The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"GTPase Activation - p120gap; domain 1
".
FunFam 5: Plexin A1
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 10 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
7 | H9XVP3 (/IPI) O96681 (/IPI) P70206 (/IPI) Q0KIF1 (/IPI) Q9V491 (/IPI) Q9V4A7 (/IPI) Q9V4A7 (/IPI) |
|
Semaphorin receptor activity GO:0017154
Combining with a semaphorin, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
|
5 | H9XVP3 (/TAS) O96681 (/TAS) Q0KIF1 (/TAS) Q9UIW2 (/TAS) Q9V491 (/TAS) |
|
GTPase activator activity GO:0005096
Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP.
|
4 | H9XVP3 (/IDA) O96681 (/IDA) Q0KIF1 (/IDA) Q9V491 (/IDA) |
|
Heparin binding GO:0008201
Interacting selectively and non-covalently with heparin, any member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells and which consist predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues.
|
4 | H9XVP3 (/IDA) O96681 (/IDA) Q0KIF1 (/IDA) Q9V491 (/IDA) |
|
Guanylate cyclase activator activity GO:0030250
Binds to and increases the activity of guanylate cyclase.
|
4 | H9XVP3 (/IDA) O96681 (/IDA) Q0KIF1 (/IDA) Q9V491 (/IDA) |
|
14-3-3 protein binding GO:0071889
Interacting selectively and non-covalently with a 14-3-3 protein. A 14-3-3 protein is any of a large family of approximately 30kDa acidic proteins which exist primarily as homo- and heterodimers within all eukaryotic cells, and have been implicated in the modulation of distinct biological processes by binding to specific phosphorylated sites on diverse target proteins, thereby forcing conformational changes or influencing interactions between their targets and other molecules. Each 14-3-3 protein sequence can be roughly divided into three sections: a divergent amino terminus, the conserved core region and a divergent carboxy-terminus. The conserved middle core region of the 14-3-3s encodes an amphipathic groove that forms the main functional domain, a cradle for interacting with client proteins.
|
4 | H9XVP3 (/IPI) O96681 (/IPI) Q0KIF1 (/IPI) Q9V491 (/IPI) |
|
Semaphorin receptor activity GO:0017154
Combining with a semaphorin, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
|
1 | P70206 (/IPI) |
|
Signaling receptor activity GO:0038023
Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response.
|
1 | Q9UIW2 (/TAS) |
|
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
|
1 | B0S5N4 (/IDA) |
|
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
|
1 | B0S5N4 (/IMP) |
There are 27 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Axon guidance GO:0007411
The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues.
|
6 | H9XVP3 (/IMP) O96681 (/IMP) Q0KIF1 (/IMP) Q9V491 (/IMP) Q9V4A7 (/IMP) Q9V4A7 (/IMP) |
|
Motor neuron axon guidance GO:0008045
The process in which the migration of an axon growth cone of a motor neuron is directed to a specific target site in response to a combination of attractive and repulsive cues.
|
6 | H9XVP3 (/NAS) O96681 (/NAS) Q0KIF1 (/NAS) Q9V491 (/NAS) Q9V4A7 (/NAS) Q9V4A7 (/NAS) |
|
Sensory neuron axon guidance GO:0097374
The process in which the migration of an axon growth cone of a sensory neuron is directed to a specific target site in response to a combination of attractive and repulsive cues. A sensory neuron is an afferent neuron conveying sensory impulses.
|
6 | H9XVP3 (/IGI) O96681 (/IGI) Q0KIF1 (/IGI) Q9V491 (/IGI) Q9V4A7 (/IGI) Q9V4A7 (/IGI) |
|
Sensory neuron axon guidance GO:0097374
The process in which the migration of an axon growth cone of a sensory neuron is directed to a specific target site in response to a combination of attractive and repulsive cues. A sensory neuron is an afferent neuron conveying sensory impulses.
|
6 | H9XVP3 (/IMP) O96681 (/IMP) Q0KIF1 (/IMP) Q9V491 (/IMP) Q9V4A7 (/IMP) Q9V4A7 (/IMP) |
|
Ras protein signal transduction GO:0007265
A series of molecular signals within the cell that are mediated by a member of the Ras superfamily of proteins switching to a GTP-bound active state.
|
4 | H9XVP3 (/IDA) O96681 (/IDA) Q0KIF1 (/IDA) Q9V491 (/IDA) |
|
Axon midline choice point recognition GO:0016199
The recognition of molecules at the central nervous system midline choice point by an axon growth cone; this choice point determines whether the growth cone will cross the midline.
|
4 | H9XVP3 (/IMP) O96681 (/IMP) Q0KIF1 (/IMP) Q9V491 (/IMP) |
|
Positive regulation of guanylate cyclase activity GO:0031284
Any process that activates or increases the frequency, rate or extent of guanylate cyclase activity.
|
4 | H9XVP3 (/IDA) O96681 (/IDA) Q0KIF1 (/IDA) Q9V491 (/IDA) |
|
Semaphorin-plexin signaling pathway involved in regulation of photoreceptor cell axon guidance GO:2000305
Any semaphorin-plexin signaling pathway that is involved in regulation of photoreceptor cell axon guidance.
|
4 | H9XVP3 (/IGI) O96681 (/IGI) Q0KIF1 (/IGI) Q9V491 (/IGI) |
|
Motor neuron axon guidance GO:0008045
The process in which the migration of an axon growth cone of a motor neuron is directed to a specific target site in response to a combination of attractive and repulsive cues.
|
3 | B0S5N4 (/IMP) Q9V4A7 (/IMP) Q9V4A7 (/IMP) |
|
Axon guidance GO:0007411
The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues.
|
2 | Q9V4A7 (/IDA) Q9V4A7 (/IDA) |
|
Axon guidance GO:0007411
The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues.
|
2 | Q9V4A7 (/IGI) Q9V4A7 (/IGI) |
|
Negative regulation of Rac protein signal transduction GO:0035021
Any process that stops, prevents, or reduces the frequency, rate or extent of Rac protein signal transduction.
|
2 | Q9V4A7 (/NAS) Q9V4A7 (/NAS) |
|
Positive regulation of Rho protein signal transduction GO:0035025
Any process that activates or increases the frequency, rate or extent of Rho protein signal transduction.
|
2 | Q9V4A7 (/NAS) Q9V4A7 (/NAS) |
|
Dendrite self-avoidance GO:0070593
The process in which dendrites recognize and avoid contact with sister dendrites from the same cell.
|
2 | Q9V4A7 (/IMP) Q9V4A7 (/IMP) |
|
Olfactory bulb axon guidance GO:0071678
The process in which the migration of an axon growth cone of a neuron in the olfactory bulb is directed to its target in the brain in response to a combination of attractive and repulsive cues.
|
2 | Q9V4A7 (/IMP) Q9V4A7 (/IMP) |
|
Multicellular organism development GO:0007275
The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).
|
1 | Q9UIW2 (/TAS) |
|
Motor neuron axon guidance GO:0008045
The process in which the migration of an axon growth cone of a motor neuron is directed to a specific target site in response to a combination of attractive and repulsive cues.
|
1 | B0S5N4 (/IGI) |
|
Regulation of smooth muscle cell migration GO:0014910
Any process that modulates the frequency, rate or extent of smooth muscle cell migration.
|
1 | P70206 (/IMP) |
|
Axon extension GO:0048675
Long distance growth of a single axon process involved in cellular development.
|
1 | B0S5N4 (/IGI) |
|
Axon extension GO:0048675
Long distance growth of a single axon process involved in cellular development.
|
1 | B0S5N4 (/IMP) |
|
Regulation of collateral sprouting in absence of injury GO:0048696
Any process that modulates the frequency, rate or extent of collateral sprouting in the absence of injury.
|
1 | B0S5N4 (/IMP) |
|
Branching morphogenesis of a nerve GO:0048755
The process in which the anatomical structures of branches in a nerve are generated and organized. This term refers to an anatomical structure (nerve) not a cell (neuron).
|
1 | B0S5N4 (/IGI) |
|
Branching morphogenesis of a nerve GO:0048755
The process in which the anatomical structures of branches in a nerve are generated and organized. This term refers to an anatomical structure (nerve) not a cell (neuron).
|
1 | B0S5N4 (/IMP) |
|
Embryonic skeletal joint morphogenesis GO:0060272
The process in which the anatomical structures of skeletal joints are generated and organized during the embryonic phase. A skeletal joint is the connecting structure between the bones of the skeleton.
|
1 | B0S5N4 (/IMP) |
|
Dichotomous subdivision of terminal units involved in salivary gland branching GO:0060666
The process in which a salivary epithelial cord bifurcates at its end.
|
1 | P70206 (/IDA) |
|
Neuron projection guidance GO:0097485
The process in which the migration of a neuron projection is directed to a specific target site in response to a combination of attractive and repulsive cues.
|
1 | P70206 (/IMP) |
|
Neuron projection extension GO:1990138
Long distance growth of a single neuron projection involved in cellular development. A neuron projection is a prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
|
1 | P70206 (/IGI) |
There are 7 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
|
4 | H9XVP3 (/ISM) O96681 (/ISM) Q0KIF1 (/ISM) Q9V491 (/ISM) |
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
2 | Q9V4A7 (/HDA) Q9V4A7 (/HDA) |
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
2 | P70206 (/TAS) Q9UIW2 (/TAS) |
|
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
|
2 | B0S5N4 (/IDA) P70206 (/IDA) |
|
Dendrite GO:0030425
A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
|
2 | Q9V4A7 (/IDA) Q9V4A7 (/IDA) |
|
Semaphorin receptor complex GO:0002116
A stable binary complex of a neurophilin and a plexin, together forming a functional semaphorin receptor.
|
1 | Q9UIW2 (/TAS) |
|
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
|
1 | Q9UIW2 (/HDA) |