The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Rhodopsin 7-helix transmembrane proteins
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 2: Olfactory receptor

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 11 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Olfactory receptor activity GO:0004984
Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell.
105 A0A0G2JDQ4 (/ISA) A0A0G2JFH3 (/ISA) A0A1B0GRW7 (/ISA) A0A1B0GSF4 (/ISA) A0A1B0GST0 (/ISA) A0A1B0GSU5 (/ISA) A0A338P761 (/ISA) A0PK48 (/ISA) A0PK59 (/ISA) A0PK70 (/ISA)
(95 more)
Olfactory receptor activity GO:0004984
Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell.
9 Q9H2C8 (/NAS) Q9H339 (/NAS) Q9H340 (/NAS) Q9H341 (/NAS) Q9H343 (/NAS) Q9H343 (/NAS) Q9H344 (/NAS) Q9H344 (/NAS) Q9Y5P0 (/NAS)
Signaling receptor activity GO:0038023
Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response.
3 O88628 (/ISS) Q9H255 (/ISS) Q9H255 (/ISS)
Steroid hormone receptor activity GO:0003707
Combining with a steroid hormone and transmitting the signal within the cell to initiate a change in cell activity or function.
2 Q9H255 (/IDA) Q9H255 (/IDA)
Steroid hormone receptor activity GO:0003707
Combining with a steroid hormone and transmitting the signal within the cell to initiate a change in cell activity or function.
2 O88628 (/ISS) Q8VBV9 (/ISS)
Olfactory receptor activity GO:0004984
Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell.
2 Q9H255 (/IDA) Q9H255 (/IDA)
Olfactory receptor activity GO:0004984
Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell.
2 Q9H255 (/IMP) Q9H255 (/IMP)
Olfactory receptor activity GO:0004984
Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell.
2 O88628 (/ISS) Q8VBV9 (/ISS)
Steroid hormone receptor activity GO:0003707
Combining with a steroid hormone and transmitting the signal within the cell to initiate a change in cell activity or function.
1 Q8VBV9 (/ISO)
Olfactory receptor activity GO:0004984
Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell.
1 Q8VBV9 (/ISO)
Signaling receptor activity GO:0038023
Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response.
1 Q8VBV9 (/IDA)

There are 25 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
G protein-coupled receptor signaling pathway GO:0007186
A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576).
105 A0A0G2JDQ4 (/ISA) A0A0G2JFH3 (/ISA) A0A1B0GRW7 (/ISA) A0A1B0GSF4 (/ISA) A0A1B0GST0 (/ISA) A0A1B0GSU5 (/ISA) A0A338P761 (/ISA) A0PK48 (/ISA) A0PK59 (/ISA) A0PK70 (/ISA)
(95 more)
Sensory perception of smell GO:0007608
The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process.
105 A0A0G2JDQ4 (/ISA) A0A0G2JFH3 (/ISA) A0A1B0GRW7 (/ISA) A0A1B0GSF4 (/ISA) A0A1B0GST0 (/ISA) A0A1B0GSU5 (/ISA) A0A338P761 (/ISA) A0PK48 (/ISA) A0PK59 (/ISA) A0PK70 (/ISA)
(95 more)
Sensory perception of smell GO:0007608
The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process.
9 Q9H2C8 (/NAS) Q9H339 (/NAS) Q9H340 (/NAS) Q9H341 (/NAS) Q9H343 (/NAS) Q9H343 (/NAS) Q9H344 (/NAS) Q9H344 (/NAS) Q9Y5P0 (/NAS)
Positive regulation of blood pressure GO:0045777
Any process in which the force of blood traveling through the circulatory system is increased.
3 O88628 (/ISS) Q9H255 (/ISS) Q9H255 (/ISS)
Cellular response to fatty acid GO:0071398
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fatty acid stimulus.
3 O88628 (/ISS) Q9H255 (/ISS) Q9H255 (/ISS)
Positive regulation of renin secretion into blood stream GO:1900135
Any process that activates or increases the frequency, rate or extent of renin secretion into blood stream.
3 O88628 (/ISS) Q9H255 (/ISS) Q9H255 (/ISS)
Cell migration GO:0016477
The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms.
2 Q9H255 (/IMP) Q9H255 (/IMP)
Cell migration GO:0016477
The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms.
2 O88628 (/ISS) Q8VBV9 (/ISS)
Melanocyte differentiation GO:0030318
The process in which a relatively unspecialized cell acquires specialized features of a melanocyte.
2 Q9H255 (/IMP) Q9H255 (/IMP)
Melanocyte differentiation GO:0030318
The process in which a relatively unspecialized cell acquires specialized features of a melanocyte.
2 O88628 (/ISS) Q8VBV9 (/ISS)
Steroid hormone mediated signaling pathway GO:0043401
A series of molecular signals mediated by a steroid hormone binding to a receptor.
2 Q9H255 (/IDA) Q9H255 (/IDA)
Steroid hormone mediated signaling pathway GO:0043401
A series of molecular signals mediated by a steroid hormone binding to a receptor.
2 O88628 (/ISS) Q8VBV9 (/ISS)
Positive regulation of cAMP-mediated signaling GO:0043950
Any process which activates, maintains or increases the frequency, rate or extent of cAMP-mediated signaling, a series of molecular signals in which a cell uses cyclic AMP to convert an extracellular signal into a response.
2 Q9H255 (/IMP) Q9H255 (/IMP)
Positive regulation of cAMP-mediated signaling GO:0043950
Any process which activates, maintains or increases the frequency, rate or extent of cAMP-mediated signaling, a series of molecular signals in which a cell uses cyclic AMP to convert an extracellular signal into a response.
2 O88628 (/ISS) Q8VBV9 (/ISS)
Melanocyte proliferation GO:0097325
The multiplication or reproduction of melanocytes, resulting in the expansion of a cell population. A melanocyte is a pigment cell derived from the neural crest. It contains melanin-filled pigment granules, which give a brown to black appearance.
2 Q9H255 (/IMP) Q9H255 (/IMP)
Melanocyte proliferation GO:0097325
The multiplication or reproduction of melanocytes, resulting in the expansion of a cell population. A melanocyte is a pigment cell derived from the neural crest. It contains melanin-filled pigment granules, which give a brown to black appearance.
2 O88628 (/ISS) Q8VBV9 (/ISS)
Sensory perception of smell GO:0007608
The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process.
1 Q8VBV9 (/ISS)
Cell migration GO:0016477
The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms.
1 Q8VBV9 (/ISO)
Melanocyte differentiation GO:0030318
The process in which a relatively unspecialized cell acquires specialized features of a melanocyte.
1 Q8VBV9 (/ISO)
Steroid hormone mediated signaling pathway GO:0043401
A series of molecular signals mediated by a steroid hormone binding to a receptor.
1 Q8VBV9 (/ISO)
Positive regulation of cAMP-mediated signaling GO:0043950
Any process which activates, maintains or increases the frequency, rate or extent of cAMP-mediated signaling, a series of molecular signals in which a cell uses cyclic AMP to convert an extracellular signal into a response.
1 Q8VBV9 (/ISO)
Positive regulation of blood pressure GO:0045777
Any process in which the force of blood traveling through the circulatory system is increased.
1 Q8VBV9 (/IMP)
Cellular response to fatty acid GO:0071398
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fatty acid stimulus.
1 Q8VBV9 (/IDA)
Melanocyte proliferation GO:0097325
The multiplication or reproduction of melanocytes, resulting in the expansion of a cell population. A melanocyte is a pigment cell derived from the neural crest. It contains melanin-filled pigment granules, which give a brown to black appearance.
1 Q8VBV9 (/ISO)
Positive regulation of renin secretion into blood stream GO:1900135
Any process that activates or increases the frequency, rate or extent of renin secretion into blood stream.
1 Q8VBV9 (/IMP)

There are 12 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
105 A0A0G2JDQ4 (/ISA) A0A0G2JFH3 (/ISA) A0A1B0GRW7 (/ISA) A0A1B0GSF4 (/ISA) A0A1B0GST0 (/ISA) A0A1B0GSU5 (/ISA) A0A338P761 (/ISA) A0PK48 (/ISA) A0PK59 (/ISA) A0PK70 (/ISA)
(95 more)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
46 A6NGY5 (/TAS) P0C7T3 (/TAS) P0C7T3 (/TAS) Q6IF63 (/TAS) Q8NGF3 (/TAS) Q8NGF3 (/TAS) Q8NGH5 (/TAS) Q8NGH5 (/TAS) Q8NGH8 (/TAS) Q8NGH8 (/TAS)
(36 more)
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
9 Q9H2C8 (/NAS) Q9H339 (/NAS) Q9H340 (/NAS) Q9H341 (/NAS) Q9H343 (/NAS) Q9H343 (/NAS) Q9H344 (/NAS) Q9H344 (/NAS) Q9Y5P0 (/NAS)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
3 Q8VBV9 (/IDA) Q9H255 (/IDA) Q9H255 (/IDA)
Early endosome membrane GO:0031901
The lipid bilayer surrounding an early endosome.
2 Q9H255 (/IDA) Q9H255 (/IDA)
Early endosome membrane GO:0031901
The lipid bilayer surrounding an early endosome.
2 O88628 (/ISS) Q8VBV9 (/ISS)
Intracellular organelle GO:0043229
Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.
2 Q9H255 (/IDA) Q9H255 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 Q8VBV9 (/ISO)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 O88628 (/ISS)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 Q8VBV9 (/ISS)
Early endosome membrane GO:0031901
The lipid bilayer surrounding an early endosome.
1 Q8VBV9 (/ISO)
Intracellular organelle GO:0043229
Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.
1 Q8VBV9 (/ISO)
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