The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Interferon lambda
".
FunFam 1: Interferon lambda 1
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 3 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Signaling receptor binding GO:0005102
Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
|
1 | Q8IU54 (/IDA) |
|
Signaling receptor binding GO:0005102
Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
|
1 | Q8CGK6 (/ISA) |
|
Interleukin-28 receptor binding GO:0032003
Interacting selectively and non-covalently with the interleukin-28 receptor.
|
1 | Q8IU54 (/IPI) |
There are 20 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Cytokine-mediated signaling pathway GO:0019221
A series of molecular signals initiated by the binding of a cytokine to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
|
3 | Q8IU54 (/TAS) Q8IZI9 (/TAS) Q8IZJ0 (/TAS) |
|
Defense response to virus GO:0051607
Reactions triggered in response to the presence of a virus that act to protect the cell or organism.
|
3 | Q8CGK6 (/ISS) Q8IZI9 (/ISS) Q8IZJ0 (/ISS) |
|
Negative regulation of cell population proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
|
2 | F1PY54 (/IDA) Q8IU54 (/IDA) |
|
Negative regulation of viral genome replication GO:0045071
Any process that stops, prevents, or reduces the frequency, rate or extent of viral genome replication.
|
2 | Q8CGK6 (/ISS) Q8IZI9 (/ISS) |
|
Positive regulation of receptor signaling pathway via JAK-STAT GO:0046427
Any process that activates or increases the frequency, rate or extent of the JAK-STAT signaling pathway activity.
|
2 | F1PY54 (/IDA) Q8IU54 (/IDA) |
|
Defense response to virus GO:0051607
Reactions triggered in response to the presence of a virus that act to protect the cell or organism.
|
2 | Q4VK74 (/IDA) Q8IU54 (/IDA) |
|
Mucosal immune response GO:0002385
An immune response taking place in mucosal tissues, including those of the intestinal tract, nasal and upper respiratory tract, and genital tract.
|
1 | Q4VK74 (/IDA) |
|
Mucosal immune response GO:0002385
An immune response taking place in mucosal tissues, including those of the intestinal tract, nasal and upper respiratory tract, and genital tract.
|
1 | Q8IZJ0 (/ISS) |
|
Negative regulation of type 2 immune response GO:0002829
Any process that stops, prevents, or reduces the frequency, rate, or extent of a type 2 immune response.
|
1 | Q8IU54 (/IDA) |
|
Negative regulation of interleukin-13 production GO:0032696
Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-13 production.
|
1 | Q8IU54 (/IDA) |
|
Negative regulation of interleukin-5 production GO:0032714
Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-5 production.
|
1 | Q8IU54 (/IDA) |
|
Positive regulation of interferon-gamma production GO:0032729
Any process that activates or increases the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon.
|
1 | Q8IU54 (/IDA) |
|
Positive regulation of tyrosine phosphorylation of STAT protein GO:0042531
Any process that activates or increases the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein.
|
1 | Q8IU54 (/IDA) |
|
Negative regulation of memory T cell differentiation GO:0043381
Any process that stops, prevents, or reduces the rate of memory T cell differentiation.
|
1 | Q8IU54 (/IDA) |
|
Innate immune response GO:0045087
Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.
|
1 | Q8CGK6 (/IDA) |
|
Positive regulation of MHC class I biosynthetic process GO:0045345
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of MHC class I.
|
1 | Q8IU54 (/IDA) |
|
Negative regulation of T cell differentiation GO:0045581
Any process that stops, prevents, or reduces the frequency, rate or extent of T cell differentiation.
|
1 | Q8IU54 (/IDA) |
|
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
|
1 | Q8IU54 (/IDA) |
|
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
|
1 | Q8IU54 (/IDA) |
|
Positive regulation of immune response GO:0050778
Any process that activates or increases the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.
|
1 | Q8IU54 (/TAS) |
There are 4 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
|
3 | Q8IU54 (/TAS) Q8IZI9 (/TAS) Q8IZJ0 (/TAS) |
|
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
|
1 | Q8IU54 (/IDA) |
|
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
|
1 | Q8CGK6 (/IDA) |
|
Interleukin-28 receptor complex GO:0032002
A protein complex that binds interleukin-28 and interleukin-29. It is composed of an alpha and a beta receptor subunit (in human IFNLR1/IL28Ralpha & IL10RB) and either Interleukin-28 (IFNL2 or IFNL3) or Interleukin-29 (IFNL1).
|
1 | Q8IU54 (/IDA) |