The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
High mobility group box domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 22: nucleolar transcription factor 1 isoform X2

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 12 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
14 P17480 (/IPI) P17480 (/IPI) P17480 (/IPI) P17480 (/IPI) P17480 (/IPI) P17480 (/IPI) P17480 (/IPI) P17480 (/IPI) P17480 (/IPI) P17480 (/IPI)
(4 more)
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
12 P17480 (/ISM) P17480 (/ISM) P17480 (/ISM) P17480 (/ISM) P17480 (/ISM) P17480 (/ISM) P17480 (/ISM) P17480 (/ISM) P17480 (/ISM) P17480 (/ISM)
(2 more)
RNA polymerase I CORE element sequence-specific DNA binding GO:0001164
Interacting selectively and non-covalently with the regulatory region composed of the transcription start site and binding sites for transcription factors of the RNA polymerase I transcription machinery. This site is often referred to as the CORE element. In mammalian cells, the CORE element functions in conjunction with the Upstream Control Element (UCE), while in fungi, protozoa, and plants, the CORE element functions without a UCE.
12 P17480 (/IDA) P17480 (/IDA) P17480 (/IDA) P17480 (/IDA) P17480 (/IDA) P17480 (/IDA) P17480 (/IDA) P17480 (/IDA) P17480 (/IDA) P17480 (/IDA)
(2 more)
RNA polymerase I upstream control element sequence-specific DNA binding GO:0001165
Interacting selectively and non-covalently with the upstream control element (UCE, or alternately referred to as the upstream element), a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase I.
12 P17480 (/IDA) P17480 (/IDA) P17480 (/IDA) P17480 (/IDA) P17480 (/IDA) P17480 (/IDA) P17480 (/IDA) P17480 (/IDA) P17480 (/IDA) P17480 (/IDA)
(2 more)
Chromatin binding GO:0003682
Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
12 P17480 (/IDA) P17480 (/IDA) P17480 (/IDA) P17480 (/IDA) P17480 (/IDA) P17480 (/IDA) P17480 (/IDA) P17480 (/IDA) P17480 (/IDA) P17480 (/IDA)
(2 more)
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
12 P17480 (/HDA) P17480 (/HDA) P17480 (/HDA) P17480 (/HDA) P17480 (/HDA) P17480 (/HDA) P17480 (/HDA) P17480 (/HDA) P17480 (/HDA) P17480 (/HDA)
(2 more)
Scaffold protein binding GO:0097110
Interacting selectively and non-covalently with a scaffold protein. Scaffold proteins are crucial regulators of many key signaling pathways. Although not strictly defined in function, they are known to interact and/or bind with multiple members of a signaling pathway, tethering them into complexes.
12 P17480 (/IPI) P17480 (/IPI) P17480 (/IPI) P17480 (/IPI) P17480 (/IPI) P17480 (/IPI) P17480 (/IPI) P17480 (/IPI) P17480 (/IPI) P17480 (/IPI)
(2 more)
Chromatin binding GO:0003682
Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
2 P25976 (/ISS) P25977 (/ISS)
RNA polymerase I CORE element sequence-specific DNA binding GO:0001164
Interacting selectively and non-covalently with the regulatory region composed of the transcription start site and binding sites for transcription factors of the RNA polymerase I transcription machinery. This site is often referred to as the CORE element. In mammalian cells, the CORE element functions in conjunction with the Upstream Control Element (UCE), while in fungi, protozoa, and plants, the CORE element functions without a UCE.
1 P25976 (/ISO)
RNA polymerase I upstream control element sequence-specific DNA binding GO:0001165
Interacting selectively and non-covalently with the upstream control element (UCE, or alternately referred to as the upstream element), a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase I.
1 P25976 (/ISO)
Chromatin binding GO:0003682
Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
1 P25976 (/ISO)
Scaffold protein binding GO:0097110
Interacting selectively and non-covalently with a scaffold protein. Scaffold proteins are crucial regulators of many key signaling pathways. Although not strictly defined in function, they are known to interact and/or bind with multiple members of a signaling pathway, tethering them into complexes.
1 P25976 (/ISO)

There are 13 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Positive regulation of transcription by RNA polymerase I GO:0045943
Any process that activates or increases the frequency, rate or extent of transcription mediated by RNA polymerase I.
16 P17480 (/ISS) P17480 (/ISS) P17480 (/ISS) P17480 (/ISS) P17480 (/ISS) P17480 (/ISS) P17480 (/ISS) P17480 (/ISS) P17480 (/ISS) P17480 (/ISS)
(6 more)
Regulation of transcription by RNA polymerase I GO:0006356
Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase I.
12 P17480 (/NAS) P17480 (/NAS) P17480 (/NAS) P17480 (/NAS) P17480 (/NAS) P17480 (/NAS) P17480 (/NAS) P17480 (/NAS) P17480 (/NAS) P17480 (/NAS)
(2 more)
Transcription by RNA polymerase I GO:0006360
The synthesis of RNA from a DNA template by RNA polymerase I (RNAP I), originating at an RNAP I promoter.
12 P17480 (/IMP) P17480 (/IMP) P17480 (/IMP) P17480 (/IMP) P17480 (/IMP) P17480 (/IMP) P17480 (/IMP) P17480 (/IMP) P17480 (/IMP) P17480 (/IMP)
(2 more)
Transcription initiation from RNA polymerase I promoter GO:0006361
Any process involved in the assembly of the RNA polymerase I preinitiation complex (PIC) at an RNA polymerase I promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. Promoter clearance, or release, is the transition between the initiation and elongation phases of transcription.
12 P17480 (/TAS) P17480 (/TAS) P17480 (/TAS) P17480 (/TAS) P17480 (/TAS) P17480 (/TAS) P17480 (/TAS) P17480 (/TAS) P17480 (/TAS) P17480 (/TAS)
(2 more)
Transcription elongation from RNA polymerase I promoter GO:0006362
The extension of an RNA molecule after transcription initiation and promoter clearance at an RNA polymerase I specific promoter by the addition of ribonucleotides catalyzed by RNA polymerase I.
12 P17480 (/TAS) P17480 (/TAS) P17480 (/TAS) P17480 (/TAS) P17480 (/TAS) P17480 (/TAS) P17480 (/TAS) P17480 (/TAS) P17480 (/TAS) P17480 (/TAS)
(2 more)
Termination of RNA polymerase I transcription GO:0006363
The process in which the synthesis of an RNA molecule by RNA polymerase I using a DNA template is completed. RNAP I termination requires binding of a terminator protein so specific sequences downstream of the transcription unit.
12 P17480 (/TAS) P17480 (/TAS) P17480 (/TAS) P17480 (/TAS) P17480 (/TAS) P17480 (/TAS) P17480 (/TAS) P17480 (/TAS) P17480 (/TAS) P17480 (/TAS)
(2 more)
Blastocyst growth GO:0001832
An increase in size of a blastocyst due to expansion of the blastocoelic cavity cell shape changes and cell proliferation.
1 Q3USZ2 (/IMP)
Transcription by RNA polymerase I GO:0006360
The synthesis of RNA from a DNA template by RNA polymerase I (RNAP I), originating at an RNAP I promoter.
1 P25976 (/ISO)
Transcription elongation from RNA polymerase I promoter GO:0006362
The extension of an RNA molecule after transcription initiation and promoter clearance at an RNA polymerase I specific promoter by the addition of ribonucleotides catalyzed by RNA polymerase I.
1 P25976 (/IDA)
Embryo implantation GO:0007566
Attachment of the blastocyst to the uterine lining.
1 Q3USZ2 (/IMP)
Regulation of gene expression GO:0010468
Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
1 Q3USZ2 (/IMP)
Positive regulation of transcription by RNA polymerase I GO:0045943
Any process that activates or increases the frequency, rate or extent of transcription mediated by RNA polymerase I.
1 P25976 (/IDA)
Cellular response to leukemia inhibitory factor GO:1990830
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leukemia inhibitory factor stimulus.
1 P25976 (/IEP)

There are 9 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
16 P17480 (/ISS) P17480 (/ISS) P17480 (/ISS) P17480 (/ISS) P17480 (/ISS) P17480 (/ISS) P17480 (/ISS) P17480 (/ISS) P17480 (/ISS) P17480 (/ISS)
(6 more)
Fibrillar center GO:0001650
A structure found most metazoan nucleoli, but not usually found in lower eukaryotes; surrounded by the dense fibrillar component; the zone of transcription from multiple copies of the pre-rRNA genes is in the border region between these two structures.
15 E9PKP7 (/IDA) E9PKP7 (/IDA) P17480 (/IDA) P17480 (/IDA) P17480 (/IDA) P17480 (/IDA) P17480 (/IDA) P17480 (/IDA) P17480 (/IDA) P17480 (/IDA)
(5 more)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
14 P17480 (/IDA) P17480 (/IDA) P17480 (/IDA) P17480 (/IDA) P17480 (/IDA) P17480 (/IDA) P17480 (/IDA) P17480 (/IDA) P17480 (/IDA) P17480 (/IDA)
(4 more)
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
13 P17480 (/IDA) P17480 (/IDA) P17480 (/IDA) P17480 (/IDA) P17480 (/IDA) P17480 (/IDA) P17480 (/IDA) P17480 (/IDA) P17480 (/IDA) P17480 (/IDA)
(3 more)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
12 P17480 (/TAS) P17480 (/TAS) P17480 (/TAS) P17480 (/TAS) P17480 (/TAS) P17480 (/TAS) P17480 (/TAS) P17480 (/TAS) P17480 (/TAS) P17480 (/TAS)
(2 more)
Fibrillar center GO:0001650
A structure found most metazoan nucleoli, but not usually found in lower eukaryotes; surrounded by the dense fibrillar component; the zone of transcription from multiple copies of the pre-rRNA genes is in the border region between these two structures.
1 P25976 (/ISO)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 P25976 (/ISO)
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
1 P25976 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q3USZ2 (/IDA)
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