The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Rhodopsin 7-helix transmembrane proteins
".
FunFam 74: probable G-protein coupled receptor 173
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 2 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
G protein-coupled receptor activity GO:0004930
Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
|
39 |
Q9NS66 (/TAS)
Q9NS66 (/TAS)
Q9NS66 (/TAS)
Q9NS66 (/TAS)
Q9NS66 (/TAS)
Q9NS66 (/TAS)
Q9NS66 (/TAS)
Q9NS66 (/TAS)
Q9NS66 (/TAS)
Q9NS66 (/TAS)
(29 more) |
|
Gonadotropin-releasing hormone receptor activity GO:0004968
Combining with gonadotropin-releasing hormone to initiate a change in cell activity. Gonadotropin-releasing hormone (GnRH) is a peptide hormone responsible for the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the anterior pituitary. GnRH is synthesized and released by the hypothalamus.
|
2 | Q6PI62 (/IMP) Q6PI62 (/IMP) |
There are 7 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Signal transduction GO:0007165
The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
|
39 |
Q9NS66 (/TAS)
Q9NS66 (/TAS)
Q9NS66 (/TAS)
Q9NS66 (/TAS)
Q9NS66 (/TAS)
Q9NS66 (/TAS)
Q9NS66 (/TAS)
Q9NS66 (/TAS)
Q9NS66 (/TAS)
Q9NS66 (/TAS)
(29 more) |
|
G protein-coupled receptor signaling pathway GO:0007186
A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576).
|
5 | Q9NS67 (/TAS) Q9NS67 (/TAS) Q9NS67 (/TAS) Q9NS67 (/TAS) Q9NS67 (/TAS) |
|
Negative regulation of neuron migration GO:2001223
Any process that stops, prevents or reduces the frequency, rate or extent of neuron migration.
|
2 | Q6PI62 (/IGI) Q6PI62 (/IGI) |
|
Negative regulation of neuron migration GO:2001223
Any process that stops, prevents or reduces the frequency, rate or extent of neuron migration.
|
2 | Q6PI62 (/IMP) Q6PI62 (/IMP) |
|
Positive regulation of insulin secretion involved in cellular response to glucose stimulus GO:0035774
Any process that increases the frequency, rate or extent of the regulated release of insulin that contributes to the response of a cell to glucose.
|
1 | O54897 (/IMP) |
|
Positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway GO:1900738
Any process that activates or increases the frequency, rate or extent of phospholipase C-activating G protein-coupled receptor signaling pathway.
|
1 | O54897 (/IDA) |
|
Positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway GO:1900738
Any process that activates or increases the frequency, rate or extent of phospholipase C-activating G protein-coupled receptor signaling pathway.
|
1 | O54897 (/IMP) |
There are 2 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
5 | Q9NS67 (/TAS) Q9NS67 (/TAS) Q9NS67 (/TAS) Q9NS67 (/TAS) Q9NS67 (/TAS) |
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
1 | O54897 (/IDA) |
