The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
EF-hand
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 57: Tubulin polymerization-promoting protein family me...

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 6 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Tubulin binding GO:0015631
Interacting selectively and non-covalently with monomeric or multimeric forms of tubulin, including microtubules.
12 A4IIY2 (/ISS) D3ZQL7 (/ISS) O94811 (/ISS) O94811 (/ISS) Q2VPM9 (/ISS) Q3ZCC8 (/ISS) Q3ZCC8 (/ISS) Q3ZCC8 (/ISS) Q5PPN5 (/ISS) Q7TQD2 (/ISS)
(2 more)
Tubulin binding GO:0015631
Interacting selectively and non-covalently with monomeric or multimeric forms of tubulin, including microtubules.
7 O94811 (/IDA) O94811 (/IDA) P59282 (/IDA) P59282 (/IDA) Q27957 (/IDA) Q9BW30 (/IDA) Q9BW30 (/IDA)
Microtubule binding GO:0008017
Interacting selectively and non-covalently with microtubules, filaments composed of tubulin monomers.
5 D3ZQL7 (/ISS) O94811 (/ISS) O94811 (/ISS) Q7TQD2 (/ISS) Q7TQD2 (/ISS)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
4 D3ZQL7 (/IPI) O94811 (/IPI) O94811 (/IPI) Q27957 (/IPI)
Tubulin binding GO:0015631
Interacting selectively and non-covalently with monomeric or multimeric forms of tubulin, including microtubules.
4 Q0P5Y3 (/ISO) Q7TQD2 (/ISO) Q7TQD2 (/ISO) Q9CRB6 (/ISO)
Microtubule binding GO:0008017
Interacting selectively and non-covalently with microtubules, filaments composed of tubulin monomers.
1 Q27957 (/IDA)

There are 12 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Microtubule bundle formation GO:0001578
A process that results in a parallel arrangement of microtubules.
12 A4IIY2 (/ISS) D3ZQL7 (/ISS) O94811 (/ISS) O94811 (/ISS) Q2VPM9 (/ISS) Q3ZCC8 (/ISS) Q3ZCC8 (/ISS) Q3ZCC8 (/ISS) Q5PPN5 (/ISS) Q7TQD2 (/ISS)
(2 more)
Microtubule bundle formation GO:0001578
A process that results in a parallel arrangement of microtubules.
5 O94811 (/IDA) O94811 (/IDA) Q27957 (/IDA) Q9BW30 (/IDA) Q9BW30 (/IDA)
Positive regulation of protein complex assembly GO:0031334
Any process that activates or increases the frequency, rate or extent of protein complex assembly.
5 D3ZQL7 (/ISS) O94811 (/ISS) O94811 (/ISS) Q7TQD2 (/ISS) Q7TQD2 (/ISS)
Microtubule polymerization GO:0046785
The addition of tubulin heterodimers to one or both ends of a microtubule.
5 O94811 (/IDA) O94811 (/IDA) Q27957 (/IDA) Q7TQD2 (/IDA) Q7TQD2 (/IDA)
Microtubule polymerization GO:0046785
The addition of tubulin heterodimers to one or both ends of a microtubule.
5 D3ZQL7 (/ISS) O94811 (/ISS) O94811 (/ISS) Q7TQD2 (/ISS) Q7TQD2 (/ISS)
Positive regulation of protein polymerization GO:0032273
Any process that activates or increases the frequency, rate or extent of the process of creating protein polymers.
4 D3ZQL7 (/ISS) Q27957 (/ISS) Q7TQD2 (/ISS) Q7TQD2 (/ISS)
Microtubule bundle formation GO:0001578
A process that results in a parallel arrangement of microtubules.
3 Q7TQD2 (/ISO) Q7TQD2 (/ISO) Q9CRB6 (/ISO)
Positive regulation of protein polymerization GO:0032273
Any process that activates or increases the frequency, rate or extent of the process of creating protein polymers.
2 O94811 (/IDA) O94811 (/IDA)
Positive regulation of protein polymerization GO:0032273
Any process that activates or increases the frequency, rate or extent of the process of creating protein polymers.
2 Q7TQD2 (/ISO) Q7TQD2 (/ISO)
Microtubule polymerization GO:0046785
The addition of tubulin heterodimers to one or both ends of a microtubule.
2 Q7TQD2 (/ISO) Q7TQD2 (/ISO)
Positive regulation of protein complex assembly GO:0031334
Any process that activates or increases the frequency, rate or extent of protein complex assembly.
1 Q27957 (/IDA)
Axon extension GO:0048675
Long distance growth of a single axon process involved in cellular development.
1 A0A2R8QB80 (/IMP)

There are 14 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
6 O94811 (/IDA) O94811 (/IDA) P59282 (/IDA) P59282 (/IDA) Q4L233 (/IDA) Q4L233 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
4 O94811 (/IDA) O94811 (/IDA) Q7TQD2 (/IDA) Q7TQD2 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
4 O94811 (/IDA) O94811 (/IDA) Q7TQD2 (/IDA) Q7TQD2 (/IDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
4 O94811 (/IDA) O94811 (/IDA) Q4L233 (/IDA) Q4L233 (/IDA)
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
4 D3ZQL7 (/ISS) Q27957 (/ISS) Q7TQD2 (/ISS) Q7TQD2 (/ISS)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
3 Q0P5Y3 (/ISO) Q7TQD2 (/ISO) Q7TQD2 (/ISO)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
2 Q7TQD2 (/ISO) Q7TQD2 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
2 Q7TQD2 (/ISO) Q7TQD2 (/ISO)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
2 Q7TQD2 (/ISO) Q7TQD2 (/ISO)
Myelin sheath GO:0043209
An electrically insulating fatty layer that surrounds the axons of many neurons. It is an outgrowth of glial cells: Schwann cells supply the myelin for peripheral neurons while oligodendrocytes supply it to those of the central nervous system.
2 Q7TQD2 (/HDA) Q7TQD2 (/HDA)
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
2 O94811 (/IDA) O94811 (/IDA)
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
2 Q7TQD2 (/ISO) Q7TQD2 (/ISO)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q27957 (/ISS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q27957 (/ISS)
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