The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Transferase(Phosphotransferase) domain 1
".
FunFam 65: Non-specific serine/threonine protein kinase
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 21 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Protein serine/threonine kinase activity GO:0004674
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
|
7 | O00141 (/TAS) O00141 (/TAS) O00141 (/TAS) O00141 (/TAS) O00141 (/TAS) Q06226 (/TAS) Q9HBY8 (/TAS) |
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
6 | O00141 (/IPI) O00141 (/IPI) O00141 (/IPI) O00141 (/IPI) O00141 (/IPI) Q9WVC6 (/IPI) |
|
Sodium channel regulator activity GO:0017080
Modulates the activity of a sodium channel.
|
6 | O00141 (/TAS) O00141 (/TAS) O00141 (/TAS) O00141 (/TAS) O00141 (/TAS) Q9HBY8 (/TAS) |
|
Protein serine/threonine/tyrosine kinase activity GO:0004712
Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; ATP + a protein threonine = ADP + protein threonine phosphate; and ATP + a protein tyrosine = ADP + protein tyrosine phosphate.
|
5 | O00141 (/IDA) O00141 (/IDA) O00141 (/IDA) O00141 (/IDA) O00141 (/IDA) |
|
Calcium channel regulator activity GO:0005246
Modulates the activity of a calcium channel.
|
5 | O00141 (/TAS) O00141 (/TAS) O00141 (/TAS) O00141 (/TAS) O00141 (/TAS) |
|
Potassium channel regulator activity GO:0015459
Modulates potassium channel activity via direct interaction interaction with a potassium channel (binding or modification).
|
5 | O00141 (/TAS) O00141 (/TAS) O00141 (/TAS) O00141 (/TAS) O00141 (/TAS) |
|
Chloride channel regulator activity GO:0017081
Modulates the activity of a chloride channel.
|
5 | O00141 (/TAS) O00141 (/TAS) O00141 (/TAS) O00141 (/TAS) O00141 (/TAS) |
|
Potassium channel regulator activity GO:0015459
Modulates potassium channel activity via direct interaction interaction with a potassium channel (binding or modification).
|
2 | Q8R4U9 (/ISS) Q9QZS5 (/ISS) |
|
Protein kinase activity GO:0004672
Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
|
1 | Q9WVC6 (/IDA) |
|
Protein serine/threonine kinase activity GO:0004674
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
|
1 | Q06226 (/IDA) |
|
Protein serine/threonine kinase activity GO:0004674
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
|
1 | Q9WVC6 (/ISO) |
|
Protein serine/threonine/tyrosine kinase activity GO:0004712
Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; ATP + a protein threonine = ADP + protein threonine phosphate; and ATP + a protein tyrosine = ADP + protein tyrosine phosphate.
|
1 | Q9WVC6 (/ISO) |
|
Potassium channel regulator activity GO:0015459
Modulates potassium channel activity via direct interaction interaction with a potassium channel (binding or modification).
|
1 | Q9HBY8 (/IDA) |
|
Potassium channel regulator activity GO:0015459
Modulates potassium channel activity via direct interaction interaction with a potassium channel (binding or modification).
|
1 | Q9QZS5 (/ISO) |
|
Sodium channel regulator activity GO:0017080
Modulates the activity of a sodium channel.
|
1 | Q9HBY8 (/NAS) |
|
3-phosphoinositide-dependent protein kinase binding GO:0043423
Interacting selectively and non-covalently with a 3-phosphoinositide-dependent protein kinase.
|
1 | Q06226 (/IPI) |
|
3-phosphoinositide-dependent protein kinase binding GO:0043423
Interacting selectively and non-covalently with a 3-phosphoinositide-dependent protein kinase.
|
1 | Q9WVC6 (/ISO) |
|
Cofactor binding GO:0048037
Interacting selectively and non-covalently with a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate.
|
1 | Q06226 (/IPI) |
|
Cofactor binding GO:0048037
Interacting selectively and non-covalently with a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate.
|
1 | Q9WVC6 (/ISO) |
|
Tau protein binding GO:0048156
Interacting selectively and non-covalently with tau protein. tau is a microtubule-associated protein, implicated in Alzheimer's disease, Down Syndrome and ALS.
|
1 | Q06226 (/IPI) |
|
Tau protein binding GO:0048156
Interacting selectively and non-covalently with tau protein. tau is a microtubule-associated protein, implicated in Alzheimer's disease, Down Syndrome and ALS.
|
1 | Q9WVC6 (/ISO) |
There are 50 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
|
7 | O00141 (/TAS) O00141 (/TAS) O00141 (/TAS) O00141 (/TAS) O00141 (/TAS) Q06226 (/TAS) Q9HBY8 (/TAS) |
|
Regulation of cell growth GO:0001558
Any process that modulates the frequency, rate, extent or direction of cell growth.
|
6 | O00141 (/TAS) O00141 (/TAS) O00141 (/TAS) O00141 (/TAS) O00141 (/TAS) Q9HBY8 (/TAS) |
|
Positive regulation of transporter activity GO:0032411
Any process that activates or increases the activity of a transporter.
|
6 | O00141 (/TAS) O00141 (/TAS) O00141 (/TAS) O00141 (/TAS) O00141 (/TAS) Q9HBY8 (/TAS) |
|
Ion transmembrane transport GO:0034220
A process in which an ion is transported across a membrane.
|
6 | O00141 (/TAS) O00141 (/TAS) O00141 (/TAS) O00141 (/TAS) O00141 (/TAS) Q9HBY8 (/TAS) |
|
Regulation of cell population proliferation GO:0042127
Any process that modulates the frequency, rate or extent of cell proliferation.
|
6 | O00141 (/TAS) O00141 (/TAS) O00141 (/TAS) O00141 (/TAS) O00141 (/TAS) Q9HBY8 (/TAS) |
|
Sodium ion transport GO:0006814
The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
|
5 | O00141 (/TAS) O00141 (/TAS) O00141 (/TAS) O00141 (/TAS) O00141 (/TAS) |
|
Long-term memory GO:0007616
The memory process that deals with the storage, retrieval and modification of information a long time (typically weeks, months or years) after receiving that information. This type of memory is typically dependent on gene transcription regulated by second messenger activation.
|
5 | O00141 (/TAS) O00141 (/TAS) O00141 (/TAS) O00141 (/TAS) O00141 (/TAS) |
|
Regulation of blood pressure GO:0008217
Any process that modulates the force with which blood travels through the circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure.
|
5 | O00141 (/TAS) O00141 (/TAS) O00141 (/TAS) O00141 (/TAS) O00141 (/TAS) |
|
Regulation of cell migration GO:0030334
Any process that modulates the frequency, rate or extent of cell migration.
|
5 | O00141 (/TAS) O00141 (/TAS) O00141 (/TAS) O00141 (/TAS) O00141 (/TAS) |
|
Regulation of apoptotic process GO:0042981
Any process that modulates the occurrence or rate of cell death by apoptotic process.
|
5 | O00141 (/TAS) O00141 (/TAS) O00141 (/TAS) O00141 (/TAS) O00141 (/TAS) |
|
Regulation of catalytic activity GO:0050790
Any process that modulates the activity of an enzyme.
|
5 | O00141 (/TAS) O00141 (/TAS) O00141 (/TAS) O00141 (/TAS) O00141 (/TAS) |
|
Regulation of DNA-binding transcription factor activity GO:0051090
Any process that modulates the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription.
|
5 | O00141 (/TAS) O00141 (/TAS) O00141 (/TAS) O00141 (/TAS) O00141 (/TAS) |
|
Regulation of gastric acid secretion GO:0060453
Any process that modulates the rate frequency or extent of gastric secretion. Gastric secretion is the regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion.
|
5 | O00141 (/TAS) O00141 (/TAS) O00141 (/TAS) O00141 (/TAS) O00141 (/TAS) |
|
Renal sodium ion absorption GO:0070294
A renal system process in which sodium ions are taken up from the collecting ducts and proximal and distal loops of the nephron. In non-mammalian species, absorption may occur in related structures.
|
5 | O00141 (/TAS) O00141 (/TAS) O00141 (/TAS) O00141 (/TAS) O00141 (/TAS) |
|
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
|
1 | Q9WVC6 (/IDA) |
|
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
|
1 | Q9HBY8 (/NAS) |
|
Cellular sodium ion homeostasis GO:0006883
Any process involved in the maintenance of an internal steady state of sodium ions at the level of a cell.
|
1 | Q06226 (/IDA) |
|
Cellular sodium ion homeostasis GO:0006883
Any process involved in the maintenance of an internal steady state of sodium ions at the level of a cell.
|
1 | Q9WVC6 (/ISO) |
|
Inflammatory response GO:0006954
The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.
|
1 | Q7ZTW4 (/IMP) |
|
Cellular response to DNA damage stimulus GO:0006974
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.
|
1 | Q9WVC6 (/IDA) |
|
Response to oxidative stress GO:0006979
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
|
1 | Q9HBY8 (/TAS) |
|
Microtubule depolymerization GO:0007019
The removal of tubulin heterodimers from one or both ends of a microtubule.
|
1 | Q06226 (/IDA) |
|
Microtubule depolymerization GO:0007019
The removal of tubulin heterodimers from one or both ends of a microtubule.
|
1 | Q9WVC6 (/ISO) |
|
Long-term memory GO:0007616
The memory process that deals with the storage, retrieval and modification of information a long time (typically weeks, months or years) after receiving that information. This type of memory is typically dependent on gene transcription regulated by second messenger activation.
|
1 | Q06226 (/IMP) |
|
Long-term memory GO:0007616
The memory process that deals with the storage, retrieval and modification of information a long time (typically weeks, months or years) after receiving that information. This type of memory is typically dependent on gene transcription regulated by second messenger activation.
|
1 | Q9WVC6 (/ISO) |
|
Visual learning GO:0008542
Any process in an organism in which a change in behavior of an individual occurs in response to repeated exposure to a visual cue.
|
1 | Q06226 (/IMP) |
|
Visual learning GO:0008542
Any process in an organism in which a change in behavior of an individual occurs in response to repeated exposure to a visual cue.
|
1 | Q9WVC6 (/ISO) |
|
Positive regulation of sodium ion transport GO:0010765
Any process that increases the frequency, rate or extent of the directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
|
1 | Q06226 (/IMP) |
|
Positive regulation of sodium ion transport GO:0010765
Any process that increases the frequency, rate or extent of the directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
|
1 | Q9WVC6 (/ISO) |
|
Peptidyl-serine phosphorylation GO:0018105
The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine.
|
1 | Q06226 (/IDA) |
|
Peptidyl-serine phosphorylation GO:0018105
The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine.
|
1 | Q9WVC6 (/ISO) |
|
Positive regulation of cell growth GO:0030307
Any process that activates or increases the frequency, rate, extent or direction of cell growth.
|
1 | Q06226 (/IDA) |
|
Positive regulation of cell growth GO:0030307
Any process that activates or increases the frequency, rate, extent or direction of cell growth.
|
1 | Q9WVC6 (/ISO) |
|
Negative regulation of microtubule polymerization GO:0031115
Any process that stops, prevents, or reduces the frequency, rate or extent of microtubule polymerization.
|
1 | Q06226 (/IDA) |
|
Negative regulation of microtubule polymerization GO:0031115
Any process that stops, prevents, or reduces the frequency, rate or extent of microtubule polymerization.
|
1 | Q9WVC6 (/ISO) |
|
Cellular response to insulin stimulus GO:0032869
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms.
|
1 | Q06226 (/IMP) |
|
Cellular response to insulin stimulus GO:0032869
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms.
|
1 | Q9WVC6 (/ISO) |
|
Regulation of protein localization GO:0032880
Any process that modulates the frequency, rate or extent of any process in which a protein is transported to, or maintained in, a specific location.
|
1 | Q06226 (/IMP) |
|
Regulation of protein localization GO:0032880
Any process that modulates the frequency, rate or extent of any process in which a protein is transported to, or maintained in, a specific location.
|
1 | Q9WVC6 (/ISO) |
|
Intracellular signal transduction GO:0035556
The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
|
1 | Q9HBY8 (/TAS) |
|
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
|
1 | Q06226 (/IMP) |
|
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
|
1 | Q9WVC6 (/ISO) |
|
Glucocorticoid mediated signaling pathway GO:0043402
A series of molecular signals mediated by the detection of a glucocorticoid hormone.
|
1 | Q06226 (/IMP) |
|
Glucocorticoid mediated signaling pathway GO:0043402
A series of molecular signals mediated by the detection of a glucocorticoid hormone.
|
1 | Q9WVC6 (/ISO) |
|
Neuron projection morphogenesis GO:0048812
The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites.
|
1 | Q06226 (/IDA) |
|
Neuron projection morphogenesis GO:0048812
The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites.
|
1 | Q9WVC6 (/ISO) |
|
Positive regulation of dendrite morphogenesis GO:0050775
Any process that activates or increases the frequency, rate or extent of dendrite morphogenesis.
|
1 | Q06226 (/IMP) |
|
Positive regulation of dendrite morphogenesis GO:0050775
Any process that activates or increases the frequency, rate or extent of dendrite morphogenesis.
|
1 | Q9WVC6 (/ISO) |
|
Regulation of cell cycle GO:0051726
Any process that modulates the rate or extent of progression through the cell cycle.
|
1 | Q06226 (/IMP) |
|
Regulation of cell cycle GO:0051726
Any process that modulates the rate or extent of progression through the cell cycle.
|
1 | Q9WVC6 (/ISO) |
There are 15 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
10 | E9PR89 (/IDA) E9PR89 (/IDA) E9PR89 (/IDA) E9PR89 (/IDA) E9PR89 (/IDA) O00141 (/IDA) O00141 (/IDA) O00141 (/IDA) O00141 (/IDA) O00141 (/IDA) |
|
Nuclear speck GO:0016607
A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy.
|
10 | E9PR89 (/IDA) E9PR89 (/IDA) E9PR89 (/IDA) E9PR89 (/IDA) E9PR89 (/IDA) O00141 (/IDA) O00141 (/IDA) O00141 (/IDA) O00141 (/IDA) O00141 (/IDA) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
7 | O00141 (/TAS) O00141 (/TAS) O00141 (/TAS) O00141 (/TAS) O00141 (/TAS) Q9HBY8 (/TAS) Q9WVC6 (/TAS) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
1 | Q06226 (/IDA) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
1 | Q9WVC6 (/ISO) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
1 | Q9HBY8 (/IDA) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
1 | Q9QZS5 (/ISO) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
1 | Q06226 (/IDA) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
1 | Q9WVC6 (/ISO) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
1 | Q9WVC6 (/ISO) |
|
Nuclear speck GO:0016607
A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy.
|
1 | Q9WVC6 (/ISO) |
|
Neuron projection GO:0043005
A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
|
1 | Q06226 (/IDA) |
|
Neuron projection GO:0043005
A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
|
1 | Q9WVC6 (/ISO) |
|
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
|
1 | Q06226 (/IDA) |
|
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
|
1 | Q9WVC6 (/ISO) |