The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"atp-gated p2x4 ion channel
".
FunFam 10: P2X receptor E
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 9 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Calcium-release channel activity GO:0015278
Enables the transmembrane transfer of a calcium ion from intracellular stores by a channel that opens when a specific intracellular ligand has been bound by the channel complex or one of its constituent parts.
|
2 | Q54JH4 (/IGI) Q86JM7 (/IGI) |
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
1 | Q86JM7 (/IPI) |
|
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
|
1 | Q54JH4 (/IC) |
|
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
|
1 | Q86JM7 (/IDA) |
|
Ligand-gated ion channel activity GO:0015276
Enables the transmembrane transfer of an ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts.
|
1 | Q86JM7 (/IDA) |
|
Calcium-release channel activity GO:0015278
Enables the transmembrane transfer of a calcium ion from intracellular stores by a channel that opens when a specific intracellular ligand has been bound by the channel complex or one of its constituent parts.
|
1 | Q86JM7 (/IMP) |
|
Rab GTPase binding GO:0017137
Interacting selectively and non-covalently with Rab protein, any member of the Rab subfamily of the Ras superfamily of monomeric GTPases.
|
1 | Q86JM7 (/IPI) |
|
ATP-gated ion channel activity GO:0035381
Enables the transmembrane transfer of an ion by a channel that opens when ATP has been bound by the channel complex or one of its constituent parts.
|
1 | Q54JH4 (/IDA) |
|
ATP-gated ion channel activity GO:0035381
Enables the transmembrane transfer of an ion by a channel that opens when ATP has been bound by the channel complex or one of its constituent parts.
|
1 | Q86JM7 (/IMP) |
There are 12 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Ion transport GO:0006811
The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
|
2 | Q54JH4 (/IDA) Q86JM7 (/IDA) |
|
Regulation of calcium-mediated signaling GO:0050848
Any process that modulates the frequency, rate or extent of calcium-mediated signaling, the process in which a cell uses calcium ions to convert an extracellular signal into a response.
|
2 | Q54JH4 (/IGI) Q86JM7 (/IGI) |
|
Calcium ion transmembrane transport GO:0070588
A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore.
|
2 | Q54JH4 (/IGI) Q86JM7 (/IGI) |
|
Cellular hypotonic response GO:0071476
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a hypotonic environment, i.e. an environment with a lower concentration of solutes than the organism or cell.
|
2 | Q54JH4 (/IGI) Q86JM7 (/IGI) |
|
Hypotonic response GO:0006971
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a hypotonic environment, i.e. an environment with a lower concentration of solutes than the organism or cell.
|
1 | Q86JM7 (/IMP) |
|
Cellular water homeostasis GO:0009992
Any process involved in the maintenance of an internal steady state of water within a cell.
|
1 | Q86JM7 (/IMP) |
|
Positive regulation of vesicle fusion GO:0031340
Any process that activates or increases the frequency, rate or extent of vesicle fusion.
|
1 | Q86JM7 (/IDA) |
|
Contractile vacuole organization GO:0033298
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a contractile vacuole. A specialized vacuole that fills with water from the cytoplasm and then discharges this externally by the opening of contractile vacuole pores.
|
1 | Q86JM7 (/IMP) |
|
Negative regulation of GTPase activity GO:0034260
Any process that stops or reduces the rate of GTP hydrolysis by a GTPase.
|
1 | Q86JM7 (/IDA) |
|
Purinergic nucleotide receptor signaling pathway GO:0035590
The series of molecular signals generated as a consequence of a receptor binding to an extracellular purine nucleotide to initiate a change in cell activity.
|
1 | Q86JM7 (/IMP) |
|
Contractile vacuole discharge GO:0070177
The regulated release of water from a contractile vacuole to the outside of a cell by fusion of the contractile vacuole membrane with the plasma membrane.
|
1 | Q86JM7 (/IMP) |
|
Calcium ion transmembrane transport GO:0070588
A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore.
|
1 | Q86JM7 (/IMP) |
There are 1 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Contractile vacuolar membrane GO:0031164
The lipid bilayer surrounding the contractile vacuole.
|
2 | Q54JH4 (/IDA) Q86JM7 (/IDA) |