The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
EF-hand
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 159: Calcium uptake protein 1, mitochondrial

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 10 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
8 A4IG32 (/ISS) D2HZB0 (/ISS) Q0IIL1 (/ISS) Q4R518 (/ISS) Q4R518 (/ISS) Q4R518 (/ISS) Q6P6Q9 (/ISS) Q8VCX5 (/ISS)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
2 Q8VCX5 (/IPI) Q9BPX6 (/IPI)
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
2 Q8VCX5 (/IPI) Q9BPX6 (/IPI)
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
1 Q9BPX6 (/IDA)
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
1 Q8VCX5 (/IMP)
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
1 Q8VCX5 (/ISO)
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
1 Q9BPX6 (/TAS)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
1 Q9BPX6 (/IPI)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
1 Q8VCX5 (/ISO)
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
1 Q8VCX5 (/ISO)

There are 24 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Mitochondrial calcium ion transmembrane transport GO:0006851
The process in which a calcium ion (Ca2+) is transported across a mitochondrial membrane, into or out of the mitochondrion.
8 A4IG32 (/ISS) D2HZB0 (/ISS) Q0IIL1 (/ISS) Q4R518 (/ISS) Q4R518 (/ISS) Q4R518 (/ISS) Q6P6Q9 (/ISS) Q8VCX5 (/ISS)
Mitochondrial calcium ion homeostasis GO:0051560
Any process involved in the maintenance of an internal steady state of calcium ions within the cytoplasm of a cell or between mitochondria and their surroundings.
8 A4IG32 (/ISS) D2HZB0 (/ISS) Q0IIL1 (/ISS) Q4R518 (/ISS) Q4R518 (/ISS) Q4R518 (/ISS) Q6P6Q9 (/ISS) Q8VCX5 (/ISS)
Positive regulation of mitochondrial calcium ion concentration GO:0051561
Any process that increases the concentration of calcium ions in mitochondria.
8 A4IG32 (/ISS) D2HZB0 (/ISS) Q0IIL1 (/ISS) Q4R518 (/ISS) Q4R518 (/ISS) Q4R518 (/ISS) Q6P6Q9 (/ISS) Q8VCX5 (/ISS)
Calcium ion import GO:0070509
The directed movement of calcium ions into a cell or organelle.
8 A4IG32 (/ISS) D2HZB0 (/ISS) Q0IIL1 (/ISS) Q4R518 (/ISS) Q4R518 (/ISS) Q4R518 (/ISS) Q6P6Q9 (/ISS) Q8VCX5 (/ISS)
Calcium import into the mitochondrion GO:0036444
A process in which a calcium ion (Ca2+) is transported from the cytosol, into the mitochondrial matrix.
7 D2HZB0 (/ISS) Q0IIL1 (/ISS) Q4R518 (/ISS) Q4R518 (/ISS) Q4R518 (/ISS) Q6P6Q9 (/ISS) Q8VCX5 (/ISS)
Regulation of cellular hyperosmotic salinity response GO:1900069
Any process that modulates the frequency, rate or extent of cellular hyperosmotic salinity response.
7 D2HZB0 (/ISS) Q0IIL1 (/ISS) Q4R518 (/ISS) Q4R518 (/ISS) Q4R518 (/ISS) Q6P6Q9 (/ISS) Q8VCX5 (/ISS)
Mitochondrial calcium ion transmembrane transport GO:0006851
The process in which a calcium ion (Ca2+) is transported across a mitochondrial membrane, into or out of the mitochondrion.
1 Q9BPX6 (/IDA)
Mitochondrial calcium ion transmembrane transport GO:0006851
The process in which a calcium ion (Ca2+) is transported across a mitochondrial membrane, into or out of the mitochondrion.
1 Q9BPX6 (/IMP)
Mitochondrial calcium ion transmembrane transport GO:0006851
The process in which a calcium ion (Ca2+) is transported across a mitochondrial membrane, into or out of the mitochondrion.
1 Q8VCX5 (/ISO)
Mitochondrial calcium ion transmembrane transport GO:0006851
The process in which a calcium ion (Ca2+) is transported across a mitochondrial membrane, into or out of the mitochondrion.
1 Q9BPX6 (/TAS)
Defense response GO:0006952
Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack.
1 Q9BPX6 (/TAS)
Calcium import into the mitochondrion GO:0036444
A process in which a calcium ion (Ca2+) is transported from the cytosol, into the mitochondrial matrix.
1 Q9BPX6 (/IMP)
Calcium import into the mitochondrion GO:0036444
A process in which a calcium ion (Ca2+) is transported from the cytosol, into the mitochondrial matrix.
1 Q8VCX5 (/ISO)
Protein homooligomerization GO:0051260
The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer.
1 Q9BPX6 (/IDA)
Protein homooligomerization GO:0051260
The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer.
1 Q8VCX5 (/ISO)
Mitochondrial calcium ion homeostasis GO:0051560
Any process involved in the maintenance of an internal steady state of calcium ions within the cytoplasm of a cell or between mitochondria and their surroundings.
1 Q9BPX6 (/IMP)
Mitochondrial calcium ion homeostasis GO:0051560
Any process involved in the maintenance of an internal steady state of calcium ions within the cytoplasm of a cell or between mitochondria and their surroundings.
1 Q8VCX5 (/ISO)
Positive regulation of mitochondrial calcium ion concentration GO:0051561
Any process that increases the concentration of calcium ions in mitochondria.
1 Q9BPX6 (/IDA)
Positive regulation of mitochondrial calcium ion concentration GO:0051561
Any process that increases the concentration of calcium ions in mitochondria.
1 Q9BPX6 (/IMP)
Positive regulation of mitochondrial calcium ion concentration GO:0051561
Any process that increases the concentration of calcium ions in mitochondria.
1 Q8VCX5 (/ISO)
Calcium ion import GO:0070509
The directed movement of calcium ions into a cell or organelle.
1 Q9BPX6 (/IDA)
Calcium ion import GO:0070509
The directed movement of calcium ions into a cell or organelle.
1 Q8VCX5 (/ISO)
Regulation of cellular hyperosmotic salinity response GO:1900069
Any process that modulates the frequency, rate or extent of cellular hyperosmotic salinity response.
1 Q9BPX6 (/IMP)
Regulation of cellular hyperosmotic salinity response GO:1900069
Any process that modulates the frequency, rate or extent of cellular hyperosmotic salinity response.
1 Q8VCX5 (/ISO)

There are 21 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Mitochondrial inner membrane GO:0005743
The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
8 A4IG32 (/ISS) D2HZB0 (/ISS) Q0IIL1 (/ISS) Q4R518 (/ISS) Q4R518 (/ISS) Q4R518 (/ISS) Q6P6Q9 (/ISS) Q8VCX5 (/ISS)
Mitochondrial intermembrane space GO:0005758
The region between the inner and outer lipid bilayers of the mitochondrial envelope.
8 A4IG32 (/ISS) D2HZB0 (/ISS) Q0IIL1 (/ISS) Q4R518 (/ISS) Q4R518 (/ISS) Q4R518 (/ISS) Q6P6Q9 (/ISS) Q8VCX5 (/ISS)
Integral component of mitochondrial membrane GO:0032592
The component of the mitochondrial membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
8 A4IG32 (/ISS) D2HZB0 (/ISS) Q0IIL1 (/ISS) Q4R518 (/ISS) Q4R518 (/ISS) Q4R518 (/ISS) Q6P6Q9 (/ISS) Q8VCX5 (/ISS)
Uniplex complex GO:1990246
A calcium channel complex in the mitochondrial inner membrane capable of highly-selective calcium channel activity. Its components include the EF-hand-containing proteins mitochondrial calcium uptake 1 (MICU1) and MICU2, the pore-forming subunit mitochondrial calcium uniporter (MCU) and its paralog MCUb, and the MCU regulator EMRE.
8 A4IG32 (/ISS) D2HZB0 (/ISS) Q0IIL1 (/ISS) Q4R518 (/ISS) Q4R518 (/ISS) Q4R518 (/ISS) Q6P6Q9 (/ISS) Q8VCX5 (/ISS)
Calcium channel complex GO:0034704
An ion channel complex through which calcium ions pass.
6 Q0IIL1 (/ISS) Q4R518 (/ISS) Q4R518 (/ISS) Q4R518 (/ISS) Q6P6Q9 (/ISS) Q9BPX6 (/ISS)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
3 A0A0U1RRK1 (/IDA) F6XEV2 (/IDA) Q9BPX6 (/IDA)
Intracellular GO:0005622
The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.
1 Q9BPX6 (/TAS)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 Q8VCX5 (/HDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 Q8VCX5 (/ISO)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 Q9BPX6 (/TAS)
Mitochondrial inner membrane GO:0005743
The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
1 Q9BPX6 (/IDA)
Mitochondrial inner membrane GO:0005743
The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
1 Q9BPX6 (/IMP)
Mitochondrial inner membrane GO:0005743
The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
1 Q8VCX5 (/ISO)
Mitochondrial inner membrane GO:0005743
The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
1 Q9BPX6 (/TAS)
Mitochondrial intermembrane space GO:0005758
The region between the inner and outer lipid bilayers of the mitochondrial envelope.
1 Q9BPX6 (/IDA)
Mitochondrial intermembrane space GO:0005758
The region between the inner and outer lipid bilayers of the mitochondrial envelope.
1 Q8VCX5 (/ISO)
Integral component of mitochondrial membrane GO:0032592
The component of the mitochondrial membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 Q9BPX6 (/IDA)
Integral component of mitochondrial membrane GO:0032592
The component of the mitochondrial membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 Q8VCX5 (/ISO)
Calcium channel complex GO:0034704
An ion channel complex through which calcium ions pass.
1 Q8VCX5 (/IDA)
Uniplex complex GO:1990246
A calcium channel complex in the mitochondrial inner membrane capable of highly-selective calcium channel activity. Its components include the EF-hand-containing proteins mitochondrial calcium uptake 1 (MICU1) and MICU2, the pore-forming subunit mitochondrial calcium uniporter (MCU) and its paralog MCUb, and the MCU regulator EMRE.
1 Q9BPX6 (/IDA)
Uniplex complex GO:1990246
A calcium channel complex in the mitochondrial inner membrane capable of highly-selective calcium channel activity. Its components include the EF-hand-containing proteins mitochondrial calcium uptake 1 (MICU1) and MICU2, the pore-forming subunit mitochondrial calcium uniporter (MCU) and its paralog MCUb, and the MCU regulator EMRE.
1 Q8VCX5 (/ISO)
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