The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Rhodopsin 7-helix transmembrane proteins
".
FunFam 121: Histamine H2 receptor
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 5 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Histamine receptor activity GO:0004969
Combining with histamine to initiate a change in cell activity. Histamine is a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans.
|
6 | P25021 (/TAS) P25021 (/TAS) P25021 (/TAS) P25021 (/TAS) P25021 (/TAS) P25021 (/TAS) |
Histamine receptor activity GO:0004969
Combining with histamine to initiate a change in cell activity. Histamine is a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans.
|
3 | A0A2R8Q9U8 (/IDA) P25102 (/IDA) Q195J0 (/IDA) |
Histamine receptor activity GO:0004969
Combining with histamine to initiate a change in cell activity. Histamine is a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans.
|
1 | P97292 (/ISO) |
Heterocyclic compound binding GO:1901363
Interacting selectively and non-covalently with heterocyclic compound.
|
1 | P25102 (/IDA) |
Heterocyclic compound binding GO:1901363
Interacting selectively and non-covalently with heterocyclic compound.
|
1 | P97292 (/ISO) |
There are 16 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Immune response GO:0006955
Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat.
|
6 | P25021 (/TAS) P25021 (/TAS) P25021 (/TAS) P25021 (/TAS) P25021 (/TAS) P25021 (/TAS) |
G protein-coupled receptor signaling pathway GO:0007186
A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576).
|
6 | P25021 (/TAS) P25021 (/TAS) P25021 (/TAS) P25021 (/TAS) P25021 (/TAS) P25021 (/TAS) |
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger GO:0007187
The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, where the pathway proceeds with activation or inhibition of a nucleotide cyclase activity and a subsequent change in the concentration of a cyclic nucleotide.
|
6 | P25021 (/TAS) P25021 (/TAS) P25021 (/TAS) P25021 (/TAS) P25021 (/TAS) P25021 (/TAS) |
Gastric acid secretion GO:0001696
The regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion.
|
1 | P97292 (/IGI) |
Histamine-induced gastric acid secretion GO:0001697
The regulated release of gastric acid induced by the interaction of histamine with H2 type receptor receptors with subsequent activation of adenylate cyclase and elevation of intracellular cyclic AMP.
|
1 | P97292 (/IMP) |
Gastrin-induced gastric acid secretion GO:0001698
The regulated release of gastric acid induced by the interaction of gastrin with its receptor.
|
1 | P97292 (/IMP) |
Epithelial cell morphogenesis GO:0003382
The change in form that occurs when an epithelial cell progresses from its initial formation to its mature state.
|
1 | P97292 (/IMP) |
Memory GO:0007613
The activities involved in the mental information processing system that receives (registers), modifies, stores, and retrieves informational stimuli. The main stages involved in the formation and retrieval of memory are encoding (processing of received information by acquisition), storage (building a permanent record of received information as a result of consolidation) and retrieval (calling back the stored information and use it in a suitable way to execute a given task).
|
1 | P97292 (/IMP) |
Visual learning GO:0008542
Any process in an organism in which a change in behavior of an individual occurs in response to repeated exposure to a visual cue.
|
1 | P97292 (/IMP) |
Regulation of synaptic plasticity GO:0048167
A process that modulates synaptic plasticity, the ability of synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers.
|
1 | P97292 (/IMP) |
Digestive tract development GO:0048565
The process whose specific outcome is the progression of the digestive tract over time, from its formation to the mature structure. The digestive tract is the anatomical structure through which food passes and is processed.
|
1 | P97292 (/IMP) |
Gland development GO:0048732
The process whose specific outcome is the progression of a gland over time, from its formation to the mature structure. A gland is an organ specialised for secretion.
|
1 | P97292 (/IMP) |
Cellular response to histamine GO:0071420
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a histamine stimulus. Histamine, the biogenic amine 2-(1H-imidazol-4-yl)ethanamine, is involved in local immune responses as well as regulating physiological function in the gut and acting as a neurotransmitter.
|
1 | P25102 (/IEP) |
Negative regulation of arachidonic acid secretion GO:1900139
Any process that stops, prevents or reduces the frequency, rate or extent of arachidonic acid secretion.
|
1 | P25102 (/IDA) |
Negative regulation of arachidonic acid secretion GO:1900139
Any process that stops, prevents or reduces the frequency, rate or extent of arachidonic acid secretion.
|
1 | P97292 (/ISO) |
Toxin transport GO:1901998
The directed movement of a toxin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
|
1 | P97292 (/IMP) |
There are 4 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
6 | P25021 (/TAS) P25021 (/TAS) P25021 (/TAS) P25021 (/TAS) P25021 (/TAS) P25021 (/TAS) |
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
|
6 | P25021 (/TAS) P25021 (/TAS) P25021 (/TAS) P25021 (/TAS) P25021 (/TAS) P25021 (/TAS) |
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
|
1 | P25102 (/IDA) |
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
|
1 | P97292 (/ISO) |