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CATH Superfamily 1.10.730.10

Isoleucyl-tRNA Synthetase; Domain 1

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Isoleucyl-tRNA Synthetase; Domain 1
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 5: Methionine--tRNA ligase

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 4 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Methionine-tRNA ligase activity GO:0004825
Catalysis of the reaction: ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met).
 11 P00959 (/IDA) P00959 (/IDA) P00959 (/IDA) P00959 (/IDA) P00959 (/IDA) P00959 (/IDA) P00959 (/IDA) P00959 (/IDA) P00959 (/IDA) P00959 (/IDA)
(1 more)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
 11 P00959 (/IPI) P00959 (/IPI) P00959 (/IPI) P00959 (/IPI) P00959 (/IPI) P00959 (/IPI) P00959 (/IPI) P00959 (/IPI) P00959 (/IPI) P00959 (/IPI)
(1 more)
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
 11 P00959 (/IDA) P00959 (/IDA) P00959 (/IDA) P00959 (/IDA) P00959 (/IDA) P00959 (/IDA) P00959 (/IDA) P00959 (/IDA) P00959 (/IDA) P00959 (/IDA)
(1 more)
Methionine-tRNA ligase activity GO:0004825
Catalysis of the reaction: ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met).
 5 Q9KT69 (/ISS) Q9KT69 (/ISS) Q9KT69 (/ISS) Q9KT69 (/ISS) Q9KT69 (/ISS)

There are 2 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Methionyl-tRNA aminoacylation GO:0006431
The process of coupling methionine to methionyl-tRNA, catalyzed by methionyl-tRNA synthetase. The methionyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a methionine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.
 11 P00959 (/IMP) P00959 (/IMP) P00959 (/IMP) P00959 (/IMP) P00959 (/IMP) P00959 (/IMP) P00959 (/IMP) P00959 (/IMP) P00959 (/IMP) P00959 (/IMP)
(1 more)
Methionyl-tRNA aminoacylation GO:0006431
The process of coupling methionine to methionyl-tRNA, catalyzed by methionyl-tRNA synthetase. The methionyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a methionine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.
 5 Q9KT69 (/ISS) Q9KT69 (/ISS) Q9KT69 (/ISS) Q9KT69 (/ISS) Q9KT69 (/ISS)

There are 2 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
 11 P00959 (/HDA) P00959 (/HDA) P00959 (/HDA) P00959 (/HDA) P00959 (/HDA) P00959 (/HDA) P00959 (/HDA) P00959 (/HDA) P00959 (/HDA) P00959 (/HDA)
(1 more)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
 11 P00959 (/HDA) P00959 (/HDA) P00959 (/HDA) P00959 (/HDA) P00959 (/HDA) P00959 (/HDA) P00959 (/HDA) P00959 (/HDA) P00959 (/HDA) P00959 (/HDA)
(1 more)