The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Translation initiation factor eIF-2B, N-terminal domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 1: Eukaryotic translation initiation factor 2B subuni...

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 9 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
9 Q14232 (/IPI) Q14232 (/IPI) Q14232 (/IPI) Q14232 (/IPI) Q14232 (/IPI) Q14232 (/IPI) Q14232 (/IPI) Q99LC8 (/IPI) Q99LC8 (/IPI)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
7 Q14232 (/IPI) Q14232 (/IPI) Q14232 (/IPI) Q14232 (/IPI) Q14232 (/IPI) Q14232 (/IPI) Q14232 (/IPI)
Translation initiation factor activity GO:0003743
Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide.
2 Q99LC8 (/ISO) Q99LC8 (/ISO)
GTP binding GO:0005525
Interacting selectively and non-covalently with GTP, guanosine triphosphate.
2 Q99LC8 (/ISO) Q99LC8 (/ISO)
GDP binding GO:0019003
Interacting selectively and non-covalently with GDP, guanosine 5'-diphosphate.
2 Q99LC8 (/ISO) Q99LC8 (/ISO)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
2 Q99LC8 (/ISO) Q99LC8 (/ISO)
Translation initiation factor activity GO:0003743
Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide.
1 Q64270 (/IDA)
GTP binding GO:0005525
Interacting selectively and non-covalently with GTP, guanosine triphosphate.
1 Q64270 (/IMP)
GDP binding GO:0019003
Interacting selectively and non-covalently with GDP, guanosine 5'-diphosphate.
1 Q64270 (/IDA)

There are 25 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Translational initiation GO:0006413
The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA.
11 Q4R4V8 (/ISS) Q4R4V8 (/ISS) Q4R4V8 (/ISS) Q4R4V8 (/ISS) Q4R4V8 (/ISS) Q4R4V8 (/ISS) Q4R4V8 (/ISS) Q4R4V8 (/ISS) Q64270 (/ISS) Q99LC8 (/ISS)
(1 more)
Oligodendrocyte development GO:0014003
The process aimed at the progression of an oligodendrocyte over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. An oligodendrocyte is a type of glial cell involved in myelinating the axons in the central nervous system.
11 Q4R4V8 (/ISS) Q4R4V8 (/ISS) Q4R4V8 (/ISS) Q4R4V8 (/ISS) Q4R4V8 (/ISS) Q4R4V8 (/ISS) Q4R4V8 (/ISS) Q4R4V8 (/ISS) Q64270 (/ISS) Q99LC8 (/ISS)
(1 more)
T cell receptor signaling pathway GO:0050852
A series of molecular signals initiated by the cross-linking of an antigen receptor on a T cell.
11 Q4R4V8 (/ISS) Q4R4V8 (/ISS) Q4R4V8 (/ISS) Q4R4V8 (/ISS) Q4R4V8 (/ISS) Q4R4V8 (/ISS) Q4R4V8 (/ISS) Q4R4V8 (/ISS) Q64270 (/ISS) Q99LC8 (/ISS)
(1 more)
Translational initiation GO:0006413
The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA.
8 Q14232 (/IDA) Q14232 (/IDA) Q14232 (/IDA) Q14232 (/IDA) Q14232 (/IDA) Q14232 (/IDA) Q14232 (/IDA) Q64270 (/IDA)
Response to heat GO:0009408
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.
7 Q14232 (/ISS) Q14232 (/ISS) Q14232 (/ISS) Q14232 (/ISS) Q14232 (/ISS) Q14232 (/ISS) Q14232 (/ISS)
Response to heat GO:0009408
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.
7 Q14232 (/TAS) Q14232 (/TAS) Q14232 (/TAS) Q14232 (/TAS) Q14232 (/TAS) Q14232 (/TAS) Q14232 (/TAS)
Response to glucose GO:0009749
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucose stimulus.
7 Q14232 (/ISS) Q14232 (/ISS) Q14232 (/ISS) Q14232 (/ISS) Q14232 (/ISS) Q14232 (/ISS) Q14232 (/ISS)
Oligodendrocyte development GO:0014003
The process aimed at the progression of an oligodendrocyte over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. An oligodendrocyte is a type of glial cell involved in myelinating the axons in the central nervous system.
7 Q14232 (/IMP) Q14232 (/IMP) Q14232 (/IMP) Q14232 (/IMP) Q14232 (/IMP) Q14232 (/IMP) Q14232 (/IMP)
Response to peptide hormone GO:0043434
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide hormone stimulus. A peptide hormone is any of a class of peptides that are secreted into the blood stream and have endocrine functions in living animals.
7 Q14232 (/ISS) Q14232 (/ISS) Q14232 (/ISS) Q14232 (/ISS) Q14232 (/ISS) Q14232 (/ISS) Q14232 (/ISS)
T cell receptor signaling pathway GO:0050852
A series of molecular signals initiated by the cross-linking of an antigen receptor on a T cell.
7 Q14232 (/IDA) Q14232 (/IDA) Q14232 (/IDA) Q14232 (/IDA) Q14232 (/IDA) Q14232 (/IDA) Q14232 (/IDA)
Translation GO:0006412
The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome.
2 Q99LC8 (/ISO) Q99LC8 (/ISO)
Translational initiation GO:0006413
The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA.
2 Q99LC8 (/ISO) Q99LC8 (/ISO)
Response to heat GO:0009408
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.
2 Q99LC8 (/ISO) Q99LC8 (/ISO)
Response to glucose GO:0009749
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucose stimulus.
2 Q99LC8 (/ISO) Q99LC8 (/ISO)
Oligodendrocyte development GO:0014003
The process aimed at the progression of an oligodendrocyte over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. An oligodendrocyte is a type of glial cell involved in myelinating the axons in the central nervous system.
2 Q99LC8 (/ISO) Q99LC8 (/ISO)
Response to peptide hormone GO:0043434
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide hormone stimulus. A peptide hormone is any of a class of peptides that are secreted into the blood stream and have endocrine functions in living animals.
2 Q99LC8 (/ISO) Q99LC8 (/ISO)
T cell receptor signaling pathway GO:0050852
A series of molecular signals initiated by the cross-linking of an antigen receptor on a T cell.
2 Q99LC8 (/ISO) Q99LC8 (/ISO)
Negative regulation of guanyl-nucleotide exchange factor activity GO:1905098
Any process that stops, prevents or reduces the frequency, rate or extent of guanyl-nucleotide exchange factor activity.
2 Q99LC8 (/ISO) Q99LC8 (/ISO)
Response to amino acid starvation GO:1990928
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of amino acids.
2 Q99LC8 (/ISO) Q99LC8 (/ISO)
Translation GO:0006412
The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome.
1 Q64270 (/IDA)
Response to heat GO:0009408
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.
1 Q64270 (/IDA)
Response to glucose GO:0009749
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucose stimulus.
1 Q64270 (/IDA)
Response to peptide hormone GO:0043434
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide hormone stimulus. A peptide hormone is any of a class of peptides that are secreted into the blood stream and have endocrine functions in living animals.
1 Q64270 (/IDA)
Negative regulation of guanyl-nucleotide exchange factor activity GO:1905098
Any process that stops, prevents or reduces the frequency, rate or extent of guanyl-nucleotide exchange factor activity.
1 Q64270 (/IDA)
Response to amino acid starvation GO:1990928
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of amino acids.
1 Q64270 (/IDA)

There are 14 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
11 Q4R4V8 (/ISS) Q4R4V8 (/ISS) Q4R4V8 (/ISS) Q4R4V8 (/ISS) Q4R4V8 (/ISS) Q4R4V8 (/ISS) Q4R4V8 (/ISS) Q4R4V8 (/ISS) Q64270 (/ISS) Q99LC8 (/ISS)
(1 more)
Eukaryotic translation initiation factor 2B complex GO:0005851
A multisubunit guanine nucleotide exchange factor which catalyzes the exchange of GDP bound to initiation factor eIF2 for GTP, generating active eIF2-GTP. In humans, it is composed of five subunits, alpha, beta, delta, gamma and epsilon.
11 Q4R4V8 (/ISS) Q4R4V8 (/ISS) Q4R4V8 (/ISS) Q4R4V8 (/ISS) Q4R4V8 (/ISS) Q4R4V8 (/ISS) Q4R4V8 (/ISS) Q4R4V8 (/ISS) Q64270 (/ISS) Q99LC8 (/ISS)
(1 more)
Eukaryotic translation initiation factor 2B complex GO:0005851
A multisubunit guanine nucleotide exchange factor which catalyzes the exchange of GDP bound to initiation factor eIF2 for GTP, generating active eIF2-GTP. In humans, it is composed of five subunits, alpha, beta, delta, gamma and epsilon.
8 Q14232 (/IDA) Q14232 (/IDA) Q14232 (/IDA) Q14232 (/IDA) Q14232 (/IDA) Q14232 (/IDA) Q14232 (/IDA) Q64270 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
7 Q14232 (/IDA) Q14232 (/IDA) Q14232 (/IDA) Q14232 (/IDA) Q14232 (/IDA) Q14232 (/IDA) Q14232 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
7 Q14232 (/TAS) Q14232 (/TAS) Q14232 (/TAS) Q14232 (/TAS) Q14232 (/TAS) Q14232 (/TAS) Q14232 (/TAS)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
7 Q14232 (/IDA) Q14232 (/IDA) Q14232 (/IDA) Q14232 (/IDA) Q14232 (/IDA) Q14232 (/IDA) Q14232 (/IDA)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
7 Q14232 (/IDA) Q14232 (/IDA) Q14232 (/IDA) Q14232 (/IDA) Q14232 (/IDA) Q14232 (/IDA) Q14232 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
2 Q99LC8 (/ISO) Q99LC8 (/ISO)
Eukaryotic translation initiation factor 2 complex GO:0005850
Complex of three heterogeneous polypeptide chains, that form a ternary complex with initiator methionyl-tRNA and GTP. This ternary complex binds to free 40S subunit, which subsequently binds the 5' end of mRNA.
2 Q99LC8 (/ISO) Q99LC8 (/ISO)
Eukaryotic translation initiation factor 2B complex GO:0005851
A multisubunit guanine nucleotide exchange factor which catalyzes the exchange of GDP bound to initiation factor eIF2 for GTP, generating active eIF2-GTP. In humans, it is composed of five subunits, alpha, beta, delta, gamma and epsilon.
2 Q99LC8 (/ISO) Q99LC8 (/ISO)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
2 Q99LC8 (/ISO) Q99LC8 (/ISO)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
2 Q99LC8 (/ISO) Q99LC8 (/ISO)
Eukaryotic translation initiation factor 2 complex GO:0005850
Complex of three heterogeneous polypeptide chains, that form a ternary complex with initiator methionyl-tRNA and GTP. This ternary complex binds to free 40S subunit, which subsequently binds the 5' end of mRNA.
1 Q64270 (/IDA)
Eukaryotic translation initiation factor 2B complex GO:0005851
A multisubunit guanine nucleotide exchange factor which catalyzes the exchange of GDP bound to initiation factor eIF2 for GTP, generating active eIF2-GTP. In humans, it is composed of five subunits, alpha, beta, delta, gamma and epsilon.
1 Q64270 (/IPI)
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