The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Rhodopsin 7-helix transmembrane proteins
".
FunFam 186: thyrotropin-releasing hormone receptor
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 6 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Thyrotropin-releasing hormone receptor activity GO:0004997
Combining with thyrotropin-releasing hormone to initiate a change in cell activity.
|
3 | P21761 (/ISO) P21761 (/ISO) Q9ERT2 (/ISO) |
|
Thyrotropin-releasing hormone receptor activity GO:0004997
Combining with thyrotropin-releasing hormone to initiate a change in cell activity.
|
2 | Q01717 (/IDA) Q9R297 (/IDA) |
|
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
|
2 | P21761 (/ISO) P21761 (/ISO) |
|
Thyrotropin-releasing hormone receptor activity GO:0004997
Combining with thyrotropin-releasing hormone to initiate a change in cell activity.
|
1 | P34981 (/TAS) |
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
1 | Q9ERT2 (/IPI) |
|
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
|
1 | Q01717 (/IDA) |
There are 6 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Positive regulation of cytosolic calcium ion concentration GO:0007204
Any process that increases the concentration of calcium ions in the cytosol.
|
2 | P21761 (/ISO) P21761 (/ISO) |
|
Positive regulation of protein homodimerization activity GO:0090073
Any process that increases the frequency, rate or extent of protein homodimerization, interacting selectively with an identical protein to form a homodimer.
|
2 | P21761 (/ISO) P21761 (/ISO) |
|
G protein-coupled receptor signaling pathway GO:0007186
A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576).
|
1 | P34981 (/TAS) |
|
Phospholipase C-activating G protein-coupled receptor signaling pathway GO:0007200
The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, where the pathway proceeds with activation of phospholipase C (PLC) and a subsequent increase in the concentration of inositol trisphosphate (IP3) and diacylglycerol (DAG).
|
1 | Q9ERT2 (/IDA) |
|
Positive regulation of cytosolic calcium ion concentration GO:0007204
Any process that increases the concentration of calcium ions in the cytosol.
|
1 | Q01717 (/IDA) |
|
Positive regulation of protein homodimerization activity GO:0090073
Any process that increases the frequency, rate or extent of protein homodimerization, interacting selectively with an identical protein to form a homodimer.
|
1 | Q01717 (/IDA) |
There are 7 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
|
2 | P21761 (/ISO) P21761 (/ISO) |
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
1 | P34981 (/TAS) |
|
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
|
1 | Q9ERT2 (/ISA) |
|
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
|
1 | P34981 (/TAS) |
|
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
|
1 | Q01717 (/IDA) |
|
Neuronal cell body GO:0043025
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
|
1 | Q9R297 (/IDA) |
|
Neuronal cell body GO:0043025
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
|
1 | Q9ERT2 (/ISO) |
