The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"PCRA; domain 4
".
FunFam 20: DNA helicase
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 3 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
2 | P12954 (/IPI) P12954 (/IPI) |
|
Enzyme activator activity GO:0008047
Binds to and increases the activity of an enzyme.
|
2 | P12954 (/IDA) P12954 (/IDA) |
|
3'-5' DNA helicase activity GO:0043138
Catalysis of the reaction: ATP + H2O = ADP + phosphate; drives the unwinding of the DNA helix in the direction 3' to 5'.
|
2 | P12954 (/IDA) P12954 (/IDA) |
There are 8 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
DNA repair GO:0006281
The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.
|
2 | P12954 (/IGI) P12954 (/IGI) |
|
Double-strand break repair via nonhomologous end joining GO:0006303
The repair of a double-strand break in DNA in which the two broken ends are rejoined with little or no sequence complementarity. Information at the DNA ends may be lost due to the modification of broken DNA ends. This term covers instances of separate pathways, called classical (or canonical) and alternative nonhomologous end joining (C-NHEJ and A-NHEJ). These in turn may further branch into sub-pathways, but evidence is still unclear.
|
2 | P12954 (/IDA) P12954 (/IDA) |
|
Positive regulation of endodeoxyribonuclease activity GO:0032079
Any process that activates or increases the frequency, rate or extent of endodeoxyribonuclease activity, the hydrolysis of ester linkages within deoxyribonucleic acid by creating internal breaks.
|
2 | P12954 (/IDA) P12954 (/IDA) |
|
DNA duplex unwinding GO:0032508
The process in which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating a region of unpaired single strands.
|
2 | P12954 (/IDA) P12954 (/IDA) |
|
Negative regulation of DNA recombination GO:0045910
Any process that stops, prevents, or reduces the frequency, rate or extent of DNA recombination.
|
2 | P12954 (/IMP) P12954 (/IMP) |
|
DNA recombinase disassembly GO:1990986
The disaggregation of a DNA recombinase complex into its constituent strand exchange proteins (recombinases).
|
2 | P12954 (/IDA) P12954 (/IDA) |
|
DNA recombinase disassembly GO:1990986
The disaggregation of a DNA recombinase complex into its constituent strand exchange proteins (recombinases).
|
2 | P12954 (/IMP) P12954 (/IMP) |
|
Negative regulation of double-strand break repair via homologous recombination GO:2000042
Any process that stops, prevents, or reduces the frequency, rate or extent of double-strand break repair via homologous recombination.
|
2 | P12954 (/IDA) P12954 (/IDA) |
There are 1 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
2 | P12954 (/IDA) P12954 (/IDA) |