The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
YojJ-like
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 2: Amiloride-sensitive sodium channel subunit beta 1

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 9 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
WW domain binding GO:0050699
Interacting selectively and non-covalently with a WW domain of a protein, a small module composed of 40 amino acids and plays a role in mediating protein-protein interactions via proline-rich regions.
7 P37088 (/IPI) P37089 (/IPI) P51168 (/IPI) P51168 (/IPI) Q61180 (/IPI) Q9WU38 (/IPI) Q9WU38 (/IPI)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
5 P37088 (/IPI) P51168 (/IPI) P51168 (/IPI) Q9WU38 (/IPI) Q9WU38 (/IPI)
Ligand-gated sodium channel activity GO:0015280
Enables the transmembrane transfer of a sodium ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts.
4 P37089 (/IDA) Q61180 (/IDA) Q9WU38 (/IDA) Q9WU38 (/IDA)
Ligand-gated sodium channel activity GO:0015280
Enables the transmembrane transfer of a sodium ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts.
3 Q61180 (/IGI) Q9WU38 (/IGI) Q9WU38 (/IGI)
Ligand-gated sodium channel activity GO:0015280
Enables the transmembrane transfer of a sodium ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts.
3 Q61180 (/ISO) Q9WU38 (/ISO) Q9WU38 (/ISO)
WW domain binding GO:0050699
Interacting selectively and non-covalently with a WW domain of a protein, a small module composed of 40 amino acids and plays a role in mediating protein-protein interactions via proline-rich regions.
3 Q61180 (/ISO) Q9WU38 (/ISO) Q9WU38 (/ISO)
Ligand-gated sodium channel activity GO:0015280
Enables the transmembrane transfer of a sodium ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts.
2 P51168 (/TAS) P51168 (/TAS)
Actin binding GO:0003779
Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments.
1 P37089 (/IDA)
Actin binding GO:0003779
Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments.
1 Q61180 (/ISO)

There are 20 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Sodium ion transmembrane transport GO:0035725
A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore.
18 A5D7U4 (/ISS) H2Q5A1 (/ISS) H2Q5A1 (/ISS) H2QAR6 (/ISS) H9GBX2 (/ISS) K7FQW8 (/ISS) K7GET2 (/ISS) O62816 (/ISS) O97741 (/ISS) O97742 (/ISS)
(8 more)
Multicellular organismal water homeostasis GO:0050891
Any process involved in the maintenance of an internal steady state of water within a tissue, organ, or a multicellular organism.
14 O62816 (/ISS) O97741 (/ISS) O97742 (/ISS) P37089 (/ISS) P51167 (/ISS) P51169 (/ISS) P55270 (/ISS) Q61180 (/ISS) Q92075 (/ISS) Q95165 (/ISS)
(4 more)
Sodium ion homeostasis GO:0055078
Any process involved in the maintenance of an internal steady state of sodium ions within an organism or cell.
14 O62816 (/ISS) O97741 (/ISS) O97742 (/ISS) P37089 (/ISS) P51167 (/ISS) P51169 (/ISS) P55270 (/ISS) Q61180 (/ISS) Q92075 (/ISS) Q95165 (/ISS)
(4 more)
Sodium ion transmembrane transport GO:0035725
A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore.
5 H1AFJ5 (/IDA) H1AFJ6 (/IDA) P37088 (/IDA) P51168 (/IDA) P51168 (/IDA)
Sodium ion transport GO:0006814
The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
4 P37089 (/IDA) Q61180 (/IDA) Q9WU38 (/IDA) Q9WU38 (/IDA)
Sodium ion transport GO:0006814
The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
3 Q61180 (/IGI) Q9WU38 (/IGI) Q9WU38 (/IGI)
Sodium ion transport GO:0006814
The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
3 Q61180 (/ISO) Q9WU38 (/ISO) Q9WU38 (/ISO)
Ion transmembrane transport GO:0034220
A process in which an ion is transported across a membrane.
3 P37088 (/TAS) P51168 (/TAS) P51168 (/TAS)
Sodium ion transmembrane transport GO:0035725
A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore.
3 Q61180 (/ISO) Q9WU38 (/ISO) Q9WU38 (/ISO)
Multicellular organismal water homeostasis GO:0050891
Any process involved in the maintenance of an internal steady state of water within a tissue, organ, or a multicellular organism.
3 P37088 (/IDA) P51168 (/IDA) P51168 (/IDA)
Multicellular organismal water homeostasis GO:0050891
Any process involved in the maintenance of an internal steady state of water within a tissue, organ, or a multicellular organism.
3 Q61180 (/ISO) Q9WU38 (/ISO) Q9WU38 (/ISO)
Sodium ion homeostasis GO:0055078
Any process involved in the maintenance of an internal steady state of sodium ions within an organism or cell.
3 P37088 (/IDA) P51168 (/IDA) P51168 (/IDA)
Sodium ion homeostasis GO:0055078
Any process involved in the maintenance of an internal steady state of sodium ions within an organism or cell.
3 Q61180 (/ISO) Q9WU38 (/ISO) Q9WU38 (/ISO)
Regulation of sodium ion transport GO:0002028
Any process that modulates the frequency, rate or extent of the directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
2 Q9WU38 (/ISO) Q9WU38 (/ISO)
Sodium ion transport GO:0006814
The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
2 P51168 (/TAS) P51168 (/TAS)
Excretion GO:0007588
The elimination by an organism of the waste products that arise as a result of metabolic activity. These products include water, carbon dioxide (CO2), and nitrogenous compounds.
2 P51168 (/TAS) P51168 (/TAS)
Wound healing, spreading of epidermal cells GO:0035313
The migration of an epidermal cell along or through a wound gap that contributes to the reestablishment of a continuous epidermis.
2 Q9WU38 (/ISO) Q9WU38 (/ISO)
Regulation of blood pressure GO:0008217
Any process that modulates the force with which blood travels through the circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure.
1 P37089 (/TAS)
Regulation of body fluid levels GO:0050878
Any process that modulates the levels of body fluids.
1 P37089 (/IMP)
Regulation of body fluid levels GO:0050878
Any process that modulates the levels of body fluids.
1 Q61180 (/ISO)

There are 36 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
14 O62816 (/ISS) O97741 (/ISS) O97742 (/ISS) P37089 (/ISS) P51167 (/ISS) P51169 (/ISS) P55270 (/ISS) Q61180 (/ISS) Q92075 (/ISS) Q95165 (/ISS)
(4 more)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
11 H1AFJ5 (/ISS) H2Q5A1 (/ISS) H2Q5A1 (/ISS) H9GBX2 (/ISS) K7GET2 (/ISS) O97741 (/ISS) P51167 (/ISS) P55270 (/ISS) Q61180 (/ISS) Q92075 (/ISS)
(1 more)
Sodium channel complex GO:0034706
An ion channel complex through which sodium ions pass.
11 O62816 (/ISS) O97741 (/ISS) O97742 (/ISS) P37089 (/ISS) P51167 (/ISS) P51169 (/ISS) P55270 (/ISS) Q92075 (/ISS) Q95165 (/ISS) Q9R1N2 (/ISS)
(1 more)
Apical plasma membrane GO:0016324
The region of the plasma membrane located at the apical end of the cell.
10 H2Q5A1 (/ISS) H2Q5A1 (/ISS) H9GBX2 (/ISS) K7GET2 (/ISS) O97741 (/ISS) P51167 (/ISS) P55270 (/ISS) Q61180 (/ISS) Q92075 (/ISS) Q9R1N2 (/ISS)
Acrosomal vesicle GO:0001669
A structure in the head of a spermatozoon that contains acid hydrolases, and is concerned with the breakdown of the outer membrane of the ovum during fertilization. It lies just beneath the plasma membrane and is derived from the lysosome.
7 H2Q5A1 (/ISS) H2Q5A1 (/ISS) O97741 (/ISS) P37088 (/ISS) P55270 (/ISS) Q61180 (/ISS) Q9R1N2 (/ISS)
Motile cilium GO:0031514
A cilium which may have a variable arrangement of axonemal microtubules and also contains molecular motors. It may beat with a whip-like pattern that promotes cell motility or transport of fluids and other cells across a cell surface, such as on epithelial cells that line the lumenal ducts of various tissues; or they may display a distinct twirling motion that directs fluid flow asymmetrically across the cellular surface to affect asymmetric body plan organization. Motile cilia can be found in single as well as multiple copies per cell.
7 O97741 (/ISS) P37089 (/ISS) P51167 (/ISS) P55270 (/ISS) Q61180 (/ISS) Q92075 (/ISS) Q9R1N2 (/ISS)
Ciliary membrane GO:0060170
The portion of the plasma membrane surrounding a cilium.
7 O97741 (/ISS) P37089 (/ISS) P51167 (/ISS) P55270 (/ISS) Q61180 (/ISS) Q92075 (/ISS) Q9R1N2 (/ISS)
Sperm principal piece GO:0097228
The segment of the sperm flagellum where the mitochondrial sheath ends, and the outer dense fibers (ODFs) associated with outer axonemal doublets 3 and 8 are replaced by the 2 longitudinal columns of the fibrous sheath (FS) which run the length of the principal piece and are stabilized by circumferential ribs. The principal piece makes up ~2/3 of the length of the sperm flagellum and is defined by the presence of the FS and of only 7 (rather than 9) ODFs which taper and then terminate near the distal end of the principal piece.
7 H2Q5A1 (/ISS) H2Q5A1 (/ISS) O97741 (/ISS) P37088 (/ISS) P55270 (/ISS) Q61180 (/ISS) Q9R1N2 (/ISS)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
3 P37088 (/TAS) P51168 (/TAS) P51168 (/TAS)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
3 P37088 (/IDA) P51168 (/IDA) P51168 (/IDA)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
3 Q61180 (/ISO) Q9WU38 (/ISO) Q9WU38 (/ISO)
External side of plasma membrane GO:0009897
The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface.
3 Q61180 (/IDA) Q9WU38 (/IDA) Q9WU38 (/IDA)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
3 Q61180 (/IDA) Q9WU38 (/IDA) Q9WU38 (/IDA)
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
3 Q61180 (/IDA) Q9WU38 (/IDA) Q9WU38 (/IDA)
Apical plasma membrane GO:0016324
The region of the plasma membrane located at the apical end of the cell.
3 H1AFJ5 (/IDA) P37088 (/IDA) P37089 (/IDA)
Apical plasma membrane GO:0016324
The region of the plasma membrane located at the apical end of the cell.
3 Q61180 (/ISO) Q9WU38 (/ISO) Q9WU38 (/ISO)
Sodium channel complex GO:0034706
An ion channel complex through which sodium ions pass.
3 P37088 (/IDA) P51168 (/IDA) P51168 (/IDA)
Sodium channel complex GO:0034706
An ion channel complex through which sodium ions pass.
3 Q61180 (/IGI) Q9WU38 (/IGI) Q9WU38 (/IGI)
Sodium channel complex GO:0034706
An ion channel complex through which sodium ions pass.
3 Q61180 (/ISO) Q9WU38 (/ISO) Q9WU38 (/ISO)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
3 P37088 (/IDA) P51168 (/IDA) P51168 (/IDA)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
3 Q61180 (/ISO) Q9WU38 (/ISO) Q9WU38 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
2 P37088 (/IDA) P37089 (/IDA)
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
2 Q9WU38 (/ISO) Q9WU38 (/ISO)
Sodium channel complex GO:0034706
An ion channel complex through which sodium ions pass.
2 H1AFJ5 (/IC) H1AFJ6 (/IC)
Acrosomal vesicle GO:0001669
A structure in the head of a spermatozoon that contains acid hydrolases, and is concerned with the breakdown of the outer membrane of the ovum during fertilization. It lies just beneath the plasma membrane and is derived from the lysosome.
1 P37089 (/IDA)
Acrosomal vesicle GO:0001669
A structure in the head of a spermatozoon that contains acid hydrolases, and is concerned with the breakdown of the outer membrane of the ovum during fertilization. It lies just beneath the plasma membrane and is derived from the lysosome.
1 Q61180 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q61180 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q61180 (/IDA)
Cortical actin cytoskeleton GO:0030864
The portion of the actin cytoskeleton, comprising filamentous actin and associated proteins, that lies just beneath the plasma membrane.
1 P37089 (/IDA)
Cortical actin cytoskeleton GO:0030864
The portion of the actin cytoskeleton, comprising filamentous actin and associated proteins, that lies just beneath the plasma membrane.
1 Q61180 (/ISO)
Motile cilium GO:0031514
A cilium which may have a variable arrangement of axonemal microtubules and also contains molecular motors. It may beat with a whip-like pattern that promotes cell motility or transport of fluids and other cells across a cell surface, such as on epithelial cells that line the lumenal ducts of various tissues; or they may display a distinct twirling motion that directs fluid flow asymmetrically across the cellular surface to affect asymmetric body plan organization. Motile cilia can be found in single as well as multiple copies per cell.
1 P37088 (/IDA)
Motile cilium GO:0031514
A cilium which may have a variable arrangement of axonemal microtubules and also contains molecular motors. It may beat with a whip-like pattern that promotes cell motility or transport of fluids and other cells across a cell surface, such as on epithelial cells that line the lumenal ducts of various tissues; or they may display a distinct twirling motion that directs fluid flow asymmetrically across the cellular surface to affect asymmetric body plan organization. Motile cilia can be found in single as well as multiple copies per cell.
1 Q61180 (/ISO)
Ciliary membrane GO:0060170
The portion of the plasma membrane surrounding a cilium.
1 P37088 (/IDA)
Ciliary membrane GO:0060170
The portion of the plasma membrane surrounding a cilium.
1 Q61180 (/ISO)
Sperm principal piece GO:0097228
The segment of the sperm flagellum where the mitochondrial sheath ends, and the outer dense fibers (ODFs) associated with outer axonemal doublets 3 and 8 are replaced by the 2 longitudinal columns of the fibrous sheath (FS) which run the length of the principal piece and are stabilized by circumferential ribs. The principal piece makes up ~2/3 of the length of the sperm flagellum and is defined by the presence of the FS and of only 7 (rather than 9) ODFs which taper and then terminate near the distal end of the principal piece.
1 P37089 (/IDA)
Sperm principal piece GO:0097228
The segment of the sperm flagellum where the mitochondrial sheath ends, and the outer dense fibers (ODFs) associated with outer axonemal doublets 3 and 8 are replaced by the 2 longitudinal columns of the fibrous sheath (FS) which run the length of the principal piece and are stabilized by circumferential ribs. The principal piece makes up ~2/3 of the length of the sperm flagellum and is defined by the presence of the FS and of only 7 (rather than 9) ODFs which taper and then terminate near the distal end of the principal piece.
1 Q61180 (/ISO)
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