The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
EF-hand
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 137: Calmodulin-like protein 11

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 7 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
3 O23320 (/IPI) O23320 (/IPI) P02599 (/IPI)
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
1 P02599 (/IDA)
Myosin I binding GO:0017024
Interacting selectively and non-covalently with a class I myosin; myosin I heavy chains are single-headed, possess tails of various lengths, and do not self-associate into bipolar filaments.
1 P02599 (/IDA)
Kinase binding GO:0019900
Interacting selectively and non-covalently with a kinase, any enzyme that catalyzes the transfer of a phosphate group.
1 P02599 (/IPI)
Protein kinase binding GO:0019901
Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
1 P02599 (/IPI)
Troponin I binding GO:0031013
Interacting selectively and non-covalently with troponin I, the inhibitory subunit of the troponin complex.
1 P02599 (/IDA)
Cell adhesion molecule binding GO:0050839
Interacting selectively and non-covalently with a cell adhesion molecule.
1 P02599 (/IPI)

There are 12 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Detection of calcium ion GO:0005513
The series of events in which a calcium ion stimulus is received by a cell and converted into a molecular signal.
2 O23320 (/ISS) O23320 (/ISS)
Calcium-mediated signaling GO:0019722
Any intracellular signal transduction in which the signal is passed on within the cell via calcium ions.
2 O23320 (/IGI) O23320 (/IGI)
Mitotic cytokinesis GO:0000281
A cell cycle process that results in the division of the cytoplasm of a cell after mitosis, resulting in the separation of the original cell into two daughter cells.
1 P02599 (/IMP)
Regulation of sorocarp stalk cell differentiation GO:0031285
Any process that modulates the frequency, rate or extent of sorocarp stalk cell differentiation. An example of this process is found in Dictyostelium discoideum.
1 P02599 (/IMP)
Positive regulation of ATPase activity GO:0032781
Any process that activates or increases the rate of ATP hydrolysis by an ATPase.
1 P02599 (/IDA)
Regulation of kinase activity GO:0043549
Any process that modulates the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
1 P02599 (/IDA)
Negative regulation of proteolysis GO:0045861
Any process that stops, prevents, or reduces the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein.
1 P02599 (/IDA)
Positive regulation of sequestering of calcium ion GO:0051284
Any process that activates or increases the frequency, rate or extent of the binding or confining calcium ions such that they are separated from other components of a biological system.
1 P02599 (/IMP)
Positive regulation of cyclic-nucleotide phosphodiesterase activity GO:0051343
Any process that activates or increases the frequency, rate or extent of cyclic nucleotide phosphodiesterase activity, the catalysis of the reaction: nucleotide 3',5'-cyclic phosphate + H2O = nucleotide 5'-phosphate.
1 P02599 (/IDA)
Positive regulation of positive chemotaxis to cAMP GO:0061122
Any process that increases the rate, frequency, or extent of directed movement of a motile cell or organism up a concentration gradient of 3',5'-cAMP.
1 P02599 (/IDA)
Establishment of protein localization to vacuole GO:0072666
The directed movement of a protein to a specific location in a vacuole.
1 P02599 (/IDA)
Negative regulation of asexual reproduction GO:1903665
Any process that stops, prevents or reduces the frequency, rate or extent of asexual reproduction.
1 P02599 (/IDA)

There are 5 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Contractile vacuole GO:0000331
A specialized vacuole of eukaryotic cells, especially Protozoa, that fills with water from the cytoplasm and then discharges this externally by the opening of contractile vacuole pores. Its function is probably osmoregulatory.
1 P02599 (/IDA)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
1 P02599 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 P02599 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 P02599 (/IDA)
Extracellular matrix GO:0031012
A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues.
1 P02599 (/IDA)
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