CATH Superfamily 1.10.840.10
Ras guanine-nucleotide exchange factors catalytic domain
The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Ras guanine-nucleotide exchange factors catalytic domain
".
FunFam 43: Uncharacterized protein
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 6 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
G-protein alpha-subunit binding GO:0001965
Interacting selectively and non-covalently with a G-protein alpha subunit. The alpha subunit binds a guanine nucleotide.
|
1 | Q54L90 (/IPI) |
|
Ras GTPase binding GO:0017016
Interacting selectively and non-covalently with any member of the Ras superfamily of monomeric GTPases.
|
1 | Q54L90 (/IPI) |
|
Rap guanyl-nucleotide exchange factor activity GO:0017034
Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rap family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.
|
1 | Q54L90 (/IDA) |
|
Rho GTPase binding GO:0017048
Interacting selectively and non-covalently with Rho protein, any member of the Rho subfamily of the Ras superfamily of monomeric GTPases. Proteins in the Rho subfamily are involved in relaying signals from cell-surface receptors to the actin cytoskeleton.
|
1 | Q54L90 (/IPI) |
|
Small GTPase binding GO:0031267
Interacting selectively and non-covalently with a small monomeric GTPase.
|
1 | Q54L90 (/IPI) |
|
Actin filament binding GO:0051015
Interacting selectively and non-covalently with an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits.
|
1 | Q54L90 (/IDA) |
There are 8 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Negative regulation of actin filament polymerization GO:0030837
Any process that stops, prevents, or reduces the frequency, rate or extent of actin polymerization.
|
1 | Q54L90 (/IMP) |
|
Rap protein signal transduction GO:0032486
A series of molecular signals within the cell that are mediated by a member of the Rap family of proteins switching to a GTP-bound active state.
|
1 | Q54L90 (/IDA) |
|
Negative regulation of Ras protein signal transduction GO:0046580
Any process that stops, prevents, or reduces the frequency, rate or extent of Ras protein signal transduction.
|
1 | Q54L90 (/IMP) |
|
Cytoskeletal rearrangement involved in phagocytosis, engulfment GO:0060097
The assembly, arrangement, or disassembly of cytoskeletal structures that is involved in the internalization of bacteria, immune complexes and other particulate matter or of an apoptotic cell by phagocytosis.
|
1 | Q54L90 (/IMP) |
|
Regulation of positive chemotaxis to cAMP GO:0061118
Any process that modulates the rate, frequency, or extent of directed movement of a motile cell or organism up a concentration gradient of 3',5'-cAMP.
|
1 | Q54L90 (/IMP) |
|
Negative regulation of protein serine/threonine kinase activity GO:0071901
Any process that decreases the rate, frequency, or extent of protein serine/threonine kinase activity.
|
1 | Q54L90 (/IMP) |
|
Activation of GTPase activity GO:0090630
Any process that initiates the activity of an inactive GTPase through the replacement of GDP by GTP.
|
1 | Q54L90 (/IMP) |
|
Positive regulation of myosin II filament assembly GO:1905511
Any process that activates or increases the frequency, rate or extent of myosin II filament assembly.
|
1 | Q54L90 (/IMP) |
There are 5 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
1 | Q54L90 (/IDA) |
|
Cell cortex GO:0005938
The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins.
|
1 | Q54L90 (/IDA) |
|
Cell leading edge GO:0031252
The area of a motile cell closest to the direction of movement.
|
1 | Q54L90 (/IDA) |
|
Macropinocytic cup cytoskeleton GO:0070687
The part of the cortical actin cytoskeleton that forms part of a macropinocytic cup.
|
1 | Q54L90 (/IDA) |
|
Cell leading edge cell cortex GO:1904269
The cell cortex of the leading edge of a cell.
|
1 | Q54L90 (/IDA) |