The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Interleukin-15/Interleukin-21
".
FunFam 2: Interleukin
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 4 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Cytokine receptor binding GO:0005126
Interacting selectively and non-covalently with a cytokine receptor.
|
6 | Q9HBE4 (/TAS) Q9HBE4 (/TAS) Q9HBE4 (/TAS) Q9HBE4 (/TAS) Q9HBE4 (/TAS) Q9HBE4 (/TAS) |
Interleukin-2 receptor binding GO:0005134
Interacting selectively and non-covalently with the interleukin-2 receptor.
|
6 | Q9HBE4 (/IPI) Q9HBE4 (/IPI) Q9HBE4 (/IPI) Q9HBE4 (/IPI) Q9HBE4 (/IPI) Q9HBE4 (/IPI) |
Cytokine receptor binding GO:0005126
Interacting selectively and non-covalently with a cytokine receptor.
|
2 | Q9ES17 (/IDA) Q9ES17 (/IDA) |
Interleukin-2 receptor binding GO:0005134
Interacting selectively and non-covalently with the interleukin-2 receptor.
|
2 | Q9ES17 (/ISO) Q9ES17 (/ISO) |
There are 29 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Positive regulation of natural killer cell mediated cytotoxicity GO:0045954
Any process that activates or increases the frequency, rate or extent of natural killer cell mediated cytotoxicity.
|
8 | Q9ES17 (/IDA) Q9ES17 (/IDA) Q9HBE4 (/IDA) Q9HBE4 (/IDA) Q9HBE4 (/IDA) Q9HBE4 (/IDA) Q9HBE4 (/IDA) Q9HBE4 (/IDA) |
Positive regulation of cytokine production GO:0001819
Any process that activates or increases the frequency, rate or extent of production of a cytokine.
|
6 | Q9HBE4 (/IDA) Q9HBE4 (/IDA) Q9HBE4 (/IDA) Q9HBE4 (/IDA) Q9HBE4 (/IDA) Q9HBE4 (/IDA) |
Signal transduction GO:0007165
The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
|
6 | Q9HBE4 (/NAS) Q9HBE4 (/NAS) Q9HBE4 (/NAS) Q9HBE4 (/NAS) Q9HBE4 (/NAS) Q9HBE4 (/NAS) |
Tyrosine phosphorylation of STAT protein GO:0007260
The process of introducing a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein.
|
6 | Q9HBE4 (/IDA) Q9HBE4 (/IDA) Q9HBE4 (/IDA) Q9HBE4 (/IDA) Q9HBE4 (/IDA) Q9HBE4 (/IDA) |
Positive regulation of cell population proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
|
6 | Q9HBE4 (/IDA) Q9HBE4 (/IDA) Q9HBE4 (/IDA) Q9HBE4 (/IDA) Q9HBE4 (/IDA) Q9HBE4 (/IDA) |
Positive regulation of B cell proliferation GO:0030890
Any process that activates or increases the rate or extent of B cell proliferation.
|
6 | Q9HBE4 (/IDA) Q9HBE4 (/IDA) Q9HBE4 (/IDA) Q9HBE4 (/IDA) Q9HBE4 (/IDA) Q9HBE4 (/IDA) |
Positive regulation of interleukin-17 production GO:0032740
Any process that activates or increases the frequency, rate, or extent of production of any member of the interleukin-17 family of cytokines.
|
6 | Q9HBE4 (/IDA) Q9HBE4 (/IDA) Q9HBE4 (/IDA) Q9HBE4 (/IDA) Q9HBE4 (/IDA) Q9HBE4 (/IDA) |
Positive regulation of tissue remodeling GO:0034105
Any process that activates or increases the frequency, rate, or extent of tissue remodeling.
|
6 | Q9HBE4 (/IC) Q9HBE4 (/IC) Q9HBE4 (/IC) Q9HBE4 (/IC) Q9HBE4 (/IC) Q9HBE4 (/IC) |
Interleukin-21-mediated signaling pathway GO:0038114
A series of molecular signals initiated by the binding of interleukin-21 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
|
6 | Q9HBE4 (/TAS) Q9HBE4 (/TAS) Q9HBE4 (/TAS) Q9HBE4 (/TAS) Q9HBE4 (/TAS) Q9HBE4 (/TAS) |
Positive regulation of T cell proliferation GO:0042102
Any process that activates or increases the rate or extent of T cell proliferation.
|
6 | Q9HBE4 (/IDA) Q9HBE4 (/IDA) Q9HBE4 (/IDA) Q9HBE4 (/IDA) Q9HBE4 (/IDA) Q9HBE4 (/IDA) |
Positive regulation of tyrosine phosphorylation of STAT protein GO:0042531
Any process that activates or increases the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein.
|
6 | Q9HBE4 (/IDA) Q9HBE4 (/IDA) Q9HBE4 (/IDA) Q9HBE4 (/IDA) Q9HBE4 (/IDA) Q9HBE4 (/IDA) |
Positive regulation of interferon-gamma biosynthetic process GO:0045078
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interferon-gamma.
|
6 | Q9HBE4 (/NAS) Q9HBE4 (/NAS) Q9HBE4 (/NAS) Q9HBE4 (/NAS) Q9HBE4 (/NAS) Q9HBE4 (/NAS) |
Cell maturation GO:0048469
A developmental process, independent of morphogenetic (shape) change, that is required for a cell to attain its fully functional state.
|
6 | Q9HBE4 (/IDA) Q9HBE4 (/IDA) Q9HBE4 (/IDA) Q9HBE4 (/IDA) Q9HBE4 (/IDA) Q9HBE4 (/IDA) |
Positive regulation of inflammatory response GO:0050729
Any process that activates or increases the frequency, rate or extent of the inflammatory response.
|
6 | Q9HBE4 (/IC) Q9HBE4 (/IC) Q9HBE4 (/IC) Q9HBE4 (/IC) Q9HBE4 (/IC) Q9HBE4 (/IC) |
B cell apoptotic process GO:0001783
Any apoptotic process in a B cell, a lymphocyte of B lineage with the phenotype CD19-positive and capable of B cell mediated immunity.
|
2 | Q9ES17 (/NAS) Q9ES17 (/NAS) |
Positive regulation of cytokine production GO:0001819
Any process that activates or increases the frequency, rate or extent of production of a cytokine.
|
2 | Q9ES17 (/ISO) Q9ES17 (/ISO) |
Positive regulation of natural killer cell cytokine production GO:0002729
Any process that activates or increases the frequency, rate, or extent of natural killer cell cytokine production.
|
2 | Q9ES17 (/IDA) Q9ES17 (/IDA) |
Tyrosine phosphorylation of STAT protein GO:0007260
The process of introducing a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein.
|
2 | Q9ES17 (/ISO) Q9ES17 (/ISO) |
Positive regulation of cell population proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
|
2 | Q9ES17 (/ISO) Q9ES17 (/ISO) |
Positive regulation of B cell proliferation GO:0030890
Any process that activates or increases the rate or extent of B cell proliferation.
|
2 | Q9ES17 (/ISO) Q9ES17 (/ISO) |
Positive regulation of interleukin-10 production GO:0032733
Any process that activates or increases the frequency, rate, or extent of interleukin-10 production.
|
2 | Q9ES17 (/IDA) Q9ES17 (/IDA) |
Positive regulation of interleukin-17 production GO:0032740
Any process that activates or increases the frequency, rate, or extent of production of any member of the interleukin-17 family of cytokines.
|
2 | Q9ES17 (/ISO) Q9ES17 (/ISO) |
Positive regulation of natural killer cell differentiation GO:0032825
Any process that activates or increases the frequency, rate or extent of natural killer cell differentiation.
|
2 | Q9ES17 (/IDA) Q9ES17 (/IDA) |
Positive regulation of T cell proliferation GO:0042102
Any process that activates or increases the rate or extent of T cell proliferation.
|
2 | Q9ES17 (/ISO) Q9ES17 (/ISO) |
Positive regulation of tyrosine phosphorylation of STAT protein GO:0042531
Any process that activates or increases the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein.
|
2 | Q9ES17 (/ISO) Q9ES17 (/ISO) |
Positive regulation of interferon-gamma biosynthetic process GO:0045078
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interferon-gamma.
|
2 | Q9ES17 (/IDA) Q9ES17 (/IDA) |
Positive regulation of B cell differentiation GO:0045579
Any process that activates or increases the frequency, rate or extent of B cell differentiation.
|
2 | Q9ES17 (/NAS) Q9ES17 (/NAS) |
Positive regulation of natural killer cell mediated cytotoxicity GO:0045954
Any process that activates or increases the frequency, rate or extent of natural killer cell mediated cytotoxicity.
|
2 | Q9ES17 (/ISO) Q9ES17 (/ISO) |
Cell maturation GO:0048469
A developmental process, independent of morphogenetic (shape) change, that is required for a cell to attain its fully functional state.
|
2 | Q9ES17 (/ISO) Q9ES17 (/ISO) |
There are 2 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
|
6 | Q9HBE4 (/TAS) Q9HBE4 (/TAS) Q9HBE4 (/TAS) Q9HBE4 (/TAS) Q9HBE4 (/TAS) Q9HBE4 (/TAS) |
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
|
6 | Q9HBE4 (/NAS) Q9HBE4 (/NAS) Q9HBE4 (/NAS) Q9HBE4 (/NAS) Q9HBE4 (/NAS) Q9HBE4 (/NAS) |