA-binding transcription factor to the basal transcription machinery. The Mediator complex, which bridges transcription factors and RNA polymerase, is also a transcription coactivator.
|
1 | Q08B36 (/TAS) |
|
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
|
1 | D6RGH6 (/IPI) |
|
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
|
1 | Q3UZ45 (/ISO) |
There are 33 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Motile cilium assembly GO:0044458
The aggregation, arrangement and bonding together of a set of components to form a motile cilium.
|
6 | D3ZDX9 (/ISS) D6RGH6 (/ISS) F1SLM8 (/ISS) F7BHS0 (/ISS) G3N1S4 (/ISS) Q3UZ45 (/ISS) |
|
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
6 | D3ZDX9 (/ISS) D6RGH6 (/ISS) F1SLM8 (/ISS) F7BHS0 (/ISS) G3N1S4 (/ISS) Q3UZ45 (/ISS) |
|
Cilium assembly GO:0060271
The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole.
|
6 | D3ZDX9 (/ISS) D6RGH6 (/ISS) F1SLM8 (/ISS) F7BHS0 (/ISS) G3N1S4 (/ISS) Q3UZ45 (/ISS) |
|
Centriole assembly GO:0098534
A cellular process that results in the assembly of one or more centrioles.
|
6 | D3ZDX9 (/ISS) D6RGH6 (/ISS) F1SLM8 (/ISS) F7BHS0 (/ISS) G3N1S4 (/ISS) Q3UZ45 (/ISS) |
|
Multi-ciliated epithelial cell differentiation GO:1903251
The process in which a relatively unspecialized cell acquires the specialized features of a multi-ciliated epithelial cell.
|
6 | D3ZDX9 (/ISS) D6RGH6 (/ISS) F1SLM8 (/ISS) F7BHS0 (/ISS) G3N1S4 (/ISS) Q3UZ45 (/ISS) |
|
Negative regulation of DNA replication GO:0008156
Any process that stops, prevents, or reduces the frequency, rate or extent of DNA replication.
|
4 | O75496 (/IDA) O75496 (/IDA) O88513 (/IDA) O88513 (/IDA) |
|
Negative regulation of cell cycle GO:0045786
Any process that stops, prevents or reduces the rate or extent of progression through the cell cycle.
|
4 | O75496 (/IDA) O75496 (/IDA) O88513 (/IDA) O88513 (/IDA) |
|
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
|
4 | O75496 (/IDA) O75496 (/IDA) O88513 (/IDA) O88513 (/IDA) |
|
Cilium assembly GO:0060271
The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole.
|
4 | Q08B36 (/IMP) Q1LU98 (/IMP) Q1LWU6 (/IMP) Q7SXL0 (/IMP) |
|
Regulation of mitotic cell cycle GO:0007346
Any process that modulates the rate or extent of progress through the mitotic cell cycle.
|
3 | F1SLM8 (/ISS) Q08B36 (/ISS) Q3UZ45 (/ISS) |
|
Negative regulation of gene expression GO:0010629
Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
|
3 | B0LHV2 (/IMP) F1NW42 (/IMP) Q5ZKE6 (/IMP) |
|
Determination of pancreatic left/right asymmetry GO:0035469
Determination of the asymmetric location of the pancreas with respect to the left and right halves of the organism.
|
3 | Q1LU98 (/IMP) Q1LWU6 (/IMP) Q7SXL0 (/IMP) |
|
Negative regulation of cell cycle GO:0045786
Any process that stops, prevents or reduces the rate or extent of progression through the cell cycle.
|
3 | B0LHV2 (/IMP) F1NW42 (/IMP) Q5ZKE6 (/IMP) |
|
Determination of heart left/right asymmetry GO:0061371
Determination of the asymmetric location of the heart with respect to the left and right halves of the organism.
|
3 | Q1LU98 (/IMP) Q1LWU6 (/IMP) Q7SXL0 (/IMP) |
|
Kupffer's vesicle development GO:0070121
The progression of the Kupffer's vesicle over time from its initial formation until its mature state. The Kupffer's vesicle is a small but distinctive epithelial sac containing fluid, located midventrally posterior to the yolk cell or its extension, and transiently present during most of the segmentation period.
|
3 | Q1LU98 (/IMP) Q1LWU6 (/IMP) Q7SXL0 (/IMP) |
|
Determination of liver left/right asymmetry GO:0071910
Determination of the asymmetric location of the liver with respect to the left and right halves of the organism.
|
3 | Q1LU98 (/IMP) Q1LWU6 (/IMP) Q7SXL0 (/IMP) |
|
Negative regulation of DNA replication origin binding GO:1902596
Any process that stops, prevents or reduces the frequency, rate or extent of DNA replication origin binding.
|
3 | B0LHV2 (/IMP) F1NW42 (/IMP) Q5ZKE6 (/IMP) |
|
G1/S transition of mitotic cell cycle GO:0000082
The mitotic cell cycle transition by which a cell in G1 commits to S phase. The process begins with the build up of G1 cyclin-dependent kinase (G1 CDK), resulting in the activation of transcription of G1 cyclins. The process ends with the positive feedback of the G1 cyclins on the G1 CDK which commits the cell to S phase, in which DNA replication is initiated.
|
2 | O75496 (/TAS) O75496 (/TAS) |
|
Regulation of DNA replication GO:0006275
Any process that modulates the frequency, rate or extent of DNA replication.
|
2 | O75496 (/IMP) O75496 (/IMP) |
|
Animal organ morphogenesis GO:0009887
Morphogenesis of an animal organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.
|
2 | O88513 (/IDA) O88513 (/IDA) |
|
Positive regulation of chromatin binding GO:0035563
Any process that increases the frequency, rate or extent of chromatin binding. Chromatin binding is the selective interaction with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
|
2 | O75496 (/IDA) O75496 (/IDA) |
|
Protein-containing complex assembly GO:0065003
The aggregation, arrangement and bonding together of a set of macromolecules to form a protein-containing complex.
|
2 | O88513 (/IDA) O88513 (/IDA) |
|
DNA replication preinitiation complex assembly GO:0071163
The aggregation, arrangement and bonding together of a set of components to form the DNA replication preinitiation complex, a protein-DNA complex that is assembled at DNA replication origins immediately prior to the initiation of DNA replication. The complex consists of proteins that initiate the DNA binding, melt the helix and enable helicase activity.
|
2 | O75496 (/IDA) O75496 (/IDA) |
|
Negative regulation of DNA-dependent DNA replication GO:2000104
Any process that stops, prevents, or reduces the frequency, rate or extent of DNA-dependent DNA replication.
|
2 | O75496 (/IDA) O75496 (/IDA) |
|
Regulation of mitotic cell cycle GO:0007346
Any process that modulates the rate or extent of progress through the mitotic cell cycle.
|
1 | D6RGH6 (/IMP) |
|
Regulation of mitotic cell cycle GO:0007346
Any process that modulates the rate or extent of progress through the mitotic cell cycle.
|
1 | Q3UZ45 (/ISO) |
|
Motile cilium assembly GO:0044458
The aggregation, arrangement and bonding together of a set of components to form a motile cilium.
|
1 | Q08B36 (/IDA) |
|
Motile cilium assembly GO:0044458
The aggregation, arrangement and bonding together of a set of components to form a motile cilium.
|
1 | D6RGH6 (/IMP) |
|
Motile cilium assembly GO:0044458
The aggregation, arrangement and bonding together of a set of components to form a motile cilium.
|
1 | Q3UZ45 (/ISO) |
|
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
1 | Q08B36 (/IDA) |
|
Centriole assembly GO:0098534
A cellular process that results in the assembly of one or more centrioles.
|
1 | Q08B36 (/IDA) |
|
Multi-ciliated epithelial cell differentiation GO:1903251
The process in which a relatively unspecialized cell acquires the specialized features of a multi-ciliated epithelial cell.
|
1 | Q08B36 (/IDA) |
|
Regulation of RNA biosynthetic process GO:2001141
Any process that modulates the frequency, rate or extent of RNA biosynthetic process.
|
1 | Q08B36 (/TAS) |
There are 10 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
12 |
A0A024QZY7 (/IDA)
A0A024QZY7 (/IDA)
B0LHV2 (/IDA)
D6RGH6 (/IDA)
E2QRF9 (/IDA)
F1NW42 (/IDA)
O75496 (/IDA)
O75496 (/IDA)
O88513 (/IDA)
O88513 (/IDA)
(2 more) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
5 | B0LHV2 (/IDA) F1NW42 (/IDA) O75496 (/IDA) O75496 (/IDA) Q5ZKE6 (/IDA) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
5 | A0A024QZY7 (/IDA) A0A024QZY7 (/IDA) E2QRF9 (/IDA) O75496 (/IDA) O75496 (/IDA) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
3 | O88513 (/ISO) O88513 (/ISO) Q3UZ45 (/ISO) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
2 | F1SLM8 (/ISS) Q3UZ45 (/ISS) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
2 | O75496 (/TAS) O75496 (/TAS) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
2 | O88513 (/ISS) O88513 (/ISS) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
2 | O75496 (/TAS) O75496 (/TAS) |
|
Nuclear body GO:0016604
Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins.
|
1 | D6RGH6 (/IDA) |
|
Nuclear body GO:0016604
Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins.
|
1 | Q3UZ45 (/ISO) |