The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"GTPase Activation - p120gap; domain 1
".
FunFam 1: Ras GTPase-activating protein nGAP isoform 2
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 48 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
7 | F6SEU4 (/IPI) Q3UHC7 (/IPI) Q5VWQ8 (/IPI) Q5VWQ8 (/IPI) Q6P730 (/IPI) Q9QUH6 (/IPI) Q9UJF2 (/IPI) |
|
Protein kinase binding GO:0019901
Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
|
4 | Q3UHC7 (/IPI) Q5VWQ8 (/IPI) Q5VWQ8 (/IPI) Q9QUH6 (/IPI) |
|
GTPase activator activity GO:0005096
Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP.
|
3 | F6SEU4 (/IDA) Q6P730 (/IDA) Q9QUH6 (/IDA) |
|
GTPase activator activity GO:0005096
Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP.
|
2 | F6SEU4 (/ISO) Q3UHC7 (/ISO) |
|
Death receptor binding GO:0005123
Interacting selectively and non-covalently with any member of the death receptor (DR) family. The DR family falls within the tumor necrosis factor receptor superfamily and is characterized by a cytoplasmic region of ~80 residues termed the death domain (DD).
|
2 | Q5VWQ8 (/IPI) Q5VWQ8 (/IPI) |
|
SH3 domain binding GO:0017124
Interacting selectively and non-covalently with a SH3 domain (Src homology 3) of a protein, small protein modules containing approximately 50 amino acid residues found in a great variety of intracellular or membrane-associated proteins.
|
2 | Q5VWQ8 (/IDA) Q5VWQ8 (/IDA) |
|
SH3 domain binding GO:0017124
Interacting selectively and non-covalently with a SH3 domain (Src homology 3) of a protein, small protein modules containing approximately 50 amino acid residues found in a great variety of intracellular or membrane-associated proteins.
|
2 | Q3UHC7 (/ISS) Q6P730 (/ISS) |
|
Kinase binding GO:0019900
Interacting selectively and non-covalently with a kinase, any enzyme that catalyzes the transfer of a phosphate group.
|
2 | Q5VWQ8 (/IPI) Q5VWQ8 (/IPI) |
|
Protein kinase binding GO:0019901
Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
|
2 | Q5VWQ8 (/IDA) Q5VWQ8 (/IDA) |
|
Protein kinase binding GO:0019901
Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
|
2 | F6SEU4 (/ISO) Q3UHC7 (/ISO) |
|
Mitogen-activated protein kinase kinase binding GO:0031434
Interacting selectively and non-covalently with a mitogen-activated protein kinase kinase, any protein that can phosphorylate a MAP kinase.
|
2 | Q5VWQ8 (/IPI) Q5VWQ8 (/IPI) |
|
Mitogen-activated protein kinase kinase kinase binding GO:0031435
Interacting selectively and non-covalently with a mitogen-activated protein kinase kinase kinase, any protein that can phosphorylate a MAP kinase kinase.
|
2 | Q5VWQ8 (/IPI) Q5VWQ8 (/IPI) |
|
Phosphatidylinositol-3-phosphate binding GO:0032266
Interacting selectively and non-covalently with phosphatidylinositol-3-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3' position.
|
2 | Q5VWQ8 (/IDA) Q5VWQ8 (/IDA) |
|
Phosphatidylinositol-3-phosphate binding GO:0032266
Interacting selectively and non-covalently with phosphatidylinositol-3-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3' position.
|
2 | Q3UHC7 (/ISS) Q6P730 (/ISS) |
|
Signaling adaptor activity GO:0035591
The binding activity of a molecule that brings together two or more molecules in a signaling pathway, permitting those molecules to function in a coordinated way. Adaptor molecules themselves do not have catalytic activity.
|
2 | Q5VWQ8 (/IDA) Q5VWQ8 (/IDA) |
|
Phosphatidylinositol 3-kinase regulatory subunit binding GO:0036312
Interacting selectively and non-covalently with a regulatory subunit of phosphatidylinositol 3-kinase. The regulatory subunit associates with the catalytic subunit to regulate both its activity and subcellular location.
|
2 | Q5VWQ8 (/IDA) Q5VWQ8 (/IDA) |
|
Phosphatidylinositol 3-kinase regulatory subunit binding GO:0036312
Interacting selectively and non-covalently with a regulatory subunit of phosphatidylinositol 3-kinase. The regulatory subunit associates with the catalytic subunit to regulate both its activity and subcellular location.
|
2 | Q3UHC7 (/ISS) Q6P730 (/ISS) |
|
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
|
2 | Q5VWQ8 (/IPI) Q5VWQ8 (/IPI) |
|
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
|
2 | Q5VWQ8 (/IPI) Q5VWQ8 (/IPI) |
|
Vascular endothelial growth factor receptor 2 binding GO:0043184
Interacting selectively and non-covalently with vascular endothelial growth factor receptor 2.
|
2 | Q5VWQ8 (/IPI) Q5VWQ8 (/IPI) |
|
Phosphatidylinositol 3-kinase binding GO:0043548
Interacting selectively and non-covalently with a phosphatidylinositol 3-kinase, any enzyme that catalyzes the addition of a phosphate group to an inositol lipid at the 3' position of the inositol ring.
|
2 | Q5VWQ8 (/IDA) Q5VWQ8 (/IDA) |
|
Phosphatidylinositol 3-kinase binding GO:0043548
Interacting selectively and non-covalently with a phosphatidylinositol 3-kinase, any enzyme that catalyzes the addition of a phosphate group to an inositol lipid at the 3' position of the inositol ring.
|
2 | Q3UHC7 (/ISS) Q6P730 (/ISS) |
|
Protein-containing complex binding GO:0044877
Interacting selectively and non-covalently with a macromolecular complex.
|
2 | Q5VWQ8 (/IDA) Q5VWQ8 (/IDA) |
|
Protein-containing complex binding GO:0044877
Interacting selectively and non-covalently with a macromolecular complex.
|
2 | Q3UHC7 (/ISS) Q6P730 (/ISS) |
|
Cadherin binding GO:0045296
Interacting selectively and non-covalently with cadherin, a type I membrane protein involved in cell adhesion.
|
2 | Q5VWQ8 (/HDA) Q5VWQ8 (/HDA) |
|
Protein phosphatase 2A binding GO:0051721
Interacting selectively and non-covalently with the enzyme protein phosphatase 2A.
|
2 | Q5VWQ8 (/IDA) Q5VWQ8 (/IDA) |
|
Phosphatidylinositol-4-phosphate binding GO:0070273
Interacting selectively and non-covalently with phosphatidylinositol-4-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 4' position.
|
2 | Q5VWQ8 (/IDA) Q5VWQ8 (/IDA) |
|
Phosphatidylinositol-4-phosphate binding GO:0070273
Interacting selectively and non-covalently with phosphatidylinositol-4-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 4' position.
|
2 | Q3UHC7 (/ISS) Q6P730 (/ISS) |
|
14-3-3 protein binding GO:0071889
Interacting selectively and non-covalently with a 14-3-3 protein. A 14-3-3 protein is any of a large family of approximately 30kDa acidic proteins which exist primarily as homo- and heterodimers within all eukaryotic cells, and have been implicated in the modulation of distinct biological processes by binding to specific phosphorylated sites on diverse target proteins, thereby forcing conformational changes or influencing interactions between their targets and other molecules. Each 14-3-3 protein sequence can be roughly divided into three sections: a divergent amino terminus, the conserved core region and a divergent carboxy-terminus. The conserved middle core region of the 14-3-3s encodes an amphipathic groove that forms the main functional domain, a cradle for interacting with client proteins.
|
2 | Q5VWQ8 (/IDA) Q5VWQ8 (/IDA) |
|
GTPase activator activity GO:0005096
Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP.
|
1 | Q9UJF2 (/TAS) |
|
Death receptor binding GO:0005123
Interacting selectively and non-covalently with any member of the death receptor (DR) family. The DR family falls within the tumor necrosis factor receptor superfamily and is characterized by a cytoplasmic region of ~80 residues termed the death domain (DD).
|
1 | Q3UHC7 (/ISO) |
|
SH3 domain binding GO:0017124
Interacting selectively and non-covalently with a SH3 domain (Src homology 3) of a protein, small protein modules containing approximately 50 amino acid residues found in a great variety of intracellular or membrane-associated proteins.
|
1 | Q3UHC7 (/ISO) |
|
Kinase binding GO:0019900
Interacting selectively and non-covalently with a kinase, any enzyme that catalyzes the transfer of a phosphate group.
|
1 | Q3UHC7 (/ISO) |
|
Mitogen-activated protein kinase kinase binding GO:0031434
Interacting selectively and non-covalently with a mitogen-activated protein kinase kinase, any protein that can phosphorylate a MAP kinase.
|
1 | Q3UHC7 (/ISO) |
|
Mitogen-activated protein kinase kinase kinase binding GO:0031435
Interacting selectively and non-covalently with a mitogen-activated protein kinase kinase kinase, any protein that can phosphorylate a MAP kinase kinase.
|
1 | Q3UHC7 (/ISO) |
|
Phosphatidylinositol-3-phosphate binding GO:0032266
Interacting selectively and non-covalently with phosphatidylinositol-3-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3' position.
|
1 | Q3UHC7 (/ISO) |
|
Signaling adaptor activity GO:0035591
The binding activity of a molecule that brings together two or more molecules in a signaling pathway, permitting those molecules to function in a coordinated way. Adaptor molecules themselves do not have catalytic activity.
|
1 | Q3UHC7 (/ISO) |
|
Phosphatidylinositol 3-kinase regulatory subunit binding GO:0036312
Interacting selectively and non-covalently with a regulatory subunit of phosphatidylinositol 3-kinase. The regulatory subunit associates with the catalytic subunit to regulate both its activity and subcellular location.
|
1 | Q3UHC7 (/ISO) |
|
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
|
1 | Q3UHC7 (/ISO) |
|
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
|
1 | Q3UHC7 (/ISO) |
|
Vascular endothelial growth factor receptor 2 binding GO:0043184
Interacting selectively and non-covalently with vascular endothelial growth factor receptor 2.
|
1 | Q3UHC7 (/ISO) |
|
Phosphatidylinositol 3-kinase binding GO:0043548
Interacting selectively and non-covalently with a phosphatidylinositol 3-kinase, any enzyme that catalyzes the addition of a phosphate group to an inositol lipid at the 3' position of the inositol ring.
|
1 | Q3UHC7 (/ISO) |
|
Protein-containing complex binding GO:0044877
Interacting selectively and non-covalently with a macromolecular complex.
|
1 | Q3UHC7 (/ISO) |
|
Protein N-terminus binding GO:0047485
Interacting selectively and non-covalently with a protein N-terminus, the end of any peptide chain at which the 2-amino (or 2-imino) function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue.
|
1 | Q6P730 (/IPI) |
|
Protein N-terminus binding GO:0047485
Interacting selectively and non-covalently with a protein N-terminus, the end of any peptide chain at which the 2-amino (or 2-imino) function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue.
|
1 | Q3UHC7 (/ISO) |
|
Protein phosphatase 2A binding GO:0051721
Interacting selectively and non-covalently with the enzyme protein phosphatase 2A.
|
1 | Q3UHC7 (/ISO) |
|
Phosphatidylinositol-4-phosphate binding GO:0070273
Interacting selectively and non-covalently with phosphatidylinositol-4-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 4' position.
|
1 | Q3UHC7 (/ISO) |
|
14-3-3 protein binding GO:0071889
Interacting selectively and non-covalently with a 14-3-3 protein. A 14-3-3 protein is any of a large family of approximately 30kDa acidic proteins which exist primarily as homo- and heterodimers within all eukaryotic cells, and have been implicated in the modulation of distinct biological processes by binding to specific phosphorylated sites on diverse target proteins, thereby forcing conformational changes or influencing interactions between their targets and other molecules. Each 14-3-3 protein sequence can be roughly divided into three sections: a divergent amino terminus, the conserved core region and a divergent carboxy-terminus. The conserved middle core region of the 14-3-3s encodes an amphipathic groove that forms the main functional domain, a cradle for interacting with client proteins.
|
1 | Q3UHC7 (/ISO) |
There are 203 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
MAPK cascade GO:0000165
An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade can also contain an additional tiers: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier to transmit a signal within a cell.
|
9 | Q5VWQ8 (/TAS) Q5VWQ8 (/TAS) Q96PV0 (/TAS) Q96PV0 (/TAS) Q96PV0 (/TAS) Q96PV0 (/TAS) Q96PV0 (/TAS) Q96PV0 (/TAS) Q9UJF2 (/TAS) |
|
Negative regulation of Ras protein signal transduction GO:0046580
Any process that stops, prevents, or reduces the frequency, rate or extent of Ras protein signal transduction.
|
7 | F6SEU4 (/ISS) Q96PV0 (/ISS) Q96PV0 (/ISS) Q96PV0 (/ISS) Q96PV0 (/ISS) Q96PV0 (/ISS) Q96PV0 (/ISS) |
|
Regulation of synaptic plasticity GO:0048167
A process that modulates synaptic plasticity, the ability of synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers.
|
7 | F6SEU4 (/ISS) Q96PV0 (/ISS) Q96PV0 (/ISS) Q96PV0 (/ISS) Q96PV0 (/ISS) Q96PV0 (/ISS) Q96PV0 (/ISS) |
|
Negative regulation of GTPase activity GO:0034260
Any process that stops or reduces the rate of GTP hydrolysis by a GTPase.
|
4 | Q3UHC7 (/ISS) Q5VWQ8 (/ISS) Q5VWQ8 (/ISS) Q6P730 (/ISS) |
|
Negative regulation of protein phosphorylation GO:0001933
Any process that stops, prevents or reduces the rate of addition of phosphate groups to amino acids within a protein.
|
3 | Q3UHC7 (/IMP) Q5VWQ8 (/IMP) Q5VWQ8 (/IMP) |
|
Negative regulation of protein phosphorylation GO:0001933
Any process that stops, prevents or reduces the rate of addition of phosphate groups to amino acids within a protein.
|
3 | Q5VWQ8 (/ISS) Q5VWQ8 (/ISS) Q6P730 (/ISS) |
|
I-kappaB phosphorylation GO:0007252
The process of introducing a phosphate group into an inhibitor of kappa B (I-kappaB) protein. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing bound NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription.
|
3 | Q5VWQ8 (/ISS) Q5VWQ8 (/ISS) Q6P730 (/ISS) |
|
Negative regulation of endothelial cell migration GO:0010596
Any process that decreases the rate, frequency, or extent of the orderly movement of an endothelial cell into the extracellular matrix to form an endothelium.
|
3 | Q3UHC7 (/IMP) Q5VWQ8 (/IMP) Q5VWQ8 (/IMP) |
|
Positive regulation of neuron projection development GO:0010976
Any process that increases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
|
3 | Q5VWQ8 (/ISS) Q5VWQ8 (/ISS) Q6P730 (/ISS) |
|
Cell motility involved in cerebral cortex radial glia guided migration GO:0021814
The movement of a cell along the process of a radial glial cell involved in cerebral cortex glial-mediated radial migration.
|
3 | Q5VWQ8 (/ISS) Q5VWQ8 (/ISS) Q6P730 (/ISS) |
|
Layer formation in cerebral cortex GO:0021819
The detachment of cells from radial glial fibers at the appropriate time when they cease to migrate and form distinct layer in the cerebral cortex.
|
3 | Q5VWQ8 (/ISS) Q5VWQ8 (/ISS) Q6P730 (/ISS) |
|
Negative regulation of vascular endothelial growth factor receptor signaling pathway GO:0030948
Any process that stops, prevents, or reduces the frequency, rate or extent of vascular endothelial growth factor receptor signaling pathway activity.
|
3 | Q3UHC7 (/IMP) Q5VWQ8 (/IMP) Q5VWQ8 (/IMP) |
|
Negative regulation of GTPase activity GO:0034260
Any process that stops or reduces the rate of GTP hydrolysis by a GTPase.
|
3 | Q3UHC7 (/IMP) Q5VWQ8 (/IMP) Q5VWQ8 (/IMP) |
|
Tube formation GO:0035148
Creation of the central hole of a tube in an anatomical structure through which gases and/or liquids flow.
|
3 | Q3UHC7 (/IMP) Q5VWQ8 (/IMP) Q5VWQ8 (/IMP) |
|
Cellular response to vascular endothelial growth factor stimulus GO:0035924
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vascular endothelial growth factor stimulus.
|
3 | Q3UHC7 (/IDA) Q5VWQ8 (/IDA) Q5VWQ8 (/IDA) |
|
Cellular response to vascular endothelial growth factor stimulus GO:0035924
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vascular endothelial growth factor stimulus.
|
3 | Q5VWQ8 (/ISS) Q5VWQ8 (/ISS) Q6P730 (/ISS) |
|
Vascular endothelial growth factor receptor-2 signaling pathway GO:0036324
Any series of molecular signals initiated by the binding of an extracellular ligand to a vascular endothelial growth factor receptor-2 (VEGFR-2) located on the surface of the receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription.
|
3 | Q5VWQ8 (/ISS) Q5VWQ8 (/ISS) Q6P730 (/ISS) |
|
Regulation of GTPase activity GO:0043087
Any process that modulates the rate of GTP hydrolysis by a GTPase.
|
3 | Q5VWQ8 (/ISS) Q5VWQ8 (/ISS) Q6P730 (/ISS) |
|
Regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122
Any process that modulates I-kappaB kinase/NF-kappaB signaling.
|
3 | Q5VWQ8 (/ISS) Q5VWQ8 (/ISS) Q6P730 (/ISS) |
|
Positive regulation of protein catabolic process GO:0045732
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds.
|
3 | Q5VWQ8 (/ISS) Q5VWQ8 (/ISS) Q6P730 (/ISS) |
|
Negative regulation of fibroblast proliferation GO:0048147
Any process that stops, prevents, or reduces the frequency, rate or extent of multiplication or reproduction of fibroblast cells.
|
3 | Q5VWQ8 (/ISS) Q5VWQ8 (/ISS) Q6P730 (/ISS) |
|
Neuron projection morphogenesis GO:0048812
The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites.
|
3 | Q5VWQ8 (/ISS) Q5VWQ8 (/ISS) Q6P730 (/ISS) |
|
Cellular response to lipopolysaccharide GO:0071222
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.
|
3 | Q3UHC7 (/IDA) Q5VWQ8 (/IDA) Q5VWQ8 (/IDA) |
|
Cellular response to interleukin-1 GO:0071347
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-1 stimulus.
|
3 | Q3UHC7 (/IDA) Q5VWQ8 (/IDA) Q5VWQ8 (/IDA) |
|
Negative regulation of protein serine/threonine kinase activity GO:0071901
Any process that decreases the rate, frequency, or extent of protein serine/threonine kinase activity.
|
3 | Q3UHC7 (/IMP) Q5VWQ8 (/IMP) Q5VWQ8 (/IMP) |
|
Positive regulation of protein serine/threonine kinase activity GO:0071902
Any process that increases the rate, frequency, or extent of protein serine/threonine kinase activity.
|
3 | Q3UHC7 (/IMP) Q5VWQ8 (/IMP) Q5VWQ8 (/IMP) |
|
Negative regulation of canonical Wnt signaling pathway GO:0090090
Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes.
|
3 | Q3UHC7 (/IMP) Q5VWQ8 (/IMP) Q5VWQ8 (/IMP) |
|
Positive regulation of synapse maturation GO:0090129
Any process that increases the extent of synapse maturation, the process that organizes a synapse so that it attains its fully functional state.
|
3 | Q5VWQ8 (/ISS) Q5VWQ8 (/ISS) Q6P730 (/ISS) |
|
Positive regulation of dendrite development GO:1900006
Any process that activates or increases the frequency, rate or extent of dendrite development.
|
3 | Q5VWQ8 (/ISS) Q5VWQ8 (/ISS) Q6P730 (/ISS) |
|
Regulation of p38MAPK cascade GO:1900744
Any process that modulates the frequency, rate or extent of p38MAPK cascade.
|
3 | Q5VWQ8 (/ISS) Q5VWQ8 (/ISS) Q6P730 (/ISS) |
|
Negative regulation of vascular endothelial growth factor signaling pathway GO:1900747
Any process that stops, prevents or reduces the frequency, rate or extent of vascular endothelial growth factor signaling pathway.
|
3 | Q5VWQ8 (/ISS) Q5VWQ8 (/ISS) Q6P730 (/ISS) |
|
Positive regulation of neuron migration GO:2001224
Any process that activates or increases the frequency, rate or extent of neuron migration.
|
3 | Q5VWQ8 (/ISS) Q5VWQ8 (/ISS) Q6P730 (/ISS) |
|
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
2 | Q5VWQ8 (/IDA) Q5VWQ8 (/IDA) |
|
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
2 | Q5VWQ8 (/IMP) Q5VWQ8 (/IMP) |
|
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
2 | Q3UHC7 (/ISS) Q6P730 (/ISS) |
|
Activation of MAPKKK activity GO:0000185
Any process that initiates the activity of the inactive enzyme MAP kinase kinase kinase (MAPKKK).
|
2 | Q5VWQ8 (/IDA) Q5VWQ8 (/IDA) |
|
Activation of MAPKKK activity GO:0000185
Any process that initiates the activity of the inactive enzyme MAP kinase kinase kinase (MAPKKK).
|
2 | Q3UHC7 (/ISS) Q6P730 (/ISS) |
|
Activation of JUN kinase activity GO:0007257
The initiation of the activity of the inactive enzyme JUN kinase (JNK).
|
2 | Q5VWQ8 (/IDA) Q5VWQ8 (/IDA) |
|
Negative regulation of cell population proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
|
2 | Q5VWQ8 (/IDA) Q5VWQ8 (/IDA) |
|
Negative regulation of cell population proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
|
2 | Q3UHC7 (/ISS) Q6P730 (/ISS) |
|
Extrinsic apoptotic signaling pathway via death domain receptors GO:0008625
A series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with a ligand binding to a death domain receptor on the cell surface, and ends when the execution phase of apoptosis is triggered.
|
2 | Q5VWQ8 (/IMP) Q5VWQ8 (/IMP) |
|
Negative regulation of epithelial cell migration GO:0010633
Any process that stops, prevents, or reduces the frequency, rate or extent of epithelial cell migration.
|
2 | Q5VWQ8 (/IMP) Q5VWQ8 (/IMP) |
|
Negative regulation of epithelial cell migration GO:0010633
Any process that stops, prevents, or reduces the frequency, rate or extent of epithelial cell migration.
|
2 | Q3UHC7 (/ISS) Q6P730 (/ISS) |
|
Negative regulation of epithelial cell migration GO:0010633
Any process that stops, prevents, or reduces the frequency, rate or extent of epithelial cell migration.
|
2 | Q5VWQ8 (/TAS) Q5VWQ8 (/TAS) |
|
Negative regulation of epithelial to mesenchymal transition GO:0010719
Any process that decreases the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell.
|
2 | Q5VWQ8 (/IDA) Q5VWQ8 (/IDA) |
|
Negative regulation of epithelial to mesenchymal transition GO:0010719
Any process that decreases the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell.
|
2 | Q5VWQ8 (/IMP) Q5VWQ8 (/IMP) |
|
Negative regulation of epithelial to mesenchymal transition GO:0010719
Any process that decreases the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell.
|
2 | Q3UHC7 (/ISS) Q6P730 (/ISS) |
|
Negative regulation of phosphatidylinositol 3-kinase signaling GO:0014067
Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the phosphatidylinositol 3-kinase cascade.
|
2 | Q5VWQ8 (/IDA) Q5VWQ8 (/IDA) |
|
Negative regulation of phosphatidylinositol 3-kinase signaling GO:0014067
Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the phosphatidylinositol 3-kinase cascade.
|
2 | Q3UHC7 (/ISS) Q6P730 (/ISS) |
|
Negative regulation of angiogenesis GO:0016525
Any process that stops, prevents, or reduces the frequency, rate or extent of angiogenesis.
|
2 | Q5VWQ8 (/IDA) Q5VWQ8 (/IDA) |
|
Negative regulation of NF-kappaB transcription factor activity GO:0032088
Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of the transcription factor NF-kappaB.
|
2 | Q5VWQ8 (/IMP) Q5VWQ8 (/IMP) |
|
Negative regulation of NF-kappaB transcription factor activity GO:0032088
Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of the transcription factor NF-kappaB.
|
2 | Q3UHC7 (/ISS) Q6P730 (/ISS) |
|
Negative regulation of toll-like receptor 4 signaling pathway GO:0034144
Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor 4 signaling pathway.
|
2 | Q5VWQ8 (/IDA) Q5VWQ8 (/IDA) |
|
Negative regulation of toll-like receptor 4 signaling pathway GO:0034144
Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor 4 signaling pathway.
|
2 | Q3UHC7 (/ISS) Q6P730 (/ISS) |
|
Cellular response to unfolded protein GO:0034620
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an unfolded protein stimulus.
|
2 | Q5VWQ8 (/TAS) Q5VWQ8 (/TAS) |
|
Swimming behavior GO:0036269
The response to external or internal stimuli that results in the locomotory process of swimming. Swimming is the self-propelled movement of an organism through the water.
|
2 | E7F1U4 (/IGI) E9QHX3 (/IGI) |
|
Swimming behavior GO:0036269
The response to external or internal stimuli that results in the locomotory process of swimming. Swimming is the self-propelled movement of an organism through the water.
|
2 | E7F1U4 (/IMP) E9QHX3 (/IMP) |
|
Negative regulation of epidermal growth factor receptor signaling pathway GO:0042059
Any process that stops, prevents, or reduces the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity.
|
2 | Q5VWQ8 (/ISS) Q5VWQ8 (/ISS) |
|
Positive regulation of apoptotic process GO:0043065
Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
|
2 | Q5VWQ8 (/IDA) Q5VWQ8 (/IDA) |
|
Negative regulation of I-kappaB kinase/NF-kappaB signaling GO:0043124
Any process that stops, prevents, or reduces the frequency, rate or extent of -kappaB kinase/NF-kappaB signaling.
|
2 | Q5VWQ8 (/IDA) Q5VWQ8 (/IDA) |
|
Negative regulation of I-kappaB kinase/NF-kappaB signaling GO:0043124
Any process that stops, prevents, or reduces the frequency, rate or extent of -kappaB kinase/NF-kappaB signaling.
|
2 | Q3UHC7 (/ISS) Q6P730 (/ISS) |
|
Regulation of protein complex assembly GO:0043254
Any process that modulates the frequency, rate or extent of protein complex assembly.
|
2 | Q5VWQ8 (/IDA) Q5VWQ8 (/IDA) |
|
Negative regulation of MAP kinase activity GO:0043407
Any process that stops, prevents, or reduces the frequency, rate or extent of MAP kinase activity.
|
2 | Q5VWQ8 (/IDA) Q5VWQ8 (/IDA) |
|
Negative regulation of MAP kinase activity GO:0043407
Any process that stops, prevents, or reduces the frequency, rate or extent of MAP kinase activity.
|
2 | Q5VWQ8 (/IMP) Q5VWQ8 (/IMP) |
|
Negative regulation of MAP kinase activity GO:0043407
Any process that stops, prevents, or reduces the frequency, rate or extent of MAP kinase activity.
|
2 | Q3UHC7 (/ISS) Q6P730 (/ISS) |
|
Positive regulation of MAPK cascade GO:0043410
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the MAPK cascade.
|
2 | Q5VWQ8 (/IDA) Q5VWQ8 (/IDA) |
|
Positive regulation of MAPK cascade GO:0043410
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the MAPK cascade.
|
2 | Q3UHC7 (/ISS) Q6P730 (/ISS) |
|
Regulation of protein heterodimerization activity GO:0043497
Any process that modulates the frequency, rate or extent of protein heterodimerization, interacting selectively with a nonidentical protein to form a heterodimer.
|
2 | Q5VWQ8 (/IDA) Q5VWQ8 (/IDA) |
|
Positive regulation of JUN kinase activity GO:0043507
Any process that activates or increases the frequency, rate or extent of JUN kinase activity.
|
2 | Q5VWQ8 (/IDA) Q5VWQ8 (/IDA) |
|
Negative regulation of phosphatidylinositol 3-kinase activity GO:0043553
Any process that stops, prevents, or reduces the frequency, rate or extent of phosphatidylinositol 3-kinase activity.
|
2 | Q5VWQ8 (/IDA) Q5VWQ8 (/IDA) |
|
Negative regulation of phosphatidylinositol 3-kinase activity GO:0043553
Any process that stops, prevents, or reduces the frequency, rate or extent of phosphatidylinositol 3-kinase activity.
|
2 | Q3UHC7 (/ISS) Q6P730 (/ISS) |
|
Cellular protein catabolic process GO:0044257
The chemical reactions and pathways resulting in the breakdown of a protein by individual cells.
|
2 | Q5VWQ8 (/IDA) Q5VWQ8 (/IDA) |
|
Cellular protein catabolic process GO:0044257
The chemical reactions and pathways resulting in the breakdown of a protein by individual cells.
|
2 | Q3UHC7 (/ISS) Q6P730 (/ISS) |
|
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
|
2 | Q5VWQ8 (/IMP) Q5VWQ8 (/IMP) |
|
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
|
2 | Q3UHC7 (/ISS) Q6P730 (/ISS) |
|
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
2 | Q5VWQ8 (/IDA) Q5VWQ8 (/IDA) |
|
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
2 | Q3UHC7 (/ISS) Q6P730 (/ISS) |
|
Positive regulation of JNK cascade GO:0046330
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the JNK cascade.
|
2 | Q5VWQ8 (/IDA) Q5VWQ8 (/IDA) |
|
Positive regulation of JNK cascade GO:0046330
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the JNK cascade.
|
2 | Q3UHC7 (/ISS) Q6P730 (/ISS) |
|
Negative regulation of Ras protein signal transduction GO:0046580
Any process that stops, prevents, or reduces the frequency, rate or extent of Ras protein signal transduction.
|
2 | Q5VWQ8 (/IC) Q5VWQ8 (/IC) |
|
Negative regulation of Ras protein signal transduction GO:0046580
Any process that stops, prevents, or reduces the frequency, rate or extent of Ras protein signal transduction.
|
2 | Q6P730 (/IDA) Q9QUH6 (/IDA) |
|
Negative regulation of Ras protein signal transduction GO:0046580
Any process that stops, prevents, or reduces the frequency, rate or extent of Ras protein signal transduction.
|
2 | F6SEU4 (/ISO) Q3UHC7 (/ISO) |
|
Brain morphogenesis GO:0048854
The process in which the anatomical structures of the brain are generated and organized. The brain is one of the two components of the central nervous system and is the center of thought and emotion. It is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.).
|
2 | E7F1U4 (/IGI) E9QHX3 (/IGI) |
|
Brain morphogenesis GO:0048854
The process in which the anatomical structures of the brain are generated and organized. The brain is one of the two components of the central nervous system and is the center of thought and emotion. It is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.).
|
2 | E7F1U4 (/IMP) E9QHX3 (/IMP) |
|
Positive regulation of epithelial cell proliferation GO:0050679
Any process that activates or increases the rate or extent of epithelial cell proliferation.
|
2 | Q3UHC7 (/ISS) Q6P730 (/ISS) |
|
Negative regulation of epithelial cell proliferation GO:0050680
Any process that stops, prevents or reduces the rate or extent of epithelial cell proliferation.
|
2 | Q5VWQ8 (/IMP) Q5VWQ8 (/IMP) |
|
Negative regulation of epithelial cell proliferation GO:0050680
Any process that stops, prevents or reduces the rate or extent of epithelial cell proliferation.
|
2 | Q3UHC7 (/ISS) Q6P730 (/ISS) |
|
Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress GO:0070059
A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced in response to a stimulus indicating endoplasmic reticulum (ER) stress, and ends when the execution phase of apoptosis is triggered. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen.
|
2 | Q5VWQ8 (/ISS) Q5VWQ8 (/ISS) |
|
Negative regulation of G0 to G1 transition GO:0070317
A cell cycle process that stops, prevents, or reduces the rate or extent of the transition from the G0 quiescent state to the G1 phase.
|
2 | Q5VWQ8 (/IDA) Q5VWQ8 (/IDA) |
|
Negative regulation of G0 to G1 transition GO:0070317
A cell cycle process that stops, prevents, or reduces the rate or extent of the transition from the G0 quiescent state to the G1 phase.
|
2 | Q3UHC7 (/ISS) Q6P730 (/ISS) |
|
Negative regulation of ERK1 and ERK2 cascade GO:0070373
Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
|
2 | Q5VWQ8 (/IDA) Q5VWQ8 (/IDA) |
|
Negative regulation of ERK1 and ERK2 cascade GO:0070373
Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
|
2 | Q3UHC7 (/ISS) Q6P730 (/ISS) |
|
Positive regulation of cell cycle arrest GO:0071158
Any process that increases the rate, frequency, or extent of cell cycle arrest, the process in which the cell cycle is halted during one of the normal phases.
|
2 | Q5VWQ8 (/IDA) Q5VWQ8 (/IDA) |
|
Positive regulation of cell cycle arrest GO:0071158
Any process that increases the rate, frequency, or extent of cell cycle arrest, the process in which the cell cycle is halted during one of the normal phases.
|
2 | Q3UHC7 (/ISS) Q6P730 (/ISS) |
|
Cellular response to tumor necrosis factor GO:0071356
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tumor necrosis factor stimulus.
|
2 | Q5VWQ8 (/IDA) Q5VWQ8 (/IDA) |
|
Cellular response to epidermal growth factor stimulus GO:0071364
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an epidermal growth factor stimulus.
|
2 | Q5VWQ8 (/ISS) Q5VWQ8 (/ISS) |
|
Negative regulation of protein serine/threonine kinase activity GO:0071901
Any process that decreases the rate, frequency, or extent of protein serine/threonine kinase activity.
|
2 | Q5VWQ8 (/IDA) Q5VWQ8 (/IDA) |
|
Positive regulation of protein serine/threonine kinase activity GO:0071902
Any process that increases the rate, frequency, or extent of protein serine/threonine kinase activity.
|
2 | Q5VWQ8 (/IDA) Q5VWQ8 (/IDA) |
|
Endothelial cell apoptotic process GO:0072577
Any apoptotic process in an endothelial cell. An endothelial cell comprises the outermost layer or lining of anatomical structures and can be squamous or cuboidal.
|
2 | Q5VWQ8 (/TAS) Q5VWQ8 (/TAS) |
|
Negative regulation of canonical Wnt signaling pathway GO:0090090
Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes.
|
2 | Q5VWQ8 (/ISS) Q5VWQ8 (/ISS) |
|
Positive regulation of proteasomal protein catabolic process GO:1901800
Any process that activates or increases the frequency, rate or extent of proteasomal protein catabolic process.
|
2 | Q5VWQ8 (/IMP) Q5VWQ8 (/IMP) |
|
Positive regulation of proteasomal protein catabolic process GO:1901800
Any process that activates or increases the frequency, rate or extent of proteasomal protein catabolic process.
|
2 | Q3UHC7 (/ISS) Q6P730 (/ISS) |
|
Negative regulation of cellular protein catabolic process GO:1903363
Any process that stops, prevents or reduces the frequency, rate or extent of cellular protein catabolic process.
|
2 | Q5VWQ8 (/IDA) Q5VWQ8 (/IDA) |
|
Negative regulation of cellular protein catabolic process GO:1903363
Any process that stops, prevents or reduces the frequency, rate or extent of cellular protein catabolic process.
|
2 | Q3UHC7 (/ISS) Q6P730 (/ISS) |
|
Positive regulation of IRE1-mediated unfolded protein response GO:1903896
Any process that activates or increases the frequency, rate or extent of the IRE1-mediated unfolded protein response.
|
2 | Q5VWQ8 (/TAS) Q5VWQ8 (/TAS) |
|
Positive regulation of apoptotic signaling pathway GO:2001235
Any process that activates or increases the frequency, rate or extent of apoptotic signaling pathway.
|
2 | Q5VWQ8 (/IDA) Q5VWQ8 (/IDA) |
|
Positive regulation of apoptotic signaling pathway GO:2001235
Any process that activates or increases the frequency, rate or extent of apoptotic signaling pathway.
|
2 | Q3UHC7 (/ISS) Q6P730 (/ISS) |
|
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
1 | Q3UHC7 (/ISO) |
|
Activation of MAPKKK activity GO:0000185
Any process that initiates the activity of the inactive enzyme MAP kinase kinase kinase (MAPKKK).
|
1 | Q3UHC7 (/ISO) |
|
Negative regulation of protein phosphorylation GO:0001933
Any process that stops, prevents or reduces the rate of addition of phosphate groups to amino acids within a protein.
|
1 | Q3UHC7 (/ISO) |
|
Signal transduction GO:0007165
The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
|
1 | Q9UJF2 (/TAS) |
|
I-kappaB phosphorylation GO:0007252
The process of introducing a phosphate group into an inhibitor of kappa B (I-kappaB) protein. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing bound NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription.
|
1 | Q3UHC7 (/IMP) |
|
Activation of JUN kinase activity GO:0007257
The initiation of the activity of the inactive enzyme JUN kinase (JNK).
|
1 | Q3UHC7 (/ISO) |
|
Ras protein signal transduction GO:0007265
A series of molecular signals within the cell that are mediated by a member of the Ras superfamily of proteins switching to a GTP-bound active state.
|
1 | F6SEU4 (/IDA) |
|
Pattern specification process GO:0007389
Any developmental process that results in the creation of defined areas or spaces within an organism to which cells respond and eventually are instructed to differentiate.
|
1 | F6SEU4 (/IMP) |
|
Negative regulation of cell population proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
|
1 | Q3UHC7 (/ISO) |
|
Visual learning GO:0008542
Any process in an organism in which a change in behavior of an individual occurs in response to repeated exposure to a visual cue.
|
1 | F6SEU4 (/IMP) |
|
Extrinsic apoptotic signaling pathway via death domain receptors GO:0008625
A series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with a ligand binding to a death domain receptor on the cell surface, and ends when the execution phase of apoptosis is triggered.
|
1 | Q3UHC7 (/ISO) |
|
Negative regulation of endothelial cell migration GO:0010596
Any process that decreases the rate, frequency, or extent of the orderly movement of an endothelial cell into the extracellular matrix to form an endothelium.
|
1 | Q3UHC7 (/ISO) |
|
Negative regulation of endothelial cell migration GO:0010596
Any process that decreases the rate, frequency, or extent of the orderly movement of an endothelial cell into the extracellular matrix to form an endothelium.
|
1 | Q6P730 (/ISS) |
|
Negative regulation of epithelial cell migration GO:0010633
Any process that stops, prevents, or reduces the frequency, rate or extent of epithelial cell migration.
|
1 | Q3UHC7 (/ISO) |
|
Negative regulation of epithelial to mesenchymal transition GO:0010719
Any process that decreases the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell.
|
1 | Q3UHC7 (/ISO) |
|
Positive regulation of neuron projection development GO:0010976
Any process that increases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
|
1 | Q3UHC7 (/IMP) |
|
Negative regulation of phosphatidylinositol 3-kinase signaling GO:0014067
Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the phosphatidylinositol 3-kinase cascade.
|
1 | Q3UHC7 (/ISO) |
|
Dendrite development GO:0016358
The process whose specific outcome is the progression of the dendrite over time, from its formation to the mature structure.
|
1 | F6SEU4 (/IMP) |
|
Negative regulation of angiogenesis GO:0016525
Any process that stops, prevents, or reduces the frequency, rate or extent of angiogenesis.
|
1 | Q3UHC7 (/IMP) |
|
Negative regulation of angiogenesis GO:0016525
Any process that stops, prevents, or reduces the frequency, rate or extent of angiogenesis.
|
1 | Q3UHC7 (/ISO) |
|
Negative regulation of angiogenesis GO:0016525
Any process that stops, prevents, or reduces the frequency, rate or extent of angiogenesis.
|
1 | Q6P730 (/ISS) |
|
Cell motility involved in cerebral cortex radial glia guided migration GO:0021814
The movement of a cell along the process of a radial glial cell involved in cerebral cortex glial-mediated radial migration.
|
1 | Q3UHC7 (/IMP) |
|
Layer formation in cerebral cortex GO:0021819
The detachment of cells from radial glial fibers at the appropriate time when they cease to migrate and form distinct layer in the cerebral cortex.
|
1 | Q3UHC7 (/IMP) |
|
Negative regulation of cell growth GO:0030308
Any process that stops, prevents, or reduces the frequency, rate, extent or direction of cell growth.
|
1 | Q6P730 (/IDA) |
|
Negative regulation of cell growth GO:0030308
Any process that stops, prevents, or reduces the frequency, rate, extent or direction of cell growth.
|
1 | Q3UHC7 (/ISO) |
|
Negative regulation of vascular endothelial growth factor receptor signaling pathway GO:0030948
Any process that stops, prevents, or reduces the frequency, rate or extent of vascular endothelial growth factor receptor signaling pathway activity.
|
1 | Q3UHC7 (/ISO) |
|
Negative regulation of vascular endothelial growth factor receptor signaling pathway GO:0030948
Any process that stops, prevents, or reduces the frequency, rate or extent of vascular endothelial growth factor receptor signaling pathway activity.
|
1 | Q6P730 (/ISS) |
|
Negative regulation of NF-kappaB transcription factor activity GO:0032088
Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of the transcription factor NF-kappaB.
|
1 | Q3UHC7 (/ISO) |
|
Negative regulation of toll-like receptor 4 signaling pathway GO:0034144
Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor 4 signaling pathway.
|
1 | Q3UHC7 (/ISO) |
|
Negative regulation of GTPase activity GO:0034260
Any process that stops or reduces the rate of GTP hydrolysis by a GTPase.
|
1 | Q3UHC7 (/ISO) |
|
Tube formation GO:0035148
Creation of the central hole of a tube in an anatomical structure through which gases and/or liquids flow.
|
1 | Q3UHC7 (/ISO) |
|
Tube formation GO:0035148
Creation of the central hole of a tube in an anatomical structure through which gases and/or liquids flow.
|
1 | Q6P730 (/ISS) |
|
Cellular response to vascular endothelial growth factor stimulus GO:0035924
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vascular endothelial growth factor stimulus.
|
1 | Q3UHC7 (/ISO) |
|
Vascular endothelial growth factor receptor-2 signaling pathway GO:0036324
Any series of molecular signals initiated by the binding of an extracellular ligand to a vascular endothelial growth factor receptor-2 (VEGFR-2) located on the surface of the receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription.
|
1 | Q3UHC7 (/IMP) |
|
Negative regulation of epidermal growth factor receptor signaling pathway GO:0042059
Any process that stops, prevents, or reduces the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity.
|
1 | Q6P730 (/IDA) |
|
Negative regulation of epidermal growth factor receptor signaling pathway GO:0042059
Any process that stops, prevents, or reduces the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity.
|
1 | Q3UHC7 (/ISO) |
|
Positive regulation of apoptotic process GO:0043065
Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
|
1 | Q3UHC7 (/IMP) |
|
Positive regulation of apoptotic process GO:0043065
Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
|
1 | Q3UHC7 (/ISO) |
|
Positive regulation of apoptotic process GO:0043065
Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
|
1 | Q6P730 (/ISS) |
|
Regulation of GTPase activity GO:0043087
Any process that modulates the rate of GTP hydrolysis by a GTPase.
|
1 | Q3UHC7 (/IMP) |
|
Receptor clustering GO:0043113
The receptor metabolic process that results in grouping of a set of receptors at a cellular location, often to amplify the sensitivity of a signaling response.
|
1 | F6SEU4 (/IMP) |
|
Regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122
Any process that modulates I-kappaB kinase/NF-kappaB signaling.
|
1 | Q3UHC7 (/IMP) |
|
Negative regulation of I-kappaB kinase/NF-kappaB signaling GO:0043124
Any process that stops, prevents, or reduces the frequency, rate or extent of -kappaB kinase/NF-kappaB signaling.
|
1 | Q3UHC7 (/ISO) |
|
Regulation of protein complex assembly GO:0043254
Any process that modulates the frequency, rate or extent of protein complex assembly.
|
1 | Q3UHC7 (/IMP) |
|
Regulation of protein complex assembly GO:0043254
Any process that modulates the frequency, rate or extent of protein complex assembly.
|
1 | Q3UHC7 (/ISO) |
|
Regulation of protein complex assembly GO:0043254
Any process that modulates the frequency, rate or extent of protein complex assembly.
|
1 | Q6P730 (/ISS) |
|
Negative regulation of MAP kinase activity GO:0043407
Any process that stops, prevents, or reduces the frequency, rate or extent of MAP kinase activity.
|
1 | Q3UHC7 (/ISO) |
|
Regulation of MAPK cascade GO:0043408
Any process that modulates the frequency, rate or extent of signal transduction mediated by the MAP kinase (MAPK) cascade.
|
1 | F6SEU4 (/IMP) |
|
Positive regulation of MAPK cascade GO:0043410
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the MAPK cascade.
|
1 | Q3UHC7 (/ISO) |
|
Regulation of protein heterodimerization activity GO:0043497
Any process that modulates the frequency, rate or extent of protein heterodimerization, interacting selectively with a nonidentical protein to form a heterodimer.
|
1 | Q3UHC7 (/ISO) |
|
Positive regulation of JUN kinase activity GO:0043507
Any process that activates or increases the frequency, rate or extent of JUN kinase activity.
|
1 | Q3UHC7 (/IMP) |
|
Positive regulation of JUN kinase activity GO:0043507
Any process that activates or increases the frequency, rate or extent of JUN kinase activity.
|
1 | Q3UHC7 (/ISO) |
|
Negative regulation of neuron apoptotic process GO:0043524
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process in neurons.
|
1 | F6SEU4 (/IMP) |
|
Negative regulation of phosphatidylinositol 3-kinase activity GO:0043553
Any process that stops, prevents, or reduces the frequency, rate or extent of phosphatidylinositol 3-kinase activity.
|
1 | Q3UHC7 (/ISO) |
|
Cellular protein catabolic process GO:0044257
The chemical reactions and pathways resulting in the breakdown of a protein by individual cells.
|
1 | Q3UHC7 (/ISO) |
|
Positive regulation of protein catabolic process GO:0045732
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds.
|
1 | Q3UHC7 (/IMP) |
|
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
|
1 | Q3UHC7 (/ISO) |
|
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
1 | Q3UHC7 (/ISO) |
|
Positive regulation of JNK cascade GO:0046330
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the JNK cascade.
|
1 | Q3UHC7 (/ISO) |
|
Negative regulation of fibroblast proliferation GO:0048147
Any process that stops, prevents, or reduces the frequency, rate or extent of multiplication or reproduction of fibroblast cells.
|
1 | Q3UHC7 (/IMP) |
|
Regulation of synaptic plasticity GO:0048167
A process that modulates synaptic plasticity, the ability of synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers.
|
1 | Q9QUH6 (/IDA) |
|
Regulation of synaptic plasticity GO:0048167
A process that modulates synaptic plasticity, the ability of synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers.
|
1 | F6SEU4 (/ISO) |
|
Regulation of long-term neuronal synaptic plasticity GO:0048169
A process that modulates long-term neuronal synaptic plasticity, the ability of neuronal synapses to change long-term as circumstances require. Long-term neuronal synaptic plasticity generally involves increase or decrease in actual synapse numbers.
|
1 | F6SEU4 (/IGI) |
|
Regulation of long-term neuronal synaptic plasticity GO:0048169
A process that modulates long-term neuronal synaptic plasticity, the ability of neuronal synapses to change long-term as circumstances require. Long-term neuronal synaptic plasticity generally involves increase or decrease in actual synapse numbers.
|
1 | F6SEU4 (/IMP) |
|
Neuron projection morphogenesis GO:0048812
The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites.
|
1 | Q3UHC7 (/IMP) |
|
Negative regulation of epithelial cell proliferation GO:0050680
Any process that stops, prevents or reduces the rate or extent of epithelial cell proliferation.
|
1 | Q3UHC7 (/ISO) |
|
Negative regulation of axonogenesis GO:0050771
Any process that stops, prevents, or reduces the frequency, rate or extent of axonogenesis.
|
1 | F6SEU4 (/IDA) |
|
Regulation of synapse structure or activity GO:0050803
Any process that modulates the physical form or the activity of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell).
|
1 | F6SEU4 (/IMP) |
|
Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress GO:0070059
A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced in response to a stimulus indicating endoplasmic reticulum (ER) stress, and ends when the execution phase of apoptosis is triggered. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen.
|
1 | Q3UHC7 (/IMP) |
|
Negative regulation of G0 to G1 transition GO:0070317
A cell cycle process that stops, prevents, or reduces the rate or extent of the transition from the G0 quiescent state to the G1 phase.
|
1 | Q3UHC7 (/ISO) |
|
Negative regulation of ERK1 and ERK2 cascade GO:0070373
Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
|
1 | Q3UHC7 (/ISO) |
|
Positive regulation of cell cycle arrest GO:0071158
Any process that increases the rate, frequency, or extent of cell cycle arrest, the process in which the cell cycle is halted during one of the normal phases.
|
1 | Q3UHC7 (/ISO) |
|
Cellular response to lipopolysaccharide GO:0071222
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.
|
1 | Q3UHC7 (/ISO) |
|
Cellular response to lipopolysaccharide GO:0071222
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.
|
1 | Q6P730 (/ISS) |
|
Cellular response to interleukin-1 GO:0071347
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-1 stimulus.
|
1 | Q3UHC7 (/ISO) |
|
Cellular response to interleukin-1 GO:0071347
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-1 stimulus.
|
1 | Q6P730 (/ISS) |
|
Cellular response to tumor necrosis factor GO:0071356
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tumor necrosis factor stimulus.
|
1 | Q3UHC7 (/IMP) |
|
Cellular response to tumor necrosis factor GO:0071356
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tumor necrosis factor stimulus.
|
1 | Q3UHC7 (/ISO) |
|
Cellular response to tumor necrosis factor GO:0071356
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tumor necrosis factor stimulus.
|
1 | Q6P730 (/ISS) |
|
Cellular response to epidermal growth factor stimulus GO:0071364
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an epidermal growth factor stimulus.
|
1 | Q6P730 (/IDA) |
|
Cellular response to epidermal growth factor stimulus GO:0071364
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an epidermal growth factor stimulus.
|
1 | Q3UHC7 (/ISO) |
|
Negative regulation of protein serine/threonine kinase activity GO:0071901
Any process that decreases the rate, frequency, or extent of protein serine/threonine kinase activity.
|
1 | Q3UHC7 (/ISO) |
|
Negative regulation of protein serine/threonine kinase activity GO:0071901
Any process that decreases the rate, frequency, or extent of protein serine/threonine kinase activity.
|
1 | Q6P730 (/ISS) |
|
Positive regulation of protein serine/threonine kinase activity GO:0071902
Any process that increases the rate, frequency, or extent of protein serine/threonine kinase activity.
|
1 | Q3UHC7 (/ISO) |
|
Positive regulation of protein serine/threonine kinase activity GO:0071902
Any process that increases the rate, frequency, or extent of protein serine/threonine kinase activity.
|
1 | Q6P730 (/ISS) |
|
Negative regulation of canonical Wnt signaling pathway GO:0090090
Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes.
|
1 | Q3UHC7 (/ISO) |
|
Positive regulation of synapse maturation GO:0090129
Any process that increases the extent of synapse maturation, the process that organizes a synapse so that it attains its fully functional state.
|
1 | Q3UHC7 (/IMP) |
|
Maintenance of postsynaptic specialization structure GO:0098880
A process which maintains the organization and the arrangement of proteins in the presynaptic specialization.
|
1 | F6SEU4 (/IDA) |
|
Maintenance of postsynaptic specialization structure GO:0098880
A process which maintains the organization and the arrangement of proteins in the presynaptic specialization.
|
1 | F6SEU4 (/IMP) |
|
Positive regulation of dendrite development GO:1900006
Any process that activates or increases the frequency, rate or extent of dendrite development.
|
1 | Q3UHC7 (/IMP) |
|
Regulation of p38MAPK cascade GO:1900744
Any process that modulates the frequency, rate or extent of p38MAPK cascade.
|
1 | Q3UHC7 (/IMP) |
|
Negative regulation of vascular endothelial growth factor signaling pathway GO:1900747
Any process that stops, prevents or reduces the frequency, rate or extent of vascular endothelial growth factor signaling pathway.
|
1 | Q3UHC7 (/IDA) |
|
Positive regulation of proteasomal protein catabolic process GO:1901800
Any process that activates or increases the frequency, rate or extent of proteasomal protein catabolic process.
|
1 | Q3UHC7 (/ISO) |
|
Negative regulation of cellular protein catabolic process GO:1903363
Any process that stops, prevents or reduces the frequency, rate or extent of cellular protein catabolic process.
|
1 | Q3UHC7 (/ISO) |
|
Positive regulation of neuron migration GO:2001224
Any process that activates or increases the frequency, rate or extent of neuron migration.
|
1 | Q3UHC7 (/IMP) |
|
Positive regulation of apoptotic signaling pathway GO:2001235
Any process that activates or increases the frequency, rate or extent of apoptotic signaling pathway.
|
1 | Q3UHC7 (/ISO) |
There are 36 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
9 | Q5VWQ8 (/TAS) Q5VWQ8 (/TAS) Q96PV0 (/TAS) Q96PV0 (/TAS) Q96PV0 (/TAS) Q96PV0 (/TAS) Q96PV0 (/TAS) Q96PV0 (/TAS) Q9UJF2 (/TAS) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
3 | Q3UHC7 (/IDA) Q5VWQ8 (/IDA) Q5VWQ8 (/IDA) |
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
3 | Q3UHC7 (/IDA) Q5VWQ8 (/IDA) Q5VWQ8 (/IDA) |
|
Axon GO:0030424
The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
|
3 | Q5VWQ8 (/ISS) Q5VWQ8 (/ISS) Q6P730 (/ISS) |
|
Neuronal cell body membrane GO:0032809
The plasma membrane of a neuron cell body - excludes the plasma membrane of cell projections such as axons and dendrites.
|
3 | Q5VWQ8 (/ISS) Q5VWQ8 (/ISS) Q6P730 (/ISS) |
|
Neuronal cell body GO:0043025
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
|
3 | Q5VWQ8 (/ISS) Q5VWQ8 (/ISS) Q6P730 (/ISS) |
|
Cerebellar mossy fiber GO:0044300
An axon arising from cerebellar projecting cells in the cochlea, vestibular nuclei, spinal cord, reticular formation, cerebellar nuclei and basilar pontine nuclei. Mossy fibers enter through all three cerebellar peduncles and send collaterals to the deep cerebellar nuclei, then branch in the white matter and terminate in the granule cell layer. Through this branching, a given mossy fiber can innervate several folia. Mossy fibers synapse on granule cells. The synaptic contacts are made at enlargements along the length of the mossy fiber called mossy fiber rosettes. The enlargements of the rosettes give the axons as \mossy\ appearance in Golgi stained preparations.
|
3 | Q5VWQ8 (/ISS) Q5VWQ8 (/ISS) Q6P730 (/ISS) |
|
Climbing fiber GO:0044301
The axon of inferior olive neuron that projects to the cerebellar cortex, largely via the inferior cerebellar peduncle. They range in diameter from 1-3 um and are myelinated until they enter the granule cell layer. They give off collaterals to the deep cerebellar nuclei. They synapse extensively with the dendrites of Purkinje cells in the molecular layer, where each fiber branches repeatedly to \climb\ along the Purkinje cell dendritic tree. Each Purkinje cell is innervated by only a single climbing fiber.
|
3 | Q5VWQ8 (/ISS) Q5VWQ8 (/ISS) Q6P730 (/ISS) |
|
Parallel fiber GO:1990032
A parallel fiber results from the bifurcation of a cerebellar granule cell axon in the molecular layer into two diametrically opposed branches, that are oriented parallel to the long axis of the folium.
|
3 | Q5VWQ8 (/ISS) Q5VWQ8 (/ISS) Q6P730 (/ISS) |
|
Postsynaptic density GO:0014069
An electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymmetric, neuron-neuron synapse. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components.
|
2 | F6SEU4 (/IDA) Q9QUH6 (/IDA) |
|
Endocytic vesicle GO:0030139
A membrane-bounded intracellular vesicle formed by invagination of the plasma membrane around an extracellular substance. Endocytic vesicles fuse with early endosomes to deliver the cargo for further sorting.
|
2 | Q5VWQ8 (/IDA) Q5VWQ8 (/IDA) |
|
Endocytic vesicle GO:0030139
A membrane-bounded intracellular vesicle formed by invagination of the plasma membrane around an extracellular substance. Endocytic vesicles fuse with early endosomes to deliver the cargo for further sorting.
|
2 | Q3UHC7 (/ISS) Q6P730 (/ISS) |
|
Glutamatergic synapse GO:0098978
A synapse that uses glutamate as a neurotransmitter.
|
2 | F6SEU4 (/IDA) Q9QUH6 (/IDA) |
|
AIP1-IRE1 complex GO:1990597
A protein complex consisting of IRE1 (inositol-requiring enzyme-1) bound to AIP1 (ASK1-interacting protein 1/DAB2-interacting protein).
|
2 | Q5VWQ8 (/IDA) Q5VWQ8 (/IDA) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
1 | Q3UHC7 (/ISO) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
1 | Q6P730 (/ISS) |
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
1 | Q3UHC7 (/ISO) |
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
1 | Q6P730 (/ISS) |
|
Postsynaptic density GO:0014069
An electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymmetric, neuron-neuron synapse. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components.
|
1 | F6SEU4 (/ISO) |
|
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
|
1 | F6SEU4 (/IDA) |
|
Endocytic vesicle GO:0030139
A membrane-bounded intracellular vesicle formed by invagination of the plasma membrane around an extracellular substance. Endocytic vesicles fuse with early endosomes to deliver the cargo for further sorting.
|
1 | Q3UHC7 (/ISO) |
|
Axon GO:0030424
The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
|
1 | Q3UHC7 (/IDA) |
|
Neuronal cell body membrane GO:0032809
The plasma membrane of a neuron cell body - excludes the plasma membrane of cell projections such as axons and dendrites.
|
1 | Q3UHC7 (/IDA) |
|
Neuronal cell body GO:0043025
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
|
1 | Q3UHC7 (/IDA) |
|
Dendritic shaft GO:0043198
Cylindric portion of the dendrite, directly stemming from the perikaryon, and carrying the dendritic spines.
|
1 | F6SEU4 (/IDA) |
|
Cerebellar mossy fiber GO:0044300
An axon arising from cerebellar projecting cells in the cochlea, vestibular nuclei, spinal cord, reticular formation, cerebellar nuclei and basilar pontine nuclei. Mossy fibers enter through all three cerebellar peduncles and send collaterals to the deep cerebellar nuclei, then branch in the white matter and terminate in the granule cell layer. Through this branching, a given mossy fiber can innervate several folia. Mossy fibers synapse on granule cells. The synaptic contacts are made at enlargements along the length of the mossy fiber called mossy fiber rosettes. The enlargements of the rosettes give the axons as \mossy\ appearance in Golgi stained preparations.
|
1 | Q3UHC7 (/IDA) |
|
Climbing fiber GO:0044301
The axon of inferior olive neuron that projects to the cerebellar cortex, largely via the inferior cerebellar peduncle. They range in diameter from 1-3 um and are myelinated until they enter the granule cell layer. They give off collaterals to the deep cerebellar nuclei. They synapse extensively with the dendrites of Purkinje cells in the molecular layer, where each fiber branches repeatedly to \climb\ along the Purkinje cell dendritic tree. Each Purkinje cell is innervated by only a single climbing fiber.
|
1 | Q3UHC7 (/IDA) |
|
Synapse GO:0045202
The junction between a nerve fiber of one neuron and another neuron, muscle fiber or glial cell. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.
|
1 | Q9QUH6 (/IDA) |
|
Synapse GO:0045202
The junction between a nerve fiber of one neuron and another neuron, muscle fiber or glial cell. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.
|
1 | F6SEU4 (/ISO) |
|
Glutamatergic synapse GO:0098978
A synapse that uses glutamate as a neurotransmitter.
|
1 | F6SEU4 (/IMP) |
|
Glutamatergic synapse GO:0098978
A synapse that uses glutamate as a neurotransmitter.
|
1 | F6SEU4 (/ISO) |
|
Postsynaptic density, intracellular component GO:0099092
A network of proteins adjacent to the postsynaptic membrane forming an electron dense disc. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize neurotransmitter receptors in the adjacent membrane, such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components.
|
1 | Q9QUH6 (/IDA) |
|
Postsynaptic density, intracellular component GO:0099092
A network of proteins adjacent to the postsynaptic membrane forming an electron dense disc. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize neurotransmitter receptors in the adjacent membrane, such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components.
|
1 | F6SEU4 (/ISO) |
|
Parallel fiber GO:1990032
A parallel fiber results from the bifurcation of a cerebellar granule cell axon in the molecular layer into two diametrically opposed branches, that are oriented parallel to the long axis of the folium.
|
1 | Q3UHC7 (/IDA) |
|
AIP1-IRE1 complex GO:1990597
A protein complex consisting of IRE1 (inositol-requiring enzyme-1) bound to AIP1 (ASK1-interacting protein 1/DAB2-interacting protein).
|
1 | Q3UHC7 (/IPI) |
|
AIP1-IRE1 complex GO:1990597
A protein complex consisting of IRE1 (inositol-requiring enzyme-1) bound to AIP1 (ASK1-interacting protein 1/DAB2-interacting protein).
|
1 | Q3UHC7 (/ISO) |