The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"GI Alpha 1, domain 2-like
".
FunFam 1: Guanine nucleotide-binding protein G(I) subunit al...
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 55 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
160 |
B2RSH2 (/IPI)
B2RSH2 (/IPI)
B2RSH2 (/IPI)
B2RSH2 (/IPI)
B2RSH2 (/IPI)
B2RSH2 (/IPI)
B2RSH2 (/IPI)
B2RSH2 (/IPI)
B2RSH2 (/IPI)
B2RSH2 (/IPI)
(150 more) |
GTPase activity GO:0003924
Catalysis of the reaction: GTP + H2O = GDP + phosphate.
|
146 |
B2RSH2 (/TAS)
B2RSH2 (/TAS)
B2RSH2 (/TAS)
B2RSH2 (/TAS)
B2RSH2 (/TAS)
B2RSH2 (/TAS)
B2RSH2 (/TAS)
B2RSH2 (/TAS)
B2RSH2 (/TAS)
B2RSH2 (/TAS)
(136 more) |
GDP binding GO:0019003
Interacting selectively and non-covalently with GDP, guanosine 5'-diphosphate.
|
130 |
B2RSH2 (/ISS)
B2RSH2 (/ISS)
B2RSH2 (/ISS)
B2RSH2 (/ISS)
B2RSH2 (/ISS)
B2RSH2 (/ISS)
B2RSH2 (/ISS)
B2RSH2 (/ISS)
B2RSH2 (/ISS)
B2RSH2 (/ISS)
(120 more) |
GTP binding GO:0005525
Interacting selectively and non-covalently with GTP, guanosine triphosphate.
|
127 |
B2RSH2 (/ISS)
B2RSH2 (/ISS)
B2RSH2 (/ISS)
B2RSH2 (/ISS)
B2RSH2 (/ISS)
B2RSH2 (/ISS)
B2RSH2 (/ISS)
B2RSH2 (/ISS)
B2RSH2 (/ISS)
B2RSH2 (/ISS)
(117 more) |
GTPase activity GO:0003924
Catalysis of the reaction: GTP + H2O = GDP + phosphate.
|
114 |
B2RSH2 (/ISS)
B2RSH2 (/ISS)
B2RSH2 (/ISS)
B2RSH2 (/ISS)
B2RSH2 (/ISS)
B2RSH2 (/ISS)
B2RSH2 (/ISS)
B2RSH2 (/ISS)
B2RSH2 (/ISS)
B2RSH2 (/ISS)
(104 more) |
Magnesium ion binding GO:0000287
Interacting selectively and non-covalently with magnesium (Mg) ions.
|
109 |
B2RSH2 (/ISS)
B2RSH2 (/ISS)
B2RSH2 (/ISS)
B2RSH2 (/ISS)
B2RSH2 (/ISS)
B2RSH2 (/ISS)
B2RSH2 (/ISS)
B2RSH2 (/ISS)
B2RSH2 (/ISS)
B2RSH2 (/ISS)
(99 more) |
G protein-coupled receptor binding GO:0001664
Interacting selectively and non-covalently with a G protein-coupled receptor.
|
109 |
B2RSH2 (/ISS)
B2RSH2 (/ISS)
B2RSH2 (/ISS)
B2RSH2 (/ISS)
B2RSH2 (/ISS)
B2RSH2 (/ISS)
B2RSH2 (/ISS)
B2RSH2 (/ISS)
B2RSH2 (/ISS)
B2RSH2 (/ISS)
(99 more) |
GTPase activity GO:0003924
Catalysis of the reaction: GTP + H2O = GDP + phosphate.
|
42 |
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
(32 more) |
GTP binding GO:0005525
Interacting selectively and non-covalently with GTP, guanosine triphosphate.
|
41 |
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
(31 more) |
G protein-coupled serotonin receptor binding GO:0031821
Interacting selectively and non-covalently with a metabotropic serotonin receptor.
|
37 |
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
(27 more) |
GTPase activating protein binding GO:0032794
Interacting selectively and non-covalently with a GTPase activating protein.
|
37 |
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
(27 more) |
GDP binding GO:0019003
Interacting selectively and non-covalently with GDP, guanosine 5'-diphosphate.
|
35 |
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
(25 more) |
Magnesium ion binding GO:0000287
Interacting selectively and non-covalently with magnesium (Mg) ions.
|
34 |
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
(24 more) |
G protein-coupled receptor binding GO:0001664
Interacting selectively and non-covalently with a G protein-coupled receptor.
|
34 |
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
(24 more) |
GTPase activity GO:0003924
Catalysis of the reaction: GTP + H2O = GDP + phosphate.
|
26 |
P08754 (/IDA)
P08754 (/IDA)
P08754 (/IDA)
P08754 (/IDA)
P08754 (/IDA)
P08754 (/IDA)
P08754 (/IDA)
P08754 (/IDA)
P08754 (/IDA)
P08754 (/IDA)
(16 more) |
GDP binding GO:0019003
Interacting selectively and non-covalently with GDP, guanosine 5'-diphosphate.
|
21 |
P04695 (/IDA)
P04695 (/IDA)
P04695 (/IDA)
P04695 (/IDA)
P04695 (/IDA)
P04695 (/IDA)
P04695 (/IDA)
P08754 (/IDA)
P08754 (/IDA)
P08754 (/IDA)
(11 more) |
GTP binding GO:0005525
Interacting selectively and non-covalently with GTP, guanosine triphosphate.
|
19 |
D3ZSS5 (/IDA)
P04695 (/IDA)
P04695 (/IDA)
P04695 (/IDA)
P04695 (/IDA)
P04695 (/IDA)
P04695 (/IDA)
P04695 (/IDA)
P10824 (/IDA)
P16378 (/IDA)
(9 more) |
Acyl binding GO:0000035
Interacting selectively and non-covalently with an acyl group, any group formally derived by removal of the hydroxyl group from the acid function of a carboxylic acid.
|
16 |
P11488 (/ISS)
P11488 (/ISS)
P11488 (/ISS)
P11488 (/ISS)
P11488 (/ISS)
P11488 (/ISS)
P11488 (/ISS)
P11488 (/ISS)
P11488 (/ISS)
P11488 (/ISS)
(6 more) |
GTPase activity GO:0003924
Catalysis of the reaction: GTP + H2O = GDP + phosphate.
|
16 |
P11488 (/NAS)
P11488 (/NAS)
P11488 (/NAS)
P11488 (/NAS)
P11488 (/NAS)
P11488 (/NAS)
P11488 (/NAS)
P11488 (/NAS)
P11488 (/NAS)
P11488 (/NAS)
(6 more) |
Protein kinase binding GO:0019901
Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
|
16 |
P11488 (/ISS)
P11488 (/ISS)
P11488 (/ISS)
P11488 (/ISS)
P11488 (/ISS)
P11488 (/ISS)
P11488 (/ISS)
P11488 (/ISS)
P11488 (/ISS)
P11488 (/ISS)
(6 more) |
GTP binding GO:0005525
Interacting selectively and non-covalently with GTP, guanosine triphosphate.
|
12 |
G1SEJ8 (/IMP)
G1TRG8 (/IMP)
P04695 (/IMP)
P04695 (/IMP)
P04695 (/IMP)
P04695 (/IMP)
P04695 (/IMP)
P04695 (/IMP)
P04695 (/IMP)
P10824 (/IMP)
(2 more) |
GDP binding GO:0019003
Interacting selectively and non-covalently with GDP, guanosine 5'-diphosphate.
|
8 | P04695 (/IMP) P04695 (/IMP) P04695 (/IMP) P04695 (/IMP) P04695 (/IMP) P04695 (/IMP) P04695 (/IMP) P10824 (/IMP) |
Acyl binding GO:0000035
Interacting selectively and non-covalently with an acyl group, any group formally derived by removal of the hydroxyl group from the acid function of a carboxylic acid.
|
7 | P04695 (/IDA) P04695 (/IDA) P04695 (/IDA) P04695 (/IDA) P04695 (/IDA) P04695 (/IDA) P04695 (/IDA) |
G protein-coupled receptor binding GO:0001664
Interacting selectively and non-covalently with a G protein-coupled receptor.
|
7 | P04695 (/IPI) P04695 (/IPI) P04695 (/IPI) P04695 (/IPI) P04695 (/IPI) P04695 (/IPI) P04695 (/IPI) |
Protein kinase binding GO:0019901
Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
|
7 | P04695 (/IDA) P04695 (/IDA) P04695 (/IDA) P04695 (/IDA) P04695 (/IDA) P04695 (/IDA) P04695 (/IDA) |
G protein-coupled serotonin receptor binding GO:0031821
Interacting selectively and non-covalently with a metabotropic serotonin receptor.
|
5 | P08753 (/IPI) P10824 (/IPI) P59215 (/IPI) P59215 (/IPI) P59215 (/IPI) |
GTP binding GO:0005525
Interacting selectively and non-covalently with GTP, guanosine triphosphate.
|
4 | P19087 (/NAS) P19087 (/NAS) P19087 (/NAS) P19087 (/NAS) |
G protein-coupled photoreceptor activity GO:0008020
Combining with incidental electromagnetic radiation, particularly visible light, and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
|
4 | P19087 (/NAS) P19087 (/NAS) P19087 (/NAS) P19087 (/NAS) |
GTPase activating protein binding GO:0032794
Interacting selectively and non-covalently with a GTPase activating protein.
|
4 | P08753 (/IPI) P59215 (/IPI) P59215 (/IPI) P59215 (/IPI) |
Signaling receptor binding GO:0005102
Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
|
3 | P59215 (/IPI) P59215 (/IPI) P59215 (/IPI) |
GDP binding GO:0019003
Interacting selectively and non-covalently with GDP, guanosine 5'-diphosphate.
|
3 | P59215 (/TAS) P59215 (/TAS) P59215 (/TAS) |
G-protein beta/gamma-subunit complex binding GO:0031683
Interacting selectively and non-covalently with a complex of G-protein beta/gamma subunits.
|
3 | P20612 (/IDA) P20612 (/IDA) P20612 (/IDA) |
Mu-type opioid receptor binding GO:0031852
Interacting selectively and non-covalently with a mu-type opioid receptor.
|
3 | P59215 (/IPI) P59215 (/IPI) P59215 (/IPI) |
Protein-containing complex binding GO:0044877
Interacting selectively and non-covalently with a macromolecular complex.
|
3 | P59215 (/IPI) P59215 (/IPI) P59215 (/IPI) |
Corticotropin-releasing hormone receptor 1 binding GO:0051430
Interacting selectively and non-covalently with the corticotropin-releasing hormone receptor 1 (CRHR1). CRHR1 is the major subtype in the pituitary corticotroph, and mediates the stimulatory actions of corticotropin-releasing hormone on corticotropin hormone secretion. CRHR1 are also located in cortical areas of the brain, cerebellum and limbic system.
|
3 | P59215 (/IPI) P59215 (/IPI) P59215 (/IPI) |
GTPase activity GO:0003924
Catalysis of the reaction: GTP + H2O = GDP + phosphate.
|
2 | P10824 (/IMP) Q00743 (/IMP) |
Signaling receptor binding GO:0005102
Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
|
2 | P18872 (/ISO) P18872 (/ISO) |
Mu-type opioid receptor binding GO:0031852
Interacting selectively and non-covalently with a mu-type opioid receptor.
|
2 | P18872 (/ISO) P18872 (/ISO) |
Protein-containing complex binding GO:0044877
Interacting selectively and non-covalently with a macromolecular complex.
|
2 | P18872 (/ISO) P18872 (/ISO) |
Corticotropin-releasing hormone receptor 1 binding GO:0051430
Interacting selectively and non-covalently with the corticotropin-releasing hormone receptor 1 (CRHR1). CRHR1 is the major subtype in the pituitary corticotroph, and mediates the stimulatory actions of corticotropin-releasing hormone on corticotropin hormone secretion. CRHR1 are also located in cortical areas of the brain, cerebellum and limbic system.
|
2 | P18872 (/ISO) P18872 (/ISO) |
Magnesium ion binding GO:0000287
Interacting selectively and non-covalently with magnesium (Mg) ions.
|
1 | P10824 (/IDA) |
Magnesium ion binding GO:0000287
Interacting selectively and non-covalently with magnesium (Mg) ions.
|
1 | P10824 (/IMP) |
G protein-coupled receptor binding GO:0001664
Interacting selectively and non-covalently with a G protein-coupled receptor.
|
1 | P10824 (/IDA) |
Opsin binding GO:0002046
Interacting selectively and non-covalently with an opsin, any of a group of hydrophobic, integral membrane glycoproteins located primarily in the disc membrane of rods or cones, involved in photoreception.
|
1 | Q9DG28 (/IPI) |
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
|
1 | P20353 (/IDA) |
GTPase activity GO:0003924
Catalysis of the reaction: GTP + H2O = GDP + phosphate.
|
1 | Q00743 (/ISA) |
GTP binding GO:0005525
Interacting selectively and non-covalently with GTP, guanosine triphosphate.
|
1 | P08752 (/ISA) |
G protein-coupled acetylcholine receptor activity GO:0016907
Combining with acetylcholine and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
|
1 | P51875 (/IGI) |
G protein-coupled acetylcholine receptor activity GO:0016907
Combining with acetylcholine and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
|
1 | P51875 (/IMP) |
Guanyl nucleotide binding GO:0019001
Interacting selectively and non-covalently with guanyl nucleotides, any compound consisting of guanosine esterified with (ortho)phosphate.
|
1 | Q00743 (/IMP) |
Protein kinase binding GO:0019901
Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
|
1 | P51875 (/IPI) |
Protein domain specific binding GO:0019904
Interacting selectively and non-covalently with a specific domain of a protein.
|
1 | P08753 (/IPI) |
Protein domain specific binding GO:0019904
Interacting selectively and non-covalently with a specific domain of a protein.
|
1 | Q9DC51 (/ISO) |
GTPase activating protein binding GO:0032794
Interacting selectively and non-covalently with a GTPase activating protein.
|
1 | P10824 (/IDA) |
Protein membrane anchor GO:0043495
Interacting selectively and non-covalently with both a protein or protein complex and a membrane, in order to maintain the localization of the protein at a specific membrane location.
|
1 | P51875 (/IPI) |
There are 192 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Response to light stimulus GO:0009416
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light.
|
180 |
A0A024R2Z1 (/ISS)
A0A024R2Z1 (/ISS)
A0A024R2Z1 (/ISS)
A0A024R2Z1 (/ISS)
A0A024R2Z1 (/ISS)
A0A024R2Z1 (/ISS)
A0A024R2Z1 (/ISS)
A0A024R2Z1 (/ISS)
A0A024R2Z1 (/ISS)
A0A024R2Z1 (/ISS)
(170 more) |
Protein folding GO:0006457
The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure.
|
118 |
A8MTJ3 (/TAS)
A8MTJ3 (/TAS)
A8MTJ3 (/TAS)
A8MTJ3 (/TAS)
A8MTJ3 (/TAS)
A8MTJ3 (/TAS)
A8MTJ3 (/TAS)
A8MTJ3 (/TAS)
A8MTJ3 (/TAS)
A8MTJ3 (/TAS)
(108 more) |
G protein-coupled receptor signaling pathway GO:0007186
A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576).
|
110 |
B2RSH2 (/ISS)
B2RSH2 (/ISS)
B2RSH2 (/ISS)
B2RSH2 (/ISS)
B2RSH2 (/ISS)
B2RSH2 (/ISS)
B2RSH2 (/ISS)
B2RSH2 (/ISS)
B2RSH2 (/ISS)
B2RSH2 (/ISS)
(100 more) |
G protein-coupled receptor signaling pathway GO:0007186
A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576).
|
109 |
A8MTJ3 (/TAS)
A8MTJ3 (/TAS)
A8MTJ3 (/TAS)
A8MTJ3 (/TAS)
A8MTJ3 (/TAS)
A8MTJ3 (/TAS)
A8MTJ3 (/TAS)
A8MTJ3 (/TAS)
A8MTJ3 (/TAS)
A8MTJ3 (/TAS)
(99 more) |
Regulation of cAMP-mediated signaling GO:0043949
Any process which modulates the frequency, rate or extent of cAMP-mediated signaling, a series of molecular signals in which a cell uses cyclic AMP to convert an extracellular signal into a response.
|
109 |
B2RSH2 (/ISS)
B2RSH2 (/ISS)
B2RSH2 (/ISS)
B2RSH2 (/ISS)
B2RSH2 (/ISS)
B2RSH2 (/ISS)
B2RSH2 (/ISS)
B2RSH2 (/ISS)
B2RSH2 (/ISS)
B2RSH2 (/ISS)
(99 more) |
Cellular response to forskolin GO:1904322
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a forskolin stimulus.
|
109 |
B2RSH2 (/ISS)
B2RSH2 (/ISS)
B2RSH2 (/ISS)
B2RSH2 (/ISS)
B2RSH2 (/ISS)
B2RSH2 (/ISS)
B2RSH2 (/ISS)
B2RSH2 (/ISS)
B2RSH2 (/ISS)
B2RSH2 (/ISS)
(99 more) |
Cell division GO:0051301
The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.
|
88 |
B2RSH2 (/ISS)
B2RSH2 (/ISS)
B2RSH2 (/ISS)
B2RSH2 (/ISS)
B2RSH2 (/ISS)
B2RSH2 (/ISS)
B2RSH2 (/ISS)
B2RSH2 (/ISS)
B2RSH2 (/ISS)
B2RSH2 (/ISS)
(78 more) |
Regulation of mitotic spindle organization GO:0060236
Any process that modulates the rate, frequency or extent of the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle.
|
76 |
B2RSH2 (/ISS)
B2RSH2 (/ISS)
B2RSH2 (/ISS)
B2RSH2 (/ISS)
B2RSH2 (/ISS)
B2RSH2 (/ISS)
B2RSH2 (/ISS)
B2RSH2 (/ISS)
B2RSH2 (/ISS)
B2RSH2 (/ISS)
(66 more) |
Positive regulation of protein localization to cell cortex GO:1904778
Any process that activates or increases the frequency, rate or extent of protein localization to cell cortex.
|
76 |
B2RSH2 (/ISS)
B2RSH2 (/ISS)
B2RSH2 (/ISS)
B2RSH2 (/ISS)
B2RSH2 (/ISS)
B2RSH2 (/ISS)
B2RSH2 (/ISS)
B2RSH2 (/ISS)
B2RSH2 (/ISS)
B2RSH2 (/ISS)
(66 more) |
Adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway GO:0007193
The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, where the pathway proceeds through inhibition of adenylyl cyclase activity and a subsequent decrease in the concentration of cyclic AMP (cAMP).
|
72 |
A8MTJ3 (/TAS)
A8MTJ3 (/TAS)
A8MTJ3 (/TAS)
A8MTJ3 (/TAS)
A8MTJ3 (/TAS)
A8MTJ3 (/TAS)
A8MTJ3 (/TAS)
A8MTJ3 (/TAS)
A8MTJ3 (/TAS)
A8MTJ3 (/TAS)
(62 more) |
Cell division GO:0051301
The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.
|
48 |
P04899 (/IMP)
P04899 (/IMP)
P04899 (/IMP)
P04899 (/IMP)
P04899 (/IMP)
P04899 (/IMP)
P04899 (/IMP)
P04899 (/IMP)
P04899 (/IMP)
P04899 (/IMP)
(38 more) |
G protein-coupled receptor signaling pathway GO:0007186
A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576).
|
39 |
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
(29 more) |
Cell division GO:0051301
The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.
|
36 |
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
(26 more) |
Response to peptide hormone GO:0043434
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide hormone stimulus. A peptide hormone is any of a class of peptides that are secreted into the blood stream and have endocrine functions in living animals.
|
35 |
P63096 (/ISS)
P63096 (/ISS)
P63096 (/ISS)
P63096 (/ISS)
P63096 (/ISS)
P63096 (/ISS)
P63096 (/ISS)
P63096 (/ISS)
P63096 (/ISS)
P63096 (/ISS)
(25 more) |
Negative regulation of synaptic transmission GO:0050805
Any process that stops, prevents, or reduces the frequency, rate or extent of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse.
|
35 |
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
(25 more) |
Regulation of cAMP-mediated signaling GO:0043949
Any process which modulates the frequency, rate or extent of cAMP-mediated signaling, a series of molecular signals in which a cell uses cyclic AMP to convert an extracellular signal into a response.
|
34 |
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
(24 more) |
Regulation of mitotic spindle organization GO:0060236
Any process that modulates the rate, frequency or extent of the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle.
|
34 |
P63096 (/IMP)
P63096 (/IMP)
P63096 (/IMP)
P63096 (/IMP)
P63096 (/IMP)
P63096 (/IMP)
P63096 (/IMP)
P63096 (/IMP)
P63096 (/IMP)
P63096 (/IMP)
(24 more) |
Regulation of mitotic spindle organization GO:0060236
Any process that modulates the rate, frequency or extent of the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle.
|
34 |
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
(24 more) |
Cellular response to forskolin GO:1904322
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a forskolin stimulus.
|
34 |
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
(24 more) |
Positive regulation of protein localization to cell cortex GO:1904778
Any process that activates or increases the frequency, rate or extent of protein localization to cell cortex.
|
34 |
P63096 (/IMP)
P63096 (/IMP)
P63096 (/IMP)
P63096 (/IMP)
P63096 (/IMP)
P63096 (/IMP)
P63096 (/IMP)
P63096 (/IMP)
P63096 (/IMP)
P63096 (/IMP)
(24 more) |
Positive regulation of protein localization to cell cortex GO:1904778
Any process that activates or increases the frequency, rate or extent of protein localization to cell cortex.
|
34 |
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
(24 more) |
Wnt signaling pathway, calcium modulating pathway GO:0007223
The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors leads to an increase in intracellular calcium and activation of protein kinase C (PKC).
|
30 |
P09471 (/TAS)
P09471 (/TAS)
P09471 (/TAS)
P09471 (/TAS)
P09471 (/TAS)
P09471 (/TAS)
P09471 (/TAS)
P09471 (/TAS)
P09471 (/TAS)
P09471 (/TAS)
(20 more) |
Negative regulation of adenylate cyclase activity GO:0007194
Any process that stops, prevents, or reduces the frequency, rate or extent of adenylate cyclase activity.
|
27 |
P04899 (/TAS)
P04899 (/TAS)
P04899 (/TAS)
P04899 (/TAS)
P04899 (/TAS)
P04899 (/TAS)
P04899 (/TAS)
P04899 (/TAS)
P04899 (/TAS)
P04899 (/TAS)
(17 more) |
Detection of light stimulus involved in visual perception GO:0050908
The series of events involved in visual perception in which a light stimulus is received and converted into a molecular signal.
|
27 |
B8JL40 (/IMP)
P11488 (/IMP)
P11488 (/IMP)
P11488 (/IMP)
P11488 (/IMP)
P11488 (/IMP)
P11488 (/IMP)
P11488 (/IMP)
P11488 (/IMP)
P11488 (/IMP)
(17 more) |
Muscle contraction GO:0006936
A process in which force is generated within muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis.
|
26 |
P09471 (/TAS)
P09471 (/TAS)
P09471 (/TAS)
P09471 (/TAS)
P09471 (/TAS)
P09471 (/TAS)
P09471 (/TAS)
P09471 (/TAS)
P09471 (/TAS)
P09471 (/TAS)
(16 more) |
Visual perception GO:0007601
The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image.
|
21 |
P11488 (/TAS)
P11488 (/TAS)
P11488 (/TAS)
P11488 (/TAS)
P11488 (/TAS)
P11488 (/TAS)
P11488 (/TAS)
P11488 (/TAS)
P11488 (/TAS)
P11488 (/TAS)
(11 more) |
G protein-coupled receptor signaling pathway GO:0007186
A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576).
|
18 |
G1SEJ8 (/IMP)
G1TRG8 (/IMP)
P10824 (/IMP)
P16378 (/IMP)
P16378 (/IMP)
P16378 (/IMP)
P16378 (/IMP)
P18872 (/IMP)
P18872 (/IMP)
P20353 (/IMP)
(8 more) |
Signal transduction GO:0007165
The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
|
16 |
P11488 (/NAS)
P11488 (/NAS)
P11488 (/NAS)
P11488 (/NAS)
P11488 (/NAS)
P11488 (/NAS)
P11488 (/NAS)
P11488 (/NAS)
P11488 (/NAS)
P11488 (/NAS)
(6 more) |
Phototransduction, visible light GO:0007603
The sequence of reactions within a cell required to convert absorbed photons from visible light into a molecular signal. A visible light stimulus is electromagnetic radiation that can be perceived visually by an organism; for organisms lacking a visual system, this can be defined as light with a wavelength within the range 380 to 780 nm.
|
16 |
P11488 (/IMP)
P11488 (/IMP)
P11488 (/IMP)
P11488 (/IMP)
P11488 (/IMP)
P11488 (/IMP)
P11488 (/IMP)
P11488 (/IMP)
P11488 (/IMP)
P11488 (/IMP)
(6 more) |
Positive regulation of cell population proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
|
16 |
P04897 (/IMP)
P04897 (/IMP)
P04899 (/IMP)
P04899 (/IMP)
P04899 (/IMP)
P04899 (/IMP)
P04899 (/IMP)
P04899 (/IMP)
P04899 (/IMP)
P04899 (/IMP)
(6 more) |
Rhodopsin mediated signaling pathway GO:0016056
The series of molecular signals generated as a consequence of excitation of rhodopsin by a photon and the events that convert the absorbed photons into a cellular response.
|
16 |
P11488 (/TAS)
P11488 (/TAS)
P11488 (/TAS)
P11488 (/TAS)
P11488 (/TAS)
P11488 (/TAS)
P11488 (/TAS)
P11488 (/TAS)
P11488 (/TAS)
P11488 (/TAS)
(6 more) |
Regulation of rhodopsin mediated signaling pathway GO:0022400
Any process that modulates the frequency, rate or extent of rhodopsin-mediated signaling.
|
16 |
P11488 (/TAS)
P11488 (/TAS)
P11488 (/TAS)
P11488 (/TAS)
P11488 (/TAS)
P11488 (/TAS)
P11488 (/TAS)
P11488 (/TAS)
P11488 (/TAS)
P11488 (/TAS)
(6 more) |
Negative regulation of cyclic-nucleotide phosphodiesterase activity GO:0051344
Any process that stops or reduces the rate of cyclic nucleotide phosphodiesterase activity, the catalysis of the reaction: nucleotide 3',5'-cyclic phosphate + H2O = nucleotide 5'-phosphate.
|
16 |
P11488 (/ISS)
P11488 (/ISS)
P11488 (/ISS)
P11488 (/ISS)
P11488 (/ISS)
P11488 (/ISS)
P11488 (/ISS)
P11488 (/ISS)
P11488 (/ISS)
P11488 (/ISS)
(6 more) |
Signal transduction GO:0007165
The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
|
14 |
P04899 (/TAS)
P04899 (/TAS)
P04899 (/TAS)
P04899 (/TAS)
P04899 (/TAS)
P04899 (/TAS)
P04899 (/TAS)
P04899 (/TAS)
P04899 (/TAS)
P04899 (/TAS)
(4 more) |
Response to nutrient GO:0007584
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nutrient stimulus.
|
14 |
P04899 (/TAS)
P04899 (/TAS)
P04899 (/TAS)
P04899 (/TAS)
P04899 (/TAS)
P04899 (/TAS)
P04899 (/TAS)
P04899 (/TAS)
P04899 (/TAS)
P04899 (/TAS)
(4 more) |
Adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway GO:0007193
The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, where the pathway proceeds through inhibition of adenylyl cyclase activity and a subsequent decrease in the concentration of cyclic AMP (cAMP).
|
13 |
P08754 (/IDA)
P08754 (/IDA)
P08754 (/IDA)
P08754 (/IDA)
P08754 (/IDA)
P08754 (/IDA)
P08754 (/IDA)
P08754 (/IDA)
P08754 (/IDA)
P08754 (/IDA)
(3 more) |
Dopamine receptor signaling pathway GO:0007212
The series of molecular signals generated as a consequence of a dopamine receptor binding to one of its physiological ligands.
|
13 |
P08754 (/IDA)
P08754 (/IDA)
P08754 (/IDA)
P08754 (/IDA)
P08754 (/IDA)
P08754 (/IDA)
P08754 (/IDA)
P08754 (/IDA)
P08754 (/IDA)
P08754 (/IDA)
(3 more) |
Positive regulation of macroautophagy GO:0016239
Any process, such as recognition of nutrient depletion, that activates or increases the rate of macroautophagy to bring cytosolic macromolecules to the vacuole/lysosome for degradation.
|
13 |
P08754 (/IMP)
P08754 (/IMP)
P08754 (/IMP)
P08754 (/IMP)
P08754 (/IMP)
P08754 (/IMP)
P08754 (/IMP)
P08754 (/IMP)
P08754 (/IMP)
P08754 (/IMP)
(3 more) |
GTP metabolic process GO:0046039
The chemical reactions and pathways involving GTP, guanosine triphosphate.
|
13 |
P08754 (/IDA)
P08754 (/IDA)
P08754 (/IDA)
P08754 (/IDA)
P08754 (/IDA)
P08754 (/IDA)
P08754 (/IDA)
P08754 (/IDA)
P08754 (/IDA)
P08754 (/IDA)
(3 more) |
Cell division GO:0051301
The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.
|
13 |
P08754 (/IDA)
P08754 (/IDA)
P08754 (/IDA)
P08754 (/IDA)
P08754 (/IDA)
P08754 (/IDA)
P08754 (/IDA)
P08754 (/IDA)
P08754 (/IDA)
P08754 (/IDA)
(3 more) |
Phototransduction GO:0007602
The sequence of reactions within a cell required to convert absorbed photons into a molecular signal.
|
11 |
P04695 (/NAS)
P04695 (/NAS)
P04695 (/NAS)
P04695 (/NAS)
P04695 (/NAS)
P04695 (/NAS)
P04695 (/NAS)
P19087 (/NAS)
P19087 (/NAS)
P19087 (/NAS)
(1 more) |
G protein-coupled receptor signaling pathway GO:0007186
A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576).
|
10 | D4AA42 (/IDA) P04897 (/IDA) P04897 (/IDA) P10824 (/IDA) P20612 (/IDA) P20612 (/IDA) P20612 (/IDA) P51875 (/IDA) Q3V3I2 (/IDA) Q3V3I2 (/IDA) |
Response to light stimulus GO:0009416
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light.
|
8 | P04695 (/IDA) P04695 (/IDA) P04695 (/IDA) P04695 (/IDA) P04695 (/IDA) P04695 (/IDA) P04695 (/IDA) Q9DG28 (/IDA) |
Negative regulation of cyclic-nucleotide phosphodiesterase activity GO:0051344
Any process that stops or reduces the rate of cyclic nucleotide phosphodiesterase activity, the catalysis of the reaction: nucleotide 3',5'-cyclic phosphate + H2O = nucleotide 5'-phosphate.
|
7 | P04695 (/IDA) P04695 (/IDA) P04695 (/IDA) P04695 (/IDA) P04695 (/IDA) P04695 (/IDA) P04695 (/IDA) |
Sensory perception of sweet taste GO:0050916
The series of events required to receive a sweet taste stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process.
|
6 | P16378 (/IMP) P16378 (/IMP) P16378 (/IMP) P16378 (/IMP) Q3V3I2 (/IMP) Q3V3I2 (/IMP) |
Detection of chemical stimulus involved in sensory perception of bitter taste GO:0001580
The series of events required for a bitter taste stimulus to be received and converted to a molecular signal.
|
5 | P20612 (/ISO) P20612 (/ISO) P20612 (/ISO) P50149 (/ISO) P50149 (/ISO) |
G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger GO:0007199
The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, followed by activation of guanylyl cyclase (GC) activity and a subsequent increase in the concentration of cyclic GMP (cGMP).
|
5 | P20612 (/TAS) P20612 (/TAS) P20612 (/TAS) P50149 (/TAS) P50149 (/TAS) |
Ventral cord development GO:0007419
The process whose specific outcome is the progression of the ventral cord over time, from its formation to the mature structure. The ventral cord is one of the distinguishing traits of the central nervous system of all arthropods (such as insects, crustaceans and arachnids) as well as many other invertebrates, such as the annelid worms.
|
5 | P16378 (/IMP) P16378 (/IMP) P16378 (/IMP) P16378 (/IMP) P20353 (/IMP) |
Visual perception GO:0007601
The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image.
|
5 | P20612 (/IMP) P20612 (/IMP) P20612 (/IMP) P50149 (/IMP) P50149 (/IMP) |
Phototransduction GO:0007602
The sequence of reactions within a cell required to convert absorbed photons into a molecular signal.
|
5 | P20612 (/IMP) P20612 (/IMP) P20612 (/IMP) P50149 (/IMP) P50149 (/IMP) |
Asymmetric cell division GO:0008356
The asymmetric division of cells to produce two daughter cells with different developmental potentials. It is of fundamental significance for the generation of cell diversity.
|
5 | P16378 (/IMP) P16378 (/IMP) P16378 (/IMP) P16378 (/IMP) P20353 (/IMP) |
Response to light intensity GO:0009642
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light intensity stimulus.
|
5 | P20612 (/ISO) P20612 (/ISO) P20612 (/ISO) P50149 (/ISO) P50149 (/ISO) |
Calcium-mediated signaling GO:0019722
Any intracellular signal transduction in which the signal is passed on within the cell via calcium ions.
|
5 | P16378 (/IMP) P16378 (/IMP) P16378 (/IMP) P16378 (/IMP) P20353 (/IMP) |
Septate junction assembly GO:0019991
The assembly of a septate junction, an intercellular junction found in invertebrate epithelia that is characterized by a ladder like appearance in electron micrographs and thought to provide structural strength and to provide a barrier to diffusion of solutes through the intercellular space.
|
5 | P16378 (/IMP) P16378 (/IMP) P16378 (/IMP) P16378 (/IMP) P20353 (/IMP) |
Cortical actin cytoskeleton organization GO:0030866
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of actin-based cytoskeletal structures in the cell cortex, i.e. just beneath the plasma membrane.
|
5 | P16378 (/IMP) P16378 (/IMP) P16378 (/IMP) P16378 (/IMP) P20353 (/IMP) |
Axon ensheathment in central nervous system GO:0032291
The process in which a glial cell membrane closes around an axon in the central nervous system. This can be a myelinating or a non-myelinating neuron-glial interaction.
|
5 | P16378 (/IMP) P16378 (/IMP) P16378 (/IMP) P16378 (/IMP) P20353 (/IMP) |
Detection of light stimulus involved in visual perception GO:0050908
The series of events involved in visual perception in which a light stimulus is received and converted into a molecular signal.
|
5 | P20612 (/ISO) P20612 (/ISO) P20612 (/ISO) P50149 (/ISO) P50149 (/ISO) |
Sensory perception of umami taste GO:0050917
The series of events required to receive an umami taste stimulus, convert it to a molecular signal, and recognize and characterize the signal. Umami taste is the savory taste of meats and other foods that are rich in glutamates. This is a neurological process.
|
5 | P20612 (/IMP) P20612 (/IMP) P20612 (/IMP) Q3V3I2 (/IMP) Q3V3I2 (/IMP) |
Establishment of glial blood-brain barrier GO:0060857
Establishment of the glial barrier between the blood and the brain. The glial cells in the brain are packed tightly together preventing the passage of most molecules from the blood into the brain. Only lipid soluble molecules or those that are actively transported can pass through the blood-brain barrier.
|
5 | P16378 (/IMP) P16378 (/IMP) P16378 (/IMP) P16378 (/IMP) P20353 (/IMP) |
Establishment of imaginal disc-derived wing hair orientation GO:0001737
Orientation of hairs in the imaginal disc-derived wing along a proximal-distal axis, such that each cell of the wing produces one wing hair which points in a distal direction.
|
4 | P16378 (/IMP) P16378 (/IMP) P16378 (/IMP) P16378 (/IMP) |
G protein-coupled receptor signaling pathway GO:0007186
A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576).
|
4 | P19087 (/NAS) P19087 (/NAS) P19087 (/NAS) P19087 (/NAS) |
Adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway GO:0007193
The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, where the pathway proceeds through inhibition of adenylyl cyclase activity and a subsequent decrease in the concentration of cyclic AMP (cAMP).
|
4 | P08753 (/ISS) P27045 (/ISS) P38403 (/ISS) Q9DC51 (/ISS) |
Dopamine receptor signaling pathway GO:0007212
The series of molecular signals generated as a consequence of a dopamine receptor binding to one of its physiological ligands.
|
4 | P08753 (/ISS) P27045 (/ISS) P38403 (/ISS) Q9DC51 (/ISS) |
Heart development GO:0007507
The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.
|
4 | P16378 (/TAS) P16378 (/TAS) P16378 (/TAS) P16378 (/TAS) |
Visual perception GO:0007601
The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image.
|
4 | P19087 (/NAS) P19087 (/NAS) P19087 (/NAS) P19087 (/NAS) |
Non-canonical Wnt signaling pathway GO:0035567
The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via effectors other than beta-catenin.
|
4 | P16378 (/IMP) P16378 (/IMP) P16378 (/IMP) P16378 (/IMP) |
Behavioral response to starvation GO:0042595
Any process that results in a change in the behavior of an organism as a result of deprivation of nourishment.
|
4 | P16378 (/IMP) P16378 (/IMP) P16378 (/IMP) P16378 (/IMP) |
Negative regulation of synaptic growth at neuromuscular junction GO:0045886
Any process that stops, prevents, or reduces the frequency, rate or extent of synaptic growth at neuromuscular junction.
|
4 | P16378 (/IMP) P16378 (/IMP) P16378 (/IMP) P16378 (/IMP) |
GTP metabolic process GO:0046039
The chemical reactions and pathways involving GTP, guanosine triphosphate.
|
4 | P08753 (/ISS) P27045 (/ISS) P38403 (/ISS) Q9DC51 (/ISS) |
Cell adhesion involved in heart morphogenesis GO:0061343
The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules that contributes to the shaping of the heart.
|
4 | P16378 (/IMP) P16378 (/IMP) P16378 (/IMP) P16378 (/IMP) |
Dopamine receptor signaling pathway GO:0007212
The series of molecular signals generated as a consequence of a dopamine receptor binding to one of its physiological ligands.
|
3 | P18872 (/IMP) P18872 (/IMP) P51875 (/IMP) |
Aging GO:0007568
A developmental process that is a deterioration and loss of function over time. Aging includes loss of functions such as resistance to disease, homeostasis, and fertility, as well as wear and tear. Aging includes cellular senescence, but is more inclusive. May precede death and may succeed developmental maturation (GO:0021700).
|
3 | P59215 (/IDA) P59215 (/IDA) P59215 (/IDA) |
Phototransduction, visible light GO:0007603
The sequence of reactions within a cell required to convert absorbed photons from visible light into a molecular signal. A visible light stimulus is electromagnetic radiation that can be perceived visually by an organism; for organisms lacking a visual system, this can be defined as light with a wavelength within the range 380 to 780 nm.
|
3 | P20612 (/ISO) P20612 (/ISO) P20612 (/ISO) |
Cell population proliferation GO:0008283
The multiplication or reproduction of cells, resulting in the expansion of a cell population.
|
3 | P20612 (/IDA) P20612 (/IDA) P20612 (/IDA) |
Response to organonitrogen compound GO:0010243
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organonitrogen stimulus. An organonitrogen compound is formally a compound containing at least one carbon-nitrogen bond.
|
3 | P59215 (/IDA) P59215 (/IDA) P59215 (/IDA) |
Response to organic cyclic compound GO:0014070
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus.
|
3 | P59215 (/IEP) P59215 (/IEP) P59215 (/IEP) |
Rhodopsin mediated signaling pathway GO:0016056
The series of molecular signals generated as a consequence of excitation of rhodopsin by a photon and the events that convert the absorbed photons into a cellular response.
|
3 | P20612 (/ISO) P20612 (/ISO) P20612 (/ISO) |
Forebrain development GO:0030900
The process whose specific outcome is the progression of the forebrain over time, from its formation to the mature structure. The forebrain is the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions).
|
3 | P59215 (/IEP) P59215 (/IEP) P59215 (/IEP) |
Neuron projection development GO:0031175
The process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
|
3 | P59215 (/IEP) P59215 (/IEP) P59215 (/IEP) |
Positive regulation of superoxide anion generation GO:0032930
Any process that activates or increases the frequency, rate or extent of enzymatic generation of superoxide by a cell.
|
3 | P04897 (/IMP) P04897 (/IMP) P08753 (/IMP) |
Positive regulation of NAD(P)H oxidase activity GO:0033864
Any process that activates or increases the activity of the enzyme NAD(P)H oxidase.
|
3 | P04897 (/IMP) P04897 (/IMP) P08753 (/IMP) |
Response to cytokine GO:0034097
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus.
|
3 | P59215 (/IEP) P59215 (/IEP) P59215 (/IEP) |
Eye photoreceptor cell development GO:0042462
Development of a photoreceptor, a sensory cell in the eye that reacts to the presence of light. They usually contain a pigment that undergoes a chemical change when light is absorbed, thus stimulating a nerve.
|
3 | P20612 (/IMP) P20612 (/IMP) P20612 (/IMP) |
Odontogenesis of dentin-containing tooth GO:0042475
The process whose specific outcome is the progression of a dentin-containing tooth over time, from its formation to the mature structure. A dentin-containing tooth is a hard, bony organ borne on the jaw or other bone of a vertebrate, and is composed mainly of dentin, a dense calcified substance, covered by a layer of enamel.
|
3 | P59215 (/IEP) P59215 (/IEP) P59215 (/IEP) |
Response to drug GO:0042493
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
|
3 | P59215 (/IEP) P59215 (/IEP) P59215 (/IEP) |
Response to hydrogen peroxide GO:0042542
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus.
|
3 | P59215 (/IEP) P59215 (/IEP) P59215 (/IEP) |
Response to morphine GO:0043278
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a morphine stimulus. Morphine is an opioid alkaloid, isolated from opium, with a complex ring structure.
|
3 | P59215 (/IEP) P59215 (/IEP) P59215 (/IEP) |
Positive regulation of GTPase activity GO:0043547
Any process that activates or increases the activity of a GTPase.
|
3 | P59215 (/IMP) P59215 (/IMP) P59215 (/IMP) |
Positive regulation of cyclic-nucleotide phosphodiesterase activity GO:0051343
Any process that activates or increases the frequency, rate or extent of cyclic nucleotide phosphodiesterase activity, the catalysis of the reaction: nucleotide 3',5'-cyclic phosphate + H2O = nucleotide 5'-phosphate.
|
3 | P20612 (/ISO) P20612 (/ISO) P20612 (/ISO) |
Negative regulation of calcium ion transport GO:0051926
Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of calcium ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
|
3 | P59215 (/IMP) P59215 (/IMP) P59215 (/IMP) |
Retina development in camera-type eye GO:0060041
The process whose specific outcome is the progression of the retina over time, from its formation to the mature structure. The retina is the innermost layer or coating at the back of the eyeball, which is sensitive to light and in which the optic nerve terminates.
|
3 | P20612 (/IMP) P20612 (/IMP) P20612 (/IMP) |
Cellular response to electrical stimulus GO:0071257
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electrical stimulus.
|
3 | P20612 (/IMP) P20612 (/IMP) P20612 (/IMP) |
Positive regulation of vascular smooth muscle cell proliferation GO:1904707
Any process that activates or increases the frequency, rate or extent of vascular smooth muscle cell proliferation.
|
3 | P04897 (/IMP) P04897 (/IMP) P08753 (/IMP) |
Negative regulation of apoptotic signaling pathway GO:2001234
Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic signaling pathway.
|
3 | P04897 (/IMP) P04897 (/IMP) P08753 (/IMP) |
Detection of chemical stimulus involved in sensory perception of bitter taste GO:0001580
The series of events required for a bitter taste stimulus to be received and converted to a molecular signal.
|
2 | D3ZSS5 (/IDA) D4AA42 (/IDA) |
Adenosine receptor signaling pathway GO:0001973
The series of molecular signals generated as a consequence of a receptor binding to extracellular adenosine and transmitting the signal to a heterotrimeric G-protein complex to initiate a change in cell activity.
|
2 | P04897 (/IDA) P04897 (/IDA) |
G protein-coupled receptor signaling pathway GO:0007186
A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576).
|
2 | P51875 (/IGI) Q00743 (/IGI) |
Adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0007189
The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, where the pathway proceeds through activation of adenylyl cyclase activity and a subsequent increase in the concentration of cyclic AMP (cAMP).
|
2 | P04897 (/IMP) P04897 (/IMP) |
Positive regulation of cytosolic calcium ion concentration GO:0007204
Any process that increases the concentration of calcium ions in the cytosol.
|
2 | P50149 (/ISO) P50149 (/ISO) |
Gamma-aminobutyric acid signaling pathway GO:0007214
The series of molecular signals generated by the binding of gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms, to a cell surface receptor.
|
2 | P04897 (/IDA) P04897 (/IDA) |
Aging GO:0007568
A developmental process that is a deterioration and loss of function over time. Aging includes loss of functions such as resistance to disease, homeostasis, and fertility, as well as wear and tear. Aging includes cellular senescence, but is more inclusive. May precede death and may succeed developmental maturation (GO:0021700).
|
2 | P18872 (/ISO) P18872 (/ISO) |
Phototransduction GO:0007602
The sequence of reactions within a cell required to convert absorbed photons into a molecular signal.
|
2 | P50149 (/TAS) P50149 (/TAS) |
Locomotory behavior GO:0007626
The specific movement from place to place of an organism in response to external or internal stimuli. Locomotion of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions.
|
2 | P18872 (/IMP) P18872 (/IMP) |
Regulation of heart contraction GO:0008016
Any process that modulates the frequency, rate or extent of heart contraction. Heart contraction is the process in which the heart decreases in volume in a characteristic way to propel blood through the body.
|
2 | P18872 (/IMP) P18872 (/IMP) |
Response to light intensity GO:0009642
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light intensity stimulus.
|
2 | D3ZSS5 (/IDA) D4AA42 (/IDA) |
Cellular process GO:0009987
Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
|
2 | P18872 (/IMP) P18872 (/IMP) |
Response to organonitrogen compound GO:0010243
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organonitrogen stimulus. An organonitrogen compound is formally a compound containing at least one carbon-nitrogen bond.
|
2 | P18872 (/ISO) P18872 (/ISO) |
Positive regulation of cell migration GO:0030335
Any process that activates or increases the frequency, rate or extent of cell migration.
|
2 | P04897 (/IMP) P04897 (/IMP) |
Positive regulation of superoxide anion generation GO:0032930
Any process that activates or increases the frequency, rate or extent of enzymatic generation of superoxide by a cell.
|
2 | P08752 (/ISO) Q9DC51 (/ISO) |
Positive regulation of NAD(P)H oxidase activity GO:0033864
Any process that activates or increases the activity of the enzyme NAD(P)H oxidase.
|
2 | P08752 (/ISO) Q9DC51 (/ISO) |
Positive regulation of urine volume GO:0035810
Any process that increases the amount of urine excreted from the body over a unit of time.
|
2 | P04897 (/IMP) P04897 (/IMP) |
Positive regulation of renal sodium excretion GO:0035815
Any process that increases the amount of sodium excreted in urine over a unit of time.
|
2 | P04897 (/IMP) P04897 (/IMP) |
Response to peptide hormone GO:0043434
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide hormone stimulus. A peptide hormone is any of a class of peptides that are secreted into the blood stream and have endocrine functions in living animals.
|
2 | G1SEJ8 (/IMP) G1TRG8 (/IMP) |
Positive regulation of GTPase activity GO:0043547
Any process that activates or increases the activity of a GTPase.
|
2 | P18872 (/ISO) P18872 (/ISO) |
Negative regulation of calcium ion-dependent exocytosis GO:0045955
Any process that stops, prevents, or reduces the frequency, rate or extent of calcium ion-dependent exocytosis.
|
2 | P04897 (/IMP) P04897 (/IMP) |
Retinal cone cell development GO:0046549
Development of a cone cell, one of the sensory cells in the eye that reacts to the presence of light. Cone cells contain the photopigment iodopsin or cyanopsin and are responsible for photopic (daylight) vision.
|
2 | P50149 (/IMP) P50149 (/IMP) |
Positive regulation of insulin receptor signaling pathway GO:0046628
Any process that increases the frequency, rate or extent of insulin receptor signaling.
|
2 | P04897 (/IMP) P04897 (/IMP) |
Negative regulation of synaptic transmission GO:0050805
Any process that stops, prevents, or reduces the frequency, rate or extent of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse.
|
2 | P04897 (/IDA) P04897 (/IDA) |
Sensory perception of taste GO:0050909
The series of events required for an organism to receive a gustatory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Gustation involves the direct detection of chemical composition, usually through contact with chemoreceptor cells. This is a neurological process.
|
2 | Q3V3I2 (/IDA) Q3V3I2 (/IDA) |
Sensory perception of taste GO:0050909
The series of events required for an organism to receive a gustatory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Gustation involves the direct detection of chemical composition, usually through contact with chemoreceptor cells. This is a neurological process.
|
2 | Q3V3I2 (/IMP) Q3V3I2 (/IMP) |
Sensory perception of bitter taste GO:0050913
The series of events required to receive a bitter taste stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process.
|
2 | Q3V3I2 (/IMP) Q3V3I2 (/IMP) |
Regulation of calcium ion transport GO:0051924
Any process that modulates the frequency, rate or extent of the directed movement of calcium ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
|
2 | P04897 (/IDA) P04897 (/IDA) |
Negative regulation of calcium ion transport GO:0051926
Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of calcium ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
|
2 | P18872 (/ISO) P18872 (/ISO) |
Positive regulation of ERK1 and ERK2 cascade GO:0070374
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
|
2 | P04897 (/IMP) P04897 (/IMP) |
Negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process GO:0140199
Any process that stops, prevents or reduces the frequency, rate or extent of an adenylate cyclase-activating adrenergic receptor signaling pathway involved in some heart process.
|
2 | P04897 (/IDA) P04897 (/IDA) |
Negative regulation of protein tyrosine phosphatase activity GO:1903614
Any process that stops, prevents or reduces the frequency, rate or extent of protein tyrosine phosphatase activity.
|
2 | P04897 (/IMP) P04897 (/IMP) |
Positive regulation of vascular smooth muscle cell proliferation GO:1904707
Any process that activates or increases the frequency, rate or extent of vascular smooth muscle cell proliferation.
|
2 | P08752 (/ISO) Q9DC51 (/ISO) |
Positive regulation of neural precursor cell proliferation GO:2000179
Any process that activates or increases the frequency, rate or extent of neural precursor cell proliferation.
|
2 | P04897 (/IMP) P04897 (/IMP) |
Negative regulation of apoptotic signaling pathway GO:2001234
Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic signaling pathway.
|
2 | P08752 (/ISO) Q9DC51 (/ISO) |
Establishment of mitotic spindle orientation GO:0000132
A cell cycle process that sets the alignment of mitotic spindle relative to other cellular structures.
|
1 | Q9N2V6 (/IMP) |
Embryonic axis specification GO:0000578
The establishment, maintenance and elaboration of a pattern along a line or a point in an embryo.
|
1 | Q9N2V6 (/IMP) |
Sporocarp development involved in sexual reproduction GO:0000909
The process whose specific outcome is the progression of a fruiting body organ over time, from its formation to the mature structure. The fruiting body is a spore bearing structure. In fungi, the sporocarp (also known as fruiting body) is a multicellular structure on which spore-producing structures, such as basidia or asci, are borne. The fruiting body is part of the sexual phase of a fungal life cycle, with the rest of the life cycle being characterized by vegetative mycelial growth. The sporocarp of a basidiomycete is known as a basidiocarp, while the fruiting body of an ascomycete is known as an ascocarp. A significant range of different shapes and morphologies is found in both basidiocarps and ascocarps; these features play an important role in the identification and taxonomy of fungi.
|
1 | Q00743 (/IMP) |
Adenosine receptor signaling pathway GO:0001973
The series of molecular signals generated as a consequence of a receptor binding to extracellular adenosine and transmitting the signal to a heterotrimeric G-protein complex to initiate a change in cell activity.
|
1 | P08752 (/ISO) |
Vesicle fusion GO:0006906
Fusion of the membrane of a transport vesicle with its target membrane.
|
1 | P08753 (/IDA) |
Vesicle fusion GO:0006906
Fusion of the membrane of a transport vesicle with its target membrane.
|
1 | Q9DC51 (/ISO) |
Signal transduction GO:0007165
The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
|
1 | Q00743 (/IMP) |
Adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0007189
The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, where the pathway proceeds through activation of adenylyl cyclase activity and a subsequent increase in the concentration of cyclic AMP (cAMP).
|
1 | P08752 (/ISO) |
Adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway GO:0007193
The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, where the pathway proceeds through inhibition of adenylyl cyclase activity and a subsequent decrease in the concentration of cyclic AMP (cAMP).
|
1 | P08752 (/IMP) |
Adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway GO:0007193
The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, where the pathway proceeds through inhibition of adenylyl cyclase activity and a subsequent decrease in the concentration of cyclic AMP (cAMP).
|
1 | P08752 (/ISA) |
Adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway GO:0007193
The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, where the pathway proceeds through inhibition of adenylyl cyclase activity and a subsequent decrease in the concentration of cyclic AMP (cAMP).
|
1 | Q9DC51 (/ISO) |
Positive regulation of cytosolic calcium ion concentration GO:0007204
Any process that increases the concentration of calcium ions in the cytosol.
|
1 | D4AA42 (/IDA) |
Dopamine receptor signaling pathway GO:0007212
The series of molecular signals generated as a consequence of a dopamine receptor binding to one of its physiological ligands.
|
1 | Q9DC51 (/ISO) |
G protein-coupled acetylcholine receptor signaling pathway GO:0007213
Any series of molecular signals initiated by an acetylcholine receptor on the surface of the target cell binding to one of its physiological ligands, and proceeding with the activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction and ends with regulation of a downstream cellular process, e.g. transcription.
|
1 | P08752 (/IMP) |
Gamma-aminobutyric acid signaling pathway GO:0007214
The series of molecular signals generated by the binding of gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms, to a cell surface receptor.
|
1 | P08752 (/ISO) |
Brain development GO:0007420
The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.).
|
1 | P08753 (/IEP) |
Cell population proliferation GO:0008283
The multiplication or reproduction of cells, resulting in the expansion of a cell population.
|
1 | P08752 (/IPI) |
Positive regulation of cell population proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
|
1 | P08752 (/ISO) |
Regulation of sterigmatocystin biosynthetic process GO:0010913
Any process that modulates the rate, frequency, or extent of sterigmatocystin biosynthesis. Sterigmatocystin biosynthetic processes are the chemical reactions and pathways resulting in the formation of sterigmatocystin, a carcinogenic mycotoxin produced in high yields by strains of the common molds.
|
1 | Q00743 (/IMP) |
Rhodopsin mediated signaling pathway GO:0016056
The series of molecular signals generated as a consequence of excitation of rhodopsin by a photon and the events that convert the absorbed photons into a cellular response.
|
1 | D3ZSS5 (/IMP) |
Positive regulation of macroautophagy GO:0016239
Any process, such as recognition of nutrient depletion, that activates or increases the rate of macroautophagy to bring cytosolic macromolecules to the vacuole/lysosome for degradation.
|
1 | Q9DC51 (/ISO) |
Positive regulation of cell migration GO:0030335
Any process that activates or increases the frequency, rate or extent of cell migration.
|
1 | P08752 (/ISO) |
Response to food GO:0032094
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a food stimulus; food is anything which, when taken into the body, serves to nourish or build up the tissues or to supply body heat.
|
1 | P51875 (/IMP) |
Negative regulation of synaptic transmission, cholinergic GO:0032223
Any process that stops, prevents, or reduces the frequency, rate or extent of cholinergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter acetylcholine.
|
1 | P51875 (/IGI) |
Negative regulation of synaptic transmission, cholinergic GO:0032223
Any process that stops, prevents, or reduces the frequency, rate or extent of cholinergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter acetylcholine.
|
1 | P51875 (/IMP) |
Regulation of protein localization GO:0032880
Any process that modulates the frequency, rate or extent of any process in which a protein is transported to, or maintained in, a specific location.
|
1 | P20353 (/IMP) |
Response to nicotine GO:0035094
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nicotine stimulus.
|
1 | P29348 (/IEP) |
Cellular response to drug GO:0035690
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
|
1 | Q00743 (/IMP) |
Positive regulation of urine volume GO:0035810
Any process that increases the amount of urine excreted from the body over a unit of time.
|
1 | P08752 (/ISO) |
Positive regulation of renal sodium excretion GO:0035815
Any process that increases the amount of sodium excreted in urine over a unit of time.
|
1 | P08752 (/ISO) |
Regulation of locomotion GO:0040012
Any process that modulates the frequency, rate or extent of locomotion of a cell or organism.
|
1 | P51875 (/IMP) |
Penicillin biosynthetic process GO:0042318
The chemical reactions and pathways resulting in the formation of any antibiotic that contains the condensed beta-lactamthiazolidine ring system.
|
1 | Q00743 (/IMP) |
Response to drug GO:0042493
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
|
1 | P51875 (/IGI) |
Response to drug GO:0042493
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
|
1 | P51875 (/IMP) |
Regulation of pharyngeal pumping GO:0043051
Any process that modulates the contraction and relaxation movements of the pharyngeal muscle that mediates feeding in nematodes.
|
1 | P51875 (/IGI) |
Regulation of cAMP-mediated signaling GO:0043949
Any process which modulates the frequency, rate or extent of cAMP-mediated signaling, a series of molecular signals in which a cell uses cyclic AMP to convert an extracellular signal into a response.
|
1 | P10824 (/IMP) |
Secondary metabolite biosynthetic process GO:0044550
The chemical reactions and pathways resulting in the formation of secondary metabolites, the compounds that are not necessarily required for growth and maintenance of cells, and are often unique to a taxon.
|
1 | Q00743 (/IMP) |
Asymmetric protein localization involved in cell fate determination GO:0045167
Any process in which a protein is transported to, or maintained in, a specific asymmetric distribution, resulting in the formation of daughter cells of different types.
|
1 | P20353 (/IMP) |
Sterigmatocystin biosynthetic process GO:0045461
The chemical reactions and pathways resulting in the formation of sterigmatocystin, a carcinogenic mycotoxin produced in high yields by strains of the common molds.
|
1 | Q00743 (/IMP) |
Negative regulation of calcium ion-dependent exocytosis GO:0045955
Any process that stops, prevents, or reduces the frequency, rate or extent of calcium ion-dependent exocytosis.
|
1 | P08752 (/ISO) |
GTP metabolic process GO:0046039
The chemical reactions and pathways involving GTP, guanosine triphosphate.
|
1 | Q9DC51 (/ISO) |
Positive regulation of insulin receptor signaling pathway GO:0046628
Any process that increases the frequency, rate or extent of insulin receptor signaling.
|
1 | P08752 (/ISO) |
Regulation of oviposition GO:0046662
Any process that modulates the frequency, rate or extent of the deposition of eggs, either fertilized or not, upon a surface or into a medium.
|
1 | P51875 (/IMP) |
Conidium formation GO:0048315
The process of producing non-motile spores, called conidia, via mitotic asexual reproduction in higher fungi. Conidia are haploid cells genetically identical to their haploid parent. They are produced by conversion of hyphal elements, or are borne on sporogenous cells on or within specialized structures termed conidiophores, and participate in dispersal of the fungus.
|
1 | Q00743 (/IMP) |
Negative regulation of axon regeneration GO:0048681
Any process that stops, prevents, or reduces the frequency, rate or extent of axon regeneration.
|
1 | P51875 (/IMP) |
Negative regulation of synaptic transmission GO:0050805
Any process that stops, prevents, or reduces the frequency, rate or extent of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse.
|
1 | P10824 (/IMP) |
Negative regulation of synaptic transmission GO:0050805
Any process that stops, prevents, or reduces the frequency, rate or extent of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse.
|
1 | P50146 (/ISS) |
Defense response to Gram-negative bacterium GO:0050829
Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism.
|
1 | P51875 (/IGI) |
Negative regulation of secretion GO:0051048
Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of a substance from a cell or a tissue.
|
1 | P08753 (/TAS) |
Establishment of spindle orientation GO:0051294
Any process that set the alignment of spindle relative to other cellular structures.
|
1 | P20353 (/IMP) |
Positive regulation of cyclic-nucleotide phosphodiesterase activity GO:0051343
Any process that activates or increases the frequency, rate or extent of cyclic nucleotide phosphodiesterase activity, the catalysis of the reaction: nucleotide 3',5'-cyclic phosphate + H2O = nucleotide 5'-phosphate.
|
1 | D3ZSS5 (/IDA) |
Regulation of calcium ion transport GO:0051924
Any process that modulates the frequency, rate or extent of the directed movement of calcium ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
|
1 | P08752 (/ISO) |
Asymmetric neuroblast division GO:0055059
The process resulting in the physical partitioning and separation of a neuroblast into two daughter cells with different developmental potentials.
|
1 | P20353 (/IMP) |
Regulation of feeding behavior GO:0060259
Any process that modulates the rate, frequency or extent of the behavior associated with the intake of food.
|
1 | P51875 (/IMP) |
Positive regulation of ERK1 and ERK2 cascade GO:0070374
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
|
1 | P08752 (/ISO) |
Regulation of conidium formation GO:0075306
Any process that modulates the frequency, rate or extent of conidium formation, a process of producing non-motile spores, called conidia, via mitotic asexual reproduction in higher fungi. Conidia are haploid cells genetically identical to their haploid parent. They are produced by conversion of hyphal elements, or are borne on sporogenous cells on or within specialized structures termed conidiophores, and participate in dispersal of the fungus.
|
1 | Q00743 (/IGI) |
Regulation of conidium formation GO:0075306
Any process that modulates the frequency, rate or extent of conidium formation, a process of producing non-motile spores, called conidia, via mitotic asexual reproduction in higher fungi. Conidia are haploid cells genetically identical to their haploid parent. They are produced by conversion of hyphal elements, or are borne on sporogenous cells on or within specialized structures termed conidiophores, and participate in dispersal of the fungus.
|
1 | Q00743 (/IMP) |
Negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process GO:0140199
Any process that stops, prevents or reduces the frequency, rate or extent of an adenylate cyclase-activating adrenergic receptor signaling pathway involved in some heart process.
|
1 | P08752 (/ISO) |
Positive regulation of penicillin biosynthetic process GO:1900198
Any process that activates or increases the frequency, rate or extent of penicillin biosynthetic process.
|
1 | Q00743 (/IMP) |
Regulation of secondary metabolite biosynthetic process GO:1900376
Any process that modulates the frequency, rate or extent of secondary metabolite biosynthetic process.
|
1 | Q00743 (/IMP) |
Negative regulation of protein tyrosine phosphatase activity GO:1903614
Any process that stops, prevents or reduces the frequency, rate or extent of protein tyrosine phosphatase activity.
|
1 | P08752 (/ISO) |
Cellular response to forskolin GO:1904322
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a forskolin stimulus.
|
1 | P10824 (/IMP) |
Positive regulation of neural precursor cell proliferation GO:2000179
Any process that activates or increases the frequency, rate or extent of neural precursor cell proliferation.
|
1 | P08752 (/ISO) |
There are 82 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
|
180 |
A0A024R2Z1 (/ISS)
A0A024R2Z1 (/ISS)
A0A024R2Z1 (/ISS)
A0A024R2Z1 (/ISS)
A0A024R2Z1 (/ISS)
A0A024R2Z1 (/ISS)
A0A024R2Z1 (/ISS)
A0A024R2Z1 (/ISS)
A0A024R2Z1 (/ISS)
A0A024R2Z1 (/ISS)
(170 more) |
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
126 |
A8MTJ3 (/TAS)
A8MTJ3 (/TAS)
A8MTJ3 (/TAS)
A8MTJ3 (/TAS)
A8MTJ3 (/TAS)
A8MTJ3 (/TAS)
A8MTJ3 (/TAS)
A8MTJ3 (/TAS)
A8MTJ3 (/TAS)
A8MTJ3 (/TAS)
(116 more) |
Midbody GO:0030496
A thin cytoplasmic bridge formed between daughter cells at the end of cytokinesis. The midbody forms where the contractile ring constricts, and may persist for some time before finally breaking to complete cytokinesis.
|
88 |
B2RSH2 (/ISS)
B2RSH2 (/ISS)
B2RSH2 (/ISS)
B2RSH2 (/ISS)
B2RSH2 (/ISS)
B2RSH2 (/ISS)
B2RSH2 (/ISS)
B2RSH2 (/ISS)
B2RSH2 (/ISS)
B2RSH2 (/ISS)
(78 more) |
Centrosome GO:0005813
A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle.
|
87 |
B2RSH2 (/ISS)
B2RSH2 (/ISS)
B2RSH2 (/ISS)
B2RSH2 (/ISS)
B2RSH2 (/ISS)
B2RSH2 (/ISS)
B2RSH2 (/ISS)
B2RSH2 (/ISS)
B2RSH2 (/ISS)
B2RSH2 (/ISS)
(77 more) |
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
86 |
B2RSH2 (/ISS)
B2RSH2 (/ISS)
B2RSH2 (/ISS)
B2RSH2 (/ISS)
B2RSH2 (/ISS)
B2RSH2 (/ISS)
B2RSH2 (/ISS)
B2RSH2 (/ISS)
B2RSH2 (/ISS)
B2RSH2 (/ISS)
(76 more) |
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
84 |
B2RSH2 (/ISS)
B2RSH2 (/ISS)
B2RSH2 (/ISS)
B2RSH2 (/ISS)
B2RSH2 (/ISS)
B2RSH2 (/ISS)
B2RSH2 (/ISS)
B2RSH2 (/ISS)
B2RSH2 (/ISS)
B2RSH2 (/ISS)
(74 more) |
Cell cortex region GO:0099738
The complete extent of cell cortex that underlies some some region of the plasma membrane
|
76 |
B2RSH2 (/ISS)
B2RSH2 (/ISS)
B2RSH2 (/ISS)
B2RSH2 (/ISS)
B2RSH2 (/ISS)
B2RSH2 (/ISS)
B2RSH2 (/ISS)
B2RSH2 (/ISS)
B2RSH2 (/ISS)
B2RSH2 (/ISS)
(66 more) |
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
70 |
D3ZSS5 (/IDA)
F1P3R0 (/IDA)
P04899 (/IDA)
P04899 (/IDA)
P04899 (/IDA)
P04899 (/IDA)
P04899 (/IDA)
P04899 (/IDA)
P04899 (/IDA)
P04899 (/IDA)
(60 more) |
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
65 |
P04897 (/IDA)
P04897 (/IDA)
P04899 (/IDA)
P04899 (/IDA)
P04899 (/IDA)
P04899 (/IDA)
P04899 (/IDA)
P04899 (/IDA)
P04899 (/IDA)
P04899 (/IDA)
(55 more) |
Centrosome GO:0005813
A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle.
|
62 |
P04899 (/IDA)
P04899 (/IDA)
P04899 (/IDA)
P04899 (/IDA)
P04899 (/IDA)
P04899 (/IDA)
P04899 (/IDA)
P04899 (/IDA)
P04899 (/IDA)
P04899 (/IDA)
(52 more) |
Midbody GO:0030496
A thin cytoplasmic bridge formed between daughter cells at the end of cytokinesis. The midbody forms where the contractile ring constricts, and may persist for some time before finally breaking to complete cytokinesis.
|
61 |
P04899 (/IDA)
P04899 (/IDA)
P04899 (/IDA)
P04899 (/IDA)
P04899 (/IDA)
P04899 (/IDA)
P04899 (/IDA)
P04899 (/IDA)
P04899 (/IDA)
P04899 (/IDA)
(51 more) |
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
|
61 |
P04899 (/HDA)
P04899 (/HDA)
P04899 (/HDA)
P04899 (/HDA)
P04899 (/HDA)
P04899 (/HDA)
P04899 (/HDA)
P04899 (/HDA)
P04899 (/HDA)
P04899 (/HDA)
(51 more) |
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
49 |
P04897 (/IDA)
P04897 (/IDA)
P08754 (/IDA)
P08754 (/IDA)
P08754 (/IDA)
P08754 (/IDA)
P08754 (/IDA)
P08754 (/IDA)
P08754 (/IDA)
P08754 (/IDA)
(39 more) |
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
|
47 |
P08754 (/IDA)
P08754 (/IDA)
P08754 (/IDA)
P08754 (/IDA)
P08754 (/IDA)
P08754 (/IDA)
P08754 (/IDA)
P08754 (/IDA)
P08754 (/IDA)
P08754 (/IDA)
(37 more) |
Lysosomal membrane GO:0005765
The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm.
|
47 |
P08754 (/HDA)
P08754 (/HDA)
P08754 (/HDA)
P08754 (/HDA)
P08754 (/HDA)
P08754 (/HDA)
P08754 (/HDA)
P08754 (/HDA)
P08754 (/HDA)
P08754 (/HDA)
(37 more) |
Heterotrimeric G-protein complex GO:0005834
Any of a family of heterotrimeric GTP-binding and hydrolyzing proteins; they belong to a superfamily of GTPases that includes monomeric proteins such as EF-Tu and RAS. Heterotrimeric G-proteins consist of three subunits; the alpha subunit contains the guanine nucleotide binding site and possesses GTPase activity; the beta and gamma subunits are tightly associated and function as a beta-gamma heterodimer; extrinsic plasma membrane proteins (cytoplasmic face) that function as a complex to transduce signals from G protein-coupled receptors to an effector protein.
|
43 |
P10824 (/TAS)
P18872 (/TAS)
P18872 (/TAS)
P20612 (/TAS)
P20612 (/TAS)
P20612 (/TAS)
P50149 (/TAS)
P50149 (/TAS)
P63096 (/TAS)
P63096 (/TAS)
(33 more) |
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
41 |
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
(31 more) |
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
|
38 |
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
(28 more) |
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
|
38 |
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
(28 more) |
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
36 |
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
(26 more) |
Centrosome GO:0005813
A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle.
|
36 |
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
(26 more) |
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
36 |
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
(26 more) |
Midbody GO:0030496
A thin cytoplasmic bridge formed between daughter cells at the end of cytokinesis. The midbody forms where the contractile ring constricts, and may persist for some time before finally breaking to complete cytokinesis.
|
36 |
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
(26 more) |
Membrane raft GO:0045121
Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions.
|
36 |
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
(26 more) |
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
|
35 |
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
(25 more) |
Cell cortex region GO:0099738
The complete extent of cell cortex that underlies some some region of the plasma membrane
|
34 |
P63096 (/IDA)
P63096 (/IDA)
P63096 (/IDA)
P63096 (/IDA)
P63096 (/IDA)
P63096 (/IDA)
P63096 (/IDA)
P63096 (/IDA)
P63096 (/IDA)
P63096 (/IDA)
(24 more) |
Cell cortex region GO:0099738
The complete extent of cell cortex that underlies some some region of the plasma membrane
|
34 |
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
B2RSH2 (/ISO)
(24 more) |
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
|
27 |
P04899 (/HDA)
P04899 (/HDA)
P04899 (/HDA)
P04899 (/HDA)
P04899 (/HDA)
P04899 (/HDA)
P04899 (/HDA)
P04899 (/HDA)
P04899 (/HDA)
P04899 (/HDA)
(17 more) |
Photoreceptor outer segment GO:0001750
The outer segment of a vertebrate photoreceptor that contains a stack of membrane discs embedded with photoreceptor proteins.
|
26 |
D3ZSS5 (/IDA)
D4AA42 (/IDA)
P04696 (/IDA)
P11488 (/IDA)
P11488 (/IDA)
P11488 (/IDA)
P11488 (/IDA)
P11488 (/IDA)
P11488 (/IDA)
P11488 (/IDA)
(16 more) |
Photoreceptor disc membrane GO:0097381
Stack of disc membranes located inside a photoreceptor outer segment, and containing densely packed molecules of photoreceptor proteins that traverse the lipid bilayer. Disc membranes arise as evaginations of the ciliary membrane during the development of the outer segment and may or may not remain contiguous with the ciliary membrane.
|
23 |
P04695 (/TAS)
P04695 (/TAS)
P04695 (/TAS)
P04695 (/TAS)
P04695 (/TAS)
P04695 (/TAS)
P04695 (/TAS)
P11488 (/TAS)
P11488 (/TAS)
P11488 (/TAS)
(13 more) |
Photoreceptor inner segment GO:0001917
The inner segment of a vertebrate photoreceptor containing mitochondria, ribosomes and membranes where opsin molecules are assembled and passed to be part of the outer segment discs.
|
22 |
D3ZSS5 (/IDA)
D4AA42 (/IDA)
P11488 (/IDA)
P11488 (/IDA)
P11488 (/IDA)
P11488 (/IDA)
P11488 (/IDA)
P11488 (/IDA)
P11488 (/IDA)
P11488 (/IDA)
(12 more) |
Photoreceptor outer segment membrane GO:0042622
The membrane surrounding the outer segment of a vertebrate photoreceptor.
|
20 |
P11488 (/ISS)
P11488 (/ISS)
P11488 (/ISS)
P11488 (/ISS)
P11488 (/ISS)
P11488 (/ISS)
P11488 (/ISS)
P11488 (/ISS)
P11488 (/ISS)
P11488 (/ISS)
(10 more) |
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
16 |
P04897 (/IDA)
P04897 (/IDA)
P04899 (/IDA)
P04899 (/IDA)
P04899 (/IDA)
P04899 (/IDA)
P04899 (/IDA)
P04899 (/IDA)
P04899 (/IDA)
P04899 (/IDA)
(6 more) |
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
16 |
P11488 (/TAS)
P11488 (/TAS)
P11488 (/TAS)
P11488 (/TAS)
P11488 (/TAS)
P11488 (/TAS)
P11488 (/TAS)
P11488 (/TAS)
P11488 (/TAS)
P11488 (/TAS)
(6 more) |
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
|
16 |
P11488 (/NAS)
P11488 (/NAS)
P11488 (/NAS)
P11488 (/NAS)
P11488 (/NAS)
P11488 (/NAS)
P11488 (/NAS)
P11488 (/NAS)
P11488 (/NAS)
P11488 (/NAS)
(6 more) |
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
|
15 |
A8MTJ3 (/IDA)
A8MTJ3 (/IDA)
A8MTJ3 (/IDA)
A8MTJ3 (/IDA)
A8MTJ3 (/IDA)
A8MTJ3 (/IDA)
A8MTJ3 (/IDA)
A8MTJ3 (/IDA)
A8MTJ3 (/IDA)
A8MTJ3 (/IDA)
(5 more) |
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
14 |
P04899 (/IDA)
P04899 (/IDA)
P04899 (/IDA)
P04899 (/IDA)
P04899 (/IDA)
P04899 (/IDA)
P04899 (/IDA)
P04899 (/IDA)
P04899 (/IDA)
P04899 (/IDA)
(4 more) |
Extracellular vesicle GO:1903561
Any vesicle that is part of the extracellular region.
|
14 |
P04899 (/HDA)
P04899 (/HDA)
P04899 (/HDA)
P04899 (/HDA)
P04899 (/HDA)
P04899 (/HDA)
P04899 (/HDA)
P04899 (/HDA)
P04899 (/HDA)
P04899 (/HDA)
(4 more) |
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
|
10 | P04897 (/IDA) P04897 (/IDA) P08753 (/IDA) P10824 (/IDA) P59215 (/IDA) P59215 (/IDA) P59215 (/IDA) Q9DG28 (/IDA) W5U9Q0 (/IDA) W5ULY8 (/IDA) |
Photoreceptor outer segment membrane GO:0042622
The membrane surrounding the outer segment of a vertebrate photoreceptor.
|
8 | P04695 (/IDA) P04695 (/IDA) P04695 (/IDA) P04695 (/IDA) P04695 (/IDA) P04695 (/IDA) P04695 (/IDA) P04696 (/IDA) |
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
|
7 | P18872 (/TAS) P18872 (/TAS) P20612 (/TAS) P20612 (/TAS) P20612 (/TAS) P50149 (/TAS) P50149 (/TAS) |
G protein-coupled receptor complex GO:0097648
A protein complex that contains G protein-coupled receptors.
|
7 | P04695 (/IDA) P04695 (/IDA) P04695 (/IDA) P04695 (/IDA) P04695 (/IDA) P04695 (/IDA) P04695 (/IDA) |
Photoreceptor outer segment GO:0001750
The outer segment of a vertebrate photoreceptor that contains a stack of membrane discs embedded with photoreceptor proteins.
|
5 | P20612 (/ISO) P20612 (/ISO) P20612 (/ISO) P50149 (/ISO) P50149 (/ISO) |
Photoreceptor inner segment GO:0001917
The inner segment of a vertebrate photoreceptor containing mitochondria, ribosomes and membranes where opsin molecules are assembled and passed to be part of the outer segment discs.
|
5 | P20612 (/ISO) P20612 (/ISO) P20612 (/ISO) P50149 (/ISO) P50149 (/ISO) |
Heterotrimeric G-protein complex GO:0005834
Any of a family of heterotrimeric GTP-binding and hydrolyzing proteins; they belong to a superfamily of GTPases that includes monomeric proteins such as EF-Tu and RAS. Heterotrimeric G-proteins consist of three subunits; the alpha subunit contains the guanine nucleotide binding site and possesses GTPase activity; the beta and gamma subunits are tightly associated and function as a beta-gamma heterodimer; extrinsic plasma membrane proteins (cytoplasmic face) that function as a complex to transduce signals from G protein-coupled receptors to an effector protein.
|
5 | D3ZSS5 (/IDA) P16378 (/IDA) P16378 (/IDA) P16378 (/IDA) P16378 (/IDA) |
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
5 | P16378 (/HDA) P16378 (/HDA) P16378 (/HDA) P16378 (/HDA) P20353 (/HDA) |
Apical plasma membrane GO:0016324
The region of the plasma membrane located at the apical end of the cell.
|
5 | P20612 (/ISO) P20612 (/ISO) P20612 (/ISO) Q3V3I2 (/ISO) Q3V3I2 (/ISO) |
Photoreceptor outer segment GO:0001750
The outer segment of a vertebrate photoreceptor that contains a stack of membrane discs embedded with photoreceptor proteins.
|
4 | P19087 (/ISS) P19087 (/ISS) P19087 (/ISS) P19087 (/ISS) |
Heterotrimeric G-protein complex GO:0005834
Any of a family of heterotrimeric GTP-binding and hydrolyzing proteins; they belong to a superfamily of GTPases that includes monomeric proteins such as EF-Tu and RAS. Heterotrimeric G-proteins consist of three subunits; the alpha subunit contains the guanine nucleotide binding site and possesses GTPase activity; the beta and gamma subunits are tightly associated and function as a beta-gamma heterodimer; extrinsic plasma membrane proteins (cytoplasmic face) that function as a complex to transduce signals from G protein-coupled receptors to an effector protein.
|
4 | P19087 (/NAS) P19087 (/NAS) P19087 (/NAS) P19087 (/NAS) |
Membrane raft GO:0045121
Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions.
|
4 | P04897 (/IDA) P04897 (/IDA) P08753 (/IDA) P10824 (/IDA) |
Heterotrimeric G-protein complex GO:0005834
Any of a family of heterotrimeric GTP-binding and hydrolyzing proteins; they belong to a superfamily of GTPases that includes monomeric proteins such as EF-Tu and RAS. Heterotrimeric G-proteins consist of three subunits; the alpha subunit contains the guanine nucleotide binding site and possesses GTPase activity; the beta and gamma subunits are tightly associated and function as a beta-gamma heterodimer; extrinsic plasma membrane proteins (cytoplasmic face) that function as a complex to transduce signals from G protein-coupled receptors to an effector protein.
|
3 | P20612 (/IC) P20612 (/IC) P20612 (/IC) |
Heterotrimeric G-protein complex GO:0005834
Any of a family of heterotrimeric GTP-binding and hydrolyzing proteins; they belong to a superfamily of GTPases that includes monomeric proteins such as EF-Tu and RAS. Heterotrimeric G-proteins consist of three subunits; the alpha subunit contains the guanine nucleotide binding site and possesses GTPase activity; the beta and gamma subunits are tightly associated and function as a beta-gamma heterodimer; extrinsic plasma membrane proteins (cytoplasmic face) that function as a complex to transduce signals from G protein-coupled receptors to an effector protein.
|
3 | P20612 (/ISO) P20612 (/ISO) P20612 (/ISO) |
Dendrite GO:0030425
A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
|
3 | P08752 (/IDA) P18872 (/IDA) P18872 (/IDA) |
Photoreceptor connecting cilium GO:0032391
The portion of the photoreceptor cell cilium linking the photoreceptor inner and outer segments. It's considered to be equivalent to the ciliary transition zone.
|
3 | P20612 (/IDA) P20612 (/IDA) P20612 (/IDA) |
Neuron projection GO:0043005
A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
|
3 | P59215 (/IDA) P59215 (/IDA) P59215 (/IDA) |
Neuronal cell body GO:0043025
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
|
3 | P20612 (/ISO) P20612 (/ISO) P20612 (/ISO) |
Myelin sheath GO:0043209
An electrically insulating fatty layer that surrounds the axons of many neurons. It is an outgrowth of glial cells: Schwann cells supply the myelin for peripheral neurons while oligodendrocytes supply it to those of the central nervous system.
|
3 | P59215 (/IDA) P59215 (/IDA) P59215 (/IDA) |
Cell body GO:0044297
The portion of a cell bearing surface projections such as axons, dendrites, cilia, or flagella that includes the nucleus, but excludes all cell projections.
|
3 | P08752 (/IDA) P18872 (/IDA) P18872 (/IDA) |
Acrosomal vesicle GO:0001669
A structure in the head of a spermatozoon that contains acid hydrolases, and is concerned with the breakdown of the outer membrane of the ovum during fertilization. It lies just beneath the plasma membrane and is derived from the lysosome.
|
2 | Q3V3I2 (/ISO) Q3V3I2 (/ISO) |
Axoneme GO:0005930
The bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements.
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2 | Q3V3I2 (/ISO) Q3V3I2 (/ISO) |
Cell cortex GO:0005938
The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins.
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2 | P51875 (/IDA) Q9N2V6 (/IDA) |
Apical plasma membrane GO:0016324
The region of the plasma membrane located at the apical end of the cell.
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2 | D3ZSS5 (/IDA) P29348 (/IDA) |
Neuron projection GO:0043005
A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
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2 | P18872 (/ISO) P18872 (/ISO) |
Myelin sheath GO:0043209
An electrically insulating fatty layer that surrounds the axons of many neurons. It is an outgrowth of glial cells: Schwann cells supply the myelin for peripheral neurons while oligodendrocytes supply it to those of the central nervous system.
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2 | P18872 (/HDA) P18872 (/HDA) |
Myelin sheath GO:0043209
An electrically insulating fatty layer that surrounds the axons of many neurons. It is an outgrowth of glial cells: Schwann cells supply the myelin for peripheral neurons while oligodendrocytes supply it to those of the central nervous system.
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2 | P18872 (/ISO) P18872 (/ISO) |
Golgi membrane GO:0000139
The lipid bilayer surrounding any of the compartments of the Golgi apparatus.
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1 | P08753 (/TAS) |
Acrosomal vesicle GO:0001669
A structure in the head of a spermatozoon that contains acid hydrolases, and is concerned with the breakdown of the outer membrane of the ovum during fertilization. It lies just beneath the plasma membrane and is derived from the lysosome.
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1 | P29348 (/IDA) |
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
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1 | P08752 (/ISO) |
Golgi apparatus GO:0005794
A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions.
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1 | Q9DC51 (/IDA) |
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
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1 | P08752 (/ISO) |
Heterotrimeric G-protein complex GO:0005834
Any of a family of heterotrimeric GTP-binding and hydrolyzing proteins; they belong to a superfamily of GTPases that includes monomeric proteins such as EF-Tu and RAS. Heterotrimeric G-proteins consist of three subunits; the alpha subunit contains the guanine nucleotide binding site and possesses GTPase activity; the beta and gamma subunits are tightly associated and function as a beta-gamma heterodimer; extrinsic plasma membrane proteins (cytoplasmic face) that function as a complex to transduce signals from G protein-coupled receptors to an effector protein.
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1 | Q00743 (/ISA) |
Heterotrimeric G-protein complex GO:0005834
Any of a family of heterotrimeric GTP-binding and hydrolyzing proteins; they belong to a superfamily of GTPases that includes monomeric proteins such as EF-Tu and RAS. Heterotrimeric G-proteins consist of three subunits; the alpha subunit contains the guanine nucleotide binding site and possesses GTPase activity; the beta and gamma subunits are tightly associated and function as a beta-gamma heterodimer; extrinsic plasma membrane proteins (cytoplasmic face) that function as a complex to transduce signals from G protein-coupled receptors to an effector protein.
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1 | Q9N2V6 (/ISS) |
Cilium GO:0005929
A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body.
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1 | Q9BIG5 (/IDA) |
Axoneme GO:0005930
The bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements.
|
1 | P29348 (/IDA) |
Cell cortex GO:0005938
The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins.
|
1 | P20353 (/TAS) |
Zymogen granule GO:0042588
A membrane-bounded, cytoplasmic secretory granule found in enzyme-secreting cells and visible by light microscopy. Contain zymogen, an inactive enzyme precursor, often of a digestive enzyme.
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1 | P08753 (/IDA) |
Zymogen granule GO:0042588
A membrane-bounded, cytoplasmic secretory granule found in enzyme-secreting cells and visible by light microscopy. Contain zymogen, an inactive enzyme precursor, often of a digestive enzyme.
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1 | Q9DC51 (/ISO) |
Neuronal cell body GO:0043025
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
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1 | D3ZSS5 (/IDA) |
Apical cortex GO:0045179
The region that lies just beneath the plasma membrane on the apical edge of a cell.
|
1 | P20353 (/IDA) |
Exocytic vesicle GO:0070382
A transport vesicle that mediates transport from an intracellular compartment to the plasma membrane, and fuses with the plasma membrane to release various cargo molecules, such as proteins or hormones, by exocytosis.
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1 | P38400 (/IDA) |
Lamellar body membrane GO:0097232
The lipid bilayer surrounding a lamellar body. A lamellar body is a membrane-bounded organelle, specialized for the storage and secretion of various substances (surfactant phospholipids, glycoproteins and acid phosphates) which are arranged in the form of tightly packed, concentric, membrane sheets or lamellae. Has some similar properties to, but is distinct from, a lysosome.
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1 | Q9DG28 (/IDA) |
Non-motile cilium GO:0097730
A cilium which may have a variable array of axonemal microtubules but does not contain molecular motors.
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1 | Q9BIG5 (/IDA) |