The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Rhodopsin 7-helix transmembrane proteins
".
FunFam 83: Melanopsin 1
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 8 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
G protein-coupled photoreceptor activity GO:0008020
Combining with incidental electromagnetic radiation, particularly visible light, and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
|
5 | G1MUG1 (/ISS) G3UT61 (/ISS) Q2KNE5 (/ISS) Q5XXP2 (/ISS) Q5YKK9 (/ISS) |
11-cis retinal binding GO:0005502
Interacting selectively and non-covalently with 11-cis retinal, an isomer of retinal that plays an important role in the visual process in most vertebrates. 11-cis retinal combines with opsin in the rods (scotopsin) to form rhodopsin or visual purple. Retinal is one of the three compounds that makes up vitamin A.
|
4 | Q5XXP2 (/ISS) Q5YKK9 (/ISS) Q8R456 (/ISS) Q9QXZ9 (/ISS) |
G protein-coupled photoreceptor activity GO:0008020
Combining with incidental electromagnetic radiation, particularly visible light, and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
|
4 | F1NEY8 (/IMP) G5EI88 (/IMP) Q2KNE6 (/IMP) Q9QXZ9 (/IMP) |
Photoreceptor activity GO:0009881
The function of absorbing and responding to incidental electromagnetic radiation, particularly visible light. The response may involve a change in conformation.
|
3 | E7FEB1 (/IDA) G8Z411 (/IDA) Q2KNE5 (/IDA) |
G protein-coupled photoreceptor activity GO:0008020
Combining with incidental electromagnetic radiation, particularly visible light, and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
|
2 | Q8R456 (/IDA) Q9UHM6 (/IDA) |
11-cis retinal binding GO:0005502
Interacting selectively and non-covalently with 11-cis retinal, an isomer of retinal that plays an important role in the visual process in most vertebrates. 11-cis retinal combines with opsin in the rods (scotopsin) to form rhodopsin or visual purple. Retinal is one of the three compounds that makes up vitamin A.
|
1 | Q9UHM6 (/IDA) |
11-cis retinal binding GO:0005502
Interacting selectively and non-covalently with 11-cis retinal, an isomer of retinal that plays an important role in the visual process in most vertebrates. 11-cis retinal combines with opsin in the rods (scotopsin) to form rhodopsin or visual purple. Retinal is one of the three compounds that makes up vitamin A.
|
1 | Q9QXZ9 (/ISO) |
G protein-coupled photoreceptor activity GO:0008020
Combining with incidental electromagnetic radiation, particularly visible light, and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
|
1 | Q9QXZ9 (/ISO) |
There are 15 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Regulation of circadian rhythm GO:0042752
Any process that modulates the frequency, rate or extent of a circadian rhythm. A circadian rhythm is a biological process in an organism that recurs with a regularity of approximately 24 hours.
|
4 | Q5XXP2 (/ISS) Q5YKK9 (/ISS) Q8R456 (/ISS) Q9UHM6 (/ISS) |
G protein-coupled receptor signaling pathway GO:0007186
A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576).
|
3 | E7FEB1 (/IDA) G8Z411 (/IDA) Q2KNE5 (/IDA) |
Phototransduction, visible light GO:0007603
The sequence of reactions within a cell required to convert absorbed photons from visible light into a molecular signal. A visible light stimulus is electromagnetic radiation that can be perceived visually by an organism; for organisms lacking a visual system, this can be defined as light with a wavelength within the range 380 to 780 nm.
|
3 | F1NEY8 (/IMP) G5EI88 (/IMP) Q2KNE6 (/IMP) |
Absorption of visible light GO:0016038
The reception of a (visible light) photon by a cell, visible light being defined as having a wavelength within the range 380-780 nm.
|
3 | F1NEY8 (/IDA) G5EI88 (/IDA) Q2KNE6 (/IDA) |
Protein-chromophore linkage GO:0018298
The covalent or noncovalent attachment of a chromophore to a protein.
|
3 | F1NEY8 (/IDA) G5EI88 (/IDA) Q2KNE6 (/IDA) |
Cellular response to light stimulus GO:0071482
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light.
|
3 | F1NEY8 (/IMP) G5EI88 (/IMP) Q2KNE6 (/IMP) |
Phototransduction GO:0007602
The sequence of reactions within a cell required to convert absorbed photons into a molecular signal.
|
2 | Q8R456 (/IDA) Q9UHM6 (/IDA) |
Phototransduction GO:0007602
The sequence of reactions within a cell required to convert absorbed photons into a molecular signal.
|
2 | Q5XXP2 (/ISS) Q5YKK9 (/ISS) |
Absorption of visible light GO:0016038
The reception of a (visible light) photon by a cell, visible light being defined as having a wavelength within the range 380-780 nm.
|
2 | G1MUG1 (/ISS) G3UT61 (/ISS) |
Protein-chromophore linkage GO:0018298
The covalent or noncovalent attachment of a chromophore to a protein.
|
2 | G1MUG1 (/ISS) G3UT61 (/ISS) |
Cellular response to light stimulus GO:0071482
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light.
|
2 | G1MUG1 (/ISS) G3UT61 (/ISS) |
G protein-coupled receptor signaling pathway GO:0007186
A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576).
|
1 | Q9UHM6 (/TAS) |
Phototransduction GO:0007602
The sequence of reactions within a cell required to convert absorbed photons into a molecular signal.
|
1 | Q9QXZ9 (/IMP) |
Phototransduction GO:0007602
The sequence of reactions within a cell required to convert absorbed photons into a molecular signal.
|
1 | Q9QXZ9 (/ISO) |
Regulation of circadian rhythm GO:0042752
Any process that modulates the frequency, rate or extent of a circadian rhythm. A circadian rhythm is a biological process in an organism that recurs with a regularity of approximately 24 hours.
|
1 | Q9QXZ9 (/IMP) |
There are 7 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
|
5 | Q5XXP2 (/TAS) Q5YKK9 (/TAS) Q8R456 (/TAS) Q9QXZ9 (/TAS) Q9UHM6 (/TAS) |
Cell GO:0005623
The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.
|
3 | F1NEY8 (/IDA) G5EI88 (/IDA) Q2KNE6 (/IDA) |
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
|
3 | F1NEY8 (/IDA) G5EI88 (/IDA) Q2KNE6 (/IDA) |
Cell body membrane GO:0044298
The plasma membrane of a cell that bears surface projections such as axons, dendrites, cilia, or flagella, excluding the plasma membrane on cell projections.
|
3 | F1NEY8 (/IDA) G5EI88 (/IDA) Q2KNE6 (/IDA) |
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
|
2 | G1MUG1 (/ISS) G3UT61 (/ISS) |
Cell body membrane GO:0044298
The plasma membrane of a cell that bears surface projections such as axons, dendrites, cilia, or flagella, excluding the plasma membrane on cell projections.
|
2 | G1MUG1 (/ISS) G3UT61 (/ISS) |
Photoreceptor disc membrane GO:0097381
Stack of disc membranes located inside a photoreceptor outer segment, and containing densely packed molecules of photoreceptor proteins that traverse the lipid bilayer. Disc membranes arise as evaginations of the ciliary membrane during the development of the outer segment and may or may not remain contiguous with the ciliary membrane.
|
1 | Q9UHM6 (/TAS) |