The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 1: Stromal interaction molecule 1

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 19 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
7 D4A5X1 (/IPI) P70302 (/IPI) P83093 (/IPI) P83093 (/IPI) Q13586 (/IPI) Q13586 (/IPI) Q9P246 (/IPI)
Calcium channel regulator activity GO:0005246
Modulates the activity of a calcium channel.
6 P70302 (/ISS) P83093 (/ISS) P83093 (/ISS) P84903 (/ISS) Q58CP9 (/ISS) Q58CP9 (/ISS)
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
6 P70302 (/ISS) P83093 (/ISS) P83093 (/ISS) P84903 (/ISS) Q58CP9 (/ISS) Q58CP9 (/ISS)
Microtubule plus-end binding GO:0051010
Interacting selectively and non-covalently with the plus end of a microtubule.
4 P70302 (/ISS) P84903 (/ISS) Q58CP9 (/ISS) Q58CP9 (/ISS)
Calcium channel regulator activity GO:0005246
Modulates the activity of a calcium channel.
3 D4A5X1 (/IMP) P84903 (/IMP) Q9P246 (/IMP)
Calcium channel regulator activity GO:0005246
Modulates the activity of a calcium channel.
3 P70302 (/ISO) P83093 (/ISO) P83093 (/ISO)
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
3 Q13586 (/IDA) Q13586 (/IDA) Q9P246 (/IDA)
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
3 P70302 (/ISO) P83093 (/ISO) P83093 (/ISO)
Store-operated calcium channel activity GO:0015279
A ligand-gated ion channel activity which transports calcium in response to emptying of intracellular calcium stores.
3 P70302 (/ISO) P83093 (/ISO) P83093 (/ISO)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
3 P70302 (/IPI) Q13586 (/IPI) Q13586 (/IPI)
Protease binding GO:0002020
Interacting selectively and non-covalently with any protease or peptidase.
2 Q13586 (/IPI) Q13586 (/IPI)
Calcium channel regulator activity GO:0005246
Modulates the activity of a calcium channel.
2 Q13586 (/IDA) Q13586 (/IDA)
Store-operated calcium channel activity GO:0015279
A ligand-gated ion channel activity which transports calcium in response to emptying of intracellular calcium stores.
2 P83093 (/ISS) P83093 (/ISS)
Microtubule plus-end binding GO:0051010
Interacting selectively and non-covalently with the plus end of a microtubule.
2 Q13586 (/IDA) Q13586 (/IDA)
Protease binding GO:0002020
Interacting selectively and non-covalently with any protease or peptidase.
1 P70302 (/ISO)
Store-operated calcium channel activity GO:0015279
A ligand-gated ion channel activity which transports calcium in response to emptying of intracellular calcium stores.
1 Q9P246 (/IDA)
Store-operated calcium channel activity GO:0015279
A ligand-gated ion channel activity which transports calcium in response to emptying of intracellular calcium stores.
1 P84903 (/IMP)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
1 P70302 (/ISO)
Microtubule plus-end binding GO:0051010
Interacting selectively and non-covalently with the plus end of a microtubule.
1 P70302 (/ISO)

There are 36 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Activation of store-operated calcium channel activity GO:0032237
A process that initiates the activity of an inactive store-operated calcium channel.
6 P70302 (/ISS) P83093 (/ISS) P83093 (/ISS) P84903 (/ISS) Q58CP9 (/ISS) Q58CP9 (/ISS)
Store-operated calcium entry GO:0002115
A calcium ion entry mechanism in the plasma membrane activated by the depletion of calcium ion from the internal calcium ion store in the endoplasmic reticulum.
4 P70302 (/ISS) P84903 (/ISS) Q58CP9 (/ISS) Q58CP9 (/ISS)
Detection of calcium ion GO:0005513
The series of events in which a calcium ion stimulus is received by a cell and converted into a molecular signal.
4 P70302 (/ISS) P84903 (/ISS) Q58CP9 (/ISS) Q58CP9 (/ISS)
Positive regulation of adenylate cyclase activity GO:0045762
Any process that activates or increases the frequency, rate or extent of adenylate cyclase activity.
4 P70302 (/ISS) P84903 (/ISS) Q58CP9 (/ISS) Q58CP9 (/ISS)
Regulation of calcium ion transport GO:0051924
Any process that modulates the frequency, rate or extent of the directed movement of calcium ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
4 P70302 (/ISS) P84903 (/ISS) Q58CP9 (/ISS) Q58CP9 (/ISS)
Enamel mineralization GO:0070166
The process in which calcium salts, mainly carbonated hydroxyapatite, are deposited in tooth enamel.
4 P70302 (/ISS) P84903 (/ISS) Q58CP9 (/ISS) Q58CP9 (/ISS)
Regulation of store-operated calcium entry GO:2001256
Any process that modulates the frequency, rate or extent of store-operated calcium entry.
4 P70302 (/ISS) P84903 (/ISS) Q58CP9 (/ISS) Q58CP9 (/ISS)
Activation of store-operated calcium channel activity GO:0032237
A process that initiates the activity of an inactive store-operated calcium channel.
3 Q13586 (/IDA) Q13586 (/IDA) Q9P246 (/IDA)
Activation of store-operated calcium channel activity GO:0032237
A process that initiates the activity of an inactive store-operated calcium channel.
3 D4A5X1 (/IMP) P84903 (/IMP) Q9P246 (/IMP)
Activation of store-operated calcium channel activity GO:0032237
A process that initiates the activity of an inactive store-operated calcium channel.
3 P70302 (/ISO) P83093 (/ISO) P83093 (/ISO)
Regulation of store-operated calcium entry GO:2001256
Any process that modulates the frequency, rate or extent of store-operated calcium entry.
3 P84903 (/IMP) Q13586 (/IMP) Q13586 (/IMP)
Store-operated calcium entry GO:0002115
A calcium ion entry mechanism in the plasma membrane activated by the depletion of calcium ion from the internal calcium ion store in the endoplasmic reticulum.
2 Q13586 (/IDA) Q13586 (/IDA)
Detection of calcium ion GO:0005513
The series of events in which a calcium ion stimulus is received by a cell and converted into a molecular signal.
2 Q13586 (/IDA) Q13586 (/IDA)
Cellular calcium ion homeostasis GO:0006874
Any process involved in the maintenance of an internal steady state of calcium ions at the level of a cell.
2 P83093 (/ISO) P83093 (/ISO)
Cellular calcium ion homeostasis GO:0006874
Any process involved in the maintenance of an internal steady state of calcium ions at the level of a cell.
2 P83093 (/ISS) P83093 (/ISS)
Positive regulation of adenylate cyclase activity GO:0045762
Any process that activates or increases the frequency, rate or extent of adenylate cyclase activity.
2 Q13586 (/IDA) Q13586 (/IDA)
Positive regulation of angiogenesis GO:0045766
Any process that activates or increases angiogenesis.
2 Q13586 (/IMP) Q13586 (/IMP)
Regulation of calcium ion transport GO:0051924
Any process that modulates the frequency, rate or extent of the directed movement of calcium ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
2 Q13586 (/IDA) Q13586 (/IDA)
Positive regulation of calcium ion transport GO:0051928
Any process that activates or increases the frequency, rate or extent of the directed movement of calcium ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
2 P83093 (/ISO) P83093 (/ISO)
Positive regulation of calcium ion transport GO:0051928
Any process that activates or increases the frequency, rate or extent of the directed movement of calcium ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
2 P83093 (/ISS) P83093 (/ISS)
Enamel mineralization GO:0070166
The process in which calcium salts, mainly carbonated hydroxyapatite, are deposited in tooth enamel.
2 Q13586 (/IMP) Q13586 (/IMP)
Regulation of cardiac conduction GO:1903779
Any process that modulates the frequency, rate or extent of cardiac conduction.
2 Q13586 (/TAS) Q13586 (/TAS)
Store-operated calcium entry GO:0002115
A calcium ion entry mechanism in the plasma membrane activated by the depletion of calcium ion from the internal calcium ion store in the endoplasmic reticulum.
1 P70302 (/IGI)
Store-operated calcium entry GO:0002115
A calcium ion entry mechanism in the plasma membrane activated by the depletion of calcium ion from the internal calcium ion store in the endoplasmic reticulum.
1 P84903 (/IMP)
Store-operated calcium entry GO:0002115
A calcium ion entry mechanism in the plasma membrane activated by the depletion of calcium ion from the internal calcium ion store in the endoplasmic reticulum.
1 P70302 (/ISO)
Detection of calcium ion GO:0005513
The series of events in which a calcium ion stimulus is received by a cell and converted into a molecular signal.
1 P70302 (/ISO)
Cation transport GO:0006812
The directed movement of cations, atoms or small molecules with a net positive charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 P70302 (/IMP)
Cellular calcium ion homeostasis GO:0006874
Any process involved in the maintenance of an internal steady state of calcium ions at the level of a cell.
1 Q9P246 (/IMP)
Myotube differentiation GO:0014902
The process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotube differentiation starts with myoblast fusion and the appearance of specific cell markers (this is the cell development step). Then individual myotubes can fuse to form bigger myotubes and start to contract. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse.
1 P70302 (/IMP)
Positive regulation of adenylate cyclase activity GO:0045762
Any process that activates or increases the frequency, rate or extent of adenylate cyclase activity.
1 P70302 (/ISO)
Positive regulation of angiogenesis GO:0045766
Any process that activates or increases angiogenesis.
1 P70302 (/ISO)
Regulation of calcium ion transport GO:0051924
Any process that modulates the frequency, rate or extent of the directed movement of calcium ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 P70302 (/ISO)
Positive regulation of calcium ion transport GO:0051928
Any process that activates or increases the frequency, rate or extent of the directed movement of calcium ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 Q9P246 (/IDA)
Positive regulation of calcium ion transport GO:0051928
Any process that activates or increases the frequency, rate or extent of the directed movement of calcium ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 Q9P246 (/IMP)
Enamel mineralization GO:0070166
The process in which calcium salts, mainly carbonated hydroxyapatite, are deposited in tooth enamel.
1 P70302 (/ISO)
Regulation of store-operated calcium entry GO:2001256
Any process that modulates the frequency, rate or extent of store-operated calcium entry.
1 P70302 (/ISO)

There are 26 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
11 E9PNJ4 (/IDA) E9PNJ4 (/IDA) E9PNJ4 (/IDA) G0XQ39 (/IDA) G0XQ39 (/IDA) H0YDB2 (/IDA) P70302 (/IDA) P84903 (/IDA) Q13586 (/IDA) Q13586 (/IDA)
(1 more)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
5 D4A5X1 (/IDA) P84903 (/IDA) Q13586 (/IDA) Q13586 (/IDA) Q9P246 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
5 P70302 (/ISS) P83093 (/ISS) P83093 (/ISS) Q58CP9 (/ISS) Q58CP9 (/ISS)
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
4 P83093 (/ISS) P83093 (/ISS) Q58CP9 (/ISS) Q58CP9 (/ISS)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
4 P70302 (/ISS) P84903 (/ISS) Q58CP9 (/ISS) Q58CP9 (/ISS)
Integral component of endoplasmic reticulum membrane GO:0030176
The component of the endoplasmic reticulum membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
4 P70302 (/ISS) P84903 (/ISS) Q58CP9 (/ISS) Q58CP9 (/ISS)
Sarcoplasmic reticulum membrane GO:0033017
The lipid bilayer surrounding the sarcoplasmic reticulum.
4 P70302 (/ISS) P84903 (/ISS) Q58CP9 (/ISS) Q58CP9 (/ISS)
Plasma membrane raft GO:0044853
A membrane raft that is part of the plasma membrane.
4 P70302 (/ISS) P84903 (/ISS) Q58CP9 (/ISS) Q58CP9 (/ISS)
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
3 P70302 (/ISO) P83093 (/ISO) P83093 (/ISO)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
3 P70302 (/ISO) P83093 (/ISO) P83093 (/ISO)
Endoplasmic reticulum membrane GO:0005789
The lipid bilayer surrounding the endoplasmic reticulum.
2 Q13586 (/TAS) Q13586 (/TAS)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
2 Q13586 (/IDA) Q13586 (/IDA)
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
2 P83093 (/ISA) P83093 (/ISA)
Integral component of endoplasmic reticulum membrane GO:0030176
The component of the endoplasmic reticulum membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
2 Q13586 (/IDA) Q13586 (/IDA)
Cortical endoplasmic reticulum GO:0032541
A cortical network of highly dynamic tubules that are juxtaposed to the plasma membrane and undergo ring closure and tubule-branching movements.
2 Q13586 (/IDA) Q13586 (/IDA)
Cortical endoplasmic reticulum GO:0032541
A cortical network of highly dynamic tubules that are juxtaposed to the plasma membrane and undergo ring closure and tubule-branching movements.
2 Q13586 (/TAS) Q13586 (/TAS)
Sarcoplasmic reticulum membrane GO:0033017
The lipid bilayer surrounding the sarcoplasmic reticulum.
2 Q13586 (/IDA) Q13586 (/IDA)
Plasma membrane raft GO:0044853
A membrane raft that is part of the plasma membrane.
2 Q13586 (/IDA) Q13586 (/IDA)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 P70302 (/ISO)
Integral component of endoplasmic reticulum membrane GO:0030176
The component of the endoplasmic reticulum membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 P70302 (/ISO)
Growth cone GO:0030426
The migrating motile tip of a growing neuron projection, where actin accumulates, and the actin cytoskeleton is the most dynamic.
1 P84903 (/IDA)
Growth cone GO:0030426
The migrating motile tip of a growing neuron projection, where actin accumulates, and the actin cytoskeleton is the most dynamic.
1 P70302 (/ISO)
Cortical endoplasmic reticulum GO:0032541
A cortical network of highly dynamic tubules that are juxtaposed to the plasma membrane and undergo ring closure and tubule-branching movements.
1 P70302 (/ISO)
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
1 P70302 (/IPI)
Sarcoplasmic reticulum membrane GO:0033017
The lipid bilayer surrounding the sarcoplasmic reticulum.
1 P70302 (/ISO)
Plasma membrane raft GO:0044853
A membrane raft that is part of the plasma membrane.
1 P70302 (/ISO)
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