The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Rhodopsin 7-helix transmembrane proteins
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 27: alpha-1A adrenergic receptor

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 11 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
11 O02824 (/ISS) O77621 (/ISS) P11615 (/ISS) P15823 (/ISS) P18130 (/ISS) P18841 (/ISS) P18841 (/ISS) P43140 (/ISS) P97717 (/ISS) P97718 (/ISS)
(1 more)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
5 P15823 (/IPI) P18841 (/IPI) P18841 (/IPI) P35348 (/IPI) P35368 (/IPI)
Alpha1-adrenergic receptor activity GO:0004937
Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of alpha1-adrenergic receptors; the activity involves transmitting the signal to the Gq alpha subunit of a heterotrimeric G protein.
4 P15823 (/IDA) P43140 (/IDA) P97717 (/IDA) P97718 (/IDA)
Alpha1-adrenergic receptor activity GO:0004937
Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of alpha1-adrenergic receptors; the activity involves transmitting the signal to the Gq alpha subunit of a heterotrimeric G protein.
2 P97717 (/IMP) P97718 (/IMP)
Alpha1-adrenergic receptor activity GO:0004937
Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of alpha1-adrenergic receptors; the activity involves transmitting the signal to the Gq alpha subunit of a heterotrimeric G protein.
2 P97717 (/ISO) P97718 (/ISO)
Alpha1-adrenergic receptor activity GO:0004937
Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of alpha1-adrenergic receptors; the activity involves transmitting the signal to the Gq alpha subunit of a heterotrimeric G protein.
2 P35348 (/TAS) P35368 (/TAS)
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
2 P35348 (/IDA) P35368 (/IDA)
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
2 P97717 (/ISO) P97718 (/ISO)
Alpha1-adrenergic receptor activity GO:0004937
Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of alpha1-adrenergic receptors; the activity involves transmitting the signal to the Gq alpha subunit of a heterotrimeric G protein.
1 P97717 (/IGI)
Alpha1-adrenergic receptor activity GO:0004937
Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of alpha1-adrenergic receptors; the activity involves transmitting the signal to the Gq alpha subunit of a heterotrimeric G protein.
1 P35348 (/ISS)
Showing 1 to 10 of 11 entries

There are 94 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Positive regulation of MAPK cascade GO:0043410
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the MAPK cascade.
10 O02824 (/ISS) O77621 (/ISS) P11615 (/ISS) P15823 (/ISS) P18130 (/ISS) P18841 (/ISS) P18841 (/ISS) P43140 (/ISS) P97717 (/ISS) Q9WU25 (/ISS)
Positive regulation of heart rate by epinephrine-norepinephrine GO:0001996
The process in which the presence of epinephrine or norepinephrine in the bloodstream activates, maintains or increases the rate of heart contraction.
2 P97717 (/IGI) P97718 (/IGI)
Positive regulation of the force of heart contraction by epinephrine-norepinephrine GO:0001997
Any process that increases the force with which the cardiac muscles of the heart pump blood through the circulatory system as a result of the presence of epinephrine or norepinephrine in the bloodstream or released from the nerve endings.
2 P97717 (/IGI) P97718 (/IGI)
G protein-coupled receptor signaling pathway GO:0007186
A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576).
2 P35348 (/TAS) P35368 (/TAS)
Positive regulation of cytosolic calcium ion concentration GO:0007204
Any process that increases the concentration of calcium ions in the cytosol.
2 P97717 (/ISO) P97718 (/ISO)
Cell-cell signaling GO:0007267
Any process that mediates the transfer of information from one cell to another. This process includes signal transduction in the receiving cell and, where applicable, release of a ligand and any processes that actively facilitate its transport and presentation to the receiving cell. Examples include signaling via soluble ligands, via cell adhesion molecules and via gap junctions.
2 P35348 (/TAS) P35368 (/TAS)
Adult heart development GO:0007512
The process whose specific outcome is the progression of the adult heart over time, from its formation to the mature structure.
2 P97717 (/IGI) P97718 (/IGI)
Response to hormone GO:0009725
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus.
2 P15823 (/IMP) P43140 (/IMP)
Response to hormone GO:0009725
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus.
2 P97717 (/ISO) P97718 (/ISO)
Negative regulation of Rho protein signal transduction GO:0035024
Any process that stops, prevents, or reduces the frequency, rate or extent of Rho protein signal transduction.
2 P15823 (/IMP) P43140 (/IMP)
Showing 1 to 10 of 94 entries

There are 34 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
11 O02824 (/ISS) O77621 (/ISS) P11615 (/ISS) P15823 (/ISS) P18130 (/ISS) P18841 (/ISS) P18841 (/ISS) P43140 (/ISS) P97717 (/ISS) P97718 (/ISS)
(1 more)
Nuclear membrane GO:0031965
Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space.
11 O02824 (/ISS) O77621 (/ISS) P11615 (/ISS) P15823 (/ISS) P18130 (/ISS) P18841 (/ISS) P18841 (/ISS) P43140 (/ISS) P97717 (/ISS) P97718 (/ISS)
(1 more)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
10 O02824 (/ISS) O77621 (/ISS) P11615 (/ISS) P15823 (/ISS) P18130 (/ISS) P18841 (/ISS) P18841 (/ISS) P97717 (/ISS) P97718 (/ISS) Q9WU25 (/ISS)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
9 O02824 (/ISS) O77621 (/ISS) P11615 (/ISS) P18130 (/ISS) P18841 (/ISS) P18841 (/ISS) P97717 (/ISS) P97718 (/ISS) Q9WU25 (/ISS)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
3 P35348 (/IDA) P35368 (/IDA) P43140 (/IDA)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
3 P15823 (/IDA) P43140 (/IDA) P97718 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
2 P35348 (/IDA) P35368 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
2 P97717 (/ISO) P97718 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
2 P35348 (/IDA) P35368 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
2 P97717 (/ISO) P97718 (/ISO)
Showing 1 to 10 of 34 entries
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