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CATH Superfamily 1.10.730.10

Isoleucyl-tRNA Synthetase; Domain 1

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Isoleucyl-tRNA Synthetase; Domain 1
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 7: Valine--tRNA ligase

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 5 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Magnesium ion binding GO:0000287
Interacting selectively and non-covalently with magnesium (Mg) ions.
 40 P07118 (/IDA) P07118 (/IDA) P07118 (/IDA) P07118 (/IDA) P07118 (/IDA) P07118 (/IDA) P07118 (/IDA) P07118 (/IDA) P07118 (/IDA) P07118 (/IDA)
(30 more)
Aminoacyl-tRNA editing activity GO:0002161
The hydrolysis of an incorrectly aminoacylated tRNA.
 40 P07118 (/IDA) P07118 (/IDA) P07118 (/IDA) P07118 (/IDA) P07118 (/IDA) P07118 (/IDA) P07118 (/IDA) P07118 (/IDA) P07118 (/IDA) P07118 (/IDA)
(30 more)
Valine-tRNA ligase activity GO:0004832
Catalysis of the reaction: L-valine + ATP + tRNA(Val) = L-valyl-tRNA(Val) + AMP + diphosphate + 2 H(+).
 40 P07118 (/IDA) P07118 (/IDA) P07118 (/IDA) P07118 (/IDA) P07118 (/IDA) P07118 (/IDA) P07118 (/IDA) P07118 (/IDA) P07118 (/IDA) P07118 (/IDA)
(30 more)
Valine-tRNA ligase activity GO:0004832
Catalysis of the reaction: L-valine + ATP + tRNA(Val) = L-valyl-tRNA(Val) + AMP + diphosphate + 2 H(+).
 40 P07118 (/IMP) P07118 (/IMP) P07118 (/IMP) P07118 (/IMP) P07118 (/IMP) P07118 (/IMP) P07118 (/IMP) P07118 (/IMP) P07118 (/IMP) P07118 (/IMP)
(30 more)
Valine-tRNA ligase activity GO:0004832
Catalysis of the reaction: L-valine + ATP + tRNA(Val) = L-valyl-tRNA(Val) + AMP + diphosphate + 2 H(+).
 6 Q9KP73 (/ISS) Q9KP73 (/ISS) Q9KP73 (/ISS) Q9KP73 (/ISS) Q9KP73 (/ISS) Q9KP73 (/ISS)

There are 4 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Valyl-tRNA aminoacylation GO:0006438
The process of coupling valine to valyl-tRNA, catalyzed by valyl-tRNA synthetase. The valyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a valine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.
 40 P07118 (/IMP) P07118 (/IMP) P07118 (/IMP) P07118 (/IMP) P07118 (/IMP) P07118 (/IMP) P07118 (/IMP) P07118 (/IMP) P07118 (/IMP) P07118 (/IMP)
(30 more)
Positive regulation of translational fidelity GO:0045903
Any process that increases the ability of the translational apparatus to interpret the genetic code.
 40 P07118 (/IMP) P07118 (/IMP) P07118 (/IMP) P07118 (/IMP) P07118 (/IMP) P07118 (/IMP) P07118 (/IMP) P07118 (/IMP) P07118 (/IMP) P07118 (/IMP)
(30 more)
Cytosolic valyl-tRNA aminoacylation GO:0061475
The process of coupling valine to valyl-tRNA in the cytosol, catalyzed by valyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA.
 40 P07118 (/IMP) P07118 (/IMP) P07118 (/IMP) P07118 (/IMP) P07118 (/IMP) P07118 (/IMP) P07118 (/IMP) P07118 (/IMP) P07118 (/IMP) P07118 (/IMP)
(30 more)
Valyl-tRNA aminoacylation GO:0006438
The process of coupling valine to valyl-tRNA, catalyzed by valyl-tRNA synthetase. The valyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a valine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.
 6 Q9KP73 (/ISS) Q9KP73 (/ISS) Q9KP73 (/ISS) Q9KP73 (/ISS) Q9KP73 (/ISS) Q9KP73 (/ISS)

There are 1 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
 40 P07118 (/IDA) P07118 (/IDA) P07118 (/IDA) P07118 (/IDA) P07118 (/IDA) P07118 (/IDA) P07118 (/IDA) P07118 (/IDA) P07118 (/IDA) P07118 (/IDA)
(30 more)