The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 1: Ski2 ATP-dependent RNA helicase

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 7 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
RNA helicase activity GO:0003724
Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of an RNA helix.
2 P35207 (/ISS) P35207 (/ISS)
RNA helicase activity GO:0003724
Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of an RNA helix.
2 Q15477 (/TAS) Q15477 (/TAS)
MRNA binding GO:0003729
Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns.
2 P35207 (/HDA) P35207 (/HDA)
Helicase activity GO:0004386
Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix.
2 Q9BI21 (/ISS) Q9VCH8 (/ISS)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
2 P35207 (/IPI) P35207 (/IPI)
RNA helicase activity GO:0003724
Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of an RNA helix.
1 F4JAA5 (/IMP)
RNA helicase activity GO:0003724
Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of an RNA helix.
1 O59801 (/ISO)

There are 15 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay GO:0070478
The chemical reactions and pathways resulting in the breakdown of the nuclear-transcribed mRNA transcript body of an mRNA in which an amino-acid codon has changed to a nonsense codon; occurs when the 3' end is not protected by a 3'-poly(A) tail; degradation proceeds in the 3' to 5' direction.
3 F4JAA5 (/IMP) P35207 (/IMP) P35207 (/IMP)
Regulation of alternative mRNA splicing, via spliceosome GO:0000381
Any process that modulates the frequency, rate or extent of alternative splicing of nuclear mRNAs.
2 Q9BI21 (/HMP) Q9VCH8 (/HMP)
Nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' GO:0034427
The chemical reactions and pathways resulting in the breakdown of the mRNA transcript body that occurs when the 3' end is not protected by a 3'-poly(A) tail; degradation proceeds in the 3' to 5' direction.
2 P35207 (/IMP) P35207 (/IMP)
Exonucleolytic catabolism of deadenylated mRNA GO:0043928
The chemical reactions and pathways resulting in the breakdown of the transcript body of a nuclear-transcribed mRNA that occurs when the ends are not protected by the 3'-poly(A) tail.
2 Q15477 (/TAS) Q15477 (/TAS)
Nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay GO:0070478
The chemical reactions and pathways resulting in the breakdown of the nuclear-transcribed mRNA transcript body of an mRNA in which an amino-acid codon has changed to a nonsense codon; occurs when the 3' end is not protected by a 3'-poly(A) tail; degradation proceeds in the 3' to 5' direction.
2 P35207 (/IGI) P35207 (/IGI)
Nuclear-transcribed mRNA catabolic process, non-stop decay GO:0070481
The chemical reactions and pathways resulting in the breakdown of the transcript body of a nuclear-transcribed mRNA that is lacking a stop codon.
2 P35207 (/IMP) P35207 (/IMP)
RNA fragment catabolic process GO:0000292
The chemical reactions and pathways resulting in the breakdown of a fragment of RNA, such as excised introns or sequences removed from ribosomal RNA during processing.
1 F4JAA5 (/IMP)
Potassium ion transport GO:0006813
The directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 F4JAA5 (/IMP)
Posttranscriptional gene silencing GO:0016441
The inactivation of gene expression by a posttranscriptional mechanism.
1 F4JAA5 (/IMP)
Endoplasmic reticulum unfolded protein response GO:0030968
The series of molecular signals generated as a consequence of the presence of unfolded proteins in the endoplasmic reticulum (ER) or other ER-related stress; results in changes in the regulation of transcription and translation.
1 O59801 (/IMP)
Response to potassium ion GO:0035864
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a potassium ion stimulus.
1 F4JAA5 (/IMP)
Nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay GO:0070478
The chemical reactions and pathways resulting in the breakdown of the nuclear-transcribed mRNA transcript body of an mRNA in which an amino-acid codon has changed to a nonsense codon; occurs when the 3' end is not protected by a 3'-poly(A) tail; degradation proceeds in the 3' to 5' direction.
1 O59801 (/ISO)
Nuclear-transcribed mRNA catabolic process, non-stop decay GO:0070481
The chemical reactions and pathways resulting in the breakdown of the transcript body of a nuclear-transcribed mRNA that is lacking a stop codon.
1 O59801 (/ISO)
Regulation of production of siRNA involved in RNA interference GO:0090065
Any process that modulates the frequency, rate or extent of the production of siRNA, the cleavage of double-stranded RNA to form small interfering RNA molecules (siRNAs) of 21-23 nucleotides, in the context of RNA interference.
1 F4JAA5 (/IMP)
Positive regulation of wax biosynthetic process GO:1904278
Any process that activates or increases the frequency, rate or extent of wax biosynthetic process.
1 F4JAA5 (/IGI)

There are 9 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Ski complex GO:0055087
A protein complex that regulates RNA degradation by the exosome complex. In Saccharomyces the complex has a heterotetrameric stoichiometry consisting of one copy each of Ski2p and Ski3 and two copies of Ski8p.
5 F4JAA5 (/IDA) P35207 (/IDA) P35207 (/IDA) Q15477 (/IDA) Q15477 (/IDA)
Ski complex GO:0055087
A protein complex that regulates RNA degradation by the exosome complex. In Saccharomyces the complex has a heterotetrameric stoichiometry consisting of one copy each of Ski2p and Ski3 and two copies of Ski8p.
5 O59801 (/ISO) Q3TW36 (/ISO) Q6NZR5 (/ISO) Q8CDP6 (/ISO) Q8R3X0 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
3 F4JAA5 (/IDA) P35207 (/IDA) P35207 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
2 Q9BI21 (/IC) Q9VCH8 (/IC)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 Q15477 (/TAS) Q15477 (/TAS)
Ski complex GO:0055087
A protein complex that regulates RNA degradation by the exosome complex. In Saccharomyces the complex has a heterotetrameric stoichiometry consisting of one copy each of Ski2p and Ski3 and two copies of Ski8p.
2 P35207 (/IPI) P35207 (/IPI)
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
1 O59801 (/ISO)
Vacuole GO:0005773
A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol.
1 F4JAA5 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 O59801 (/HDA)