The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
YojJ-like
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 5: Amiloride-sensitive sodium channel subunit gamma

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 11 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
WW domain binding GO:0050699
Interacting selectively and non-covalently with a WW domain of a protein, a small module composed of 40 amino acids and plays a role in mediating protein-protein interactions via proline-rich regions.
4 P37091 (/IPI) P51170 (/IPI) P51170 (/IPI) Q9WU39 (/IPI)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
3 P37091 (/IPI) P51170 (/IPI) P51170 (/IPI)
Ion channel activity GO:0005216
Enables the facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. May be either selective (it enables passage of a specific ion only) or non-selective (it enables passage of two or more ions of same charge but different size).
2 P51170 (/IMP) P51170 (/IMP)
Sodium channel activity GO:0005272
Enables the facilitated diffusion of a sodium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.
2 P51170 (/TAS) P51170 (/TAS)
Ligand-gated sodium channel activity GO:0015280
Enables the transmembrane transfer of a sodium ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts.
2 P37091 (/IDA) Q9WU39 (/IDA)
Ligand-gated sodium channel activity GO:0015280
Enables the transmembrane transfer of a sodium ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts.
2 P51170 (/TAS) P51170 (/TAS)
Ion channel activity GO:0005216
Enables the facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. May be either selective (it enables passage of a specific ion only) or non-selective (it enables passage of two or more ions of same charge but different size).
1 Q9WU39 (/ISO)
Ligand-gated sodium channel activity GO:0015280
Enables the transmembrane transfer of a sodium ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts.
1 Q9WU39 (/IGI)
Ligand-gated sodium channel activity GO:0015280
Enables the transmembrane transfer of a sodium ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts.
1 P37091 (/IMP)
Ligand-gated sodium channel activity GO:0015280
Enables the transmembrane transfer of a sodium ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts.
1 Q9WU39 (/ISO)
WW domain binding GO:0050699
Interacting selectively and non-covalently with a WW domain of a protein, a small module composed of 40 amino acids and plays a role in mediating protein-protein interactions via proline-rich regions.
1 Q9WU39 (/ISO)

There are 19 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Sodium ion transmembrane transport GO:0035725
A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore.
5 F1MJW3 (/ISS) H2QAR5 (/ISS) O13263 (/ISS) P51171 (/ISS) Q28738 (/ISS)
Multicellular organismal water homeostasis GO:0050891
Any process involved in the maintenance of an internal steady state of water within a tissue, organ, or a multicellular organism.
4 P37091 (/ISS) P51171 (/ISS) Q28738 (/ISS) Q9WU39 (/ISS)
Sodium ion homeostasis GO:0055078
Any process involved in the maintenance of an internal steady state of sodium ions within an organism or cell.
4 P37091 (/ISS) P51171 (/ISS) Q28738 (/ISS) Q9WU39 (/ISS)
Sodium ion transmembrane transport GO:0035725
A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore.
3 H1AFJ7 (/IDA) P51170 (/IDA) P51170 (/IDA)
Sodium ion transport GO:0006814
The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
2 P37091 (/IDA) Q9WU39 (/IDA)
Sodium ion transport GO:0006814
The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
2 P51170 (/TAS) P51170 (/TAS)
Excretion GO:0007588
The elimination by an organism of the waste products that arise as a result of metabolic activity. These products include water, carbon dioxide (CO2), and nitrogenous compounds.
2 P51170 (/TAS) P51170 (/TAS)
Ion transmembrane transport GO:0034220
A process in which an ion is transported across a membrane.
2 P51170 (/TAS) P51170 (/TAS)
Multicellular organismal water homeostasis GO:0050891
Any process involved in the maintenance of an internal steady state of water within a tissue, organ, or a multicellular organism.
2 P51170 (/IDA) P51170 (/IDA)
Sodium ion homeostasis GO:0055078
Any process involved in the maintenance of an internal steady state of sodium ions within an organism or cell.
2 P51170 (/IDA) P51170 (/IDA)
Response to hypoxia GO:0001666
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
1 P37091 (/IEP)
Sodium ion transport GO:0006814
The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 Q9WU39 (/IGI)
Sodium ion transport GO:0006814
The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 P37091 (/IMP)
Sodium ion transport GO:0006814
The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 Q9WU39 (/ISO)
Wound healing, spreading of epidermal cells GO:0035313
The migration of an epidermal cell along or through a wound gap that contributes to the reestablishment of a continuous epidermis.
1 P37091 (/IMP)
Wound healing, spreading of epidermal cells GO:0035313
The migration of an epidermal cell along or through a wound gap that contributes to the reestablishment of a continuous epidermis.
1 Q9WU39 (/ISO)
Sodium ion transmembrane transport GO:0035725
A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore.
1 Q9WU39 (/ISO)
Multicellular organismal water homeostasis GO:0050891
Any process involved in the maintenance of an internal steady state of water within a tissue, organ, or a multicellular organism.
1 Q9WU39 (/ISO)
Sodium ion homeostasis GO:0055078
Any process involved in the maintenance of an internal steady state of sodium ions within an organism or cell.
1 Q9WU39 (/ISO)

There are 23 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
4 A5X2V1 (/IDA) A5X2V1 (/IDA) P51170 (/IDA) P51170 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
4 A5X2V1 (/IDA) A5X2V1 (/IDA) P51170 (/IDA) P51170 (/IDA)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
4 P37091 (/ISS) P51171 (/ISS) Q28738 (/ISS) Q9WU39 (/ISS)
Sodium channel complex GO:0034706
An ion channel complex through which sodium ions pass.
3 P37091 (/ISS) P51171 (/ISS) Q28738 (/ISS)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
2 P51170 (/TAS) P51170 (/TAS)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
2 P51170 (/IDA) P51170 (/IDA)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
2 P51170 (/TAS) P51170 (/TAS)
Sodium channel complex GO:0034706
An ion channel complex through which sodium ions pass.
2 P51170 (/IDA) P51170 (/IDA)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
2 P51170 (/IDA) P51170 (/IDA)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
1 Q9WU39 (/ISO)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 Q9WU39 (/ISO)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 Q9WU39 (/ISO)
External side of plasma membrane GO:0009897
The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface.
1 Q9WU39 (/IDA)
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
1 P37091 (/IDA)
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
1 Q9WU39 (/ISO)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
1 Q9WU39 (/IDA)
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 Q9WU39 (/IDA)
Apical plasma membrane GO:0016324
The region of the plasma membrane located at the apical end of the cell.
1 P37091 (/IDA)
Apical plasma membrane GO:0016324
The region of the plasma membrane located at the apical end of the cell.
1 Q9WU39 (/ISO)
Sodium channel complex GO:0034706
An ion channel complex through which sodium ions pass.
1 H1AFJ7 (/IC)
Sodium channel complex GO:0034706
An ion channel complex through which sodium ions pass.
1 Q9WU39 (/IGI)
Sodium channel complex GO:0034706
An ion channel complex through which sodium ions pass.
1 Q9WU39 (/ISO)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
1 Q9WU39 (/ISO)
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