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CATH Superfamily 1.10.510.40

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 1: Aerobactin siderophore biosynthesis protein iucC

There are 1 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Aerobactin synthase. [EC: 6.3.2.39]
ATP + N(2)-citryl-N(6)-acetyl-N(6)-hydroxy-L-lysine + N(6)-acetyl-N(6)- hydroxy-L-lysine = AMP + diphosphate + aerobactin.
  • Requires Mg(2+).
  • The enzyme is involved in the biosynthesis of aerobactin, a dihydroxamate siderophore.
  • It belongs to a class of siderophore synthases known as type C nonribosomal peptide synthase-independent synthases (NIS).
  • Type C enzymes are responsible for the formation of amide or ester bonds between a variety of substrates and a prochiral carboxyl group of a citrate molecule that is already linked to a different moiety at its other prochiral carboxyl group.
  • The enzyme is believed to form an adenylate intermediate prior to ligation.
 1 Q47318