The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Rhodopsin 7-helix transmembrane proteins
".
FunFam 34: G-protein coupled receptor 1
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 39 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Complement component C5a receptor activity GO:0004878
Combining with the C5a product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
|
12 |
O70129 (/ISS)
P0C7U5 (/ISS)
P30992 (/ISS)
P30993 (/ISS)
P79175 (/ISS)
P79188 (/ISS)
P79234 (/ISS)
P79240 (/ISS)
P79240 (/ISS)
Q6UNA4 (/ISS)
(2 more) |
|
N-formyl peptide receptor activity GO:0004982
Combining with an N-formyl peptide to initiate a change in cell activity.
|
7 | A4FUQ5 (/IDA) O88536 (/IDA) O88537 (/IDA) P21462 (/IDA) P33766 (/IDA) Q3SXG2 (/IDA) Q71MR7 (/IDA) |
|
N-formyl peptide receptor activity GO:0004982
Combining with an N-formyl peptide to initiate a change in cell activity.
|
5 | P21462 (/TAS) P25089 (/TAS) P25089 (/TAS) P25090 (/TAS) P25090 (/TAS) |
|
Complement component C5a binding GO:0001856
Interacting selectively and non-covalently with the C5a product of the complement cascade.
|
4 | A0A060YND6 (/IPI) A0A060YND6 (/IPI) Q6UNA4 (/IPI) Q6UNA4 (/IPI) |
|
G protein-coupled receptor activity GO:0004930
Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
|
4 | P25090 (/TAS) P25090 (/TAS) P46091 (/TAS) Q9Y5Y4 (/TAS) |
|
Scavenger receptor binding GO:0005124
Interacting selectively and non-covalently with scavenger receptors, a family of proteins that are expressed on myeloid cells and are involved in the uptake of effete cellular components and foreign particles.
|
4 | D4A7Q2 (/IPI) F1M670 (/IPI) P25090 (/IPI) P25090 (/IPI) |
|
Signaling receptor activity GO:0038023
Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response.
|
4 | O08790 (/IDA) O88536 (/IDA) P25090 (/IDA) P25090 (/IDA) |
|
Amyloid-beta binding GO:0001540
Interacting selectively and non-covalently with amyloid-beta peptide/protein and/or its precursor.
|
3 | O88536 (/IPI) P25090 (/IPI) P25090 (/IPI) |
|
Complement component C5a receptor activity GO:0004878
Combining with the C5a product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
|
3 | P21730 (/IDA) P30993 (/IDA) P97520 (/IDA) |
|
G protein-coupled receptor activity GO:0004930
Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
|
3 | P25090 (/NAS) P25090 (/NAS) Q99788 (/NAS) |
Showing 1 to 10 of 39 entries
There are 129 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Positive regulation of ERK1 and ERK2 cascade GO:0070374
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
|
15 |
O70129 (/ISS)
P0C7U5 (/ISS)
P25090 (/ISS)
P25090 (/ISS)
P30992 (/ISS)
P30993 (/ISS)
P79175 (/ISS)
P79188 (/ISS)
P79234 (/ISS)
P79240 (/ISS)
(5 more) |
|
MRNA transcription by RNA polymerase II GO:0042789
The cellular synthesis of messenger RNA (mRNA) from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter.
|
13 |
O70129 (/ISS)
P0C7U5 (/ISS)
P30992 (/ISS)
P30993 (/ISS)
P79175 (/ISS)
P79188 (/ISS)
P79234 (/ISS)
P79240 (/ISS)
P79240 (/ISS)
P97520 (/ISS)
(3 more) |
|
Positive regulation of epithelial cell proliferation GO:0050679
Any process that activates or increases the rate or extent of epithelial cell proliferation.
|
13 |
O70129 (/ISS)
P0C7U5 (/ISS)
P30992 (/ISS)
P30993 (/ISS)
P79175 (/ISS)
P79188 (/ISS)
P79234 (/ISS)
P79240 (/ISS)
P79240 (/ISS)
P97520 (/ISS)
(3 more) |
|
G protein-coupled receptor signaling pathway GO:0007186
A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576).
|
9 | P21462 (/TAS) P21730 (/TAS) P25089 (/TAS) P25089 (/TAS) P25090 (/TAS) P25090 (/TAS) P46091 (/TAS) Q99788 (/TAS) Q9Y5Y4 (/TAS) |
|
Chemotaxis GO:0006935
The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).
|
7 | O08790 (/TAS) P21462 (/TAS) P21730 (/TAS) P25090 (/TAS) P25090 (/TAS) P33766 (/TAS) Q99788 (/TAS) |
|
Chemotaxis GO:0006935
The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).
|
6 | B1PHQ8 (/ISS) B1PHQ8 (/ISS) B9VR26 (/ISS) O35786 (/ISS) Q6XKD3 (/ISS) Q9Z2J6 (/ISS) |
|
G protein-coupled receptor signaling pathway GO:0007186
A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576).
|
6 | B1PHQ8 (/ISS) B1PHQ8 (/ISS) B9VR26 (/ISS) O35786 (/ISS) Q6XKD3 (/ISS) Q9Z2J6 (/ISS) |
|
Negative regulation of NF-kappaB transcription factor activity GO:0032088
Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of the transcription factor NF-kappaB.
|
6 | B1PHQ8 (/ISS) B1PHQ8 (/ISS) B9VR26 (/ISS) O35786 (/ISS) P97468 (/ISS) P97468 (/ISS) |
|
G protein-coupled receptor signaling pathway GO:0007186
A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576).
|
5 | O08790 (/IDA) P33766 (/IDA) Q71MR7 (/IDA) Q99788 (/IDA) Q9Y5Y4 (/IDA) |
|
Negative regulation of interleukin-12 production GO:0032695
Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-12 production.
|
5 | B1PHQ8 (/ISS) B1PHQ8 (/ISS) B9VR26 (/ISS) O35786 (/ISS) Q99788 (/ISS) |
Showing 1 to 10 of 129 entries
There are 31 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Basolateral plasma membrane GO:0016323
The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.
|
13 |
O70129 (/ISS)
P0C7U5 (/ISS)
P30992 (/ISS)
P30993 (/ISS)
P79175 (/ISS)
P79188 (/ISS)
P79234 (/ISS)
P79240 (/ISS)
P79240 (/ISS)
P97520 (/ISS)
(3 more) |
|
Apical part of cell GO:0045177
The region of a polarized cell that forms a tip or is distal to a base. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue.
|
13 |
O70129 (/ISS)
P0C7U5 (/ISS)
P30992 (/ISS)
P30993 (/ISS)
P79175 (/ISS)
P79188 (/ISS)
P79234 (/ISS)
P79240 (/ISS)
P79240 (/ISS)
P97520 (/ISS)
(3 more) |
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
8 | P21462 (/TAS) P21730 (/TAS) P25089 (/TAS) P25089 (/TAS) P25090 (/TAS) P25090 (/TAS) Q99788 (/TAS) Q9Y5Y4 (/TAS) |
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
7 | D4A7Q2 (/IDA) F1M670 (/IDA) P25090 (/IDA) P25090 (/IDA) P46091 (/IDA) P97520 (/IDA) Q99788 (/IDA) |
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
7 | B1PHQ8 (/ISS) B1PHQ8 (/ISS) B9VR26 (/ISS) O35786 (/ISS) P21462 (/ISS) P25090 (/ISS) P25090 (/ISS) |
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
6 | O88536 (/ISO) P30993 (/ISO) P33766 (/ISO) P97468 (/ISO) P97468 (/ISO) Q8K087 (/ISO) |
|
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
|
5 | P21462 (/TAS) P25089 (/TAS) P25089 (/TAS) P25090 (/TAS) P25090 (/TAS) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
4 | D4A7Q2 (/IDA) F1M670 (/IDA) P25090 (/IDA) P25090 (/IDA) |
|
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
|
4 | P21730 (/TAS) P46091 (/TAS) Q99788 (/TAS) Q9Y5Y4 (/TAS) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
3 | P21462 (/ISS) P25090 (/ISS) P25090 (/ISS) |
Showing 1 to 10 of 31 entries
