The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Rhodopsin 7-helix transmembrane proteins
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 87: prostaglandin E2 receptor EP3 subtype

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 6 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Prostaglandin E receptor activity GO:0004957
Combining with prostaglandin E (PGE(2)) to initiate a change in cell activity.
3 E7FD73 (/IDA) P30557 (/IDA) P34980 (/IDA)
Prostaglandin E receptor activity GO:0004957
Combining with prostaglandin E (PGE(2)) to initiate a change in cell activity.
3 O00325 (/NAS) P43115 (/NAS) P43115 (/NAS)
Prostaglandin E receptor activity GO:0004957
Combining with prostaglandin E (PGE(2)) to initiate a change in cell activity.
2 P30557 (/IMP) P34980 (/IMP)
Prostaglandin E receptor activity GO:0004957
Combining with prostaglandin E (PGE(2)) to initiate a change in cell activity.
2 P43115 (/TAS) P43115 (/TAS)
Prostaglandin E receptor activity GO:0004957
Combining with prostaglandin E (PGE(2)) to initiate a change in cell activity.
1 P30557 (/ISO)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
1 P30557 (/IPI)
Showing 1 to 6 of 6 entries

There are 82 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
G protein-coupled receptor signaling pathway GO:0007186
A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576).
2 P43115 (/TAS) P43115 (/TAS)
Cell death GO:0008219
Any biological process that results in permanent cessation of all vital functions of a cell. A cell should be considered dead when any one of the following molecular or morphological criteria is met: (1) the cell has lost the integrity of its plasma membrane; (2) the cell, including its nucleus, has undergone complete fragmentation into discrete bodies (frequently referred to as apoptotic bodies). The cell corpse (or its fragments) may be engulfed by an adjacent cell in vivo, but engulfment of whole cells should not be considered a strict criteria to define cell death as, under some circumstances, live engulfed cells can be released from phagosomes (see PMID:18045538).
2 P43115 (/TAS) P43115 (/TAS)
Positive regulation of fever generation GO:0031622
Any process that activates or increases the frequency, rate, or extent of fever generation.
2 P43115 (/ISS) P43115 (/ISS)
Fever generation GO:0001660
The heat generation process that results in a rise in body temperature above the normal, often as a response to infection.
1 P30557 (/IDA)
Fever generation GO:0001660
The heat generation process that results in a rise in body temperature above the normal, often as a response to infection.
1 P30557 (/IMP)
Positive regulation of protein phosphorylation GO:0001934
Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein.
1 P34980 (/IMP)
Positive regulation of protein phosphorylation GO:0001934
Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein.
1 P30557 (/ISO)
Desensitization of G protein-coupled receptor signaling pathway GO:0002029
The process that stops, prevents, or reduces the frequency, rate or extent of G protein-coupled receptor signaling pathway after prolonged stimulation with an agonist of the pathway.
1 P34980 (/IMP)
Desensitization of G protein-coupled receptor signaling pathway GO:0002029
The process that stops, prevents, or reduces the frequency, rate or extent of G protein-coupled receptor signaling pathway after prolonged stimulation with an agonist of the pathway.
1 P30557 (/ISO)
Adenylate cyclase-modulating G protein-coupled receptor signaling pathway GO:0007188
The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, where the pathway proceeds through activation or inhibition of adenylyl cyclase activity and a subsequent change in the concentration of cyclic AMP (cAMP).
1 P30557 (/IDA)
Showing 1 to 10 of 82 entries

There are 18 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
3 O00325 (/NAS) P43115 (/NAS) P43115 (/NAS)
Nuclear envelope GO:0005635
The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space).
2 P43115 (/TAS) P43115 (/TAS)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
2 P30557 (/IDA) P34980 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
2 P43115 (/TAS) P43115 (/TAS)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
2 P43115 (/TAS) P43115 (/TAS)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 P30557 (/ISO)
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
1 P34980 (/IDA)
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
1 P30557 (/ISO)
Brush border membrane GO:0031526
The portion of the plasma membrane surrounding the brush border.
1 P34980 (/IDA)
Brush border membrane GO:0031526
The portion of the plasma membrane surrounding the brush border.
1 P30557 (/ISO)
Showing 1 to 10 of 18 entries
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