The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Rhodopsin 7-helix transmembrane proteins
".
FunFam 217: neurotensin receptor type 1
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 15 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
G protein-coupled neurotensin receptor activity GO:0016492
Combining with the tridecapeptide neurotensin to initiate a G-protein mediated change in cell activity. A G-protein is a signal transduction molecule that alternates between an inactive GDP-bound and an active GTP-bound state.
|
3 | O88319 (/ISS) O88319 (/ISS) P20789 (/ISS) |
|
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
|
3 | O88319 (/ISO) O88319 (/ISO) P70310 (/ISO) |
|
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
|
3 | O88319 (/ISO) O88319 (/ISO) P70310 (/ISO) |
|
G protein-coupled receptor activity GO:0004930
Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
|
2 | O95665 (/TAS) P30989 (/TAS) |
|
Neuropeptide receptor activity GO:0008188
Combining with a neuropeptide to initiate a change in cell activity.
|
2 | O88319 (/TAS) O88319 (/TAS) |
|
G protein-coupled neurotensin receptor activity GO:0016492
Combining with the tridecapeptide neurotensin to initiate a G-protein mediated change in cell activity. A G-protein is a signal transduction molecule that alternates between an inactive GDP-bound and an active GTP-bound state.
|
2 | P30989 (/IDA) P70310 (/IDA) |
|
G protein-coupled neurotensin receptor activity GO:0016492
Combining with the tridecapeptide neurotensin to initiate a G-protein mediated change in cell activity. A G-protein is a signal transduction molecule that alternates between an inactive GDP-bound and an active GTP-bound state.
|
2 | O88319 (/ISO) O88319 (/ISO) |
|
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
|
2 | O88319 (/ISO) O88319 (/ISO) |
|
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
|
2 | P20789 (/IDA) Q63384 (/IDA) |
|
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
|
2 | P20789 (/IPI) Q63384 (/IPI) |
Showing 1 to 10 of 15 entries
There are 58 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
|
3 | O88319 (/ISS) O88319 (/ISS) P20789 (/ISS) |
|
Temperature homeostasis GO:0001659
A homeostatic process in which an organism modulates its internal body temperature.
|
2 | O88319 (/ISO) O88319 (/ISO) |
|
Negative regulation of systemic arterial blood pressure GO:0003085
The process that reduces the force with which blood travels through the systemic arterial circulatory system.
|
2 | O88319 (/ISO) O88319 (/ISO) |
|
Regulation of membrane depolarization GO:0003254
Any process that modulates the rate, frequency or extent of membrane depolarization. Membrane depolarization is the process in which membrane potential changes in the depolarizing direction from the resting potential, usually from negative to positive.
|
2 | O88319 (/ISO) O88319 (/ISO) |
|
G protein-coupled receptor signaling pathway GO:0007186
A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576).
|
2 | O95665 (/TAS) P30989 (/TAS) |
|
Neuropeptide signaling pathway GO:0007218
The series of molecular signals generated as a consequence of a peptide neurotransmitter binding to a cell surface receptor.
|
2 | O88319 (/ISO) O88319 (/ISO) |
|
Learning GO:0007612
Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs as the result of experience.
|
2 | O88319 (/ISO) O88319 (/ISO) |
|
Adult locomotory behavior GO:0008344
Locomotory behavior in a fully developed and mature organism.
|
2 | O88319 (/IGI) O88319 (/IGI) |
|
Positive regulation of glutamate secretion GO:0014049
Any process that activates or increases the frequency, rate or extent of the controlled release of glutamate.
|
2 | O88319 (/ISO) O88319 (/ISO) |
|
Positive regulation of gamma-aminobutyric acid secretion GO:0014054
Any process that activates or increases the frequency, rate or extent of the regulated release of gamma-aminobutyric acid.
|
2 | O88319 (/ISO) O88319 (/ISO) |
Showing 1 to 10 of 58 entries
There are 49 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
3 | O88319 (/ISO) O88319 (/ISO) P70310 (/ISO) |
|
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
|
3 | O88319 (/ISS) O88319 (/ISS) P20789 (/ISS) |
|
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
|
3 | O88319 (/ISO) O88319 (/ISO) P70310 (/ISO) |
|
Dendritic shaft GO:0043198
Cylindric portion of the dendrite, directly stemming from the perikaryon, and carrying the dendritic spines.
|
3 | O88319 (/ISO) O88319 (/ISO) P70310 (/ISO) |
|
Perikaryon GO:0043204
The portion of the cell soma (neuronal cell body) that excludes the nucleus.
|
3 | O88319 (/ISO) O88319 (/ISO) P70310 (/ISO) |
|
Membrane raft GO:0045121
Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions.
|
3 | O88319 (/ISS) O88319 (/ISS) P20789 (/ISS) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
2 | O88319 (/ISO) O88319 (/ISO) |
|
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
|
2 | O88319 (/ISO) O88319 (/ISO) |
|
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
|
2 | O88319 (/ISO) O88319 (/ISO) |
|
Golgi apparatus GO:0005794
A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions.
|
2 | O88319 (/ISO) O88319 (/ISO) |
Showing 1 to 10 of 49 entries
