The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"DNA breaking-rejoining enzymes
".
FunFam 1: zinc finger protein 263 isoform X1
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 38 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
|
34 |
O14709 (/ISA)
O14978 (/ISA)
O60304 (/ISA)
O95125 (/ISA)
O95125 (/ISA)
P17022 (/ISA)
P17028 (/ISA)
P17040 (/ISA)
P28698 (/ISA)
P28698 (/ISA)
(24 more) |
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
29 |
A0A087WUM8 (/IPI)
O14978 (/IPI)
O95125 (/IPI)
O95125 (/IPI)
P17022 (/IPI)
P17028 (/IPI)
P28698 (/IPI)
P28698 (/IPI)
Q16670 (/IPI)
Q3URR7 (/IPI)
(19 more) |
|
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
|
15 |
A1YGJ4 (/ISS)
A2T7D7 (/ISS)
P17028 (/ISS)
Q5RAE6 (/ISS)
Q5RAE6 (/ISS)
Q5RAE6 (/ISS)
Q5RAE6 (/ISS)
Q5RAE6 (/ISS)
Q5RAE6 (/ISS)
Q5RAE6 (/ISS)
(5 more) |
|
RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978
Interacting selectively and non-covalently with a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in the proximal promoter of a gene transcribed by RNA polymerase II. The proximal promoter is in cis with and relatively close to the core promoter.
|
13 |
A1L358 (/ISO)
E9Q2D3 (/ISO)
F6VC78 (/ISO)
O70162 (/ISO)
Q07231 (/ISO)
Q6P9Q8 (/ISO)
Q8C879 (/ISO)
Q8K4N4 (/ISO)
Q91VW9 (/ISO)
Q99PG8 (/ISO)
(3 more) |
|
DNA-binding transcription repressor activity, RNA polymerase II-specific GO:0001227
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to repress or decrease transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
|
12 |
A1L358 (/ISO)
E9Q2D3 (/ISO)
F6VC78 (/ISO)
O70162 (/ISO)
Q6P9Q8 (/ISO)
Q8C879 (/ISO)
Q8K4N4 (/ISO)
Q91VW9 (/ISO)
Q99PG8 (/ISO)
Q99PG9 (/ISO)
(2 more) |
|
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
|
11 |
O14709 (/NAS)
O95125 (/NAS)
O95125 (/NAS)
P17028 (/NAS)
P28698 (/NAS)
P28698 (/NAS)
Q15697 (/NAS)
Q8N0Y2 (/NAS)
Q8N0Y2 (/NAS)
Q96GC6 (/NAS)
(1 more) |
|
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
|
10 | A1L358 (/ISO) B9EJW5 (/ISO) F6VC78 (/ISO) O70162 (/ISO) Q6P9Q8 (/ISO) Q7TNK4 (/ISO) Q8K4N4 (/ISO) Q9CSE2 (/ISO) S4R1C2 (/ISO) S4R1L6 (/ISO) |
|
DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to activate or increase transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
|
9 | A1L358 (/ISO) F6VC78 (/ISO) O70162 (/ISO) Q07231 (/ISO) Q6P9Q8 (/ISO) Q8K4N4 (/ISO) Q91VN1 (/ISO) S4R1C2 (/ISO) S4R1L6 (/ISO) |
|
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
|
9 | B9EJW5 (/ISO) E0CZ03 (/ISO) Q7TMI6 (/ISO) Q8CF60 (/ISO) Q8K439 (/ISO) Q91VN1 (/ISO) Q91VW9 (/ISO) Q921B4 (/ISO) Q923B3 (/ISO) |
|
Transcription regulatory region DNA binding GO:0044212
Interacting selectively and non-covalently with a DNA region that regulates the transcription of a region of DNA, which may be a gene, cistron, or operon. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors.
|
8 | A1L358 (/ISO) B9EJW5 (/ISO) F6VC78 (/ISO) O70162 (/ISO) Q6P9Q8 (/ISO) Q8K4N4 (/ISO) S4R1C2 (/ISO) S4R1L6 (/ISO) |
|
RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978
Interacting selectively and non-covalently with a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in the proximal promoter of a gene transcribed by RNA polymerase II. The proximal promoter is in cis with and relatively close to the core promoter.
|
7 | O95125 (/IDA) O95125 (/IDA) P28698 (/IDA) P28698 (/IDA) Q9BRR0 (/IDA) Q9Y5A6 (/IDA) Q9Y5A6 (/IDA) |
|
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
|
7 | O14709 (/TAS) O14978 (/TAS) O95125 (/TAS) O95125 (/TAS) Q3URR7 (/TAS) Q91VN1 (/TAS) Q96GC6 (/TAS) |
|
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
|
7 | E9Q6F9 (/ISO) G3X9U2 (/ISO) Q149D4 (/ISO) Q149D5 (/ISO) Q3UQ55 (/ISO) Q80Y64 (/ISO) Q8C9M8 (/ISO) |
|
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
|
7 | O14978 (/IDA) P17028 (/IDA) Q15697 (/IDA) Q3URR7 (/IDA) Q91VN1 (/IDA) Q96GC6 (/IDA) Q9BRR0 (/IDA) |
|
DNA-binding transcription repressor activity, RNA polymerase II-specific GO:0001227
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to repress or decrease transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
|
5 | O95125 (/IDA) O95125 (/IDA) P28698 (/IDA) P28698 (/IDA) Q9BRR0 (/IDA) |
|
DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to activate or increase transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
|
5 | P17028 (/IDA) P28698 (/IDA) P28698 (/IDA) Q9Y5A6 (/IDA) Q9Y5A6 (/IDA) |
|
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
|
5 | B9EJW5 (/ISS) D3ZNW1 (/ISS) Q3SZL2 (/ISS) Q91VW9 (/ISS) Q96SZ4 (/ISS) |
|
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
|
4 | P28698 (/NAS) P28698 (/NAS) Q07644 (/NAS) Q16670 (/NAS) |
|
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
|
3 | Q07231 (/IDA) Q5SXI5 (/IDA) Q9BRR0 (/IDA) |
|
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
|
3 | Q91VW9 (/ISS) Q96IT1 (/ISS) Q96IT1 (/ISS) |
|
Chromatin binding GO:0003682
Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
|
3 | Q91VW9 (/ISO) Q921B4 (/ISO) Q923B3 (/ISO) |
|
Chromatin binding GO:0003682
Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
|
3 | A6QPT6 (/ISS) Q4R8H9 (/ISS) Q91VW9 (/ISS) |
|
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
|
3 | Q969J2 (/IPI) Q969J2 (/IPI) Q96JS3 (/IPI) |
|
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
|
3 | P28698 (/IPI) P28698 (/IPI) Q15697 (/IPI) |
|
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
|
3 | B9EJW5 (/ISS) D3ZNW1 (/ISS) Q3SZL2 (/ISS) |
|
Transcription regulatory region DNA binding GO:0044212
Interacting selectively and non-covalently with a DNA region that regulates the transcription of a region of DNA, which may be a gene, cistron, or operon. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors.
|
3 | P28698 (/IDA) P28698 (/IDA) Q15697 (/IDA) |
|
Transcription regulatory region DNA binding GO:0044212
Interacting selectively and non-covalently with a DNA region that regulates the transcription of a region of DNA, which may be a gene, cistron, or operon. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors.
|
3 | B9EJW5 (/ISS) D3ZNW1 (/ISS) Q3SZL2 (/ISS) |
|
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
|
2 | P17040 (/ISM) Q63HK3 (/ISM) |
|
DNA-binding transcription repressor activity, RNA polymerase II-specific GO:0001227
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to repress or decrease transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
|
2 | O14978 (/IC) Q15697 (/IC) |
|
Chromatin binding GO:0003682
Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
|
2 | Q96GC6 (/IDA) Q9BRR0 (/IDA) |
|
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
|
2 | Q15697 (/IDA) Q9BRR0 (/IDA) |
|
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
|
2 | B9EJW5 (/ISO) Q91VW9 (/ISO) |
|
Neurotrophin p75 receptor binding GO:0005166
Interacting selectively and non-covalently with the neurotrophin p75 receptor.
|
2 | Q921B4 (/IPI) Q923B3 (/IPI) |
|
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
|
2 | Q7TNK4 (/ISO) Q9CSE2 (/ISO) |
|
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
|
1 | Q91VW9 (/ISO) |
|
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
|
1 | Q3URR7 (/IMP) |
|
Transcription corepressor activity GO:0003714
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to repress the transcription of specific genes. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. A third class occludes DNA-binding transcription factor protein-protein interaction domains. A fourth class of corepressors prevents interactions of DNA bound DNA-binding transcription factor with coactivators.
|
1 | Q96GC6 (/TAS) |
|
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
|
1 | P17028 (/NAS) |
There are 42 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
17 |
A1L358 (/ISO)
B9EJW5 (/ISO)
E0CZ03 (/ISO)
E9Q2D3 (/ISO)
F6VC78 (/ISO)
O70162 (/ISO)
Q6P9Q8 (/ISO)
Q7TMI6 (/ISO)
Q8C879 (/ISO)
Q8CF60 (/ISO)
(7 more) |
|
Myelination GO:0042552
The process in which myelin sheaths are formed and maintained around neurons. Oligodendrocytes in the brain and spinal cord and Schwann cells in the peripheral nervous system wrap axons with compact layers of their plasma membrane. Adjacent myelin segments are separated by a non-myelinated stretch of axon called a node of Ranvier.
|
11 |
A1YGJ4 (/ISS)
A2T7D7 (/ISS)
P17028 (/ISS)
Q5RAE6 (/ISS)
Q5RAE6 (/ISS)
Q5RAE6 (/ISS)
Q5RAE6 (/ISS)
Q5RAE6 (/ISS)
Q5RAE6 (/ISS)
Q5RAE6 (/ISS)
(1 more) |
|
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
9 | A1L358 (/ISO) F6VC78 (/ISO) O70162 (/ISO) Q07231 (/ISO) Q6P9Q8 (/ISO) Q8K4N4 (/ISO) Q91VN1 (/ISO) S4R1C2 (/ISO) S4R1L6 (/ISO) |
|
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
|
8 | A1L358 (/ISO) F6VC78 (/ISO) O70162 (/ISO) Q07231 (/ISO) Q6P9Q8 (/ISO) Q8K4N4 (/ISO) S4R1C2 (/ISO) S4R1L6 (/ISO) |
|
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
7 | O14978 (/IDA) O95125 (/IDA) O95125 (/IDA) P28698 (/IDA) P28698 (/IDA) Q15697 (/IDA) Q9BRR0 (/IDA) |
|
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
|
5 | B9EJW5 (/ISO) Q7TNK4 (/ISO) Q91VN1 (/ISO) Q91VW9 (/ISO) Q9CSE2 (/ISO) |
|
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
|
5 | B9EJW5 (/ISS) D3ZNW1 (/ISS) Q3SZL2 (/ISS) Q91VW9 (/ISS) Q96SZ4 (/ISS) |
|
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
5 | P17028 (/IDA) P28698 (/IDA) P28698 (/IDA) Q9Y5A6 (/IDA) Q9Y5A6 (/IDA) |
|
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
|
4 | O14978 (/TAS) P28698 (/TAS) P28698 (/TAS) Q96GC6 (/TAS) |
|
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
|
4 | Q07231 (/IDA) Q5SXI5 (/IDA) Q9BRR0 (/IDA) Q9EQB9 (/IDA) |
|
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
3 | B9EJW5 (/ISS) D3ZNW1 (/ISS) Q3SZL2 (/ISS) |
|
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
|
3 | P17028 (/IDA) Q15697 (/IDA) Q9BRR0 (/IDA) |
|
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
|
3 | Q91VW9 (/ISS) Q96IT1 (/ISS) Q96IT1 (/ISS) |
|
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
2 | O95125 (/TAS) O95125 (/TAS) |
|
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
|
2 | P28698 (/IDA) P28698 (/IDA) |
|
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
|
2 | Q9Y5A6 (/IMP) Q9Y5A6 (/IMP) |
|
Transcription by RNA polymerase II GO:0006366
The synthesis of RNA from a DNA template by RNA polymerase II (RNAP II), originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs).
|
2 | O95125 (/TAS) O95125 (/TAS) |
|
Lipid metabolic process GO:0006629
The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids.
|
2 | O95125 (/TAS) O95125 (/TAS) |
|
Spermatogonial cell division GO:0007284
The mitotic divisions of the primary spermatogonial cell (a primordial male germ cell) to form secondary spermatogonia (primary spermatocytes).
|
2 | Q8CB76 (/IDA) Q9CTS7 (/IDA) |
|
Regulation of histone H3-K9 trimethylation GO:1900112
Any process that modulates the frequency, rate or extent of histone H3-K9 trimethylation.
|
2 | A6QPT6 (/ISS) Q4R8H9 (/ISS) |
|
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
|
1 | Q16670 (/NAS) |
|
Lysosome organization GO:0007040
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lysosome. A lysosome is a cytoplasmic, membrane-bounded organelle that is found in most animal cells and that contains a variety of hydrolases.
|
1 | Q9BRR0 (/IMP) |
|
Lysosome organization GO:0007040
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lysosome. A lysosome is a cytoplasmic, membrane-bounded organelle that is found in most animal cells and that contains a variety of hydrolases.
|
1 | Q91VW9 (/ISO) |
|
Lysosome organization GO:0007040
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lysosome. A lysosome is a cytoplasmic, membrane-bounded organelle that is found in most animal cells and that contains a variety of hydrolases.
|
1 | Q91VW9 (/ISS) |
|
Negative regulation of autophagy GO:0010507
Any process that stops, prevents, or reduces the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm.
|
1 | Q9BRR0 (/IMP) |
|
Negative regulation of autophagy GO:0010507
Any process that stops, prevents, or reduces the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm.
|
1 | Q91VW9 (/ISO) |
|
Negative regulation of autophagy GO:0010507
Any process that stops, prevents, or reduces the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm.
|
1 | Q91VW9 (/ISS) |
|
Somatic stem cell population maintenance GO:0035019
Any process by which an organism retains a population of somatic stem cells, undifferentiated cells in the embryo or adult which can undergo unlimited division and give rise to cell types of the body other than those of the germ-line.
|
1 | Q96SZ4 (/TAS) |
|
Regulation of cytokine biosynthetic process GO:0042035
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cytokines.
|
1 | Q9EQB9 (/IDA) |
|
Myelination GO:0042552
The process in which myelin sheaths are formed and maintained around neurons. Oligodendrocytes in the brain and spinal cord and Schwann cells in the peripheral nervous system wrap axons with compact layers of their plasma membrane. Adjacent myelin segments are separated by a non-myelinated stretch of axon called a node of Ranvier.
|
1 | Q91VN1 (/IMP) |
|
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
|
1 | Q3URR7 (/IMP) |
|
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
|
1 | Q91VW9 (/ISO) |
|
Regulation of JNK cascade GO:0046328
Any process that modulates the frequency, rate or extent of signal transduction mediated by the JNK cascade.
|
1 | Q923B3 (/IMP) |
|
Stem cell differentiation GO:0048863
The process in which a relatively unspecialized cell acquires specialized features of a stem cell. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells.
|
1 | Q3URR7 (/TAS) |
|
Neuron apoptotic process GO:0051402
Any apoptotic process in a neuron, the basic cellular unit of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the nervous system.
|
1 | Q923B3 (/IMP) |
|
Regulation of cell cycle GO:0051726
Any process that modulates the rate or extent of progression through the cell cycle.
|
1 | Q921B4 (/IDA) |
|
Extrinsic apoptotic signaling pathway GO:0097191
A series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with either a ligand binding to a cell surface receptor, or a ligand being withdrawn from a cell surface receptor (e.g. in the case of signaling by dependence receptors), and ends when the execution phase of apoptosis is triggered.
|
1 | Q923B3 (/IMP) |
|
Regulation of histone H3-K9 trimethylation GO:1900112
Any process that modulates the frequency, rate or extent of histone H3-K9 trimethylation.
|
1 | Q96GC6 (/IMP) |
|
Retinal cell apoptotic process GO:1990009
Any apoptotic process in a retinal cell.
|
1 | Q923B3 (/IMP) |
|
Negative regulation of cellular senescence GO:2000773
Any process that stops, prevents or reduces the frequency, rate or extent of cellular senescence.
|
1 | Q9BRR0 (/IMP) |
|
Negative regulation of cellular senescence GO:2000773
Any process that stops, prevents or reduces the frequency, rate or extent of cellular senescence.
|
1 | Q91VW9 (/ISO) |
|
Negative regulation of cellular senescence GO:2000773
Any process that stops, prevents or reduces the frequency, rate or extent of cellular senescence.
|
1 | Q91VW9 (/ISS) |
There are 27 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
18 |
A1YGJ4 (/ISS)
A2T7D7 (/ISS)
B9EJW5 (/ISS)
D3ZNW1 (/ISS)
P17028 (/ISS)
Q3SZL2 (/ISS)
Q5RAE6 (/ISS)
Q5RAE6 (/ISS)
Q5RAE6 (/ISS)
Q5RAE6 (/ISS)
(8 more) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
15 |
A0A024R4T5 (/IDA)
A0A024R4T5 (/IDA)
I3L4J6 (/IDA)
O60304 (/IDA)
P17028 (/IDA)
P28698 (/IDA)
P28698 (/IDA)
Q07231 (/IDA)
Q3URR7 (/IDA)
Q5SXI5 (/IDA)
(5 more) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
13 |
A0A024RCN4 (/IDA)
A0A0S2Z658 (/IDA)
A0A0S2Z658 (/IDA)
I3L2H2 (/IDA)
I3L4J6 (/IDA)
O60304 (/IDA)
Q15697 (/IDA)
Q16670 (/IDA)
Q8NF99 (/IDA)
Q969J2 (/IDA)
(3 more) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
11 |
A1L358 (/ISO)
F6VC78 (/ISO)
O70162 (/ISO)
Q6P9Q8 (/ISO)
Q7TNK4 (/ISO)
Q8K4N4 (/ISO)
Q91VN1 (/ISO)
Q91VW9 (/ISO)
Q9CSE2 (/ISO)
S4R1C2 (/ISO)
(1 more) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
10 | A0A024RCN4 (/IDA) A0A0S2Z658 (/IDA) A0A0S2Z658 (/IDA) I3L2H2 (/IDA) O60304 (/IDA) Q15697 (/IDA) Q16670 (/IDA) Q969J2 (/IDA) Q969J2 (/IDA) Q9BRR0 (/IDA) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
5 | B9EJW5 (/ISO) Q5RJ54 (/ISO) Q7TNK4 (/ISO) Q91VW9 (/ISO) Q9CSE2 (/ISO) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
4 | B9EJW5 (/ISS) D3ZNW1 (/ISS) Q3SZL2 (/ISS) Q91VW9 (/ISS) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
3 | B9EJW5 (/ISO) Q5RJ54 (/ISO) Q91VW9 (/ISO) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
3 | Q921B4 (/IDA) Q923B3 (/IDA) Q9BRR0 (/IDA) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
3 | Q7TNK4 (/ISO) Q91VW9 (/ISO) Q9CSE2 (/ISO) |
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
3 | I3L2H2 (/IDA) Q15697 (/IDA) Q8NF99 (/IDA) |
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
3 | B9EJW5 (/ISO) Q7TNK4 (/ISO) Q9CSE2 (/ISO) |
|
Actin cytoskeleton GO:0015629
The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes.
|
3 | B9EJW5 (/ISS) D3ZNW1 (/ISS) Q3SZL2 (/ISS) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
2 | Q15697 (/NAS) Q16670 (/NAS) |
|
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
|
2 | Q7TNK4 (/ISO) Q9CSE2 (/ISO) |
|
Actin cytoskeleton GO:0015629
The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes.
|
2 | I3L2H2 (/IDA) Q15697 (/IDA) |
|
Microtubule cytoskeleton GO:0015630
The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins.
|
2 | Q7TNK4 (/ISO) Q9CSE2 (/ISO) |
|
Intracellular membrane-bounded organelle GO:0043231
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
|
2 | I3L4J6 (/IDA) Q9UNY5 (/IDA) |
|
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
|
1 | Q9NWS9 (/HDA) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
1 | P17028 (/IC) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
1 | Q96SZ4 (/TAS) |
|
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
|
1 | Q8NF99 (/IDA) |
|
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
|
1 | Q96GC6 (/TAS) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
1 | Q923B3 (/TAS) |
|
Actin cytoskeleton GO:0015629
The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes.
|
1 | B9EJW5 (/ISO) |
|
Microtubule cytoskeleton GO:0015630
The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins.
|
1 | Q8NF99 (/IDA) |
|
Nuclear body GO:0016604
Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins.
|
1 | Q3ZBY5 (/IDA) |